CN102260225A - 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 - Google Patents
用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 Download PDFInfo
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- CN102260225A CN102260225A CN2011101468354A CN201110146835A CN102260225A CN 102260225 A CN102260225 A CN 102260225A CN 2011101468354 A CN2011101468354 A CN 2011101468354A CN 201110146835 A CN201110146835 A CN 201110146835A CN 102260225 A CN102260225 A CN 102260225A
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- Prior art keywords
- phenylpiperazine
- acceptable salt
- analog derivative
- pharmacy acceptable
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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Abstract
Description
Claims (10)
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CN2011101468354A CN102260225B (zh) | 2011-06-02 | 2011-06-02 | 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 |
PCT/CN2012/076384 WO2012163291A1 (zh) | 2011-06-02 | 2012-06-01 | 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012163291A1 (zh) * | 2011-06-02 | 2012-12-06 | 广州翰鼎医药科技有限公司 | 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 |
CN103965159A (zh) * | 2014-05-17 | 2014-08-06 | 广州医科大学 | 醚类芳基哌嗪衍生物及其盐、制备方法和用途 |
CN105061352A (zh) * | 2015-07-29 | 2015-11-18 | 广州市广金投资管理有限公司 | 芳基哌嗪衍生物ⅲ及其盐、制备方法和用途 |
CN107879997A (zh) * | 2017-12-25 | 2018-04-06 | 三峡大学 | 一种小分子抑制剂sld1338及其在制药中的应用 |
CN108530391A (zh) * | 2018-05-17 | 2018-09-14 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
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JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
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CN102260225B (zh) * | 2011-06-02 | 2013-08-21 | 蒋杰 | 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012163291A1 (zh) * | 2011-06-02 | 2012-12-06 | 广州翰鼎医药科技有限公司 | 用于抑制肿瘤转移和肿瘤血管生长的苯基哌嗪类衍生物 |
CN103965159A (zh) * | 2014-05-17 | 2014-08-06 | 广州医科大学 | 醚类芳基哌嗪衍生物及其盐、制备方法和用途 |
CN105061352A (zh) * | 2015-07-29 | 2015-11-18 | 广州市广金投资管理有限公司 | 芳基哌嗪衍生物ⅲ及其盐、制备方法和用途 |
CN107879997A (zh) * | 2017-12-25 | 2018-04-06 | 三峡大学 | 一种小分子抑制剂sld1338及其在制药中的应用 |
CN107879997B (zh) * | 2017-12-25 | 2021-01-26 | 三峡大学 | 一种小分子抑制剂sld1338及其在制药中的应用 |
CN108530391A (zh) * | 2018-05-17 | 2018-09-14 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
CN108530391B (zh) * | 2018-05-17 | 2022-05-17 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
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WO2012163291A1 (zh) | 2012-12-06 |
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