CN102238959A - 包含卡介菌多糖和卡介菌核酸的组合物及其在制备药剂中的应用 - Google Patents
包含卡介菌多糖和卡介菌核酸的组合物及其在制备药剂中的应用 Download PDFInfo
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- CN102238959A CN102238959A CN2009801485026A CN200980148502A CN102238959A CN 102238959 A CN102238959 A CN 102238959A CN 2009801485026 A CN2009801485026 A CN 2009801485026A CN 200980148502 A CN200980148502 A CN 200980148502A CN 102238959 A CN102238959 A CN 102238959A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (7)
- 权 利 要 求 书1. 一种包含卡介菌多糖和卡介菌核酸的组合物,其特征在于,该组合 物中多糖的质量百分含量为 10%〜69%, 该组合物中核酸的质量百分含量 为 30%〜89%。
- 2. 根据权利要求 1所述的包含卡介菌多糖和卡介菌核酸的组合物,其 特征在于, 该组合物由卡介菌多糖和卡介菌核酸经混合制成; 其中卡介菌 多糖和卡介菌核酸通过以下方法从卡介菌培养物中提取得到:( 1 ) 从卡介菌培养物中提取卡介菌多糖、 核酸混合物;(2) 通过离子交换层析法从卡介菌多糖、 核酸混合物中分离出卡介 菌多糖和卡介菌核酸;(3 ) 将步骤 (2) 所得卡介菌多糖与卡介菌核酸按比例混合。
- 3. 根据权利要求 2所述的包含卡介菌多糖和卡介菌核酸的组合物,其 特征在于, 步骤 (1 ) 包括以下步骤:( 11 ) 将卡介菌菌种接种于适合分支杆菌生长的培养基中培养至对 数期时收集菌体;( 12) 上述菌体经破碎后离心收集上清液;( 13 ) 上清液经有机溶剂抽提后, 通过透析法或凝胶层析法除去有
- 4. 根据权利要求 2所述的包含卡介菌多糖和卡介菌核酸的组合物,其 特征在于, 步骤 (2) 中所述的离子交换层析法为采用阴离子交换介质的 柱层析法。
- 5. 根据权利要求 4所述的包含卡介菌多糖和卡介菌核酸的组合物,其 特征在于, 所述阴离子交换介质为 Q S<sub>e</sub>ph<sub>ar0Se</sub><sup>TM</sup> XL。
- 6. 根据权利要求 5所述的包含卡介菌多糖和卡介菌核酸的组合物,其 特征在于, 其特征在于, 步骤 (2) 包括以下步骤:(21 ) 将步骤(1 ) 获得的卡介菌多糖、 核酸混合物上样, 同时开始 收集流穿液;(22 ) 上样结束后, 用生理盐水洗柱, 收集洗柱液, 将流穿液和洗 柱液合并;(23 ) 将合并液采用脱盐柱进行脱盐, 得到卡介菌多糖;(24) 步骤 (22 ) 洗柱结束后, 采用浓度为 0.1~2mol/L的氯化钠溶 液进行洗脱, 收集洗脱峰;(24) 将收集的洗脱液采用脱盐柱进行脱盐, 得到卡介菌核酸
- 7. 权利要求 1 所述的包含卡介菌多糖和卡介菌核酸的组合物在制备 治疗或预防微生物感染、 肿瘤或变态反应疾病的药物中的应用。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2009/000069 WO2010081257A1 (zh) | 2009-01-16 | 2009-01-16 | 包含卡介菌多糖和卡介菌核酸的组合物及其在制备药剂中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN102238959A true CN102238959A (zh) | 2011-11-09 |
CN102238959B CN102238959B (zh) | 2013-03-06 |
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CN2009801485026A Active CN102238959B (zh) | 2009-01-16 | 2009-01-16 | 包含卡介菌多糖和卡介菌核酸的组合物及其在制备药剂中的应用 |
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CN (1) | CN102238959B (zh) |
WO (1) | WO2010081257A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10598995B2 (en) | 2015-09-28 | 2020-03-24 | Boe Technology Group Co., Ltd. | Array substrate, fabrication method, and corresponding display panel and electronic device |
CN113462762A (zh) * | 2020-03-30 | 2021-10-01 | 湖南斯奇生物制药有限公司 | 多糖核酸免疫调节药物的质量检测方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102166220A (zh) * | 2011-01-29 | 2011-08-31 | 广州医学院第一附属医院 | 一种bcg免疫抑制剂及其制备方法和用途 |
CN103923851B (zh) * | 2013-11-15 | 2017-02-15 | 吉林亚泰生物药业股份有限公司 | 一种卡介菌多糖核酸制备过程中的斜面培养新工艺 |
CN104306408B (zh) * | 2014-10-31 | 2019-02-01 | 潘霞 | 一种治疗小儿湿疹的多糖核酸药物组合物 |
CN107446886A (zh) * | 2016-05-31 | 2017-12-08 | 湖南斯奇生物制药有限公司 | 卡介菌多糖核酸在促进cik细胞增殖和提高cik细胞的杀瘤活性中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1494918A (zh) * | 2002-07-18 | 2004-05-12 | 李伟华 | 一种治疗癌症的药物组合物及制备方法 |
CN1470286A (zh) * | 2002-07-25 | 2004-01-28 | 李伟华 | 一种增强免疫力的药物组合物及制备方法 |
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- 2009-01-16 CN CN2009801485026A patent/CN102238959B/zh active Active
- 2009-01-16 WO PCT/CN2009/000069 patent/WO2010081257A1/zh active Application Filing
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10598995B2 (en) | 2015-09-28 | 2020-03-24 | Boe Technology Group Co., Ltd. | Array substrate, fabrication method, and corresponding display panel and electronic device |
CN113462762A (zh) * | 2020-03-30 | 2021-10-01 | 湖南斯奇生物制药有限公司 | 多糖核酸免疫调节药物的质量检测方法 |
CN113462762B (zh) * | 2020-03-30 | 2022-05-27 | 湖南斯奇生物制药有限公司 | 多糖核酸免疫调节药物的质量检测方法 |
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CN102238959B (zh) | 2013-03-06 |
WO2010081257A1 (zh) | 2010-07-22 |
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Application publication date: 20111109 Assignee: Hunan Siqi Biopharmaceutical Co., Ltd. Assignor: Jiuzhitang Co., Ltd. Contract record no.: 2013430000114 Denomination of invention: Composition comprising bacillus calmette guerin polysaccharides and bacillus calmette guerin nucleic acids and use of preparing medicament thereof Granted publication date: 20130306 License type: Exclusive License Record date: 20130719 |
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Effective date of registration: 20160725 Address after: 410331 No. 21, link road, Liuyang biological medicine Park, Hunan Patentee after: Hunan Siqi Biopharmaceutical Co., Ltd. Address before: Section 129, Furong Middle Road, Changsha City, Hunan Province, China Patentee before: Jiuzhitang Co., Ltd. |