CN102233010B - Children bellyache patch, and preparation method thereof - Google Patents
Children bellyache patch, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medical patch for treating children bellyache, and a preparation method of the patch. The patch is prepared from main materials of wrinkled giant hyssop, dahurian angelica, perilla frutescens, cortex magnoliae officinalis, paeonia lactiflora pallas, licorice, rhizoma corydalis, radix aucklandiae and common fennel fruit, and auxiliary materials of glycerin, sodium carboxymethyl cellulose and sorbitol. The patch is prepared from the materials according to certain proportions. According to the invention, the curative effect of the medicine is brought through the transdermal absorption at areas of umbilical skins. The patch brings a substantial treating effect to children functional bellyache, and the effective rate reaches above 96%. The patch has characteristics of quick affecting and convenient use. With the patch, toxic and side effects of the medicine to children alimentary canal and liver can be avoided. Therefore, the patch is an ideal Chinese medical preparation for treating children functional bellyache.
Description
Technical field
The present invention relates to a kind of Chinese herbs paste for the treatment of abdominal pain in children and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Stomachache is one of children's's common sympton, refers to that the lower abdomen pain that reaches of the following umbilicus of gastral cavilty is main disease on every side.The reason that causes abdominal pain in children is complicated, get rid of other diseases, such as, the stomachache that bellyworm, adenomesenteritis, appendicitis, hernia, abdominal epilepsy, abdomen purpura, Surgical Acute Venter Diseases etc. cause, how because of due to the product of climate change, eating and drinking without temperance and surfeit cold.The doctor trained in Western medicine at present cooperation Anisodamine such as vitamin B1, B6, oryzanol that adopt reaches therapeutic purposes by alleviating smooth muscle spasm and trophic nerve more, determined curative effect, but cure the symptoms, not the disease, can only when the stomachache outbreak, play mitigation, effectively Control in recurring.The traditional Chinese medical science to the treatment of this disease mainly take endo-medicine as main, as, traditional HUOXIANG ZHENGQI WAN, lenitive pill etc., and for example, China Patent Publication No. CN1147390A is disclosed is the Chinese medicine for oral administration of the treatment abdominal pain in children made of raw material by Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Rhizoma Alpiniae Officinarum, Fructus Aurantii, Semen Arecae sheet, Radix Codonopsis, Poria, the Radix Linderae, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched), Radix Glycyrrhizae.Though these medicines all have certain effect to abdominal pain in children Emergent therapy and treatment at a specified future date, its slow curative effect, effect are also not ideal enough, easily digestant for baby road and Liver and kidney are had side effects.And Chinese medicine for oral administration is difficult for being accepted by children's, is easy to cause the resistance of children's's instinct, if force, tends to strengthen child's psychological feelings, brings out mental maladjustment, affects mental health.Therefore, having better curative effect and effect from the thinking of " inner disease outer treat " research and development treats rapidly the Chinese medicine for external application of abdominal pain in children and seems particularly necessary.
Technology contents
Purpose of the present invention is exactly for above-mentioned disease, a kind for the treatment of both the principal and secondary aspects of a disease is provided, good effect, effect is rapidly, easy to use, be easy to accept and Eexternal-use Chinese medicine plaster--the children bellyache patch of the treatment abdominal pain in children that can not have side effects to digestant for baby road and Liver and kidney for children's.
Another object of the present invention provides the preparation method of this children bellyache patch.
Children bellyache patch of the present invention is to be prepared from according to the following weight proportioning by crude drug Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi and adjuvant glycerol, Carboxymethyl cellulose sodium, sorbitol:
Herba Pogostemonis 300-600 part; Radix Angelicae Dahuricae 200-500 part; Folium Perillae 200-400 part;
Cortex Magnoliae Officinalis 200-400 part; Radix Paeoniae Alba 400-800 part; Radix Glycyrrhizae 100-300 part;
Rhizoma Corydalis 200-500 part; Radix Aucklandiae 100-300 part; Fructus Foeniculi 50-200 part.
Glycerol 15-30 part; Carboxymethyl cellulose sodium 10-25 part; Sorbitol 10-25 part.
The preferred weight proportioning of each crude drug and each adjuvant is in the children bellyache patch of the present invention:
Herba Pogostemonis 400-500 part; Radix Angelicae Dahuricae 300-400 part; Folium Perillae 250-350 part;
Cortex Magnoliae Officinalis 250-350 part; Radix Paeoniae Alba 500-700 part; Radix Glycyrrhizae 150-250 part;
Rhizoma Corydalis 300-400 part; Radix Aucklandiae 150-250 part; Fructus Foeniculi 80-150 part.
Glycerol 20-30 part; Carboxymethyl cellulose sodium 10-20 part; Sorbitol 10-20 part.
The optimum weight proportioning of each crude drug and each adjuvant is in the children bellyache patch of the present invention:
450 parts of Herba Pogostemoniss; 350 parts of the Radixs Angelicae Dahuricae; 300 parts of Folium Perillaes;
300 parts of Cortex Magnoliae Officinalis; 600 parts of the Radix Paeoniae Albas; 200 parts in Radix Glycyrrhizae;
350 parts of Rhizoma Corydalis; 200 parts of the Radix Aucklandiae; 100 parts of Fructus Foeniculi.
25 parts of glycerol; 15 parts of Carboxymethyl cellulose sodium; 15 parts of sorbitol.
Theory of Chinese medical science thinks that the multiple reason of abdominal pain in children is that the spleen and stomach in children is weak, and passages through which vital energy circulates is not contained, be subject to it is attacked by the cold and evil, children's's breast food can not save certainly in addition again, is easily hindered by the breast food, thereby causes that infantile dyspepsia, mechanism of qi heap soil or fertilizer over and around the roots are held back, passages through which vital energy circulates is lacked of proper care, obstructed, the stagnation of QI and blood may bring about pain of the stagnation of QI.Record in " General Treatise on the Cause and Symptoms of Diseases ": " children's's cardiac and abdominal pain person, the intestines and stomach place is held under the arm cold, is cruelly added by cold again, front and back cold air is repetitious moving, fights mutually with visceral-qi, impacts between the trusted subordinate up and down with gas, so make cardiac and abdominal pain also ".The Etiological that this shows abdominal pain in children is cold, folder food.Pharmaceutical formulation of the present invention is reused Herba Pogostemonis, because of Herba Pogostemonis slightly warm in nature acrid in the mouth, returns the taste lung meridian, hot dispersing wind and cold, and eliminating turbid pathogen with aromatics, ascending the clear and descending the turbid can be driven away the cold-evil of the intestines and stomach, and the effect of warming middle-JIAO to relieve pain is arranged.Be aided with hot using warming therapy Folium Perillae, the Radix Angelicae Dahuricae, play altogether and deliver cold expelling, circulation of qi promoting and in, the merit of pain relieving.Assistant is with Cortex Magnoliae Officinalis, the Radix Aucklandiae, Rhizoma Corydalis, the damp eliminating of Fructus Foeniculi warming middle-JIAO, the promoting the circulation of QI to relieve pain removing food stagnancy relieving dyspepsia of holding concurrently; Help again with the Radix Paeoniae Alba, Radix Glycyrrhizae, get its suppressing the hyperactive liver pain relieving, the merit of astringing YIN to stop sweating, the modern medicine study Radix Paeoniae Alba, Radix Glycyrrhizae are share and can alleviate smooth muscle spasm, reach the effect of relieving spasm to stop pain.All medicines share, and the cold-evil must be fallen apart, and food stagnation must be changed, and rises clearly turbid falling, and mechanism of qi is unobstructed, the spontaneous recovery of then suffering from abdominal pain.Glycerol has preferably moisture-keeping function in this prescription adjuvant, and Carboxymethyl cellulose sodium and sorbitol are stabilizing agent and the moisture-keeping function of having held concurrently.
The preparation method step of children bellyache patch of the present invention is as follows:
A) in accordance with regulations proportioning weighting raw materials Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi and adjuvant glycerol, Carboxymethyl cellulose sodium, sorbitol mix each crude drug that takes by weighing and pulverize and be coarse powder, place for subsequent use;
B) the crude drug coarse powder behind the co-grinding is inserted the sand of lid, in copper or the enamelled vessel, the cold water that adds 3-5 times of weight of spice soaks, soak time 12-20 hour, after immersion is finished medicinal liquid is warming up to 75-85 ℃, and kept this temperature 1.5-2.5 hour, then medicine liquid heating is boiled, keep slight boiling condition to decoct 1-3 hour with little fire again, cross its decocting liquid of leaching, then adding boiled water in medicinal residues decocts twice under slight boiling condition again, the 2-3 that each amount of water is spice weight doubly, each decocting time is 1.5-2 hour, merges three times decocting liquid, staticly settles, use again four layers of filtered through gauze three times, with the decocting liquid of finishing filtration under agitated conditions with little fiery simmer down to thick paste;
C) will stipulate that the adjuvant glycerol, Carboxymethyl cellulose sodium of proportioning and sorbitol add step b) in the crude drug thick paste that makes, evenly coat pressure sensitive adhesive and stick adding thick paste behind the adjuvant, be covered with facial film, namely get this Chinese herbs paste.Every subsides contain concentrated thick paste 2 grams of crude drug.
The using method of this children bellyache patch: this plaster is external use plaster, throws off the plaster surface protection film during use and is affixed on umbilical part, and one time one subsides were changed 1 time in 24 hours.During use, the greasy and stodgy food of avoiding eating anything raw or cold, skin ulceration place forbidding the umbilical part pruritus occurs, redness has erythra person after use, should stop using.
This Chinese herbs paste is to children's's functional abdominal pain, and is evident in efficacy.Through selection 108 routine abdominal pain in children disease patient clinicals are observed, concrete outcome is as follows:
(1) physical data: accept altogether 108 routine abdominal pain in children disease patients for medical treatment, male 58 examples wherein, women 50 examples are age 2-9 one full year of life, 5.5 years old mean age, the course of disease the shortest a few hours, the longest 3 years.
(2) diagnostic criteria:
1. paroxysmal abdominal pain, with umbilicus Zhou Duojian, time remaining a few minutes to 30 minute are not waited, and can accompany n or V, and stool is normal, and the outbreak intermission, all were normal;
2. without diarrhoea, bloody purulent stool etc., look into stool routine examination, routine blood test is normal;
3. get rid of the other diseases that causes stomachache, as, bellyworm, adenomesenteritis, appendicitis, hernia, abdominal epilepsy, abdomen purpura, Surgical Acute Venter Diseases etc.;
4. antibiotic therapy is invalid.
(3) Therapeutic Method: use this Chinese herbs paste, be affixed on umbilical part, one time one subsides were changed 1 time in 24 hours, and seven days is a course for the treatment of, uses continuously for two courses for the treatment of.
(4) efficacy assessment standard: recovery from illness: use continuously two courses for the treatment of, stomachache disappears, drug withdrawal nothing recurrence in 5 months; Take a turn for the better: used continuously for two courses for the treatment of, stomachache takes a turn for the better, recurrent number＜3 time in the drug withdrawal 5 months; Invalid: as to be used in conjunction 2 courses for the treatment of stomachache without changing, though or the stomachache recurrent number 〉=3 time person in the drug withdrawal 5 months that takes a turn for the better.
(5), therapeutic outcome: cure 98 examples, 6 examples that take a turn for the better, total effective rate 96.3%.The fastest onset 20 minutes.
Chinese herbs paste of the present invention mainly produces therapeutical effect by umbilicus Transdermal absorption medicine effective ingredient, is easy to be accepted by children's, has effectively avoided the toxic and side effects of medicine to organs such as child's digestive tract and livers, has effect rapidly, characteristics easy to use.This medicine manufacture method is simple, and medicine is with low cost, for vast family can bear, is a kind of ideal Chinese medicine preparation of the children's's for the treatment of functional abdominal pain.
The specific embodiment
The below narrates three embodiment of the present invention:
Embodiment 1
Crude drug Herba Pogostemonis 480g, the Radix Angelicae Dahuricae 300g that takes by weighing, Folium Perillae 330g, Cortex Magnoliae Officinalis 250g, Radix Paeoniae Alba 650g, Radix Glycyrrhizae 150g, Rhizoma Corydalis 380g, Radix Aucklandiae 150g, Fructus Foeniculi 120g and adjuvant glycerol 20g, Carboxymethyl cellulose sodium 18g, sorbitol 12g.
Preparation method:
A) crude drug Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi mixing and the pulverizing with above-mentioned weight is coarse powder, places for subsequent use;
B) the crude drug coarse powder behind the co-grinding is inserted in the copper vessel of lid, the cold water that adds 5 times of weight of spice soaks, soak time 12 hours, after immersion is finished medicinal liquid is warming up to 85 ℃, and kept this temperature 1.5 hours, then medicine liquid heating is boiled, keep slight boiling condition to decoct 2.5 hours with little fire again, cross its decocting liquid of leaching, then in medicinal residues, add boiled water and under slight boiling condition, decoct again twice, each amount of water is 2 times of spice weight, each decocting time is 2 hours, merges three times decocting liquid, staticly settles, use again four layers of filtered through gauze three times, with the decocting liquid of finishing filtration under agitated conditions with little fiery simmer down to thick paste;
C) the adjuvant glycerol of above-mentioned weight, Carboxymethyl cellulose sodium and sorbitol are added step b) in the crude drug thick paste that makes, evenly coat pressure sensitive adhesive and stick adding thick paste behind the adjuvant, be covered with facial film, namely get this Chinese herbs paste.Every subsides contain concentrated thick paste 2 grams of crude drug.
Using method: external, be affixed on umbilical part, one time one subsides were changed 1 time in 24 hours.
Implementation column 2
Crude drug Herba Pogostemonis 400g, the Radix Angelicae Dahuricae 400g that takes by weighing, Folium Perillae 250g, Cortex Magnoliae Officinalis 350g, Radix Paeoniae Alba 500g, Radix Glycyrrhizae 250g, Rhizoma Corydalis 300g, Radix Aucklandiae 250g, Fructus Foeniculi 80g and adjuvant glycerol 28g, Carboxymethyl cellulose sodium 10g, sorbitol 20g.
Preparation method:
A) crude drug Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi mixing and the pulverizing with above-mentioned weight is coarse powder, places for subsequent use;
B) the crude drug coarse powder behind the co-grinding is inserted in the copper vessel of lid, the cold water that adds 3 times of weight of spice soaks, soak time 18 hours, after immersion is finished medicinal liquid is warming up to 75 ℃, and kept this temperature 2.5 hours, then medicine liquid heating is boiled, keep slight boiling condition to decoct 1.5 hours with little fire again, cross its decocting liquid of leaching, then in medicinal residues, add boiled water and under slight boiling condition, decoct again twice, each amount of water is 3 times of spice weight, each decocting time is 1.5 hours, merges three times decocting liquid, staticly settles, use again four layers of filtered through gauze three times, with the decocting liquid of finishing filtration under agitated conditions with little fiery simmer down to thick paste;
C) the adjuvant glycerol of above-mentioned weight, Carboxymethyl cellulose sodium and sorbitol are added step b) in the crude drug thick paste that makes, evenly coat pressure sensitive adhesive and stick adding thick paste behind the adjuvant, be covered with facial film, namely get this Chinese herbs paste.Every subsides contain concentrated thick paste 2 grams of crude drug.
Using method is with embodiment 1.
Embodiment 3
Crude drug Herba Pogostemonis 450g, the Radix Angelicae Dahuricae 350g that takes by weighing, Folium Perillae 300g, Cortex Magnoliae Officinalis 300g, Radix Paeoniae Alba 600g, Radix Glycyrrhizae 200g, Rhizoma Corydalis 350g, Radix Aucklandiae 200g, Fructus Foeniculi 100g and adjuvant glycerol 25g, Carboxymethyl cellulose sodium 15g, sorbitol 15g.
Preparation method:
A) crude drug Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi mixing and the pulverizing with above-mentioned weight is coarse powder, places for subsequent use;
B) the crude drug coarse powder behind the co-grinding is inserted in the sand container made of lid, the cold water that adds 4 times of weight of spice soaks, soak time 15 hours, after immersion is finished medicinal liquid is warming up to 80 ℃, and kept this temperature 2 hours, then medicine liquid heating is boiled, keep slight boiling condition to decoct 2 hours with little fire again, cross its decocting liquid of leaching, then in medicinal residues, add boiled water and under slight boiling condition, decoct again twice, each amount of water is 2.5 times of spice weight, each decocting time is 2 hours, merges three times decocting liquid, staticly settles, use again four layers of filtered through gauze three times, with the decocting liquid of finishing filtration under agitated conditions with little fiery simmer down to thick paste;
C) the adjuvant glycerol of above-mentioned weight, Carboxymethyl cellulose sodium and sorbitol are added step b) in the crude drug thick paste that makes, evenly coat pressure sensitive adhesive and stick adding thick paste behind the adjuvant, be covered with facial film, namely get this Chinese herbs paste.Every subsides contain concentrated thick paste 2 grams of crude drug.
Using method is with embodiment 1.
Claims (4)
1. treat the patch of abdominal pain in children, it is characterized in that it is to be prepared from according to the following weight proportioning by crude drug Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi and adjuvant glycerol, Carboxymethyl cellulose sodium, sorbitol:
Herba Pogostemonis 300-600 part; Radix Angelicae Dahuricae 200-500 part; Folium Perillae 200-400 part;
Cortex Magnoliae Officinalis 200-400 part; Radix Paeoniae Alba 400-800 part; Radix Glycyrrhizae 100-300 part;
Rhizoma Corydalis 200-500 part; Radix Aucklandiae 100-300 part; Fructus Foeniculi 50-200 part;
Glycerol 15-30 part; Carboxymethyl cellulose sodium 10-25 part; Sorbitol 10-25 part.
2. the patch for the treatment of abdominal pain in children according to claim 1 is characterized in that, the weight proportion of each crude drug and each adjuvant is:
Herba Pogostemonis 400-500 part; Radix Angelicae Dahuricae 300-400 part; Folium Perillae 250-350 part;
Cortex Magnoliae Officinalis 250-350 part; Radix Paeoniae Alba 500-700 part; Radix Glycyrrhizae 150-250 part;
Rhizoma Corydalis 300-400 part; Radix Aucklandiae 150-250 part; Fructus Foeniculi 80-150 part;
Glycerol 20-30 part; Carboxymethyl cellulose sodium 10-20 part; Sorbitol 10-20 part.
3. the patch for the treatment of abdominal pain in children according to claim 1 is characterized in that, the weight proportion of each crude drug and each adjuvant is:
450 parts of Herba Pogostemoniss; 350 parts of the Radixs Angelicae Dahuricae; 300 parts of Folium Perillaes;
300 parts of Cortex Magnoliae Officinalis; 600 parts of the Radix Paeoniae Albas; 200 parts in Radix Glycyrrhizae;
350 parts of Rhizoma Corydalis; 200 parts of the Radix Aucklandiae; 100 parts of Fructus Foeniculi;
25 parts of glycerol; 15 parts of Carboxymethyl cellulose sodium; 15 parts of sorbitol.
4. the preparation method of the patch of claim 1,2 or 3 described treatment abdominal pain in children is characterized in that, described preparation method adopts following steps:
A) in accordance with regulations proportioning weighting raw materials Herba Pogostemonis, the Radix Angelicae Dahuricae, Folium Perillae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis, the Radix Aucklandiae, Fructus Foeniculi and adjuvant glycerol, Carboxymethyl cellulose sodium, sorbitol mix each crude drug that takes by weighing and pulverize and be coarse powder, place for subsequent use;
B) the crude drug coarse powder behind the co-grinding is inserted the sand of lid, in copper or the enamelled vessel, the cold water that adds 3-5 times of weight of spice soaks, soak time 12-20 hour, after immersion is finished medicinal liquid is warming up to 75-85 ℃, and kept this temperature 1.5-2.5 hour, then medicine liquid heating is boiled, keep slight boiling condition to decoct 1-3 hour with little fire again, cross its decocting liquid of leaching, then adding boiled water in medicinal residues decocts twice under slight boiling condition again, the 2-3 that each amount of water is spice weight doubly, each decocting time is 1.5-2 hour, merges three times decocting liquid, staticly settles, use again four layers of filtered through gauze three times, with the decocting liquid of finishing filtration under agitated conditions with little fiery simmer down to thick paste;
C) will stipulate that the adjuvant glycerol, Carboxymethyl cellulose sodium of proportioning and sorbitol add step b) in the crude drug thick paste that makes, thick paste behind the adding adjuvant is evenly coated pressure sensitive adhesive to be sticked, be covered with facial film, namely get this Chinese herbs paste, every subsides contain concentrated thick paste 2 grams of crude drug.
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| CN 201010157504 CN102233010B (en) | 2010-04-28 | 2010-04-28 | Children bellyache patch, and preparation method thereof |
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| CN 201010157504 CN102233010B (en) | 2010-04-28 | 2010-04-28 | Children bellyache patch, and preparation method thereof |
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| CN102233010A CN102233010A (en) | 2011-11-09 |
| CN102233010B true CN102233010B (en) | 2013-03-20 |
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| CN 201010157504 Expired - Fee Related CN102233010B (en) | 2010-04-28 | 2010-04-28 | Children bellyache patch, and preparation method thereof |
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| CN106421041A (en) * | 2016-10-19 | 2017-02-22 | 丁奇 | Traditional Chinese medicine patch for treating infant recurrent respiratory tract infection |
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| CN1915411A (en) * | 2006-08-01 | 2007-02-21 | 黄必问 | Prepared Chinese medicine for treating disease of alimentary canal and herbalist doctor described typhoid fever, and preparation method |
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| CN1915411A (en) * | 2006-08-01 | 2007-02-21 | 黄必问 | Prepared Chinese medicine for treating disease of alimentary canal and herbalist doctor described typhoid fever, and preparation method |
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