CN102227217A - 改善认知功能的方法和组合物 - Google Patents

改善认知功能的方法和组合物 Download PDF

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Publication number
CN102227217A
CN102227217A CN2009801474233A CN200980147423A CN102227217A CN 102227217 A CN102227217 A CN 102227217A CN 2009801474233 A CN2009801474233 A CN 2009801474233A CN 200980147423 A CN200980147423 A CN 200980147423A CN 102227217 A CN102227217 A CN 102227217A
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CN
China
Prior art keywords
oxo
methyl
hydrogen
alkyl
pharmaceutically acceptable
Prior art date
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Pending
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CN2009801474233A
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English (en)
Chinese (zh)
Inventor
M·伽拉赫尔
R·哈比尔曼
M·T·高
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Johns Hopkins University
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Johns Hopkins University
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Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Priority to CN201710440380.4A priority Critical patent/CN107243007A/zh
Publication of CN102227217A publication Critical patent/CN102227217A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801474233A 2008-10-16 2009-10-16 改善认知功能的方法和组合物 Pending CN102227217A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710440380.4A CN107243007A (zh) 2008-10-16 2009-10-16 改善认知功能的方法和组合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10584708P 2008-10-16 2008-10-16
US61/105,847 2008-10-16
US15263109P 2009-02-13 2009-02-13
US61/152,631 2009-02-13
US17553609P 2009-05-05 2009-05-05
US61/175,536 2009-05-05
PCT/US2009/005647 WO2010044878A1 (en) 2008-10-16 2009-10-16 Methods and compositions for improving cognitive function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710440380.4A Division CN107243007A (zh) 2008-10-16 2009-10-16 改善认知功能的方法和组合物

Publications (1)

Publication Number Publication Date
CN102227217A true CN102227217A (zh) 2011-10-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN2009801474233A Pending CN102227217A (zh) 2008-10-16 2009-10-16 改善认知功能的方法和组合物
CN201710440380.4A Pending CN107243007A (zh) 2008-10-16 2009-10-16 改善认知功能的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201710440380.4A Pending CN107243007A (zh) 2008-10-16 2009-10-16 改善认知功能的方法和组合物

Country Status (11)

Country Link
US (5) US20100099735A1 (https=)
EP (2) EP2346500B1 (https=)
JP (3) JP5917148B2 (https=)
CN (2) CN102227217A (https=)
AU (1) AU2009303834B2 (https=)
CA (1) CA2740610C (https=)
DK (2) DK3260118T3 (https=)
EA (1) EA033130B1 (https=)
ES (2) ES2865504T3 (https=)
HK (1) HK1245099A1 (https=)
WO (1) WO2010044878A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021063414A1 (zh) * 2019-09-30 2021-04-08 厦门大学 戊酸衍生物在治疗唐氏综合征中的应用

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ES2865504T3 (es) 2008-10-16 2021-10-15 Univ Johns Hopkins Procedimientos y composiciones para la mejora de la función cognitiva
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EP2968257A4 (en) * 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
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CN109892247B (zh) * 2019-04-19 2023-08-18 桂林医学院 一种猫参与的检测大鼠认知功能的实验装置
CN116075302A (zh) * 2020-07-10 2023-05-05 艾吉因生物股份有限公司 GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法
JP2024508052A (ja) * 2021-02-26 2024-02-21 シンデシ セラピューティクス ソシエテ アノニム 認知障害の治療のための化合物
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021063414A1 (zh) * 2019-09-30 2021-04-08 厦门大学 戊酸衍生物在治疗唐氏综合征中的应用

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DK3260118T3 (da) 2021-04-19
CA2740610C (en) 2020-01-07
EA201170571A1 (ru) 2011-12-30
JP6271641B2 (ja) 2018-01-31
US20100099735A1 (en) 2010-04-22
BRPI0920342A2 (pt) 2020-06-23
DK2346500T3 (en) 2017-07-17
JP2014169339A (ja) 2014-09-18
EA033130B1 (ru) 2019-08-30
HK1245099A1 (zh) 2018-08-24
AU2009303834A1 (en) 2010-04-22
EP2346500A1 (en) 2011-07-27
US20220218665A1 (en) 2022-07-14
CN107243007A (zh) 2017-10-13
EP2346500B1 (en) 2017-05-17
HK1248543A1 (en) 2018-10-19
JP2012505883A (ja) 2012-03-08
JP5917148B2 (ja) 2016-05-11
US20240293363A1 (en) 2024-09-05
EP3260118B1 (en) 2021-03-24
US20150094352A1 (en) 2015-04-02
ES2637497T3 (es) 2017-10-13
JP2016147915A (ja) 2016-08-18
WO2010044878A1 (en) 2010-04-22
EP3260118A1 (en) 2017-12-27
CA2740610A1 (en) 2010-04-22
US20120046336A1 (en) 2012-02-23
AU2009303834B2 (en) 2016-08-11
ES2865504T3 (es) 2021-10-15
US8604075B2 (en) 2013-12-10

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