CN102178816A - 一种治疗颈腰腿痛的中药组合物 - Google Patents
一种治疗颈腰腿痛的中药组合物 Download PDFInfo
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Abstract
一种治疗颈腰腿痛的中药组合物，该中药组合物是由独活，秦艽，红花，穿山龙，伸筋草，茯苓，瞿麦，五灵脂，威灵仙，川乌，香附，没药，乳香，桑寄生，甘松，蒲公英，续断制成。临床可用于治疗颈腰腿痛。
Description
技术领域
本发明属于中药技术领域，尤其是涉及一种治疗颈腰腿痛的中药组合物。
背景技术
颈腰腿痛是常见病，中医将颈腰腿痛统属于“痹病”范畴，“痹”即闭阻不通之意。痹证是指人体正气不足时，外由风寒湿等邪气侵袭，内由痰、瘀、热毒引起经脉闭阻，致气血运行不畅，故见关节肿痛、僵硬、屈伸不利、活动障碍等病证。中医认为颈腰腿痛的病因“病从风起”，因此，方剂所用药物大多针对风而下药。针对上述原则，选用了清热利湿、通络止痛、益气祛邪等药物进行组合，得到一种中药组合物：并根据中医理论进行组方，如主药有祛风除寒湿、暖脾补肾，对风湿痛、脾痛关节酸痛有镇痛之功效，其余药物有舒经活血，清热解毒等作用。对其进行了药效学试验，并取得了较好的效果。
发明内容
本发明的目的在于提供一种治疗效果好、有效率高、对人体无毒副作用的治疗颈腰腿痛的中药组合物。
本发明的目的是这样实现的，根据中医药理论，利用中药独特的药性，采用独活，秦艽，红花，穿山龙，伸筋草，茯苓，瞿麦，五灵脂，威灵仙，川乌，香附，没药，乳香，桑寄生，甘松，蒲公英，续断按照一定的配伍要求，经过加工制成。
制备本发明中药组合物由下述原料药制成：独活40-60份，秦艽40-60份，红花40-60份，穿山龙40-60份，伸筋草40-60份，茯苓40-60份，瞿麦40－60份，五灵脂40-60份，威灵仙40-60份，川乌5-10份，香附10-30份，没药10-30份，乳香10-30份，桑寄生40-60份，甘松10-30份，蒲公英10-30份，续断40-60份。
本发明中药组合物原料药的最佳重量份为：独活50份，秦艽50份，红花50份，穿山龙50份，伸筋草50份，茯苓50份，瞿麦50份，五灵脂50份，威灵仙50份，川乌7份，香附20份，没药20份，乳香20份，桑寄生50份，甘松20份，蒲公英20份，续断50份。
可以将上述药物制成药剂学上的任何一种剂型，如片剂、丸剂、散剂、胶囊剂等。
本发明中药的药理作用如下：
独活：辛、苦，微温。归肝、膀胱经。祛风湿，止痹痛，解表。用于风寒湿痹痛，外感风寒挟湿表证。
秦艽：苦、辛，微寒。祛风湿，止痹痛，退虚热，清湿热。用于风湿痹痛，骨蒸潮热。
红花：辛、温。归心、肝经。活血通经，祛瘀止痛。用于血滞经闭，痛经，心腹瘀痛。
穿山龙：苦，微寒。归肝、肺经。祛风湿，活血通络，清肺化痰。用于风湿关节痛及关节扭伤，还可用于热痰咳嗽。
伸筋草：苦、辛，温。归肝经。祛风湿，舒筋活络。用于风湿痹痛，四肢关节酸痛。
茯苓：甘、淡，平。归心、脾、肾经。利水渗湿，健脾安神。用于各种水肿，脾虚诸证。
瞿麦：苦、寒。归心、小肠、膀胱经。利尿通淋，活血通经。用于湿热淋证，血热瘀阻之经闭活月经不调。
五灵脂：苦、咸、甘，问。归肝经。活血止痛，化瘀止血。用于瘀血阻滞诸证。
威灵仙：辛、咸，辛温。归膀胱经。祛风湿，通经络，消骨鲠。用于风湿痹痛，诸骨哽咽。
川乌：辛、苦，温。归心、脾、肝、肾经。用于风寒湿痹，跌打损伤。
香附：辛、微苦、微甘、平。归肝、脾、三焦经。用于气滞胁痛，腹痛，痛经，乳房胀痛。
没药：苦、辛，平。归心、肝、脾经。活血止痛，消肿生肌。用于外伤科跌打损伤，疮疡痈肿，瘀血阻滞诸痛证。
乳香：辛、苦、温。归肝、心、脾经。活血行气，消肿生肌。用于外伤科跌打损伤，疮疡痈肿，瘀血阻滞诸痛证。
桑寄生：苦、甘，平。归肝、肾经。祛风湿，益肝肾，强筋骨，安胎。用于风湿痹痛，腰膝酸痛，胎漏下血，胎动不安。
甘松：辛、甘、温。归脾、胃经。行气止痛，开郁醒脾。用于思虑伤脾，气机郁滞。
蒲公英：苦、甘、寒。归肝、胃经。清热解毒，消痈散结，利湿通淋。用于痈肿疔毒，热淋涩痛。
续断：苦、甘、辛。归肝、肾经。补肝肾，强筋骨，止血安胎，疗伤续折。用于肝肾不足，腰痛脚弱，风湿痹痛。
下述实验例通过观察本中药组合物治疗颈腰腿痛的疗效，进一步说明本发明药物的医疗用途。
试验一、本发明药物镇痛(小鼠热板致痛)作用的试验研究
1、材料
雄性小白鼠，体重18～22g，由山东中医药大学实验动物中心提供。动物许可证号：SCXK-2010-003。
药物：本发明药物浓缩液(高浓度2.38g/ml、中浓度1.25g/ml、低浓度0.59g/ml)；布诺芬(0.0065g/ml，批号：100826)；生理盐水。
2、试验方法
调节恒温水浴锅水温为(55±0.5)℃，预热10min；每次放1只小鼠到热板上，同时开始计时，记录出现舔后足所需时间(s)，选择30s以内舔后足的小鼠做后面实验。
将合格的小鼠随机分为5组，每组各10只，分组如下：(1)空白组：口服生理盐水15ml/kg；(2)阳性对照组：口服布诺芬0.0105g/kg；(3)～(5)本发明药物高、中、低剂量组：分别口服本发明药物40.500g/kg，20.250g/kg，10.125g/kg。上述各组分别给药三天。
3、结果
第4天给药后，测量15min和30min后的痛阈值。超过60s仍不舔后足的记60s。测得的结果见表1：
表1 本发明药物对小鼠热板法致痛的影响( ±s)
| 组别 | 剂量（g/kg） | n | 基础痛阈（s） | 给药15分钟痛阈（s） | 给药30分钟痛阈（s） |
| 空白组 | 13.500 | 10 | 21.9±5.34 | 22.14±4.28 | 22±2.76 |
| 布诺芬组 | 0.0105 | 10 | 18.43±3.58 | 38.2±16.68① | 37.1±11.4① |
| （3）组 | 40.500 | 10 | 23.5±2.81 | 35.8±8.89① | 35.3±8.8① |
| （4）组 | 20.250 | 10 | 23.6±4.12 | 31.5±7.05② | 33.5±11.0① |
| （5）组 | 10.125 | 10 | 22.3±5.31 | 37.1±13.47① | 35.3±12.0① |
注：①与空白对照组比较，P＜0.01；②与空白对照组比较，P＜0.05。
4、结论
上述结果表明，本发明药物对于小鼠由热板法引起的痛疼具有很好的镇痛效果。表明本发明药物的镇痛效果好。
试验二、本发明药物对大鼠足跖肿胀试验研究
1、材料
健康SD大鼠，清洁级，雄性，体重250～320g，由山东中医药大学实验动物中心提供。
受试药物：本发明药物，制成1.32g生药/ml的浓缩液。
2、试验方法
大鼠随机分为5组，每组8只：生理盐水对照组、元胡止痛片组(700mg/kg)、阿斯匹林组(100mg/kg)、发明药物A组(1000mg/kg)、发明药物B组(500mg/kg)。灌胃给药1次/d，共3d。
试验如下：给药前用于分尺测量每只鼠正常左后肢足跖厚度，作为正常值，同时按6ml/100g灌服常水。并自左后肢足跖中部皮下注射10％蛋清水溶液0.1ml/只，随后给药。各组均在用药0.5、1、2、3h后测其足跖厚度，最后求出每组足肿胀百分率。计算肿胀率。结果见表2。
3、试验结果
表2 本发明药物对鸡蛋清所致大鼠足跖肿胀的影响(n＝10，±s)
注：与生理盐水组比较，*P＜0.05，**P＜0.01，***P＜0.001
结果表明，本发明药物的2个剂量组对鸡蛋清所致大鼠右后足距肿胀具有明显的抑制作用，且都优于阿斯匹林的抑制效果。可见本发明中的中药组合物对试验性动物的抗炎作用较强，疗效明显。
试验三、本发明药物的急性毒性试验研究
1、材料
昆明种小鼠，雌雄各半。由山东中医药大学实验动物中心提供。
受试药物：本发明药物，制成可供小鼠灌胃的最大浓度(3.56g生药/ml)。
2、试验方法
小鼠40只，随机分为2组，雌雄各半。给药组：药物(3.56g生药/ml)，一次灌胃0.8ml/20g体重，灌胃前禁食不禁水14h，给药后常规饲养，观察7天；对照组：灌胃等量饮用水，其余同给药组。
给药前和给药后的第1、3、5、7天，分别测小鼠食量和体重，数据以 
±s表示，结果见表3、表4。
3、结果
表3 本发明药物急性毒性试验小鼠体重变化(g，
±s，n＝10)
注：与对照组比较，*P＜0.05
表4本发明药物急性毒性试验小鼠摄食量变化(g，
±s，n＝20)
注：与对照组比较，△P＜0.01，*P＜0.05
上述试验结果表明，给小鼠灌胃本发明药物后，其体重和摄食量变化差异不大，未出现异常现象。可见本发明药物的毒性小，可以用于临床。
典型病例
1、程某，男，28岁。患者于4年前患风湿性关节炎，曾用西药强的松，阿斯匹林，青霉素等药物治疗，疗效不显著。以膝，踝，腕关节痛为主。辩证为风寒湿痹，脾肾阳虚，用本药物后，同时停用西药，10天后活动时关节仅有轻微疼痛感，继续使用30天后，症状消失，随访无复发。
2、吴某，女，38岁，公务员。因长期伏案工作引起颈椎组织出现增生影响脑部的血液供应不足，当她第1、2颈椎出现增生时会出现脑部症状：如头昏、失眠、多梦、易醒、记忆力下降；第3、4颈椎出现增生时，症状：皮肤干燥，脱皮，长斑，随着时间的延长且没有注意保健，严重出现脑部缺氧，使用本发明药物50天后，完全恢复正常状态。
3、柳某，女，32岁，教师。腰部疼痛时轻时重，近半年加重，夜间加剧，腰部僵硬，翻身困难，并伴有下肢，麻木抽搐，卧床不起，勉强扶起，双下肢颤抖，经过多方治疗无效。检查，一般情况良好，腰部僵硬，活动受限，腰骶两侧压痛，双下肢直腿抬高在50度以下，臂上皮神经区压痛显著，舌边有淤点和齿痕，苔薄白，脉沉。X片显示，腰椎1-5椎体明显唇样变，并有骨桥形成。使用本药物40天后疼痛减轻，腰部有轻快感，精神好转，食欲增加，能下床活动，双下肢发抖症状减轻，继续使用半年后复查己恢复正常活动。
4、王某，男53岁，工人。关节疼痛，反复发作已3年，以膝关节为甚，阴雨或风雪则疼痛加剧，关节曲伸不便，走路艰难，局部肿胀，皮色不红，经X光检查为膝关节骨质增生，骨刺16厘米长，经服用抗骨质增生丸药3个月后无效，改用本发明所述的药物30天后肿胀感明显消退，疼痛减轻，继续使用7个月后膝关节功能完全恢复，活动自如。
具体实施方式
下面结合实施例对本发明作进一步的说明，下述该实施例仅用于说明本发明而对本发明没有限制。
实施例1，一种治疗颈腰腿痛的中药组合物，是由独活50g，秦艽50g，红花50g，穿山龙50g，伸筋草50g，茯苓50g，瞿麦50g，五灵脂50g，威灵仙50g，川乌7g，香附20g，没药20g，乳香20g，桑寄生50g，甘松20g，蒲公英20g，续断50g制成。
实施例2，一种治疗颈腰腿痛的中药组合物，是由独活40g，秦艽40g，红花40g，穿山龙40g，伸筋草40g，茯苓40g，瞿麦40g，五灵脂40g，威灵仙40g，川乌5g，香附10g，没药10g，乳香10g，桑寄生40g，甘松10g，蒲公英10g，续断40g制成。
实施例3，一种治疗颈腰腿痛的中药组合物，是由独活60g，秦艽60g，红花60g，穿山龙60g，伸筋草60g，茯苓60g，瞿麦60g，五灵脂60g，威灵仙60g，川乌10g，香附30g，没药30g，乳香30g，桑寄生60g，甘松30g，蒲公英30g，续断60g制成。
Claims (2)
1.一种治疗颈腰腿痛的中药组合物，其特征在于它是由下述原料药制成：独活40-60份 秦艽40-60份 红花40-60份 穿山龙40-60份 伸筋草40-60份 茯苓40-60份 瞿麦40-60份 五灵脂40-60份 威灵仙40-60份 川乌5-10份 香附10-30份 没药10-30份 乳香10-30份 桑寄生40-60份 甘松10-30份 蒲公英10-30份 续断40－60份。
2.根据权利要求1所述的中药组合物，其特征在于它是由下述原料药制成：独活50份 秦艽50份 红花50份 穿山龙50份 伸筋草50份 茯苓50份 瞿麦50份 五灵脂50份 威灵仙50份 川乌7份 香附20份 没药20份 乳香20份 桑寄生50份 甘松20份 蒲公英20份 续断50份。
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| CN106880724A (zh) * | 2017-02-18 | 2017-06-23 | 成都市飞龙水处理技术研究所青白江第分所 | 一种用于治疗颈腰腿痛的中药组合物及其制备方法 |
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| CN1145798A (zh) * | 1996-07-03 | 1997-03-26 | 陈洁 | 治疗腰椎间盘突出症的药物及使用方法 |
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| CN106880724A (zh) * | 2017-02-18 | 2017-06-23 | 成都市飞龙水处理技术研究所青白江第分所 | 一种用于治疗颈腰腿痛的中药组合物及其制备方法 |
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