CN102178631A - Skin care combination with effect of dispelling wrinkles, preparation and preparation method - Google Patents
Skin care combination with effect of dispelling wrinkles, preparation and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine mask with anti-wrinkle effect and a preparation method of the mask. Based on the traditional Chinese medicine theory of our nation, the mask aims for skin health and is formulated with the prescription traditional Chinese medicine extract as the main effect additive and the general matrix ingredients in cosmetics as the auxiliary material. The traditional Chinese medicine mask is not only simple in technology, natural and mild, safe and free of stimulation and easy to absorb, but also capable of invigorating the circulation of blood and eliminating stasis, promoting the circulation of qi and dredging collaterals, clearing radical and improving facial metabolism, thus moistening skin and deferring skin aging.
Description
Technical field
The present invention relates to a kind of skin care compositions, specifically a kind of Chinese medicine skin care compositions with wrinkle removal effect reaches the Chinese medicine skin care formulation that is prepared by this skin care compositions.
Background technology
Along with the raising of development of science and technology, people's living standard and the raising that skin health is realized, people are also more and more higher to the due care degree of cosmetics.Natural, green, safe and effective Chinese medicine cosmetics more and more receive the concern of numerous people and like.China is the cradle that traditional Chinese medicine is learned, and Chinese herbal medicine is used the history in existing several thousand, and Chinese herbal medicine external beauty treatment is also just on the books as far back as Ancient Times in China.Chinese herbal medicine often has nutrition and curative effect dual function concurrently, and effect relaxes the very suitable additive of doing in the cosmetics.
At present the Chinese medicine cosmetics are of a great variety, but the prescription that really can form the monarch compatibility seldom, and the principle of Chinese medicine restriction or checking relation in five elements also makes a lot of raw material of Chinese medicine not use as skin care item.At present the composition of Chinese medicine cosmetics and skin care item is single, and cooperates not goodly with skin care item and cosmetics adjuvant, and not only the compatibility is poor, also causes toxic and side effects or anaphylaxis easily.
Therefore, on safety, healthy skin health preserving basis,,, prepare by compound recipe that to develop the skin care formulation with fine effect be the focus that those skilled in the art study according to monarch, minister, the traditional Chinese medical science thought helping, make in conjunction with China's Chinese medicine theory.
Summary of the invention
The objective of the invention is to propose a kind of Chinese medicine composition with good wrinkle removal effect.
A further object of the present invention is to propose a kind of above-mentioned Chinese medicine composition extraction method of active ingredients.
The 3rd purpose of the present invention is to propose to utilize the skin care compositions of above-mentioned Chinese medicine extract preparation.
The 4th purpose of the present invention is to propose a kind of best preparation method of above-mentioned skin care compositions.
Invention thinking of the present invention is: based on the Chinese medical science theory, with the skin health is aim, according to monarch, minister, the traditional Chinese medical science prescription thought helping, make, Chinese herbal medicine Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Chuanxiong, the Radix Paeoniae Alba are effectively combined, and be main functional additive with the prescription Chinese medicine extract, be aided with the formulated crease-resistant skin care formulation of Chinese medicine of matrix components commonly used in the cosmetics.The natural gentleness of Chinese medicine skin care item of the present invention, safe and non-stimulating, and very easily by skin absorbs, nourishes rough skin reaches the effect of delaying decrepitude of skin.
The present invention selects Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Chuanxiong and the combination of Radix Paeoniae Alba four Chinese medicine thing for use, thereby effectively plays the effect of wrinkle removal reduce wrinkle.The brief introduction of four Chinese medicine thing effect is as follows:
Radix Angelicae Sinensis: warm in nature, hide sweet, hot.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Rehmanniae: effect: the clearing away heat and promoting production of body fluid YIN nourishing, nourish blood.Cure mainly: control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation.Nature and flavor: sweetness and bitterness, cold.Go into the heart, liver, kidney channel.
Rhizoma Chuanxiong: nature and flavor suffering, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia etc.
The Radix Paeoniae Alba: nature and flavor picric acid, cold.Go into liver, spleen channel.Effect: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
In the present invention's prescription, Radix Angelicae Sinensis can not only be enriched blood and be invigorated blood circulation, and can also effectively remove oxygen-derived free radicals, improves skin color, delaying decrepitude of skin; Radix Paeoniae Alba yin nourishing easing the affected liver; Radix Rehmanniae polysaccharide Wheat Protein; Rhizoma Chuanxiong can not only blood-activating and qi-promoting, stasis-dispelling and pain-killing, also has the removing free radical, promotes the effect of Transdermal absorption.Play altogether full side, can blood circulation promoting and blood stasis dispelling, promoting of the circulation of QI and removing the obstruction in the collaterals, removing free radical, improve facial metabolism, thus moist skin, delaying decrepitude of skin.Each medicine produces cooperative effect, and external wrinkle removal anti-wrinkle effect is very remarkable, is natural plant wrinkle removal agent.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with crease-resistant effect, described compositions is made by following raw materials in weight portion medicine:
Radix Angelicae Sinensis 10～20 weight portions, Radix Rehmanniae 8～15 weight portions, Rhizoma Chuanxiong 6～15 weight portions, the Radix Paeoniae Alba 10～18 weight portions.
Described compositions optimum weight part proportioning is:
Radix Angelicae Sinensis 15 weight portions, Radix Rehmanniae 10 weight portions, Rhizoma Chuanxiong 10 weight portions, the Radix Paeoniae Alba 15 weight portions.
A kind of Chinese medicine extract with crease-resistant effect, described extract are extracted through the conventional extracting method of Chinese materia medica by above-mentioned compositions and obtain.
Above-mentioned Chinese medicine extract can be prepared into various skin care formulations in conjunction with the conventional adjuvant of skin care field, as facial film, essence, facial cream, cleansing milk, cosmetic water etc.
A kind of preparation method of above-mentioned Chinese medicine composition, concrete steps are as follows:
(1) takes by weighing each crude drug according to said ratio;
(2) with the crude drug extracting in water, the mass ratio of crude drug and water is 1: 8～12, and extracting temperature is 70～90 ℃, and extraction time is 2～4 hours.
(3) filter, centrifugal, get supernatant, secondary filter promptly obtains activity extract.
Filter in the described step (3) is that 100～200 orders filter; Centrifugal is 3000～5000 rev/mins, and secondary filter is that 600～800 orders filter.
A kind of skin care compositions with wrinkle removal effect, described skin care compositions is made by the raw material of following mass percent:
Described Chinese medicine extract is the Chinese medicine extract that method for preparing obtains.
The best in quality percentage ratio proportioning of each raw material of described skin care compositions is:
Described Chinese medicine extract is the Chinese medicine extract that method for preparing obtains.
A kind of method for preparing above-mentioned skin care compositions, described concrete steps are as follows:
(1) prepares each component in above-mentioned ratio;
(2) earlier butanediol, glycerol, HANSHENGJIAO are stirred after, it is even to join deionized water for stirring;
(3) add trehalose, be heated to 70～85 ℃ after stirring and dissolving, cool to and add hyaluronate sodium and Chinese medicine extract below 50 ℃, continue to stir;
(4) continue to be cooled to below 40 ℃, add antiseptic, promptly;
A kind of facial treatment mask with wrinkle removal effect, described facial treatment mask is obtained through method for preparing by above-mentioned raw material.
The preparation that method for preparing obtains is a facial film.According to use approach difference, the present composition is made external preparation, as external facial cream, cosmetic water, cleansing milk, spray or essence etc.But be not limited to above-mentioned dosage form, can be according to known method in the skin care item industrial circle, aforementioned pharmaceutical compositions is made various external preparation after by the known method degerming.
Preparation of the present invention, its usage and consumption are as follows:
Method: spread on the 20～30min of face before sleeping, get final product with warm water cleaning.2～3 times weekly, after one month, skin water profit is smooth, wrinkle obviously shoals or reduce.
Consumption: determine according to individual demand, smear preparation of the present invention in right amount and get final product.For the position that is prone to wrinkle, locating smearing thickness as canthus etc. suitably increases, and is as the criterion with whole coverings.
Beneficial effect of the present invention:
The invention provides the Chinese medicine extract that Chinese medicine composition obtains through extraction and have good wrinkle removal effect, utilize its facial film for preparing, preparation method is easy, the products obtained therefrom green safety, and effect is remarkable, easily absorbs.Chinese medicine extract itself has effects such as blood-activating and qi-promoting, antioxidation, slow down aging, so it can be added in the cosmetics as the plant functional additive, especially has in the cosmetics of crease-resistant effect in preparation, has extensive use.
Description of drawings
Fig. 1 is that Chinese medicine facial mask liquid provided by the invention is to DPPH measured by esr technique figure;
Fig. 2 is that Chinese medicine facial mask liquid provided by the invention is to ultra-oxygen anion free radical scavenging action figure;
Fig. 3 is that Chinese medicine facial mask liquid provided by the invention is to hydroxyl radical free radical scavenging action figure.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Other raw material sources see Table 1.
Table 1
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following proportioning:
Radix Angelicae Sinensis 15g, Radix Rehmanniae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 15g;
(2) with the crude drug extracting in water, the mass ratio of crude drug and water is 1: 10, and extracting temperature is 90 ℃, and extraction time is 2 hours;
(3) 100 orders filter, and 3000r/min is centrifugal, gets supernatant, and secondary filter promptly obtains activity extract.
After testing: solid content is 2～4%, pH value is 5.0～7.0, electrical conductivity 800～1000 μ s/cm.
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following proportioning:
Radix Angelicae Sinensis 10g, Radix Rehmanniae 15g, Rhizoma Chuanxiong 6g, Radix Paeoniae Alba 18g;
(2) with the crude drug extracting in water, the mass ratio of crude drug and water is 1: 8, and extracting temperature is 70 ℃, and extraction time is 3 hours;
(3) 200 orders filter, and 4000r/min is centrifugal, gets supernatant, and secondary filter promptly obtains activity extract.
After testing: solid content is 2～4%, pH value is 5.0～7.0, electrical conductivity 800～1000 μ s/cm.
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following proportioning:
Radix Angelicae Sinensis 20g, Radix Rehmanniae 8g, Rhizoma Chuanxiong 15g, Radix Paeoniae Alba 10g;
(2) with the crude drug extracting in water, the mass ratio of crude drug and water is 1: 12, and extracting temperature is 80 ℃, and extraction time is 4 hours;
(3) 200 orders filter, and 5000r/min is centrifugal, gets supernatant, and secondary filter promptly obtains activity extract.
After testing: solid content is 2～4%, pH value is 5.0～7.0, electrical conductivity 800～1000 μ s/cm.
The preparation of embodiment 4 facial treatment mask of the present invention
Raw material and proportioning (mass percent):
Preparation method:
(1) prepares each component in above-mentioned ratio;
(2) earlier butanediol, glycerol, HANSHENGJIAO are stirred after, it is even to join deionized water for stirring;
(3) add trehalose, be heated to 70 ℃ after stirring and dissolving, cool to and add hyaluronate sodium and Chinese medicine extract below 50 ℃;
(4) continue to be cooled to below 40 ℃, add antiseptic, promptly.
The preparation of embodiment 5 facial treatment mask of the present invention
Raw material and proportioning (mass percent):
Preparation method:
(1) prepares each component in above-mentioned ratio;
(2) earlier butanediol, glycerol, HANSHENGJIAO are stirred after, it is even to join deionized water for stirring;
(3) add trehalose, be heated to 80 ℃ after stirring and dissolving, cool to and add hyaluronate sodium and Chinese medicine extract below 50 ℃;
(4) continue to be cooled to below 40 ℃, add antiseptic, promptly.
The preparation of embodiment 6 facial treatment mask of the present invention
Raw material and proportioning (mass percent):
Preparation method:
(1) prepares each component in above-mentioned ratio;
(2) earlier butanediol, glycerol, HANSHENGJIAO are stirred after, it is even to join deionized water for stirring;
(3) add trehalose, be heated to 85 ℃ after stirring and dissolving, cool to and add hyaluronate sodium and Chinese medicine extract below 50 ℃;
(4) continue to be cooled to below 40 ℃, add antiseptic, promptly.
The preparation of embodiment 7 emulsions of the present invention
1, raw material and consumption:
A phase: cetearyl alcohol 5wt%
Behenyl alcohol 2wt%
The two stearate 2wt% of tetramethylolmethane
Glyceryl monostearate 2wt%
Shea butter 5wt%
Dimethicone 3wt%
B phase: cetearyl glucoside 3wt%
Carbomer 0.1wt%
Disodium EDTA 0.15wt%
The Chinese medicine extract 1wt% of embodiment 1 preparation
C phase: antiseptic 0.5wt%
Essence 0.2wt%
Collagen protein 3wt%
10％NaOH 0.5wt％
Surplus is a deionized water.
2, preparation method:
(1) takes by weighing each raw material by above-mentioned component and consumption;
(2) A being heated to 80 ℃ of stirrings respectively mutually with B mutually makes material dissolution complete;
(3) A is added in the emulsifying pot stirs, stir speed (S.S.) is 80 rev/mins, B is added in the emulsifying pot while stirring, the speed that adds is as the criterion with the whole emulsifyings of B phase raw material in the emulsifying pot, evacuation after B phase raw material all adds (vacuum is-0.1 atmospheric pressure), stirring homogenizing 4 minutes, stir speed (S.S.) is 80 rev/mins, be heated to 80 ℃ of insulations, begin cooling after 20 minutes, when dropping to 30 ℃, temperature adds C phase raw material, stir and continue cooling, when temperature during at 40 ℃ homogenizing discharging in 1～2 minute get final product.
The Chinese medicine extract efficacy test
1, removes DPPH free radical ability and measure (extract of embodiment 1 preparation)
This test method is carried out with reference to the method that following document provides:
Wang Chen, Zhang Jinmu. Study on Antioxidant Activity of Extracts of Celery Leaf [J]. Anhui agricultural sciences, 2006,34 (13): 3174-3175,3177.
LARRAURI?J?A，SNCHEZMORENO?C，SAURACALLIXTO. ?Effect?of?temperature?on?the?free?radical?scavenging?capacity?of?extracts?from?red?and?white?grape
DPPH be a kind of very stable be the free radical at center with nitrogen, if extract can be removed it, then point out extract to have to reduce the valid density of hydroxy radical, alkane free radical or oxyradical and interrupt the effect (Wang Chen etc., 2006) of lipid peroxidation chain reaction.DPPH is highly stable in organic solvent, is purple, and a characteristic absorption peak is arranged at the 517nm place, and when it ran into free radical scavenger, the lone electron of DPPH was matched, and its color is shoaled, and diminishes at the absorbance of maximum absorption wave strong point.Therefore, can estimate removing effect by the variation of measuring absorbance to DPPH.
According to Larrauri (1998) method, accurately take by weighing 20mgDPPH, in the 250ml volumetric flask, obtaining concentration is the DPPH solution of 20mmol/L, the extract sample is become the test fluid of variable concentrations respectively with distilled water diluting with the dehydrated alcohol standardize solution.Get the 20mmol/L DPPH mixing afterreaction 30min of 2ml test fluid and 2ml, measure the variation of absorbance under the wavelength 517nm, control solvent replaces with dehydrated alcohol, is calculated as follows the suppression ratio of antioxidant.
Suppression ratio (%)=[1-(A
i-A
j)/Ac] * 100
In the formula, A
iAbsorbance for 2mlDPPH liquid and 2ml extracting solution; A
jAbsorbance for 2ml extracting solution and 2ml dehydrated alcohol; Ac is the absorbance of 2mlDPPH liquid and 2ml dehydrated alcohol.
Remove the experimental result of DPPH free radical ability mensuration and see Fig. 1, as can be seen from Figure 1, the concentration of extract is big more, and is strong more to the removing ability of DPPH free radical, just have when extract concentration reaches 3% and well know effect, this shows that extracting solution has the ability of good removing DPPH.
2, remove the superoxide anion ability and measure (extracts of embodiment 2 preparations)
This test method is carried out according to the method that following document provides: model is known, Yan Xiaojun, and Fang Guoming, etc. high molecular Brown algae polyphenol antioxidant properties research [J]. aquatile journal, 1999,23 (5): 494-499.
Get the Tris-HCl buffer 4.5ml of 0.05mol/L pH8.2, place 25 ℃ of water-bath preheating 20min, the sample and the 0.4ml that add the 1ml variable concentrations respectively, the pyrogallol solution of 25mmol/L, in 25 ℃ of water-baths, react 5min behind the mixing, add 8mol/LHCl 1.0ml cessation reaction, make reference with the Tris-HCl buffer, measure absorbance at the 299nm place, calculate clearance rate.The blank group replaces sample with 1ml sample solvent, and each is handled and all does three repetitions.
The computing formula of clearance rate: ultra-oxygen anion free radical clearance rate (%)=100 (A
1-A
2)/A
1, A wherein
1Be barren mean light absorbency, A
2Mean light absorbency for sample.
Extracting solution to ultra-oxygen anion free radical scavenging action see Fig. 2, as can be seen from Figure 2, extract concentration is big more, and is strong more to the removing ability of superoxide anion.100% stock solution can keep 92.56% clearance rate, proves that extracting solution provided by the invention has the ability of stronger removing ultra-oxygen anion free radical, can be used for preparing cosmetics, especially is used for preparing the cosmetics with anti-ageing effect.
3, to the mensuration (salicylic acid method) of Hydroxyl Radical Scavenging (extracts of embodiment 3 preparations)
This test method is carried out according to the method that following document provides: Ding Lijun, all ditch between fields brightness, Lin Yanru. the extraction of flavonoid substance and Study on antioxidation thereof [J] in the Dicranopteris dichotoma. and Food Science, 2005,26 (8): 77-83.
Hydroxyl radical free radical is produced by the Fenton reaction, and OH oxidation salicylic acid produces has 2 of characteristic absorption to 510nm light, and the 3-resorcylic acid is caught the clearance rate that the resulting product of OH is determined OH by measuring salicylic acid.Hydroxyl radical free radical is the most active free radical of chemical property in the active oxygen, and it almost can react with any biomacromolecule in the living cells, and response speed is exceedingly fast, and is to the maximum free radical of body harm.Catch the clearance rate that the resulting product of OH is determined OH by measuring salicylic acid, can reduce this light absorption value if add material in the reaction system with removing OH effect.Therefore can the amount of hydroxyl and the ability that test substance is removed hydroxyl radical free radical be described by its content of spectrophotometry.
2mmol/L FeSO43ml, 1mmol/L H2O23ml shake up in the 25ml color comparison tube, then add 6mmol/L salicylic acid 3ml, shake up, and take out behind 37 ℃ of heating in water bath 15min, survey its absorbance A 0.Add certain density liquid 0.2ml to be measured, 0.4ml, 0.6ml, 0.8ml, 1.0ml then respectively, and then add distilled water 0.8ml, 0.6ml, 0.4ml, 0.2ml, 0ml respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance A x.The reduction of the system absorbance that is caused for common 1.0ml liquid and the distilled water to be measured that adds after eliminating, method is the same, surveys its absorbance A00 behind the constant temperature 15min, adds the 1ml distilled water, surveys once its absorbance A xx, A reduction=A00-Axx after shaking up again.
Liquid to be measured to the OH clearance rate is: OH clearance rate (%)=100 (A0-Ax-A reduction)/A0
Measurement result to Hydroxyl Radical Scavenging is seen Fig. 3, and as can be seen from Figure 3, extract concentration is big more, and is strong more to the removing ability of hydroxy radical.
The extract that above-mentioned experiment prepares at the embodiment of the invention 1 to 3 carries out, through above-mentioned experiment as can be seen, the consumption of Chinese medicine composition of the present invention is best in scope disclosed by the invention, surpasses or is less than through some experiment confirms and all can not realize best wrinkle removal effect.
Clinical experiment of the present invention and result
Experimental technique: select age bracket at 35 years old to 60 years old volunteer, 40 of male volunteers, 40 of women volunteers.
Cardinal symptom: face has microgroove, some position wrinkle is obvious, the colour of skin is obscure.Volunteer is divided into two groups at random, every group 40 people.
Test group: after clean of every day, the facial film with embodiment 4 preparations before sleeping spreads on the 20～30min of face, gets final product with warm water cleaning, does not apply other skin care item.2～3 times weekly, one month experimental period.
Matched group: after clean of every day, on facial skin, apply commercially available wrinkle removal facial film 20～30min before sleeping, get final product, do not apply other skin care item with warm water cleaning.2～3 times weekly, one month experimental period.
3 days, 7 days, 1 month each statistics once.
Evaluation criterion:, do skin texture experiment and naked eyes visual experiment by patient's readme impression.Effectively: skin water profit is smooth, tender flexible in vain.The skin texture degree obviously attenuates greasy, and perusal face microgroove obviously reduces, and dark stricture of vagina shoals.Invalid: skin texture and the preceding no any variation of experiment.
Result on trial: this product had the wrinkle removal effect that obviously is better than the commercially available prod in 3 days, effective 33 examples of test group, and effective percentage is higher than 80%.Effective 18 examples in commercially available prod, effective percentage only are about 45%.Use that the test group effective percentage reaches 100% after 30 days, the commercially available prod effective percentage is about 70%.Test group can obviously increase the glossiness of skin, and the skin exquisiteness is mellow and full, also has certain whitening effect.There is not an example reaction phenomenons such as allergy, skin discomfort to occur.
The inventor has also done the effect experiment of some other preparations, as facial cream, emulsion and cosmetic water, final result shows extract of the present invention and the wrinkle removal effect that the foregoing description 4,5,6 described compositions make up and compatibility can produce the best in this amount ranges, is prepared into the facial film effect and is better than other dosage forms.But other dosage forms of the present invention also have good wrinkle removal effect, and dosage form is not limited to facial film.
Claims (10)
1. the Chinese medicine composition with crease-resistant effect is characterized in that, described compositions is made by following raw materials in weight portion medicine:
Radix Angelicae Sinensis 10～20 weight portions, Radix Rehmanniae 8～15 weight portions, Rhizoma Chuanxiong 6～15 weight portions, the Radix Paeoniae Alba 10～18 weight portions.
2. Chinese medicine composition according to claim 1 is characterized in that, described compositions is made by following raw materials in weight portion medicine:
Radix Angelicae Sinensis 15 weight portions, Radix Rehmanniae 10 weight portions, Rhizoma Chuanxiong 10 weight portions, the Radix Paeoniae Alba 15 weight portions.
3. the Chinese medicine extract with crease-resistant effect is characterized in that, described extract is extracted through the conventional extracting method of Chinese materia medica by claim 1 or 2 described compositionss and obtains.
4. the application of the described Chinese medicine extract of claim 3 in the preparation skin care formulation.
5. the preparation method of the described Chinese medicine composition of claim 1 is characterized in that, concrete steps are as follows:
(4) proportioning according to claim 1 or 2 takes by weighing each crude drug;
(5) with the crude drug extracting in water, the mass ratio of crude drug and water is 1: 8～12, and extracting temperature is 70～90 ℃, and extraction time is 2～4 hours;
(6) filter, centrifugal, get supernatant, secondary filter promptly obtains activity extract.
6. the preparation method of Chinese medicine composition according to claim 5 is characterized in that, filtering in the described step (3) is that 100～200 orders filter; Centrifugal is 3000～5000r/min; Secondary filter is that 600～800 orders filter.
7. the skin care compositions with wrinkle removal effect is characterized in that, described skin care compositions is made by the raw material of following mass percent:
Described Chinese medicine extract is the Chinese medicine extract of described extract of claim 3 or claim 4 preparation.
8. skin care compositions according to claim 7 is characterized in that, described skin care compositions is made by the raw material of following mass percent:
Described Chinese medicine extract is the Chinese medicine extract of described extract of claim 3 or claim 4 preparation.
9. method for preparing claim 7 or 8 described skin care compositionss is characterized in that described concrete steps are as follows:
(5) prepare each component in claim 7 or 8 described ratios;
(6) earlier butanediol, glycerol, HANSHENGJIAO are stirred after, it is even to join deionized water for stirring;
(7) add trehalose, be heated to 70～85 ℃ after stirring and dissolving, cool to and add hyaluronate sodium and Chinese medicine extract below 50 ℃, continue to stir;
(8) continue to be cooled to below 40 ℃, add antiseptic, promptly.
10. the facial treatment mask with wrinkle removal effect is characterized in that, described facial treatment mask is prepared through the described method of claim 8 by claim 6 or 7 described raw materials.
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| CN103479744A (en) * | 2013-09-30 | 2014-01-01 | 四川德培源中药科技开发有限公司 | Traditional Chinese medicine composition with functions of soothing liver and maintaining beauty |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449778A (en) * | 2002-04-09 | 2003-10-22 | 深圳太太药业有限公司 | Traditional Chinese medicine composition with function of treating dysmenorrhea and beautifying |
| CN1490019A (en) * | 2002-10-17 | 2004-04-21 | 金铁洙 | Health cosmetic composition |
| CN101870945A (en) * | 2010-06-01 | 2010-10-27 | 毛成艺 | Skin moisturizing, beautifying and health-care wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1449778A (en) * | 2002-04-09 | 2003-10-22 | 深圳太太药业有限公司 | Traditional Chinese medicine composition with function of treating dysmenorrhea and beautifying |
| CN1490019A (en) * | 2002-10-17 | 2004-04-21 | 金铁洙 | Health cosmetic composition |
| CN101870945A (en) * | 2010-06-01 | 2010-10-27 | 毛成艺 | Skin moisturizing, beautifying and health-care wine |
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| CN103479744A (en) * | 2013-09-30 | 2014-01-01 | 四川德培源中药科技开发有限公司 | Traditional Chinese medicine composition with functions of soothing liver and maintaining beauty |
| CN103479744B (en) * | 2013-09-30 | 2015-01-07 | 四川德培源中药科技开发有限公司 | Traditional Chinese medicine composition with functions of soothing liver and maintaining beauty |
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