CN102176915A - 具有糖胺聚糖的药物组合物及其在治疗慢性溃疡中的应用 - Google Patents

具有糖胺聚糖的药物组合物及其在治疗慢性溃疡中的应用 Download PDF

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Publication number
CN102176915A
CN102176915A CN2009801338633A CN200980133863A CN102176915A CN 102176915 A CN102176915 A CN 102176915A CN 2009801338633 A CN2009801338633 A CN 2009801338633A CN 200980133863 A CN200980133863 A CN 200980133863A CN 102176915 A CN102176915 A CN 102176915A
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CN
China
Prior art keywords
molecular weight
low molecular
healing
sulfo
glucosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801338633A
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English (en)
Chinese (zh)
Inventor
伊万·洛佩斯-贝尔蒙特·恩西纳
玛丽亚德洛斯·安赫莱斯·卡纳莱斯·马约多莫
埃莱娜·塞瓦德拉·米兰达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Publication of CN102176915A publication Critical patent/CN102176915A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801338633A 2008-07-01 2009-06-30 具有糖胺聚糖的药物组合物及其在治疗慢性溃疡中的应用 Pending CN102176915A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200802002A ES2340902B1 (es) 2008-07-01 2008-07-01 Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
ESP200802002 2008-07-01
PCT/ES2009/070264 WO2010000904A1 (es) 2008-07-01 2009-06-30 Composición farmacéutica con glicosaminoglicanos y su uso en tratamiento de úlceras crónicas

Publications (1)

Publication Number Publication Date
CN102176915A true CN102176915A (zh) 2011-09-07

Family

ID=41319881

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801338633A Pending CN102176915A (zh) 2008-07-01 2009-06-30 具有糖胺聚糖的药物组合物及其在治疗慢性溃疡中的应用

Country Status (15)

Country Link
US (2) US20110201572A1 (https=)
EP (1) EP2308497B1 (https=)
JP (1) JP2011526608A (https=)
CN (1) CN102176915A (https=)
AU (1) AU2009265623B2 (https=)
BR (1) BRPI0913839A2 (https=)
CA (1) CA2766483C (https=)
CY (1) CY1115780T1 (https=)
DK (1) DK2308497T3 (https=)
ES (2) ES2340902B1 (https=)
MX (1) MX2010014552A (https=)
PL (1) PL2308497T3 (https=)
PT (1) PT2308497E (https=)
RU (1) RU2011103459A (https=)
WO (3) WO2010000906A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109477829A (zh) * 2016-07-19 2019-03-15 罗维药物实验室股份有限公司 糖胺聚糖、肝素及其衍生物的核磁共振分析方法
CN115485308A (zh) * 2020-04-27 2022-12-16 罗维实验室制药股份公司 制备低分子量肝素的方法以及由此获得的低分子量肝素

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2357601B1 (es) 2011-01-26 2012-03-21 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas.
JP2012245943A (ja) * 2011-05-31 2012-12-13 Hitachi Automotive Systems Ltd 制御装置
JP5942133B2 (ja) * 2012-09-11 2016-06-29 学校法人関西文理総合学園 蛍光プローブ及びこれを用いた酵素活性検出方法
EP3973958A3 (en) * 2015-03-20 2022-06-22 Aarhus Universitet Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders
TWI698241B (zh) * 2017-09-05 2020-07-11 國立成功大學 用於治療缺血的肝素組合物
MX2022002760A (es) 2019-09-06 2022-04-06 Consejo Nacional De Investigaciones Cientificas Y Tecn Una composicion farmaceutica para el tratamiento topico de heridas.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004A (en) * 1849-01-09 chinnqck
IT1192564B (it) * 1977-08-08 1988-04-20 Choay Sa Composizioni di eparina esenti da sali minerali,in particolare ossalati,e procedimento per produrle
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
IT1245907B (it) * 1991-05-17 1994-10-25 Alfa Wassermann Spa Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.
WO1999026984A1 (fr) * 1997-11-20 1999-06-03 Ikuo Yamashina Modification de l'heparine de faible masse moleculaire et remede contre l'ulcere de la peau
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
AU2002309473A1 (en) 2001-01-08 2002-10-08 Human Genome Sciences, Inc. Keratinocyte growth factor-2
CU23043A1 (es) 2001-12-20 2005-05-20 Ct Ingenieria Genetica Biotech Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.
MXPA04008646A (es) 2002-05-02 2004-12-06 Pfizer Prod Inc Tratamiento para la diabetes y complicaciones diabeticas con inhibidores del nhe-1.
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
CU23388B6 (es) 2006-01-31 2009-07-16 Ct Ingenieria Genetica Biotech Composición farmacéutica de microesferas para prevenir la amputación del pie diabético

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109477829A (zh) * 2016-07-19 2019-03-15 罗维药物实验室股份有限公司 糖胺聚糖、肝素及其衍生物的核磁共振分析方法
CN109477829B (zh) * 2016-07-19 2022-06-21 罗维药物实验室股份有限公司 糖胺聚糖、肝素及其衍生物的核磁共振分析方法
CN115485308A (zh) * 2020-04-27 2022-12-16 罗维实验室制药股份公司 制备低分子量肝素的方法以及由此获得的低分子量肝素

Also Published As

Publication number Publication date
CA2766483A1 (en) 2010-01-07
WO2010000905A1 (es) 2010-01-07
MX2010014552A (es) 2011-04-26
US20140066402A1 (en) 2014-03-06
CA2766483C (en) 2017-01-17
RU2011103459A (ru) 2012-08-10
JP2011526608A (ja) 2011-10-13
AU2009265623B2 (en) 2014-11-20
AU2009265623A1 (en) 2010-01-07
EP2308497B1 (en) 2014-04-16
PL2308497T3 (pl) 2014-10-31
BRPI0913839A2 (pt) 2015-10-20
WO2010000904A1 (es) 2010-01-07
EP2308497A1 (en) 2011-04-13
ES2476966T3 (es) 2014-07-15
ES2340902A1 (es) 2010-06-10
US9211305B2 (en) 2015-12-15
CY1115780T1 (el) 2017-01-25
US20110201572A1 (en) 2011-08-18
DK2308497T3 (da) 2014-07-14
WO2010000906A1 (es) 2010-01-07
PT2308497E (pt) 2014-07-24
ES2340902B1 (es) 2011-05-03

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Application publication date: 20110907