CN102170914B - 制备超极化分子的水溶液的方法 - Google Patents

制备超极化分子的水溶液的方法 Download PDF

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Publication number
CN102170914B
CN102170914B CN200980138851.XA CN200980138851A CN102170914B CN 102170914 B CN102170914 B CN 102170914B CN 200980138851 A CN200980138851 A CN 200980138851A CN 102170914 B CN102170914 B CN 102170914B
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China
Prior art keywords
hydrogenation
hyperpolarization
molecule
water
aqueous solution
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CN200980138851.XA
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Chinese (zh)
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CN102170914A (zh
Inventor
F·雷纳利
A·威尔勒
G·B·吉奥温扎纳
D·桑特利亚
W·达斯特鲁
R·格贝托
S·艾米
F·尤吉里
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Bracco Imaging SpA
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Bracco Imaging SpA
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Priority claimed from ITMI2008A001765A external-priority patent/IT1391330B1/it
Priority claimed from ITMI2009A000942A external-priority patent/IT1395345B1/it
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of CN102170914A publication Critical patent/CN102170914A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN200980138851.XA 2008-10-03 2009-09-30 制备超极化分子的水溶液的方法 Active CN102170914B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI2008A001765A IT1391330B1 (it) 2008-10-03 2008-10-03 Processo per la preparazione di molecole iperpolarizzate.
ITMI2008A001765 2008-10-03
ITMI2009A000942A IT1395345B1 (it) 2009-05-28 2009-05-28 Processo per la preparazione di molecole iperpolarizzate
ITMI2009A000942 2009-05-28
PCT/EP2009/062674 WO2010037771A1 (en) 2008-10-03 2009-09-30 A process for the preparation of aqueous solutions of hyperpolarized molecules

Publications (2)

Publication Number Publication Date
CN102170914A CN102170914A (zh) 2011-08-31
CN102170914B true CN102170914B (zh) 2016-02-10

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CN200980138851.XA Active CN102170914B (zh) 2008-10-03 2009-09-30 制备超极化分子的水溶液的方法

Country Status (13)

Country Link
US (1) US8961933B2 (da)
EP (1) EP2349350B1 (da)
JP (1) JP5518874B2 (da)
CN (1) CN102170914B (da)
DK (1) DK2349350T3 (da)
ES (1) ES2616265T3 (da)
HR (1) HRP20170238T1 (da)
HU (1) HUE031915T2 (da)
IL (1) IL212117A0 (da)
PL (1) PL2349350T3 (da)
PT (1) PT2349350T (da)
SI (1) SI2349350T1 (da)
WO (1) WO2010037771A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
WO2011124672A1 (en) * 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
WO2015063020A1 (en) * 2013-10-28 2015-05-07 Bracco Imaging Spa Process for the preparation of hyperpolarized carboxylate compounds
DE102016125583A1 (de) * 2016-12-23 2018-06-28 Stefan Glöggler Verfahren zur Herstellung eines Kontrastmittels für die MR-Spektroskopie
GB201703658D0 (en) * 2017-03-07 2017-04-19 Univ York Hyperpolarization in aqueous media via SABRE
GB201710677D0 (en) * 2017-07-03 2017-08-16 Univ York Polorisation transfer via a second metal complex
WO2019071090A1 (en) * 2017-10-06 2019-04-11 University Of Florida Research Foundation METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS
US11571686B2 (en) 2019-02-15 2023-02-07 Board Of Trustees Of Southern Illinois University Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP
EP4313174A1 (en) * 2021-03-23 2024-02-07 NVision Imaging Technologies GmbH Systems and method for generation of hyperpolarized materials

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306441A (zh) * 1997-11-12 2001-08-01 耐克麦德英梅金公司 仲氢标记剂及其在磁共振成像中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3615723A (en) 1970-04-15 1971-10-26 Pillsbury Co Spray-drying apparatus
US5334791A (en) * 1992-05-22 1994-08-02 Ligands Inc. Hydrogenation process with transition metal catalysts derived from bifunctional phosphorus-nitrogen ligands
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
GB9911681D0 (en) 1999-05-19 1999-07-21 Nycomed Imaging As Process
ES2654520T3 (es) * 2005-10-11 2018-02-14 Huntington Medical Research Institutes Agentes de formación de imágenes y métodos de uso de los mismos
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306441A (zh) * 1997-11-12 2001-08-01 耐克麦德英梅金公司 仲氢标记剂及其在磁共振成像中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FERENC JOO."Aqueous Biphasic Hydrogenations".《ACCOUNTS OF CHEMICAL RESERCH》.2002,第35卷(第9期),第738－745页. *

Also Published As

Publication number Publication date
PT2349350T (pt) 2017-01-23
PL2349350T3 (pl) 2017-05-31
WO2010037771A1 (en) 2010-04-08
HRP20170238T1 (hr) 2017-04-07
US20110178393A1 (en) 2011-07-21
JP5518874B2 (ja) 2014-06-11
EP2349350B1 (en) 2016-11-30
ES2616265T3 (es) 2017-06-12
DK2349350T3 (da) 2017-02-27
CN102170914A (zh) 2011-08-31
JP2012504438A (ja) 2012-02-23
US8961933B2 (en) 2015-02-24
HUE031915T2 (en) 2017-08-28
SI2349350T1 (sl) 2017-03-31
IL212117A0 (en) 2011-07-31
EP2349350A1 (en) 2011-08-03

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