CN102151258B - α-倒捻子素在制备阿尔兹海默氏病药物中的应用 - Google Patents
α-倒捻子素在制备阿尔兹海默氏病药物中的应用 Download PDFInfo
- Publication number
- CN102151258B CN102151258B CN201110040746A CN201110040746A CN102151258B CN 102151258 B CN102151258 B CN 102151258B CN 201110040746 A CN201110040746 A CN 201110040746A CN 201110040746 A CN201110040746 A CN 201110040746A CN 102151258 B CN102151258 B CN 102151258B
- Authority
- CN
- China
- Prior art keywords
- mangostin
- disease
- alzheimer
- alpha
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (6)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110040746A CN102151258B (zh) | 2011-02-18 | 2011-02-18 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
US13/985,413 US20140080903A1 (en) | 2011-02-18 | 2012-02-14 | Application of alpha-mangostin in preparation of medicaments for alzheimer's disease |
EP12746907.0A EP2676665A4 (en) | 2011-02-18 | 2012-02-14 | USE OF ALPHA-MANGOSTINE IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF ALZHEIMER |
PCT/CN2012/071112 WO2012109976A1 (zh) | 2011-02-18 | 2012-02-14 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
JP2013552826A JP5552575B2 (ja) | 2011-02-18 | 2012-02-14 | アルツハイマー病治療用医薬の製造におけるα−マンゴスチンの使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110040746A CN102151258B (zh) | 2011-02-18 | 2011-02-18 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102151258A CN102151258A (zh) | 2011-08-17 |
CN102151258B true CN102151258B (zh) | 2012-10-10 |
Family
ID=44433153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110040746A Expired - Fee Related CN102151258B (zh) | 2011-02-18 | 2011-02-18 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20140080903A1 (zh) |
EP (1) | EP2676665A4 (zh) |
JP (1) | JP5552575B2 (zh) |
CN (1) | CN102151258B (zh) |
WO (1) | WO2012109976A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102151258B (zh) * | 2011-02-18 | 2012-10-10 | 夏铮 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
CN104434907A (zh) * | 2013-09-25 | 2015-03-25 | 中国中医科学院医学实验中心 | α-倒捻子素的药物新用途 |
US10568862B2 (en) | 2014-02-26 | 2020-02-25 | Deakin University | Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders |
KR101621162B1 (ko) | 2014-09-17 | 2016-05-23 | 동국대학교 산학협력단 | 알파-망고스틴을 유효성분으로 포함하는 신경교종 예방 또는 치료용 약학적 조성물 |
CN106176713A (zh) * | 2016-08-24 | 2016-12-07 | 雷闽湘 | α-山竹黄酮的新用途 |
CN109956952B (zh) * | 2017-12-14 | 2020-11-13 | 浙江工业大学 | α-楝子素衍生物及其制备方法与应用 |
CN110183459B (zh) * | 2019-05-21 | 2020-11-13 | 浙江工业大学 | α-倒捻子素衍生物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5140231B2 (ja) * | 2004-04-08 | 2013-02-06 | 株式会社ロッテ | IκBキナーゼ阻害剤 |
DE102004034683A1 (de) * | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Isolierung von α-Mangostin |
WO2009093255A2 (en) * | 2008-01-21 | 2009-07-30 | Ganga Raju Gokaraju | A new nutraceutical composition from garcinia mangostana |
CN102151258B (zh) * | 2011-02-18 | 2012-10-10 | 夏铮 | α-倒捻子素在制备阿尔兹海默氏病药物中的应用 |
-
2011
- 2011-02-18 CN CN201110040746A patent/CN102151258B/zh not_active Expired - Fee Related
-
2012
- 2012-02-14 JP JP2013552826A patent/JP5552575B2/ja not_active Expired - Fee Related
- 2012-02-14 US US13/985,413 patent/US20140080903A1/en not_active Abandoned
- 2012-02-14 EP EP12746907.0A patent/EP2676665A4/en not_active Withdrawn
- 2012-02-14 WO PCT/CN2012/071112 patent/WO2012109976A1/zh active Application Filing
Non-Patent Citations (1)
Title |
---|
Jose Pedraza-Chaverr et,al.ROS scavenging capacity and neuroprotectiv effect of a-mangostin against 3-nitropropionic acid in cerebellar granule neurons.《Experimental and Toxicologic Pathology》.2009,第61卷491-501. * |
Also Published As
Publication number | Publication date |
---|---|
EP2676665A1 (en) | 2013-12-25 |
JP5552575B2 (ja) | 2014-07-16 |
EP2676665A4 (en) | 2014-09-24 |
CN102151258A (zh) | 2011-08-17 |
US20140080903A1 (en) | 2014-03-20 |
JP2014505080A (ja) | 2014-02-27 |
WO2012109976A1 (zh) | 2012-08-23 |
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Owner name: HANGZHOU BOMAI PHARMACEUTICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: XIA ZHENG Effective date: 20130508 |
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Free format text: CORRECT: ADDRESS; FROM: 310016 HANGZHOU, ZHEJIANG PROVINCE TO: 310013 HANGZHOU, ZHEJIANG PROVINCE |
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Effective date of registration: 20130508 Address after: 310013, B, room 334, Zhejiang University Science Park, 525 Xixi Road, Zhejiang, Hangzhou, Xihu District, China Patentee after: BOMAI MEDITECH CO., LTD. Address before: 501, room 1, unit 11, Hualong square, Binjiang four district, Shangcheng District, Zhejiang, Hangzhou, 310016 Patentee before: Xia Zheng |
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CF01 | Termination of patent right due to non-payment of annual fee |