CN102138897B - 洛美沙星化合物与氯化钠的组合物制剂及其制备方法 - Google Patents
洛美沙星化合物与氯化钠的组合物制剂及其制备方法 Download PDFInfo
- Publication number
- CN102138897B CN102138897B CN201110085258A CN201110085258A CN102138897B CN 102138897 B CN102138897 B CN 102138897B CN 201110085258 A CN201110085258 A CN 201110085258A CN 201110085258 A CN201110085258 A CN 201110085258A CN 102138897 B CN102138897 B CN 102138897B
- Authority
- CN
- China
- Prior art keywords
- injection
- sodium chloride
- lomefloxacin
- water
- milligrams
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title claims abstract description 118
- 229960002422 lomefloxacin Drugs 0.000 title claims abstract description 58
- 239000011780 sodium chloride Substances 0.000 title claims abstract description 58
- -1 lomefloxacin compound Chemical class 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title abstract 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000007924 injection Substances 0.000 claims abstract description 52
- 238000002347 injection Methods 0.000 claims abstract description 52
- ZEKZLJVOYLTDKK-UHFFFAOYSA-N lomefloxacin Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1 ZEKZLJVOYLTDKK-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000008215 water for injection Substances 0.000 claims abstract description 34
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 19
- 239000004220 glutamic acid Substances 0.000 claims abstract description 19
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 13
- 239000000243 solution Substances 0.000 claims description 43
- 239000002131 composite material Substances 0.000 claims description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 2
- 241000289690 Xenarthra Species 0.000 abstract 2
- 239000007788 liquid Substances 0.000 description 24
- 235000015165 citric acid Nutrition 0.000 description 15
- 239000003643 water by type Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 238000006555 catalytic reaction Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000190932 Rhodopseudomonas Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
组别 | 性状 | 颜色 | 澄明度 | 有关物质(%) |
对照组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.37 |
对照组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.12 |
对照组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.98 |
对照组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.05 |
实验组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.02 |
实验组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.93 |
实验组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.86 |
实验组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.89 |
组别 | 性状 | 颜色 | 澄明度 | 有关物质(%) |
对照组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.19 |
对照组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.07 |
对照组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.85 |
对照组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.96 |
实验组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.99 |
实验组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.87 |
实验组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.79 |
实验组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 0.83 |
组别 | 性状 | 颜色 | 澄明度 | 有关物质(%) |
对照组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 4.36 |
对照组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 3.91 |
对照组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 4.07 |
对照组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 3.96 |
实验组1 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.13 |
实验组2 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 2.05 |
实验组3 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.84 |
实验组4 | 黄绿色的澄明液体 | 符合规定 | 符合规定 | 1.97 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110085258A CN102138897B (zh) | 2011-04-06 | 2011-04-06 | 洛美沙星化合物与氯化钠的组合物制剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110085258A CN102138897B (zh) | 2011-04-06 | 2011-04-06 | 洛美沙星化合物与氯化钠的组合物制剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102138897A CN102138897A (zh) | 2011-08-03 |
CN102138897B true CN102138897B (zh) | 2012-09-05 |
Family
ID=44406843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110085258A Expired - Fee Related CN102138897B (zh) | 2011-04-06 | 2011-04-06 | 洛美沙星化合物与氯化钠的组合物制剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102138897B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1078887A (zh) * | 1992-05-18 | 1993-12-01 | 赵本樱 | 洛美沙星注射剂制配方法 |
CN101690713A (zh) * | 2009-09-28 | 2010-04-07 | 洛阳普莱柯生物工程有限公司 | 一种喹诺酮注射液的制备方法 |
-
2011
- 2011-04-06 CN CN201110085258A patent/CN102138897B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1078887A (zh) * | 1992-05-18 | 1993-12-01 | 赵本樱 | 洛美沙星注射剂制配方法 |
CN101690713A (zh) * | 2009-09-28 | 2010-04-07 | 洛阳普莱柯生物工程有限公司 | 一种喹诺酮注射液的制备方法 |
Non-Patent Citations (3)
Title |
---|
张秀芝等.盐酸洛美沙星注射液的稳定性研究.《中国药科大学学报》.1996,第27卷(第6期),341-344. * |
杨俊.盐酸洛美沙星注射液的稳定性及有效性预测.《中国医药指南》.2010,第8卷(第34期),234-235. * |
段艳冰等.门冬氨酸洛美沙星氯化钠注射液处方工艺研究.《科学技术与工程》.2010,第10卷(第26期),6521-6523. * |
Also Published As
Publication number | Publication date |
---|---|
CN102138897A (zh) | 2011-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108078872B (zh) | 天然低共熔溶剂作为防腐剂的应用 | |
JP2003508416A (ja) | 金属含有組成物、その製法および用法 | |
CN104323987B (zh) | 一种乙酰甲喹注射液及其制备方法 | |
CN101810569A (zh) | 一种恩诺沙星注射液及其制备方法 | |
CN110973157A (zh) | 水产养殖用抗菌消毒液及其制备方法 | |
CN102138897B (zh) | 洛美沙星化合物与氯化钠的组合物制剂及其制备方法 | |
CN100402033C (zh) | 氟罗沙星注射液及其制备方法 | |
CN105560166A (zh) | 银离子妇科外用抗菌凝胶及其制备方法 | |
CN105687126A (zh) | 一种兽用左氧氟沙星注射液及其制备方法 | |
CN101181270A (zh) | 一种盐酸洛美沙星注射液及其制备方法 | |
CN102204884B (zh) | 氧氟沙星化合物与甘露醇组合物制剂及其制备方法 | |
CN102067902A (zh) | 肉制品保鲜剂 | |
JP7199794B2 (ja) | 液状抗菌剤及び液状抗菌剤の製造方法 | |
CN101716139A (zh) | 一种兽用盐酸洛美沙星长效缓释注射液及其制备方法 | |
CN110313488A (zh) | 防霉型粘合剂及其制备方法和应用 | |
CN102961328B (zh) | 一种左氧氟沙星注射液及其制备方法 | |
CN103142510A (zh) | 一种含有盐酸莫西沙星组合物的注射剂 | |
CN103341167A (zh) | 一种兽用复方醋酸溶液及其制备工艺 | |
CN111317713B (zh) | 一种氧氟沙星注射液的制备方法 | |
CN104000777B (zh) | 一种左氧氟沙星制剂 | |
CN111035614B (zh) | 一种高含量土霉素注射液及其制备方法 | |
CN102688299A (zh) | 杀菌洗剂 | |
CN110592174A (zh) | 一种拮抗抑菌成分选择性增菌培养基及其制备和使用方法 | |
CN110235899B (zh) | 新的食品防腐剂及其制备方法和应用 | |
CN101029043A (zh) | 门冬氨酸洛美沙星水合物及其制备和用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CI01 | Publication of corrected invention patent application |
Correction item: Applicant Correct: Guangdong Rulai Pharmaceutical Import & Export Co., Ltd. False: Guangdong Rulai Pharmaceutical Import & Export Co., Ltd. Number: 31 Volume: 27 |
|
CI02 | Correction of invention patent application |
Correction item: Applicant Correct: Guangdong Rulai Pharmaceutical Import & Export Co., Ltd. False: Guangdong Rulai Pharmaceutical Import & Export Co., Ltd. Number: 31 Page: The title page Volume: 27 |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120905 Termination date: 20140406 |