CN102124331B - 自组装性多细胞体和使用其制备三维生物结构的方法 - Google Patents

自组装性多细胞体和使用其制备三维生物结构的方法 Download PDF

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CN102124331B
CN102124331B CN2009801319242A CN200980131924A CN102124331B CN 102124331 B CN102124331 B CN 102124331B CN 2009801319242 A CN2009801319242 A CN 2009801319242A CN 200980131924 A CN200980131924 A CN 200980131924A CN 102124331 B CN102124331 B CN 102124331B
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multicell
cell
filling body
group
inoblast
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CN102124331A (zh
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G·福加克斯
F·S·马尔加
C·诺罗特
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University of Missouri Columbia
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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CN2009801319242A 2008-06-24 2009-06-24 自组装性多细胞体和使用其制备三维生物结构的方法 Expired - Fee Related CN102124331B (zh)

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US13297708P 2008-06-24 2008-06-24
US61/132,977 2008-06-24
PCT/US2009/048530 WO2010008905A2 (en) 2008-06-24 2009-06-24 Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same

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CN102124331A CN102124331A (zh) 2011-07-13
CN102124331B true CN102124331B (zh) 2013-10-30

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Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262229B1 (en) * 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
JP5624981B2 (ja) 2008-06-24 2014-11-12 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ 自己集合性多細胞体、および前記多細胞体を用いて３次元の生物構造体を作製する方法
JP2013518591A (ja) * 2010-02-02 2013-05-23 ザ キュレーターズ オブ ザ ユニバーシティ オブ ミズーリ 改変された生物学的神経移植片の製造およびその用途
US9267099B2 (en) 2010-03-15 2016-02-23 Indiana University Research And Technology Corporation Engineered lumenized vascular networks and support matrix
GB2478801B (en) * 2010-03-16 2012-05-30 Organovo Inc Multilayered vascular tubes
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US20120089238A1 (en) * 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
KR20160125530A (ko) 2010-10-21 2016-10-31 오가노보, 인크. 조직의 제작을 위한 디바이스, 시스템 및 방법
PL2736357T3 (pl) * 2011-07-26 2019-02-28 The Curators Of The University Of Missouri Poddawane inżynierii jadalne mięso
HK1199812A1 (en) * 2011-09-12 2015-07-24 奥加诺沃公司 Platform for engineered implantable tissues and organs and methods of making the same
BR112014005746A2 (pt) * 2011-09-12 2017-03-28 Organovo Inc tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos
CN103857787B (zh) * 2011-09-27 2019-05-17 公立大学法人横滨市立大学 组织和器官的制作方法
KR101374478B1 (ko) * 2012-01-18 2014-03-13 주승연 세포 블록 제조용 조성물, 키트, 및 이들을 이용한 세포 블록 제조 방법
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140099709A1 (en) * 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
WO2014039938A1 (en) * 2012-09-07 2014-03-13 Modern Meadow, Inc. Spherical multicellular aggregates with endogenous extracellular matrix
US20160022870A1 (en) * 2013-03-15 2016-01-28 Cyfuse Biomedical K.K. Cardiac or vascular tissue spheroid
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
JP6332782B2 (ja) * 2013-06-07 2018-05-30 国立大学法人 鹿児島大学 細胞凝集塊作製法
CN103350572B (zh) * 2013-07-18 2016-05-25 符晓友 3d堆叠打印方法及3d堆叠打印机
US20150037445A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
WO2015077262A1 (en) 2013-11-19 2015-05-28 Guill Tool & Engineering Coextruded, multilayered and multicomponent 3d printing inputs
AU2015214092B2 (en) 2014-02-05 2018-11-15 Fork & Goode, Inc. Dried food products formed from cultured muscle cells
EP3808838B1 (en) 2014-04-04 2024-04-10 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP2949350B1 (en) 2014-05-29 2022-05-11 Sabanci Üniversitesi Artificial hollow biological tissue network and method for preparation thereof
EP3202894A4 (en) 2014-09-29 2018-05-23 Public University Corporation Yokohama City University Method for producing three-dimensional cell aggregates
MA40495A (fr) 2014-10-06 2016-04-14 Organovo Inc Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
US11529436B2 (en) 2014-11-05 2022-12-20 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
CN104490489B (zh) * 2014-12-02 2017-02-01 淮安皓运生物科技有限公司 基于3d生物打印技术制备组织工程血管的方法
SG11201704439QA (en) * 2014-12-30 2017-06-29 Agency Science Tech & Res Technique for formation and assembly of 3d cellular structures
CN105983134A (zh) * 2015-03-05 2016-10-05 刘畅 一种人工血管及其制备方法
CN104880408B (zh) * 2015-04-21 2018-05-01 上海交通大学医学院附属第九人民医院 无创性动态监测材料降解速率与组织再生匹配程度的方法
CN104840272B (zh) * 2015-05-11 2016-09-07 浙江大学 一种具有内置营养通道的三维生物结构的打印方法
CN104906636B (zh) * 2015-05-19 2018-01-12 河海大学常州校区 一种三维管状多细胞结构的制备方法
JP6629332B2 (ja) * 2015-08-24 2020-01-15 Ｎｅｃソリューションイノベータ株式会社 細胞インク、細胞インクの製造容器、細胞インクの製造キット、細胞インクの製造方法、インクカートリッジ、立体造形物の製造方法、および立体造形物
KR20190057168A (ko) 2015-08-31 2019-05-27 셀링크 에이비 3d 프린터 및 바이오프린터용 클린 챔버 기술
ES2842501T5 (es) 2015-09-21 2023-04-13 Modern Meadow Inc Materiales compuestos de tejido reforzados con fibras
CA3000712A1 (en) * 2015-10-02 2017-04-06 Wake Forest University Health Sciences Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same
CN106606804B (zh) * 2015-10-22 2020-05-12 四川蓝光英诺生物科技股份有限公司 一种制备复合结构的方法
AU2016352873B2 (en) 2015-11-09 2023-01-05 Organovo, Inc. Improved methods for tissue fabrication
CN111303641A (zh) 2016-02-15 2020-06-19 现代牧场股份有限公司 含有胶原原纤维的生物制造材料
US20190126043A1 (en) 2016-04-14 2019-05-02 The Trustees Of The University Of Pennsylvania Implantable living electrodes and methods for use thereof
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CN109153961B (zh) * 2016-05-24 2022-07-12 日本电信电话株式会社 内包微小颗粒的三维薄膜结构体和其制造方法
EP3471789B1 (en) * 2016-06-16 2025-07-09 Aspect Biosystems Ltd. Bioprinted meniscus implant and methods of using same
US10345208B2 (en) 2016-07-12 2019-07-09 Deka Products Limited Partnership System and method for applying force to a device
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
US11655456B2 (en) 2016-11-10 2023-05-23 Organovo, Inc. Engineered intestinal tissue and uses thereof
EP3538169A4 (en) 2016-11-10 2020-09-30 Organovo, Inc. BIO-PRINTED PILEUX FOLLICLES AND THEIR USES
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP6889363B2 (ja) * 2016-12-05 2021-06-18 澁谷工業株式会社 細胞の集合構造体の作製方法および作製装置
KR101849737B1 (ko) * 2016-12-27 2018-04-18 한국기계연구원 인공 장 및 그 제조 방법
US12252712B2 (en) 2017-04-03 2025-03-18 Organovo, Inc. Use of engineered liver tissue constructs for modeling liver disorders
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
US12398358B2 (en) * 2017-05-30 2025-08-26 The Trustees Of Princeton University Three-dimensional (3D) tissue scaffold with cell alignment
US20180356398A1 (en) 2017-06-09 2018-12-13 Fujifilm Corporation Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
WO2019087988A1 (ja) * 2017-10-30 2019-05-09 公立大学法人横浜市立大学 構造体と細胞塊を連結した構築物
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
EP3727484A1 (en) 2017-12-20 2020-10-28 Aspect Biosystems Ltd. Bioprinted meniscus implant and methods of using same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
US11167375B2 (en) 2018-08-10 2021-11-09 The Research Foundation For The State University Of New York Additive manufacturing processes and additively manufactured products
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12241049B2 (en) 2019-01-10 2025-03-04 Brown University Multi-compartment device containing human three-dimensional (3D) microtissues for toxicity testing
AU2020209847B2 (en) 2019-01-17 2024-10-17 Modern Meadow, Inc. Layered collagen materials and methods of making the same
US11423536B2 (en) 2019-03-29 2022-08-23 Advanced Solutions Life Sciences, Llc Systems and methods for biomedical object segmentation
CN113189317B (zh) * 2021-04-29 2024-11-15 广东省人民医院 一套人工血管三维静态培养的实验装置及其使用方法
WO2022230977A1 (ja) * 2021-04-30 2022-11-03 国立研究開発法人理化学研究所 網膜色素上皮細胞のひも状凝集体、それを製造するためのデバイスおよび製造方法、ならびに該ひも状凝集体を含有する治療薬
WO2025169815A1 (ja) * 2024-02-06 2025-08-14 国立大学法人東北大学 分岐人工血管モデルの製造方法
CN119286639B (zh) * 2024-10-10 2025-07-01 中南大学湘雅医院 一种修复子宫内膜损伤的多细胞组装体安装辅助设备

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4759764A (en) 1985-05-24 1988-07-26 Clayton Foundation For Research Peripheral nerve regeneration
US4808435A (en) 1987-04-06 1989-02-28 International Business Machines Corporation Screen printing method for producing lines of uniform width and height
US5099090A (en) 1988-05-11 1992-03-24 Ariel Electronics, Inc. Circuit writer
US5596251A (en) 1995-06-07 1997-01-21 Alcoa Closure Systems International, Inc. Servo motor-driven plastic cutter system for compression molding
CA2306346C (en) 1997-07-03 2010-09-14 Massachusetts Institute Of Technology Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
US6401795B1 (en) 1997-10-28 2002-06-11 Sandia Corporation Method for freeforming objects with low-binder slurry
JP4564655B2 (ja) 1998-04-21 2010-10-20 ユニバーシティ オブ コネチカット 多光子励起を用いたフリーフォームナノ製作
US6697694B2 (en) 1998-08-26 2004-02-24 Electronic Materials, L.L.C. Apparatus and method for creating flexible circuits
US7338798B2 (en) 1998-09-15 2008-03-04 The Regents Of The University Of Michigan System and method for forming a cardiac muscle construct
DE69907397T2 (de) 1999-02-17 2004-01-22 Hewlett-Packard Co. (N.D.Ges.D.Staates Delaware), Palo Alto Druckvorrichtung
US6979670B1 (en) * 1999-03-10 2005-12-27 Biora Bioex Ab Matrix protein compositions for grafting
JP2001145956A (ja) 1999-11-19 2001-05-29 Meiko:Kk 光硬化性樹脂三次元造形物の積層造形装置及びその積層造形方法
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6454972B1 (en) 1999-11-24 2002-09-24 Sandia Corporation Solid freeform fabrication using chemically reactive suspensions
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6315469B1 (en) 2000-01-19 2001-11-13 Hewlett-Packard Company Tool and method for adjustment of printhead to platen spacing in a printer
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
US20050091576A1 (en) 2003-10-24 2005-04-28 Microsoft Corporation Programming interface for a computer platform
DE10018987A1 (de) 2000-04-17 2001-10-31 Envision Technologies Gmbh Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten
AU2001283492A1 (en) 2000-07-11 2002-01-21 The Johns Hopkins University School Of Medicine Methods of patterning protein and cell adhesivity
US7998735B2 (en) 2000-08-21 2011-08-16 Victorian Tissue Engineering Centre Pty. Ltd. Vascularized tissue graft
US6561607B1 (en) 2000-10-05 2003-05-13 Eastman Kodak Company Apparatus and method for maintaining a substantially constant closely spaced working distance between an inkjet printhead and a printing receiver
US20020129485A1 (en) 2001-03-13 2002-09-19 Milling Systems And Concepts Pte Ltd Method and apparatus for producing a prototype
US6939489B2 (en) 2001-03-23 2005-09-06 Ivoclar Vivadent Ag Desktop process for producing dental products by means of 3-dimensional plotting
US6849223B2 (en) 2001-04-19 2005-02-01 Case Western Reserve University Fabrication of a polymeric prosthetic implant
ATE406436T1 (de) 2001-07-26 2008-09-15 Transparent Inc Konstrukt aus kultivierten zellen mit spheroiden von kultivierten tierzellen und verwendung davon
US20030049839A1 (en) 2001-08-01 2003-03-13 The University Of Texas System Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient
AU2002324775A1 (en) 2001-08-23 2003-03-10 Sciperio, Inc. Architecture tool and methods of use
US6934600B2 (en) 2002-03-14 2005-08-23 Auburn University Nanotube fiber reinforced composite materials and method of producing fiber reinforced composites
WO2003079985A2 (en) 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20100254900A1 (en) 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US6907307B2 (en) 2002-07-02 2005-06-14 3D Systems, Inc. Support volume calculation for a CAD model
WO2004006840A2 (en) 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US6998264B2 (en) 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US20050238746A1 (en) 2002-12-31 2005-10-27 E.I. Dupont De Nemours & Company Apparatus, system and method for making hydrogel particles
US7641898B2 (en) 2003-03-21 2010-01-05 Materials Evolution And Development Usa, Inc. Keratinocyte-fibrocyte concomitant grafting for wound healing
US20040197375A1 (en) 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
WO2005003300A2 (en) 2003-06-04 2005-01-13 University Of South Carolina Tissue scaffold having aligned fibrils, apparatus and method for producing same, and methods of using same
JP4474858B2 (ja) 2003-07-07 2010-06-09 セイコーエプソン株式会社 ギャップ調整装置、これに使用されるキャリブレーション用治具、およびギャップ調整装置を備えた液滴吐出装置、並びに電気光学装置の製造方法
US20050074877A1 (en) 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
FR2859128B1 (fr) 2003-08-29 2006-03-10 Centre Nat Rech Scient Procede et dispositif de fabrication d'un composant multimateriaux tridimensionnel par impression du type jet d'encre
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
US20050276791A1 (en) 2004-02-20 2005-12-15 The Ohio State University Multi-layer polymer scaffolds
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
WO2007115337A2 (en) 2006-04-05 2007-10-11 William Marsh Rice University Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
US7625198B2 (en) 2004-08-11 2009-12-01 Cornell Research Foundation, Inc. Modular fabrication systems and methods
US7651665B2 (en) 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
US7767446B2 (en) 2004-09-16 2010-08-03 Becton, Dickinson And Company Perfusion bioreactors for culturing cells
JP4539316B2 (ja) 2004-12-08 2010-09-08 セイコーエプソン株式会社 ヘッド位置補正方法およびヘッド位置補正装置、並びに液滴吐出装置、電気光学装置の製造方法
US7568904B2 (en) 2005-03-03 2009-08-04 Laser Solutions Co., Ltd. Stereolithography apparatus
JP4729948B2 (ja) 2005-03-09 2011-07-20 ブラザー工業株式会社 液体供給装置、この液体供給装置を備えたインクジェット記録装置
US7780897B2 (en) 2005-04-22 2010-08-24 Board Of Regents, The University Of Texas System Hydrogel constructs using stereolithography
JP2008545410A (ja) 2005-05-24 2008-12-18 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 微小規模のマイクロパターン化インビトロ操作・作製組織
JP5475283B2 (ja) 2005-07-28 2014-04-16 カーネギー メロン ユニバーシティ 生体適合性ポリマーおよび使用方法
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
US20070200276A1 (en) 2006-02-24 2007-08-30 Micron Technology, Inc. Method for rapid printing of near-field and imprint lithographic features
JP4919464B2 (ja) 2006-03-02 2012-04-18 国立大学法人大阪大学 三次元組織の製造方法およびそれに用いる細胞外マトリックスの製造方法。
US7680555B2 (en) 2006-04-03 2010-03-16 Stratasys, Inc. Auto tip calibration in an extrusion apparatus
US20070231787A1 (en) 2006-04-04 2007-10-04 Voelker Mark A Methods and devices for imaging and manipulating biological samples
US20090208466A1 (en) 2006-04-21 2009-08-20 James Yoo Ink-jet printing of tissues
JP4051077B2 (ja) 2006-04-28 2008-02-20 シャープ株式会社 液滴塗布装置、液滴吐出部のギャップ測定方法、および、液滴吐出部のギャップ調整方法
FR2901143B1 (fr) 2006-05-16 2008-10-03 Centre Nat Rech Scient "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications"
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
DE102006053121B3 (de) 2006-11-10 2007-12-27 Eos Gmbh Electro Optical Systems Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes mittels eines Beschichters für pulverförmiges Aufbaumaterial
US8764828B2 (en) 2007-02-02 2014-07-01 The Regents Of The University Of Michigan System and method for forming bone, ligament, and bone-ligament constructs
US8343740B2 (en) 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
JP2010527285A (ja) 2007-04-26 2010-08-12 シグモイド・ファーマ・リミテッド 複数のミニカプセルの製造
AU2008262331B2 (en) 2007-06-07 2013-10-17 Wake Forest University Health Sciences Inkjet gene printing
EP2664443B1 (en) 2007-07-25 2021-08-25 Stratasys Ltd. Solid freeform fabrication using a plurality of modeling materials
US20090076531A1 (en) 2007-09-18 2009-03-19 Richardson Charles L Method and apparatus for bypass graft
CA2701884A1 (en) 2007-10-15 2009-04-23 Wake Forest University Health Sciences Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
KR100922232B1 (ko) 2008-02-13 2009-10-16 연세대학교 산학협력단 전기수력학 프린팅 기법을 이용한 살아있는 세포의 직접패터닝 방법 및 장치
EP2090584A1 (en) 2008-02-13 2009-08-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identification of a novel cysteine-rich cell penetrating peptide
WO2009102484A2 (en) 2008-02-14 2009-08-20 Wake Forest University Health Sciences Inkjet printing of tissues and cells
US20090248145A1 (en) 2008-03-28 2009-10-01 Nanyang Technological University Method of forming a three-dimensional structure of unidirectionally aligned cells
US8876513B2 (en) 2008-04-25 2014-11-04 3D Systems, Inc. Selective deposition modeling using CW UV LED curing
US9303245B2 (en) 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
JP5624981B2 (ja) 2008-06-24 2014-11-12 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ 自己集合性多細胞体、および前記多細胞体を用いて３次元の生物構造体を作製する方法
WO2010030964A2 (en) 2008-09-12 2010-03-18 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
US20110250688A1 (en) 2008-11-24 2011-10-13 Immunotrex Corporation Three Dimensional Tissue Generation
EP2450707B1 (en) 2010-11-04 2016-04-27 University of Pécs Lung tissue model
US8691974B2 (en) 2009-09-28 2014-04-08 Virginia Tech Intellectual Properties, Inc. Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering
US8409603B2 (en) 2009-10-01 2013-04-02 University Of South Carolina Compositions and methods for tissue engineering, tissue regeneration and wound healing
EP2521587B1 (en) 2010-01-08 2020-04-08 Wake Forest University Health Sciences Delivery system
JP2013518591A (ja) 2010-02-02 2013-05-23 ザ キュレーターズ オブ ザ ユニバーシティ オブ ミズーリ 改変された生物学的神経移植片の製造およびその用途
ES2671594T3 (es) 2010-03-04 2018-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Puesto de bioimpresión, ensamblaje que comprende dicho puesto de bioimpresión y método de bioimpresión
GB2478801B (en) 2010-03-16 2012-05-30 Organovo Inc Multilayered vascular tubes
US9012415B2 (en) 2010-03-26 2015-04-21 Stemmatters, Biotecnologia E Medicina Regenerativa S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
WO2012003465A2 (en) 2010-07-01 2012-01-05 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
KR20160125530A (ko) 2010-10-21 2016-10-31 오가노보, 인크. 조직의 제작을 위한 디바이스, 시스템 및 방법
JP5283747B2 (ja) 2011-02-09 2013-09-04 富士フイルム株式会社 着色感放射線性組成物、カラーフィルタ、その製造方法、固体撮像素子、及び液晶表示装置
DE202011003443U1 (de) 2011-03-02 2011-12-23 Bego Medical Gmbh Vorrichtung zur generativen Herstellung dreidimensionaler Bauteile
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
JP5599356B2 (ja) 2011-03-31 2014-10-01 富士フイルム株式会社 シミュレーション方法、プログラムおよびそれを記録した記録媒体、並びに、それらを利用した液滴配置パターンの作成方法、ナノインプリント方法、パターン化基板の製造方法およびインクジェット装置。
BR112014005746A2 (pt) 2011-09-12 2017-03-28 Organovo Inc tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos
HK1199812A1 (en) 2011-09-12 2015-07-24 奥加诺沃公司 Platform for engineered implantable tissues and organs and methods of making the same
WO2013116443A1 (en) 2012-02-01 2013-08-08 Nscrypt, Inc. Micro-dispensing multi-layered 3d objects with curing steps
WO2013130823A1 (en) 2012-02-29 2013-09-06 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
HK1202270A1 (en) 2012-03-06 2015-09-25 Uab研究基金会 Three-dimesional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140099709A1 (en) 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
US20140042657A1 (en) 2012-08-08 2014-02-13 Makerbot Industries, Llc Printed circuit board with integrated temperature sensing
WO2014144255A2 (en) 2013-03-15 2014-09-18 Matterfab Corp. Laser sintering apparatus and methods
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
US9802360B2 (en) 2013-06-04 2017-10-31 Stratsys, Inc. Platen planarizing process for additive manufacturing system
US20150037445A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
EP3808838B1 (en) 2014-04-04 2024-04-10 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
US11529436B2 (en) 2014-11-05 2022-12-20 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
US20170130192A1 (en) 2015-11-09 2017-05-11 Organovo, Inc. Methods for tissue fabrication

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Developmental Biology and Tissue Engineering;Marga, F. et al;《Birth Defects Research (Part C)》;20071231;第81卷;摘要 *
Kelm, J. et al.Microscale tissue engineering using gravity-enforced cell assembly.《Trends in Biotechnology》.2004,第22卷(第4期),摘要.
Marga, F. et al.Developmental Biology and Tissue Engineering.《Birth Defects Research (Part C)》.2007,第81卷摘要.
Microscale tissue engineering using gravity-enforced cell assembly;Kelm, J. et al;《Trends in Biotechnology》;20040404;第22卷(第4期);摘要 *

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