CN102119700B - Synergetic antibacterial composition containing fluazinam and iprobenfos and use thereof - Google Patents
Synergetic antibacterial composition containing fluazinam and iprobenfos and use thereof Download PDFInfo
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- CN102119700B CN102119700B CN 201010017618 CN201010017618A CN102119700B CN 102119700 B CN102119700 B CN 102119700B CN 201010017618 CN201010017618 CN 201010017618 CN 201010017618 A CN201010017618 A CN 201010017618A CN 102119700 B CN102119700 B CN 102119700B
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- fluazinam
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Abstract
The invention discloses a synergetic antibacterial composition containing fluazinam and iprobenfos and use thereof. The main ingredients of the antibacterial composition are fluazinam and iprobenfos, wherein the mass ratio of the fluazinam to the iprobenfos is 50:1 to 1:30. The antibacterial composition can be used for preparing antibacterial agent for preventing and controlling diseases in crops. The two active ingredients of the composition can produce a synergetic effect; and when the synergetic antibacterial composition is used, the dose can be reduced; moreover, the synergetic antibacterial composition enlarges antibacterial spectrum, prolongs medicament application period, produces remarkable bacteriostatic and antibacterial effects, overcomes drawbacks caused by the single use of a certain ingredient, avoids the risk of arousing medicine resistance in plant diseases, has an obvious prevention and control effect on rice blast caused by fungi in rice and lowers cost.
Description
Technical field
The present invention relates to a kind of broad spectrum activity bactericidal composition, especially a kind of fluazinam and demeton series bactericidal agent iprobenfos bactericidal composition of containing.This bactericidal composition can be used for preparing the bactericide of preventing and treating corps diseases.
Background technology
The plant disease economic loss is many-sided.At first, concerning the producer, because disease causes crop yield minimizing and quality of products, cause income to reduce; Owing to spraying insecticide or otherwise expenses for prevention and control increases production cost; Sometimes have to plant disease-resistant but kind that output is not high or replant the low crop species of other economic benefits; Impact front owing to results on the fruits and vegetables product or the duration of storage disease has to sell off at a low price when product goes on the market in a large number, or increases fresh-keeping expense for adjusting selling period.Secondly, concerning the consumer, because the disease underproduction causes agricultural product constantly to appreciate, they have been increased live spending or minimizing consumption figure or buy substandard products or substitute, affected quality of life; For the intermediate consumer who comes other commodity of processing with agricultural product, agricultural product price goes up can be increased production cost or affect the end product quality, tends to the expense of increase is imputed to it the ultimate consumer as the producer's intermediate consumer.The 3rd, on the impact of national economy: estimate that according to FAO (Food and Agriculture Organization of the United Nation) average loss was about 10%～15% of gross yield after plant suffered disease.In addition, along with long-term a large amount of unscientific uses of bactericide, the resistance that germ produces is also more and more higher, has brought difficulty to control.Therefore, for the resistance, the delaying drug resistance development speed that overcome germ, prolong the shelf life of each composition etc., research and development can enlarge fungicidal spectrum, and the complex preparation of mutually synergy seems more and more important.
Fluazinam belongs to 2,6-dinitroanilines, is protective fungicide, is mitochondrial oxidation phosphorylated uncoupler.The course of infection in all stages always by suppressing spore germination, mycelia breakthrough, growth and sporulation.The fungicidal spectrum of fluazinam is very wide, and its effect is better than the GPF (General Protection False bactericide.Interlink spore genus, Botrytis, Phytophthora, single shaft Pseudomonas, Sclerotinia and Venturia there are special efficacy, the Botrytis cinerea of anti-benzimidazole type and dicarboximide series bactericidal agent are belonged to good effect is also arranged.This medicine also has the effect that resistance of rainwater washing against, lasting period are long, have two control phytophagous mites concurrently in addition, and the club root of crucifer is also had remarkable preventive effect, for the microbial paddy rice damping off of head mold good control efficiency is arranged also.
Interior suction organic phosphorus type disinfectant iprobenfos has interior sorptivety transparent transmission and leads effect, is systemic fungicide, has protection, treatment and good systemic activity, is chitin synthesis inhibitor, suppresses the normal growth of bacterial cell wall, stops the normal development of bacterium.Iprobenfos mainly is the interference cell membrane permeability, stops some lipophilic chitin prerequisite by cytoplasma membrane, and chitinous biosynthesis block is hindered, and cell wall can not be grown, and suppresses the normal development of thalline.
But these two kinds of compositions use separately on agricultural, and consumption is large, and bactericidal effect is unstable, also are faced with resistance problem simultaneously, and control efficiency descends.Particularly the fluazinam import price is high, and usable floor area is confined on the high some crops of economic value added, and it is less to use area, can not use in the crop pests control widely.
Summary of the invention
The objective of the invention is to provide for above-mentioned weak point the Synergistic bactericidal composition of a kind of containing fluazinam and interior suction organic phosphorus type disinfectant iprobenfos.
Another object of the present invention provides this bactericidal composition and prevents and treats application, the particularly application in the bactericide of preparation control rice blast in the bactericide of rice disease in preparation.
The Synergistic bactericidal composition of a kind of containing fluazinam and interior suction organic phosphorus type disinfectant iprobenfos, it is characterized in that this bactericidal composition is take fluazinam and interior suction organic phosphorus type disinfectant iprobenfos as main effectively active component, wherein, the mass ratio of fluazinam and interior suction organic phosphorus type disinfectant iprobenfos is 50: 1～1: 30, the mass ratio of preferred fluazinam and iprobenfos is 30: 1～1: 20, and most preferred mass ratio is 20: 1～1: 10.
Among the present invention, after the combination of two active component fluazinams and iprobenfos with agricultural chemicals on known additive compound become any one formulation that allows on the agricultural chemicals, preferably be processed into suspending agent, wetting powder, pulvis, granule or missible oil etc., the two quality percentage composition of active ingredient fluazinam and iprobenfos is 5%～70% in the composition, is preferably 10%～60%.
Bactericidal composition of the present invention can prevent the various agricultural disease, is mainly used in preventing and treating the disease of paddy rice, corn, cotton crop, especially to by fungus-caused rice blast obvious control efficiency being arranged.
Bactericidal composition of the present invention can be used in the bactericide of preparation control corps diseases, preferably uses in the bactericide of preparation control rice crop disease, particularly uses in the bactericide of preparation control rice blast.
Beneficial effect of the present invention: two active components of the present composition have synergistic function, can reduce dosage when using; Enlarge simultaneously fungicidal spectrum and widened dispenser period, has better antibacterial and sterilization double effects, overcome the deficiency of a certain composition of single use, avoided plant disease to produce the risk of resistance, especially to by fungus-caused rice blast obvious control efficiency being arranged, reduced simultaneously cost.
Embodiment
For better explaination technical scheme of the present invention and advantage, special the invention will be further described with following embodiment and application examples, but the present invention absolutely not only only limits to these embodiment.
Embodiment 1:50% fluazinam iprobenfos suspending agent
Fluazinam 35%
Iprobenfos 15%
Alkyl naphthalene formaldehyde condensate sulfonates 8%
Alkylphenol-polyethenoxy base phosphate 2%
Xanthans 1%
Water complements to 100%
Above-mentioned respectively the metering stirred by the one-level sand mill after composition mixes, behind the secondary sand mill sand milling, in modulation kettle, allocate, carry out metering, distributing, packaging after inspection by sampling is qualified and namely get the suspending agent formulation products.
Embodiment 2:10% fluazinam iprobenfos wetting powder
Fluazinam 6%
Iprobenfos 4%
Pull open powder 3%
Naphthalene sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, namely get the wetting powder formulation products.
Embodiment 3:40% fluazinam iprobenfos missible oil
Fluazinam 10%
Iprobenfos 30%
Calcium dodecyl benzene sulfonate 6%
Alkylphenol polyoxyethylene 4%
Dimethylbenzene complements to 100%
Above-mentioned metering composition fully mixed as homogeneous phase transparent liquid namely get the cream preparation product.
Embodiment 4:70% fluazinam iprobenfos water dispersion granule
Fluazinam 55%
Iprobenfos 15%
Alkylphenol polyoxyethylene carboxylate 6%
Sodium lignin sulfonate 7%
Sodium bicarbonate 4%
Talcum powder 4%
Kaolin complements to 100%
Active ingredient iprobenfos and fluazinam are pulverized the rear wetting dispersing agent sodium lignin sulfonate that adds, the alkylphenol polyoxyethylene carboxylate, sodium bicarbonate and the talcum powder rear interpolation filler kaolin that stirs grinds the pressure granulation after the mixing, oven dry namely gets the water dispersion granule formulation products.
Embodiment 5:5% fluazinam iprobenfos wetting powder
Fluazinam 2.5%
Iprobenfos 2.5%
Pull open powder 3%
Naphthalene sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, namely get the wetting powder formulation products.
Embodiment 6:55% fluazinam iprobenfos missible oil
Fluazinam 5%
Iprobenfos 50%
Calcium dodecyl benzene sulfonate 6%
Alkylphenol polyoxyethylene 4%
Dimethylbenzene complements to 100%
Above-mentioned metering composition fully mixed as homogeneous phase transparent liquid namely get the cream preparation product.
Embodiment 7:52% fluazinam iprobenfos wetting powder
Fluazinam 50%
Iprobenfos 2%
Pull open powder 2%
Naphthalene sulfonate 10%
White carbon 10%
Kaolin complements to 100%
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, namely get the wetting powder formulation products.
Embodiment 8:31% fluazinam iprobenfos missible oil
Fluazinam 1%
Iprobenfos 30%
Calcium dodecyl benzene sulfonate 10%
Alkylphenol polyoxyethylene 6%
Dimethylbenzene complements to 100%
Above-mentioned metering composition fully mixed as homogeneous phase transparent liquid namely get the cream preparation product.
Embodiment 9:31.5% fluazinam iprobenfos wetting powder
Fluazinam 30%
Iprobenfos 1.5%
Pull open powder 4%
Naphthalene sulfonate 10%
White carbon 10%
Kaolin complements to 100%
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, namely get the wetting powder formulation products.
Embodiment 10:23.5% fluazinam iprobenfos wetting powder
Fluazinam 1.5%
Iprobenfos 22%
Pull open powder 6%
Naphthalene sulfonate 14%
White carbon 12%
Kaolin complements to 100%
Above metering composition is mixed laggard promoting the circulation of qi stream pulverize, namely get the wetting powder formulation products.
Application Example 1: the different proportionings from iprobenfos of fluazinam are to the toxicity test of rice blast
By a large amount of Seiving Tests, co-toxicity coefficient method analysis synergistic effect is between the two asked in utilization, finds in certain ratio range, and fluazinam and iprobenfos combination antagonism Pyricularia oryzae have obvious synergistic function, rather than simple summation action, specifically test as follows:
Test material: the sick leaf of rice blast that picks up from the field
Test method: choose the rice seedlings of 2～3 consistent leaf leaf periods of growing way, with the processing of spraying of the drug concentration for preparing, each medicament arranges 5 concentration, and each processing arranges three repetitions.Chemicals treatment connect bacterium after 24 hours, suspension is made in the germ extraction of picking up from the sick leaf of rice blast in field inoculated, and then placed in the greenhouse and cultivated.Check the blade disease index after 7 days, calculate the EC of each proportioning
50And co-toxicity coefficient (CTC).
Analytical method: when CTC＜100, then the composition performance is antagonism; When CTC=100, then composition performance is summation action, and when CTC＞100, then the composition performance is synergistic effect.
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
ATI=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in the percentage composition of TTI=A medicament toxicity index * mixed concentrated A+B medicament toxicity index * mixture
Measurement result shows, fluazinam and iprobenfos have obvious synergistic effect in proportioning between 50: 1～1: 30, and especially between 20: 1～1: 10, synergistic effect is more remarkable, and co-toxicity coefficient (is seeing the following form) more than 160
The different proportionings from iprobenfos of fluazinam are to the Toxicity Determination result of rice blast
Application Example 2: the field control effectiveness test of control rice blast
1. test is processed: this test medicine consumption is the consumption of active ingredient, different preparations are established respectively three concentration for the treatment of, and the contrast medicament is respectively commercially available agricultural chemicals 50% fluazinam suspending agent (SC) and 40% iprobenfos missible oil (EC) and the test of blank clear water.
2. test method: each residential quarter area is 66.7m
2, repeat 3 times; Inspection drug effect method before the dispenser behind the Investigation and Prevention is: random sampling 5 points in the test treatment region, every 50 fringes check Occurrence Degree of Rice Blast.
3. result of the test sees the following form:
Annotate: a is illustrated on α=0.05 level remarkable, and b is illustrated on α=0.05 level variant, and c is illustrated on α=0.05 level not remarkable.
Field control effectiveness test shows that the composition of fluazinam and iprobenfos has significant control efficiency to rice blast, has the preventive effect than certain medicine excellence of single use.
Claims (7)
1. the Synergistic bactericidal composition of a containing fluazinam and iprobenfos is characterized in that this bactericidal composition take fluazinam and iprobenfos as active ingredient, and wherein, the mass ratio of fluazinam and iprobenfos is 50:1,5:1,1:5,1:10 or 1:20.
2. bactericidal composition according to claim 1 is characterized in that the two gross mass percentage composition that accounts for composition of described fluazinam and iprobenfos is 5% ~ 70%.
3. described bactericidal composition according to claim 1 is characterized in that fluazinam and iprobenfos become any one formulation that allows on the agricultural chemicals with known additive compound.
4. bactericidal composition according to claim 3 is characterized in that described formulation is suspending agent, wetting powder, pulvis, granule or missible oil.
5. the application of bactericidal composition claimed in claim 1 in the bactericide of preparation control corps diseases.
6. the application of bactericidal composition according to claim 5 in the bactericide of preparation control rice crop disease.
7. the application of bactericidal composition according to claim 6 in the bactericide of preparation control rice blast.
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| CN 201010017618 CN102119700B (en) | 2010-01-08 | 2010-01-08 | Synergetic antibacterial composition containing fluazinam and iprobenfos and use thereof |
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| CN 201010017618 CN102119700B (en) | 2010-01-08 | 2010-01-08 | Synergetic antibacterial composition containing fluazinam and iprobenfos and use thereof |
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| CN102119700A CN102119700A (en) | 2011-07-13 |
| CN102119700B true CN102119700B (en) | 2013-03-20 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1870895A (en) * | 2003-10-23 | 2006-11-29 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
| CN101755824A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
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- 2010-01-08 CN CN 201010017618 patent/CN102119700B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1870895A (en) * | 2003-10-23 | 2006-11-29 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
| CN101755824A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
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| CN102119700A (en) | 2011-07-13 |
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