Summary of the invention
The object of the present invention is to provide a kind of composition and method of making the same for the treatment of eczema, have favorable effects, have no adverse reaction for eczema.
For solving the problems of the technologies described above, embodiments of the present invention provide a kind of compositions for the treatment of eczema, and said composition is made up of pharmaceutically acceptable carrier and active ingredient, and active ingredient is made of the component of following weight proportion:
The Herba Asari of 1-5 weight portion;
The Cortex Cinnamomi of 1-5 weight portion;
The Herba Ephedrae of 1-5 weight portion;
The Rhizoma Atractylodis of 1-5 weight portion;
The Radix Saposhnikoviae of 1-5 weight portion;
The Radix Aconiti Lateralis Preparata of 1-5 weight portion;
The Fructus Kochiae of 1-5 weight portion.
Embodiments of the present invention also provide a kind of preparation method for compositions above, the component of following weight proportion is mixed with pharmaceutically acceptable carrier, thereby obtain above compositions:
The Herba Asari of 1-5 weight portion;
The Cortex Cinnamomi of 1-5 weight portion;
The Herba Ephedrae of 1-5 weight portion;
The Rhizoma Atractylodis of 1-5 weight portion;
The Radix Saposhnikoviae of 1-5 weight portion;
The Radix Aconiti Lateralis Preparata of 1-5 weight portion;
The Fructus Kochiae of 1-5 weight portion.
Embodiments of the present invention also provide a kind of method for preparing the herbal application sheet for the treatment of eczema, may further comprise the steps:
The component of following weight proportion is mixed:
The Herba Asari of 1-5 weight portion;
The Cortex Cinnamomi of 1-5 weight portion;
The Herba Ephedrae of 1-5 weight portion;
The Rhizoma Atractylodis of 1-5 weight portion;
The Radix Saposhnikoviae of 1-5 weight portion;
The Radix Aconiti Lateralis Preparata of 1-5 weight portion;
The Fructus Kochiae of 1-5 weight portion;
To beat fine powder through blended said components, and add polyvinylpyrrolidone and the made mixture of water, and make soft material, and cross 12 mesh sieves, oven dry is taken out, granulate, with uniform particles be tiled on the dish;
Other gets Herba Menthae 1-5 weight portion, extracts volatile oil,
Gained volatile oil is sprayed on the granule equably, after treating fully to absorb, adds Pulvis Talci or magnesium stearate, stir evenly compression molding.
Embodiment of the present invention compared with prior art, the main distinction and effect thereof are:
Have favorable effects for eczema, therapeutic effect is excellent, has no adverse reaction.
Further, to above-mentioned composition, make the herbal application sheet, be put in place, regulation acupuncture point,, can give full play to drug effect by Transdermal absorption, so both there be not the apply ointment or plaster time upper limit system of the treating winter disease in summer that exists of tradition, can save again and add the safety issue that exists with acusector, improve patient's compliance greatly, be convenient to patient's Heal Thyself.
The specific embodiment
In the following description, in order to make the reader understand the application better many ins and outs have been proposed.But, persons of ordinary skill in the art may appreciate that even without these ins and outs with based on the many variations and the modification of following each embodiment, also can realize each claim of the application technical scheme required for protection.
For making the purpose, technical solutions and advantages of the present invention clearer, embodiments of the present invention are described in further detail below in conjunction with accompanying drawing.
First embodiment of the invention relates to a kind of compositions for the treatment of eczema.The compositions said composition of this treatment eczema is made up of pharmaceutically acceptable carrier and active ingredient, and active ingredient is made of the component of following weight proportion:
The Herba Asari of 1-5 weight portion.Herba Asari has another name called thin ginseng, bowl of a pipe flower.The Semen Oroxyli section of being born in the year of horse, herbaceos perennial.Be conventional Chinese medicine.Shennong's Herbal is classified as top grade.Because of its root is thin, acrid in the mouth, so gain the name.
The Cortex Cinnamomi of 1-5 weight portion.Cinnamomic English name Chinese Cinnamcn, Cassia Bark calls beautiful osmanthus, male osmanthus, Cortex Cinnamomi, tube osmanthus, Da Gui, peppery osmanthus, osmanthus.Bark for canella Cortex Cinnamomi Cinnamomumcassia Presl.This product shallow slot shape or drum, long 30~50cm, wide or barrel dliameter 3~10cm, thick 2~8mm.The outer surface taupe brown, coarse slightly, the hole skin and the fine wrinkle of horizontal micro-protuberance are arranged; The inner surface brownish red, level and smooth, thin longitudinal grin is arranged, the apparent oil trace of drawing.Matter is crisp firmly, the section graininess, and outer brown, the internal layer rufous is and glossy, and two interlayers have a faint yellow strain line (stone cell band).Gas is aromatic strong.Contain and contain cinnamic aldehyde (cinnamaldehyde), cinnamyl acetate (cinnamylacetate), eugenol, cinnamic acid, stupid beautiful sour acetic acid, osmanthus diterpene alcohol (cinnzeylanol), acetyl osmanthus diterpene alcohol (cinnzeylanine) in volatile oil, the oil.Extremely hot in nature, acrid in the mouth, sweet.
The Herba Ephedrae of 1-5 weight portion.Herba Ephedrae Chinese crude drug formal name used at school is Herbal Ephedrae, another name dragon sand, Os Canitis, inferior phase, inferior salt, be Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, the herb stem of epheday intermedia Ephedra intermedia Schrenk ex C.A.Mey. or ephedra equisetina Ephedraequisetina Bge..Hot, little hardship, temperature.Return lung, urinary bladder channel.
The Rhizoma Atractylodis of 1-5 weight portion.The Latin of Rhizoma Atractylodis is called Rhizoma Atractylodis, another name: red art, blue or green art, magic arts.It is cylindrical to be irregular beaded or nodositas, and slightly crooked, idol has branch, long 3~10cm, diameter 1~2cm.The surface taupe brown has wrinkle, lateral flexure stricture of vagina and residual fibrous root, top tool stem trace or residual stem foot.Matter is solid, section yellow-white or canescence, and loosing has most orange-yellow or brownish red grease chambeies, exposes for a long time slightly, can separate out white fine needle crystal.Gas perfume (or spice) is special, and it is little sweet, hot, bitter to distinguish the flavor of.
The Radix Saposhnikoviae of 1-5 weight portion.Radix Saposhnikoviae is the dry root of Saposhnikovia divaricata (Turcz.) Schischk..Acrid in the mouth, sweet, slightly warm in nature.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
The Radix Aconiti Lateralis Preparata of 1-5 weight portion.The English RADIX ACONITI LATERALISPREPARATA by name of Radix Aconiti Lateralis Preparata is the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx..Nature and flavor: hot, sweet, big heat; Poisonous.
The Fructus Kochiae of 1-5 weight portion.The Fructus Kochiae (Fructus Kochiae), another name: broom colza, broom.Fruit for chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor: cold in nature, acrid in the mouth, hardship.Function: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Term in the present invention " pharmaceutically acceptable carrier " refers to be used for the treatment of the carrier of agent administration, comprises various excipient and diluent.This term refers to some medicament carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.(Mack Pub.Co. can find discussing fully about pharmaceutically acceptable excipient in N.J.1991) at Remington ' s Pharmaceutical Science.Acceptable carrier can comprise liquid on combination of Chinese medicine is learned, as water, saline, glycerol and ethanol.In addition, also may there be complementary material in these carriers, as disintegrating agent, wetting agent, emulsifying agent, pH buffer substance etc.
Said composition has favorable effects for eczema, and therapeutic effect is excellent, has no adverse reaction.
From the pharmacology angle above-mentioned composition is analyzed below.
Monarch drug: Herba Asari, property and flavor of peppery and warm is returned lung, kidney, heart channel, and effect expelling wind and cold, warming the lung to resolve fluid-retention, modern pharmacology show that this medicine contains volatile oil, have effects such as the immunity of inhibition, anti-inflammation, antiallergic.
Ministerial drug: Cortex Cinnamomi, nature and flavor suffering, big heat are returned liver, kidney, the heart, spleen channel, and effect mends that fire is supporing yang, guiding fire to origin, cold expelling, promoting blood circulation to remove obstruction in the collateral, and modern pharmacology shows that this medicine contains volatile oil, has effects such as regulating immune, antibiotic, expansion blood vessel; Herba Ephedrae, property and flavor of peppery and warm is returned lung, urinary bladder channel, effect diaphoresis cold expelling, freeing lung-Qi and eliminating damp, modern pharmacological research, this medicine contains alkaloid, has effects such as diaphoresis, antiinflammatory, antipathogen; Rhizoma Atractylodis, the arduous temperature of nature and flavor is returned spleen, stomach, Liver Channel, the effect functions dispelling wind and clearing away cold, removing dampness, modern pharmacological research confirms that this medicine contains volatile oil, has effects such as antiinflammatory, antipathogen.
Adjuvant drug: Radix Aconiti Lateralis Preparata, nature and flavor suffering, big heat, GUIXIN, kidney, spleen channel, the supporing yang cold expelling of effect, modern pharmacological research shows that this medicine contains alkaloid, has effects such as antiinflammatory and immunomodulating; Radix Saposhnikoviae, property and flavor of peppery and warm is returned bladder, liver, spleen channel, and effect is delivered and is dispeled the wind, dehumidifies; Modern pharmacology shows that this medicine contains volatile oil, has effects such as antiinflammatory, antiallergic and enhance immunity; The Fructus Kochiae, nature and flavor are cold, toil, return kidney, urinary bladder channel, and effect clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, modern pharmacology show that this medical instrument has effects such as antimicrobial antiphlogistic, adjusting immunity.
Messenger drug: Herba Menthae, pungent in flavor and cool in property, return lung, Liver Channel, effect dispelling wind heat, rash, modern pharmacological research shows that this medical instrument has effects such as antipathogen, antiinflammatory and short transdermal.
For eczema, the traditional Chinese medical science be it is generally acknowledged many by due to the ailment said due to cold or exposure, accumulates wet forming, or arises from the tire biography, and rheumatism is tied mutually, and it is unbearable very to itch, and is sick difficult for a long time; Modern clinical research proves that primary disease is many to be brought out because of allergy, due to immunomodulating is unbalance.This case is outside the Chinese medicine of routine or antiallergic agent are for oral administration, off the beaten track, use for reference the method for the treatment of winter disease in summer, improve yang-energy with external application of Chinese medicine acupuncture point, set upright getting rid of evils, more than eight flavor drug matching externals, totally with hot Wen Weizhu, mostly traveling lung, kidney, heart channel, common performance is dispeled the wind, lung qi dispersing, dehumidifying, effect such as antipruritic, thereby makes emaciation due to emotional upset, wetly remove, itch and end.From the modern pharmacological research angle, eight flavor Chinese medicines share, owing to contain volatile oil mostly, have effects such as good antiinflammatory, antiallergic, adjusting immunity, the hot mostly temperature of the property of medicine has the good transdermal effect of invigorating blood circulation in addition, therefore plays the effect of treatment eczema by the point application method.
Second embodiment of the invention relates to a kind of compositions for the treatment of eczema.
Second embodiment has further adopted more accurate component ratio on the basis of first embodiment, specifically, and in the active ingredient:
Herba Asari is the 2.7-3.3 weight portion.
Cortex Cinnamomi is the 2.7-3.3 weight portion.
Herba Ephedrae is the 2.7-3.3 weight portion.
Rhizoma Atractylodis are the 2.7-3.3 weight portion.
Radix Saposhnikoviae is the 2.7-3.3 weight portion.
Radix Aconiti Lateralis Preparata is the 2.7-3.3 weight portion.
The Fructus Kochiae is the 2.7-3.3 weight portion.
Third embodiment of the invention relates to a kind of compositions for the treatment of eczema.
The 3rd embodiment is on the basis of first or second embodiment, and the dosage form of the compositions that first or second embodiment is proposed is improved to the herbal application sheet, and this herbal application sheet is put in place, regulation acupuncture point, passes through Transdermal absorption.
Make the herbal application sheet, be put in place, regulation acupuncture point, pass through Transdermal absorption, can give full play to drug effect, so both not have the apply ointment or plaster time upper limit system of the treating winter disease in summer that exists of tradition, can save again and add the safety issue that exists with acusector, improve patient's compliance greatly, be convenient to patient's Heal Thyself.
Certainly, the compositions in first, second embodiment also can be other dosage form, for example, and decoction, tablet etc.
Four embodiment of the invention relates to a kind of method for compositions for the treatment of eczema for preparing.This method is mixed the component of following weight proportion with pharmaceutically acceptable carrier, thus the compositions of the eczema that obtains medical treatment:
The Herba Asari of 1-5 weight portion.
The Cortex Cinnamomi of 1-5 weight portion.
The Herba Ephedrae of 1-5 weight portion.
The Rhizoma Atractylodis of 1-5 weight portion.
The Radix Saposhnikoviae of 1-5 weight portion.
The Radix Aconiti Lateralis Preparata of 1-5 weight portion.
The Fructus Kochiae of 1-5 weight portion.
Present embodiment is and first, second or the corresponding method embodiment of the 3rd embodiment, present embodiment can with the enforcement of working in coordination of first, second or the 3rd embodiment.The correlation technique details of mentioning in first, second or the 3rd embodiment is still effective in the present embodiment, in order to reduce repetition, repeats no more here.Correspondingly, the correlation technique details of mentioning in the present embodiment also can be applicable in first, second or the 3rd embodiment.
Fifth embodiment of the invention relates to a kind of method for preparing the herbal application sheet for the treatment of eczema.This method may further comprise the steps:
The component of following weight proportion is mixed:
The Herba Asari of 1-5 weight portion.
The Cortex Cinnamomi of 1-5 weight portion.
The Herba Ephedrae of 1-5 weight portion.
The Rhizoma Atractylodis of 1-5 weight portion.
The Radix Saposhnikoviae of 1-5 weight portion.
The Radix Aconiti Lateralis Preparata of 1-5 weight portion.
The Fructus Kochiae of 1-5 weight portion.
To break into fine powder through blended said components, and add polyvinylpyrrolidone and the made mixture of water, and make soft material, and cross 12 mesh sieves, oven dry is taken out, granulate, with uniform particles be tiled on the dish.
Other gets Herba Menthae 1-5 weight portion, extracts volatile oil,
Gained volatile oil is sprayed on the granule equably, after treating fully to absorb, adds Pulvis Talci or magnesium stearate, stir evenly compression molding.
Present embodiment is and first, second or the corresponding method embodiment of the 3rd embodiment, present embodiment can with the enforcement of working in coordination of first, second or the 3rd embodiment.The correlation technique details of mentioning in first, second or the 3rd embodiment is still effective in the present embodiment, in order to reduce repetition, repeats no more here.Correspondingly, the correlation technique details of mentioning in the present embodiment also can be applicable in first, second or the 3rd embodiment.
Sixth embodiment of the invention relates to a kind of method for preparing the herbal application sheet for the treatment of eczema.
The 6th embodiment improves on the basis of the 5th embodiment, and main improvements are:
Gained volatile oil is no less than 0.8%ml/g.
Pulvis Talci is 1% Pulvis Talci.
Magnesium stearate is 0.3% magnesium stearate.
The ratio of polyvinylpyrrolidone and water is: the 100g polyvinylpyrrolidone is converted 2000ml water.
Though by with reference to some of the preferred embodiment of the invention, the present invention has been carried out and describe, those of ordinary skill in the art should be understood that and can do various changes to it in the form and details, and without departing from the spirit and scope of the present invention.