CN102106906A - Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities - Google Patents
Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities Download PDFInfo
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- CN102106906A CN102106906A CN2009102006891A CN200910200689A CN102106906A CN 102106906 A CN102106906 A CN 102106906A CN 2009102006891 A CN2009102006891 A CN 2009102006891A CN 200910200689 A CN200910200689 A CN 200910200689A CN 102106906 A CN102106906 A CN 102106906A
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- oral cavity
- chinese medicine
- medicine composition
- cavity cleaning
- breath freshening
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Abstract
The invention discloses a traditional Chinese medicine composition for freshening breath and cleansing oral cavities, which comprises the following bulk drugs in percentage by weight: 5-90% of clove essential oil, 5-90% of tea polyphenols and 5-90% of chlorogenic acids. In addition, the invention also discloses breath freshening and oral cavity cleansing preparations containing the traditional Chinese medicine composition, and the preparations comprise chewing gum, candy, collut and the like. Through pharmacodynamic studies, the traditional Chinese medicine composition disclosed by the invention has a strong synergistic inhibition effect on oral pathogens, and can be used for freshening breath and cleansing oral cavities.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition and preparation thereof that is used for breath freshening and oral cavity cleaning.
Background technology
Along with growth in the living standard, confectionery increases, and brings some bad consequences, particularly oral disease, halitosis etc.; And breath freshening also is the very important part of daily life, and becomes a kind of fashion, and therefore the product of considerable consumers need fresh breath or cleaning oral cavity is arranged.But present oral cavities such as chewing gum deliver the preparation majority with sugar and colloid as primary raw material, can not kill the oral cavity bacterium of curing the disease effectively, and use dental care products such as toothbrush or dental floss out of doors or travelling seem very inconvenient.
Flos Caryophylli plays a very important role for breath freshening and oral cavity cleaning tool as the founder of Ancient Chinese for chewing gum.Chemical constitution study shows: Flos Caryophylli contains volatile oil, is mainly eugenol, tanning, oleanolic acid etc.; Modern pharmacological research shows: Flos Caryophylli volatile oil has effects such as antibiotic, parasite killing, pain relieving.And tea polyphenols and chlorogenic acid have stronger inhibitory action to the main pathogenic bacterium in oral cavity.Still no-trump Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid make up the bibliographical information that is used for breath freshening and oral cavity cleaning as Chinese medicine preparation with certain proportion in the prior art.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of preparation that is used for the Chinese medicine composition of breath freshening and oral cavity cleaning and contains this Chinese medicine composition.
In one aspect of the invention, provide a kind of Chinese medicine composition that is used for breath freshening and oral cavity cleaning, form by the crude drug of following weight ratio:
Flos Caryophylli volatile oil: 5-90%
Tea polyphenols: 5-90%
Chlorogenic acid: 5-90%.
This Chinese medicine composition preferred ingredients ratio is:
Flos Caryophylli volatile oil: 40%
Tea polyphenols: 40%
Chlorogenic acid: 20%.
The present invention selects Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid to make up, and makes each efficacy of drugs produce synergism the combination of these medical materials, thereby can effectively suppress the oral cavity bacterium of curing the disease, and reaches the effect of breath freshening and oral cavity cleaning.Flos Caryophylli plays a very important role for breath freshening and oral cavity cleaning tool as the founder of Ancient Chinese for chewing gum.Chemical constitution study shows: Flos Caryophylli contains volatile oil, is mainly eugenol, tannin, oleanolic acid etc.; Modern pharmacological research shows: Flos Caryophylli volatile oil has effects such as antibiotic, parasite killing, pain relieving.And tea polyphenols and chlorogenic acid have stronger inhibitory action to the main pathogenic bacterium in oral cavity.The present invention finds after deliberation: Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid have very strong coordinate repression to the oral cavity bacterium of curing the disease in the certain proportion combination.
This Chinese medicine composition method is routinely mixed Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid promptly.
In another aspect of this invention, a kind of breath freshening and oral cavity cleaning preparation are provided, this breath freshening and oral cavity cleaning preparation comprise Chinese medicine composition and sugar or the gum base or the suitable adjuvant of above-mentioned Flos Caryophylli volatile oil, tea polyphenols and chlorogenic acid, and described breath freshening and oral cavity cleaning preparation comprise chewing gum, confection and collut etc.The ratio of Chinese medicine composition in preparation in this breath freshening and the oral cavity cleaning preparation is 0.1-10%.Chewing gum, confection can coatings or coating not, and can be various flavour, shape, size.Can increase different taste flavoring agents in this breath freshening and the oral cavity cleaning preparation and be prepared into different tastes, comprise Herba Menthae, stay indigo plant, the taste of Fructus Citri Limoniae, milk, various fruit etc.
Breath freshening of the present invention and oral cavity cleaning preparation adopt conventional preparation method, and for example, chewing-gum preparation can be prepared by following method:
1. after gum base being placed 45-80 ℃ baking oven softening, put into agitator, stir.
2. after malt oligosaccharide syrup being preheated to 43 ℃, put into agitator, stir.
3. with behind the sweeting agent mix homogeneously such as 85% Fructus Hordei Germinatus oligose powder, aspartame, palatinose, put into agitator.
4. behind the sweeting agent mixing with Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Fructus Citri Limoniae quintessence oil and residue 15%, and put into agitator, again Pulvis Talci is put into agitator, discharging behind the mixing.
With mass transport to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, placed 24 hours after the compression moulding, pack again and get final product.
The present invention has following beneficial effect: find that through pharmacodynamic study Chinese medicine composition of the present invention has very strong coordinate repression to the oral cavity bacterium of curing the disease, and can be used for breath freshening and oral cavity cleaning.
The specific embodiment
Below by test the example beneficial effect of the present invention is further elaborated:
The pharmacodynamic study method and the result of test example 1 Chinese medicine composition of the present invention
Antibacterial culturing: the bacterial isolates that this test is adopted is all available from DSMZ of the Chinese Academy of Sciences.(Tryptlcase vbroth, B), anaerobism is cultivated 18h (90%N to adopt the trypsinization soya broth
2, 5%CO
237 ℃) 2～3d (my god).Bacteria resuscitation is after be inoculated in corresponding agar plate after the biochemical identification.The single bacterium colony of picking agar surface is suspended in corresponding cross in the body culture medium, and (1 diameter 1mm bacterium colony/ml) cultivate makes bacterial concentration be 10 after cultivating the corresponding time
5-6CFU/ml.
Medicine: Flos Caryophylli volatile oil (being called for short DXH), tea polyphenols (being called for short CDF), chlorogenic acid (being called for short LYS) available from Shaanxi Sen Fu Bioisystech Co., Ltd available from section's natural plants technology company in the Hangzhou available from the extra large natural perfume material oil of Jishui County gold Science and Technology Ltd..
MIC measures: the various medicines 50 μ l that draw dilution in gradient with aseptic micro sample adding appliance add equivalent bacterium liquid again in aseptic 96 hole microwell plates, mix.Place under the suitable condition of culture and hatch, need O
2Bacterium 24h, observed result behind other 48h, the lowest concentration of drug that the meat limit is observed no bacterial growth is MIC.
MBC measures: do not have culture in the microwell plate of bacterial growth with the perusal of aseptic inoculation ring picking, streak inoculation is in corresponding flat board.Felicity condition is cultivated the back down and is observed, and the lowest concentration of drug of no bacterial growth is MBC.
Positive control: do not add various medicines, only add bacterium liquid and equivalent fluid medium.Negative control: do not add bacterium liquid, only add various medicines and equivalent fluid medium.
Table 1 Chinese medicine and compositions thereof are to the antimicrobial susceptibility MIC test result (μ g/ml) of oral cavity pathogen
Table 2 Chinese medicine and compositions thereof are to the antimicrobial susceptibility MBC test result (μ g/ml) of oral cavity pathogen
From table 1,2 data as can be seen, Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid all have fungistatic effect preferably to the 8 kinds of pathogenic bacterium in oral cavity, and based on Flos Caryophylli volatile oil, equivalent proportioning tea polyphenols, chlorogenic acid fungistatic effect are better, illustrate between Flos Caryophylli volatile oil, tea polyphenols, the chlorogenic acid three to have collaborative bacteriostasis.
Table 3 Chinese medicine and compositions thereof are to the antimicrobial susceptibility MIC test result (μ g/ml) of oral cavity pathogen
Table 4 Chinese medicine and compositions thereof are to the antimicrobial susceptibility MBC test result (μ g/ml) of oral cavity pathogen
From table 3,4 data as can be seen, the different proportionings of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid are all effective than individually dosed to the fungistatic effect of the 8 kinds of pathogenic bacterium in oral cavity, illustrate and have collaborative bacteriostasis between the three really, when Flos Caryophylli volatile oil, tea polyphenols, when the chlorogenic acid ratio is 2: 2: 1, fungistatic effect is best.
The invention will be further elaborated by the following examples:
Adopted in following examples: Flos Caryophylli volatile oil, be called for short DXH, available from the extra large natural perfume material oil of Jishui County gold Science and Technology Ltd.; Tea polyphenols is called for short CDF, available from section's natural plants technology company in the Hangzhou; Chlorogenic acid is called for short LYS, available from Shaanxi Sen Fu Bioisystech Co., Ltd.
One. contain the preparation of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid chewing gum
Table 5 contains the chewing gum prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, gum base is placed 55 ℃ baking oven softening after, put into agitator, stir.
2, malt oligosaccharide syrup is preheated to 43 ℃ after, put into agitator, stir.
3, sweeting agents such as 85% Fructus Hordei Germinatus oligose powder, aspartame, palatinose are mixed all with after, put into agitator.
4, behind the sweeting agent mixing with Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Fructus Citri Limoniae quintessence oil and residue 15%, and put into agitator, again Pulvis Talci is put into agitator, discharging behind the mixing.
5, with mass transport to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, placed 24 hours after the compression moulding, pack again and get final product.
Two. contain the preparation of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid chewing gum
Table 6 contains the chewing gum prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, gum base is placed 80 ℃ baking oven softening after, put into agitator, stir.
2, corn syrup is preheated to 43 ℃ after, put into agitator, stir.
3,85% sweeting agents such as Fructus Hordei Germinatus oligose powder are mixed all with after, put into agitator.
4, behind the sweeting agent mixing with Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Herba Menthae quintessence oil and residue 15%, and put into agitator, again Pulvis Talci is put into agitator, discharging behind the mixing.
5, with mass transport to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, placed 24 hours after the compression moulding, pack again and get final product.
Three. contain the preparation of the confection of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Table 7 contains the confection prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, corn syrup is preheated to 43-50 ℃ after, put into agitator, stir.
2,85% sweeting agents such as Fructus Hordei Germinatus oligose powder are mixed all with after, put into agitator.
3, behind the sweeting agent mixing with Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Herba Menthae quintessence oil, polyhydric alcohol, milk and residue 15%, and put into agitator, again Pulvis Talci is put into agitator, discharging behind the mixing.
4, with mass transport to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, placed 24 hours after the compression moulding, pack again and get final product.
Four. the mouth that contains Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid is gargled the preparation of agent
Table 8 contains the mouth of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid and gargles the agent prescription
Preparation technology:
1, ethanol, glycerol mix homogeneously.
2, Flos Caryophylli volatile oil is added in the mixed liquor of ethanol and glycerol.
3, tea polyphenols, chlorogenic acid are added in the entry dissolve, stir.
4, with step 2,3 liquid mixing, and add lecithin, tween 80, Durio Zibethinus murr essence, stir, fill, packing get final product.
Claims (5)
1. a Chinese medicine composition that is used for breath freshening and oral cavity cleaning is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight ratio:
Flos Caryophylli volatile oil: 5-90%
Tea polyphenols: 5-90%
Chlorogenic acid: 5-90%.
2. the Chinese medicine composition that is used for breath freshening and oral cavity cleaning as claimed in claim 1 is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight ratio:
Flos Caryophylli volatile oil: 40%
Tea polyphenols: 40%
Chlorogenic acid: 20%.
3. breath freshening and oral cavity cleaning preparation, it is characterized in that, this breath freshening and oral cavity cleaning preparation comprise claim 1 or the 2 described Chinese medicine compositions and the suitable adjuvant of effective dose, and described breath freshening and oral cavity cleaning preparation comprise chewing gum, confection and collut.
4. breath freshening as claimed in claim 3 and oral cavity cleaning preparation is characterized in that the ratio of Chinese medicine composition in preparation in this breath freshening and the oral cavity cleaning preparation is 0.1-10%.
5. one kind as claim 3 or 4 described breath freshenings and oral cavity cleaning preparation, it is characterized in that, can add different taste flavoring agents in this breath freshening and the oral cavity cleaning preparation and be prepared into different tastes, comprise Herba Menthae, stay indigo plant, the taste of Fructus Citri Limoniae, milk and various fruit.
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| CN200910200689.1A CN102106906B (en) | 2009-12-24 | 2009-12-24 | Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities |
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| CN200910200689.1A CN102106906B (en) | 2009-12-24 | 2009-12-24 | Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities |
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| CN102106906B CN102106906B (en) | 2014-04-16 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705912A (en) * | 2013-12-20 | 2014-04-09 | 江苏雪豹日化有限公司 | Composite lysozyme oral spray and preparation method thereof |
| CN106309173A (en) * | 2015-06-16 | 2017-01-11 | 赵丹青 | Pure natural mouthwash and preparation method thereof |
| CN107927305A (en) * | 2017-12-15 | 2018-04-20 | 阜阳健诺生物科技有限公司 | A kind of antibacterial tasty and refreshing sugar of halitosis of dispelling and preparation method thereof |
| CN109464319A (en) * | 2018-11-02 | 2019-03-15 | 东莞波顿香料有限公司 | Breath freshening capsule and preparation method thereof |
| CN109998975A (en) * | 2019-05-24 | 2019-07-12 | 福建中合医药股份有限公司 | A kind of efficient toothpaste |
| CN110267637A (en) * | 2017-12-01 | 2019-09-20 | 高露洁-棕榄公司 | Oral care composition |
| CN115211486A (en) * | 2022-07-26 | 2022-10-21 | 山东大学 | Chewing gum capable of promoting breath freshening and preparation method thereof |
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| WO2001017494A1 (en) * | 1999-09-08 | 2001-03-15 | The Procter & Gamble Company | Oral compositions comprising tea polyphenol |
| JP2005154339A (en) * | 2003-11-26 | 2005-06-16 | Morinaga & Co Ltd | Bad breath-reducing composition |
| CN1965855A (en) * | 2005-11-14 | 2007-05-23 | 陈祖辉 | Microecological formulation for treating and caring mouth cavity disease |
| JP2008024696A (en) * | 2006-06-19 | 2008-02-07 | Morishita Jintan Kk | Multiple soft capsule for removing halitosis |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2001017494A1 (en) * | 1999-09-08 | 2001-03-15 | The Procter & Gamble Company | Oral compositions comprising tea polyphenol |
| JP2005154339A (en) * | 2003-11-26 | 2005-06-16 | Morinaga & Co Ltd | Bad breath-reducing composition |
| CN1965855A (en) * | 2005-11-14 | 2007-05-23 | 陈祖辉 | Microecological formulation for treating and caring mouth cavity disease |
| JP2008024696A (en) * | 2006-06-19 | 2008-02-07 | Morishita Jintan Kk | Multiple soft capsule for removing halitosis |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705912A (en) * | 2013-12-20 | 2014-04-09 | 江苏雪豹日化有限公司 | Composite lysozyme oral spray and preparation method thereof |
| CN103705912B (en) * | 2013-12-20 | 2015-10-28 | 江苏雪豹日化有限公司 | A kind of composite lysozyme oral spray and preparation method thereof |
| CN106309173A (en) * | 2015-06-16 | 2017-01-11 | 赵丹青 | Pure natural mouthwash and preparation method thereof |
| CN110267637A (en) * | 2017-12-01 | 2019-09-20 | 高露洁-棕榄公司 | Oral care composition |
| CN107927305A (en) * | 2017-12-15 | 2018-04-20 | 阜阳健诺生物科技有限公司 | A kind of antibacterial tasty and refreshing sugar of halitosis of dispelling and preparation method thereof |
| CN109464319A (en) * | 2018-11-02 | 2019-03-15 | 东莞波顿香料有限公司 | Breath freshening capsule and preparation method thereof |
| CN109998975A (en) * | 2019-05-24 | 2019-07-12 | 福建中合医药股份有限公司 | A kind of efficient toothpaste |
| CN115211486A (en) * | 2022-07-26 | 2022-10-21 | 山东大学 | Chewing gum capable of promoting breath freshening and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN102106906B (en) | 2014-04-16 |
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Effective date of registration: 20200103 Address after: 201203 Shanghai city Pudong New Area Cailun Road No. 1200 Patentee after: Shanghai University of Traditional Chinese Medicine Address before: 201203 Shanghai city Pudong New Area Cailun Road No. 781 room 423 Patentee before: Shanghai Zhangjiang Traditional Chinese Medicine Modern Pharmaceutical Preparation Technology Engineering Research Center |