CN102106906B - Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities - Google Patents
Traditional Chinese medicine composition and preparations thereof for freshening breath and cleansing oral cavities Download PDFInfo
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- CN102106906B CN102106906B CN200910200689.1A CN200910200689A CN102106906B CN 102106906 B CN102106906 B CN 102106906B CN 200910200689 A CN200910200689 A CN 200910200689A CN 102106906 B CN102106906 B CN 102106906B
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Abstract
The invention discloses a traditional Chinese medicine composition for freshening breath and cleansing oral cavities, which comprises the following bulk drugs in percentage by weight: 5-90% of clove essential oil, 5-90% of tea polyphenols and 5-90% of chlorogenic acids. In addition, the invention also discloses breath freshening and oral cavity cleansing preparations containing the traditional Chinese medicine composition, and the preparations comprise chewing gum, candy, collut and the like. Through pharmacodynamic studies, the traditional Chinese medicine composition disclosed by the invention has a strong synergistic inhibition effect on oral pathogens, and can be used for freshening breath and cleansing oral cavities.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for breath freshening and oral cavity cleaning and preparation thereof.
Background technology
Along with growth in the living standard, confectionery increases, and band is served bad consequence, particularly oral disease, halitosis etc.; And breath freshening is also the very important part of daily life, and become a kind of fashion, therefore have considerable consumer to need the product of fresh breath or cleaning oral cavity.But the oral cavity such as current chewing gum is delivered preparation majority and is usingd sugar and colloid as primary raw material, can not effectively kill the oral cavity bacterium of curing the disease, and use the dental care products such as toothbrush or dental floss out of doors or travelling seem very inconvenient.
Flos Caryophylli, as the founder of ancient Chinese chewing gum, plays a very important role for breath freshening and oral cavity cleaning tool.Chemical constitution study shows: Flos Caryophylli, containing volatile oil, is mainly eugenol, tanning, oleanolic acid etc.; Modern pharmacological research shows: Flos Caryophylli volatile oil has the effects such as antibacterial, parasite killing, pain relieving.And tea polyphenols and chlorogenic acid have stronger inhibitory action to oral cavity Main Pathogenic Bacteria.In prior art, there is no by Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid using certain proportion combination as Chinese medicine preparation the bibliographical information for breath freshening and oral cavity cleaning.
Summary of the invention
The preparation that the technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for breath freshening and oral cavity cleaning and contains this Chinese medicine composition.
In one aspect of the invention, provide a kind of Chinese medicine composition for breath freshening and oral cavity cleaning, by the crude drug of following weight ratio, formed:
Flos Caryophylli volatile oil: 5-90%
Tea polyphenols: 5-90%
Chlorogenic acid: 5-90%.
The preferred component ratio of this Chinese medicine composition is:
Flos Caryophylli volatile oil: 40%
Tea polyphenols: 40%
Chlorogenic acid: 20%.
The present invention selects Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid to combine, and makes each efficacy of drugs produce synergism the combination of these medical materials, thereby can effectively suppress the oral cavity bacterium of curing the disease, and reaches the effect of breath freshening and oral cavity cleaning.Flos Caryophylli, as the founder of ancient Chinese chewing gum, plays a very important role for breath freshening and oral cavity cleaning tool.Chemical constitution study shows: Flos Caryophylli, containing volatile oil, is mainly eugenol, tannin, oleanolic acid etc.; Modern pharmacological research shows: Flos Caryophylli volatile oil has the effects such as antibacterial, parasite killing, pain relieving.And tea polyphenols and chlorogenic acid have stronger inhibitory action to oral cavity Main Pathogenic Bacteria.The present invention finds after deliberation: Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid have very strong coordinate repression to the oral cavity bacterium of curing the disease in certain proportion combination.
This Chinese medicine composition method is routinely mixed Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid and get final product.
In another aspect of this invention, a kind of breath freshening and oral cavity cleaning preparation are provided, the Chinese medicine composition that this breath freshening and oral cavity cleaning preparation comprise above-mentioned Flos Caryophylli volatile oil, tea polyphenols and chlorogenic acid and sugar or gum base or suitable adjuvant, described breath freshening and oral cavity cleaning preparation comprise chewing gum, confection and collut etc.The ratio of Chinese medicine composition in this breath freshening and oral cavity cleaning preparation in preparation is 0.1-10%.Chewing gum, confection can coatings or coating not, and can be various flavour, shape, size.In this breath freshening and oral cavity cleaning preparation, can increase different taste flavoring agents and be prepared into different tastes, comprise Herba Menthae, stay indigo plant, the taste of Fructus Citri Limoniae, milk, various fruit etc.
Breath freshening of the present invention and oral cavity cleaning preparation adopt conventional preparation method, and for example, chewing-gum preparation can be prepared by following method:
1. gum base is placed in the baking oven of 45-80 ℃ softening after, put into agitator, stir.
2. malt oligosaccharide syrup is preheated to after 43 ℃, puts into agitator, stir.
3. by after the sweeting agent mix homogeneously such as 85% Fructus Hordei Germinatus oligose powder, aspartame, palatinose, put into agitator.
4. after the sweeting agent of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Fructus Citri Limoniae quintessence oil and residue 15% being mixed, and put into agitator, then Pulvis Talci is put into agitator, mix rear discharging.
5. transport material to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, place 24 hours after compressing, then pack.
The present invention has following beneficial effect: through pharmacodynamic study, find, Chinese medicine composition of the present invention has very strong coordinate repression to the oral cavity bacterium of curing the disease, and can be used for breath freshening and oral cavity cleaning.
The specific embodiment
By test example, beneficial effect of the present invention is further elaborated below:
Pharmacodynamic study method and the result of test example 1 Chinese medicine composition of the present invention
Antibacterial culturing: the bacterial isolates that this test adopts is all purchased from DSMZ of the Chinese Academy of Sciences.Adopt trypsinization soya broth (Tryptlcase vbroth, B), anaerobism is cultivated 18h (90%N
2, 5%CO
237 ℃) 2～3d (my god).Bacteria resuscitation is inoculated in corresponding agar plate after by biochemical identification.The single bacterium colony of picking agar surface is suspended in corresponding cross in body culture medium (1 diameter 1mm bacterium colony/ml) and cultivates, and makes bacterial concentration be 10 after cultivating the corresponding time
5-6cFU/ml.
Medicine: Flos Caryophylli volatile oil (is called for short DXH, purchased from the extra large natural perfume material oil of Jishui County gold Science and Technology Ltd.), tea polyphenols (being called for short CDF, purchased from Hangzhou Zhong Ke natural plants technology company), chlorogenic acid (being called for short LYS, purchased from Shaanxi Sen Fu Bioisystech Co., Ltd).
MIC measures: the various medicines 50 μ l that draw dilution in gradient with aseptic micro sample adding appliance, in aseptic 96 hole microwell plates, then add equivalent bacterium liquid, mix.Place under suitable condition of culture and hatch, need O
2bacterium 24h, observed result after other 48h, the lowest drug concentration that meat limit is observed without bacterial growth is MIC.
MBC measures: with the perusal of aseptic inoculation ring picking, without culture in the microwell plate of bacterial growth, streak inoculation is in corresponding flat board.After cultivating under felicity condition, observing, is MBC without the lowest drug concentration of bacterial growth.
Positive control: do not add various medicines, only add bacterium liquid and equivalent fluid medium.Negative control: do not add bacterium liquid, only add various medicines and equivalent fluid medium.
Table 1 Chinese medicine and compositions thereof the antimicrobial susceptibility MIC test result (μ g/ml) to oral cavity pathogen
Table 2 Chinese medicine and compositions thereof the antimicrobial susceptibility MBC test result (μ g/ml) to oral cavity pathogen
From table 1,2 data, can find out, Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid all have good fungistatic effect to 8 kinds, oral cavity pathogenic bacterium, and take Flos Caryophylli volatile oil as basis, equivalent proportioning tea polyphenols, chlorogenic acid fungistatic effect are better, illustrate between Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid three and may have collaborative bacteriostasis.
Table 3 Chinese medicine and compositions thereof the antimicrobial susceptibility MIC test result (μ g/ml) to oral cavity pathogen
Table 4 Chinese medicine and compositions thereof the antimicrobial susceptibility MBC test result (μ g/ml) to oral cavity pathogen
From table 3,4 data, can find out, the different proportionings of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid are all effective than individually dosed to the fungistatic effect of the 8 kinds of pathogenic bacterium in oral cavity, illustrate between three and really exist and work in coordination with bacteriostasis, when Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid ratio are 2: 2: 1, fungistatic effect is best.
The invention will be further elaborated by the following examples:
In following examples, adopt: Flos Caryophylli volatile oil, is called for short DXH, purchased from the extra large natural perfume material oil of Jishui County gold Science and Technology Ltd.; Tea polyphenols, is called for short CDF, purchased from Hangzhou Zhong Ke natural plants technology company; Chlorogenic acid, is called for short LYS, purchased from Shaanxi Sen Fu Bioisystech Co., Ltd.
One. containing the preparation of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid chewing gum
Table 5 is containing the chewing gum prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, gum base is placed in the baking oven of 55 ℃ softening after, put into agitator, stir.
2, malt oligosaccharide syrup is preheated to after 43 ℃, puts into agitator, stir.
3, the sweeting agent such as 85% Fructus Hordei Germinatus oligose powder, aspartame, palatinose is mixed all with after, put into agitator.
4, after the sweeting agent of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Fructus Citri Limoniae quintessence oil and residue 15% is mixed, and put into agitator, then Pulvis Talci is put into agitator, mix rear discharging.
5, transport material to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, place 24 hours after compressing, then pack.
Two. containing the preparation of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid chewing gum
Table 6 is containing the chewing gum prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, gum base is placed in the baking oven of 80 ℃ softening after, put into agitator, stir.
2, corn syrup is preheated to after 43 ℃, puts into agitator, stir.
3, the sweeting agent such as 85% Fructus Hordei Germinatus oligose powder is mixed all with after, put into agitator.
4, after Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Herba Menthae quintessence oil are mixed with the sweeting agent that remains 15%, and put into agitator, then Pulvis Talci is put into agitator, mix rear discharging.
5, transport material to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, place 24 hours after compressing, then pack.
Three. contain the preparation of the confection of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Table 7 is containing the confection prescription of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, corn syrup is preheated to after 43-50 ℃, puts into agitator, stir.
2, the sweeting agent such as 85% Fructus Hordei Germinatus oligose powder is mixed all with after, put into agitator.
3, after the sweeting agent of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, Herba Menthae quintessence oil, polyhydric alcohol, milk and residue 15% is mixed, and put into agitator, then Pulvis Talci is put into agitator, mix rear discharging.
4, transport material to extrusion shaping machine, in the environment of 18 ℃ of temperature, relative humidity 50%, place 24 hours after compressing, then pack.
Four. containing the mouth of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid, gargle the preparation of agent
Table 8 is gargled agent prescription containing the mouth of Flos Caryophylli volatile oil, tea polyphenols, chlorogenic acid
Preparation technology:
1, ethanol, glycerol mix homogeneously.
2, Flos Caryophylli volatile oil is added in the mixed liquor of ethanol and glycerol.
3, tea polyphenols, chlorogenic acid are added to the water to dissolving, stir.
4, by step 2,3 liquid mixing, and add lecithin, tween 80, Durio Zibethinus murr essence, stir, fill, packing.
Claims (5)
1. for a Chinese medicine composition for breath freshening and oral cavity cleaning, it is characterized in that, described Chinese medicine composition is comprised of the crude drug of following weight ratio:
Flos Caryophylli volatile oil: 5-90%
Tea polyphenols: 5-90%
Chlorogenic acid: 5-90%.
2. the Chinese medicine composition for breath freshening and oral cavity cleaning as claimed in claim 1, is characterized in that, described Chinese medicine composition is comprised of the crude drug of following weight ratio:
Flos Caryophylli volatile oil: 40%
Tea polyphenols: 40%
Chlorogenic acid: 20%.
3. a breath freshening and oral cavity cleaning preparation, it is characterized in that, Chinese medicine composition described in the claim 1 or 2 that this breath freshening and oral cavity cleaning preparation comprise effective dose and suitable adjuvant, described breath freshening and oral cavity cleaning preparation are chewing gum, confection and collut.
4. breath freshening as claimed in claim 3 and an oral cavity cleaning preparation, is characterized in that, the ratio of the Chinese medicine composition in this breath freshening and oral cavity cleaning preparation in preparation is 0.1-10%.
5. breath freshening and the oral cavity cleaning preparation as described in claim 3 or 4, it is characterized in that, in this breath freshening and oral cavity cleaning preparation, can add different taste flavoring agents and be prepared into different tastes, for Herba Menthae, stay the taste of indigo plant, milk and various fruit.
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| CN103705912B (en) * | 2013-12-20 | 2015-10-28 | 江苏雪豹日化有限公司 | A kind of composite lysozyme oral spray and preparation method thereof |
| CN106309173B (en) * | 2015-06-16 | 2019-05-21 | 赵丹青 | A kind of natural mouthwash and preparation method thereof based on tea extraction |
| CA3081541A1 (en) * | 2017-12-01 | 2019-06-06 | Colgate-Palmolive Company | Oral care compositions comprising a hemostatic agent |
| CN107927305A (en) * | 2017-12-15 | 2018-04-20 | 阜阳健诺生物科技有限公司 | A kind of antibacterial tasty and refreshing sugar of halitosis of dispelling and preparation method thereof |
| CN109464319A (en) * | 2018-11-02 | 2019-03-15 | 东莞波顿香料有限公司 | Breath freshening capsule and preparation method thereof |
| CN109998975A (en) * | 2019-05-24 | 2019-07-12 | 福建中合医药股份有限公司 | A kind of efficient toothpaste |
| CN115211486A (en) * | 2022-07-26 | 2022-10-21 | 山东大学 | Chewing gum capable of promoting breath freshening and preparation method thereof |
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| CN1965855A (en) * | 2005-11-14 | 2007-05-23 | 陈祖辉 | Microecological formulation for treating and caring mouth cavity disease |
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| CN1367663A (en) * | 1999-09-08 | 2002-09-04 | Amt技术公司 | Ocular biometer |
| JP2005154339A (en) * | 2003-11-26 | 2005-06-16 | Morinaga & Co Ltd | Bad breath-reducing composition |
| JP5183104B2 (en) * | 2006-06-19 | 2013-04-17 | 森下仁丹株式会社 | Multiple soft capsules for bad breath removal |
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Effective date of registration: 20200103 Address after: 201203 Shanghai city Pudong New Area Cailun Road No. 1200 Patentee after: Shanghai University of Traditional Chinese Medicine Address before: 201203 Shanghai city Pudong New Area Cailun Road No. 781 room 423 Patentee before: Shanghai Zhangjiang Traditional Chinese Medicine Modern Pharmaceutical Preparation Technology Engineering Research Center |