CN102105166A - 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 - Google Patents

脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 Download PDF

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CN102105166A
CN102105166A CN200980125861XA CN200980125861A CN102105166A CN 102105166 A CN102105166 A CN 102105166A CN 200980125861X A CN200980125861X A CN 200980125861XA CN 200980125861 A CN200980125861 A CN 200980125861A CN 102105166 A CN102105166 A CN 102105166A
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strain
gene
vaccine
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genetically modified
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W·D·佐林格
M·多内茨
D·施米尔
B·约宁
R·马奎斯
E·E·莫兰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200980125861XA 2008-05-30 2009-06-01 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 Pending CN102105166A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5746208P 2008-05-30 2008-05-30
US61/057,462 2008-05-30
PCT/US2009/045818 WO2009158142A1 (en) 2008-05-30 2009-06-01 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Publications (1)

Publication Number Publication Date
CN102105166A true CN102105166A (zh) 2011-06-22

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CN200980125861XA Pending CN102105166A (zh) 2008-05-30 2009-06-01 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用

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US (2) US9387239B2 (https=)
EP (1) EP2296699A4 (https=)
JP (2) JP5723768B2 (https=)
KR (1) KR20110053314A (https=)
CN (1) CN102105166A (https=)
AU (1) AU2009262893B2 (https=)
BR (1) BRPI0913268A2 (https=)
CA (1) CA2726465A1 (https=)
CO (1) CO6341569A2 (https=)
CR (1) CR11812A (https=)
DO (1) DOP2010000364A (https=)
EC (1) ECSP10010723A (https=)
IL (1) IL209660A0 (https=)
MX (1) MX2010012999A (https=)
NZ (1) NZ589812A (https=)
RU (1) RU2477145C2 (https=)
UA (1) UA99659C2 (https=)
WO (1) WO2009158142A1 (https=)
ZA (1) ZA201008548B (https=)

Cited By (4)

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CN107961370A (zh) * 2017-03-22 2018-04-27 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN110248681A (zh) * 2016-11-25 2019-09-17 葛兰素史密丝克莱恩生物有限公司 nOMV-抗原缀合物及其用途
CN113151354A (zh) * 2021-03-22 2021-07-23 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN119020251A (zh) * 2024-08-26 2024-11-26 南昌大学 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用

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BR112013005626B1 (pt) * 2010-09-10 2022-07-26 Glaxosmithkline Biologicals Sa Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
CA2846290A1 (en) * 2011-08-31 2013-03-07 Children's Hospital & Research Center Oakland Engineered sequences to facilitate expression of antigens in neisseria and methods of use
JP5957541B2 (ja) * 2012-02-02 2016-07-27 ノバルティス アーゲー 髄膜炎菌における増加したタンパク質発現のためのプロモータ
JP2015517089A (ja) 2012-03-08 2015-06-18 ノバルティス アーゲー タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MX359256B (es) 2012-03-09 2018-09-19 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
KR101452830B1 (ko) * 2012-04-06 2014-10-21 아이진 주식회사 두 가지 항암물질을 동시에 제공하는 대장균 균주
US9764027B2 (en) 2012-09-18 2017-09-19 Glaxosmithkline Biologicals Sa Outer membrane vesicles
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
BR112018015237A2 (pt) * 2016-01-28 2018-12-26 De Staat Der Nederlanden Vert Door De Mini Van Vws Miniie Van Volksgezondheid Welzijn En Sport lps de neisseria hexa-acilado modificado
EP3263695A1 (en) 2016-06-29 2018-01-03 GlaxoSmithKline Biologicals SA Immunogenic compositions
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN114080232A (zh) 2019-03-21 2022-02-22 科迪亚克生物科学公司 用于疫苗递送的细胞外囊泡
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
IT202400003229A1 (it) 2024-02-15 2025-08-15 Cioccio Vito Di Procedimento per la purificazione di omv da batteri gram-negativi, e relativi usi

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110248681A (zh) * 2016-11-25 2019-09-17 葛兰素史密丝克莱恩生物有限公司 nOMV-抗原缀合物及其用途
CN107961370A (zh) * 2017-03-22 2018-04-27 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN107961370B (zh) * 2017-03-22 2020-08-11 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN113151354A (zh) * 2021-03-22 2021-07-23 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN113151354B (zh) * 2021-03-22 2022-03-08 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN119020251A (zh) * 2024-08-26 2024-11-26 南昌大学 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用

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ZA201008548B (en) 2012-06-27
KR20110053314A (ko) 2011-05-20
IL209660A0 (en) 2011-02-28
AU2009262893A9 (en) 2015-05-21
WO2009158142A1 (en) 2009-12-30
US20170100471A1 (en) 2017-04-13
RU2010153658A (ru) 2012-08-10
NZ589812A (en) 2012-08-31
MX2010012999A (es) 2012-03-07
AU2009262893B2 (en) 2015-05-21
CO6341569A2 (es) 2011-11-21
AU2009262893A1 (en) 2009-12-30
EP2296699A4 (en) 2013-11-13
JP5723768B2 (ja) 2015-05-27
CA2726465A1 (en) 2009-12-30
BRPI0913268A2 (pt) 2016-03-15
US20110182942A1 (en) 2011-07-28
UA99659C2 (uk) 2012-09-10
ECSP10010723A (es) 2011-05-31
CR11812A (es) 2011-07-06
EP2296699A1 (en) 2011-03-23
JP2011521976A (ja) 2011-07-28
JP2015061870A (ja) 2015-04-02
US9387239B2 (en) 2016-07-12
RU2477145C2 (ru) 2013-03-10
DOP2010000364A (es) 2011-07-15

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