CN102089273A - 新方法 - Google Patents

新方法 Download PDF

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Publication number
CN102089273A
CN102089273A CN2009801189268A CN200980118926A CN102089273A CN 102089273 A CN102089273 A CN 102089273A CN 2009801189268 A CN2009801189268 A CN 2009801189268A CN 200980118926 A CN200980118926 A CN 200980118926A CN 102089273 A CN102089273 A CN 102089273A
Authority
CN
China
Prior art keywords
acid
gamma
tartrate
lyrica
enantiomorph enrichment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801189268A
Other languages
English (en)
Chinese (zh)
Inventor
维纳亚克·戈雷
德巴希什·达塔
马赫什库马·加达卡尔
基兰·波克哈尔卡尔
维拉杰·曼卡尔
斯奈哈·瓦夫哈尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of CN102089273A publication Critical patent/CN102089273A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2009801189268A 2008-04-04 2009-04-02 新方法 Pending CN102089273A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN679KO2008 2008-04-04
IN679/KOL/2008 2008-04-04
PCT/GB2009/050326 WO2009122215A1 (en) 2008-04-04 2009-04-02 Novel process

Publications (1)

Publication Number Publication Date
CN102089273A true CN102089273A (zh) 2011-06-08

Family

ID=40674128

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801189268A Pending CN102089273A (zh) 2008-04-04 2009-04-02 新方法

Country Status (8)

Country Link
US (1) US20110124909A1 (enExample)
EP (1) EP2262761A1 (enExample)
JP (1) JP2011516459A (enExample)
CN (1) CN102089273A (enExample)
AU (1) AU2009233536A1 (enExample)
CA (1) CA2719892A1 (enExample)
NZ (1) NZ588894A (enExample)
WO (1) WO2009122215A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348124A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以氧代吡咯烷为中间体合成普瑞巴林的方法
CN108456144A (zh) * 2017-11-03 2018-08-28 乳源东阳光药业有限公司 一种小粒径晶状普瑞巴林、组合物及其制备工艺

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5557292B2 (ja) 2009-03-26 2014-07-23 第一三共株式会社 二環性γ−アミノ酸誘導体の製造方法
HUP1000186A2 (en) 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2012030938A1 (en) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP2527319A1 (en) * 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Crystalline forms of pregabalin and co-formers in the treatment of pain
JP6482465B2 (ja) 2012-11-07 2019-03-13 ハイカル リミテッド プレガバリンの調製方法
CN113801031B (zh) * 2021-10-26 2023-12-26 浙江华海药业股份有限公司 一种普瑞巴林的纯化方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040617A1 (en) * 1995-06-07 1996-12-19 Warner-Lambert Company Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
WO2008117305A2 (en) * 2007-03-28 2008-10-02 Glenmark Pharmaceuticals Limited A novel process for preparing pregabalin and its acid addition salts
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1736462A1 (en) * 2005-06-22 2006-12-27 Sandoz AG Recovery of optically active tartaric acid resolving agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040617A1 (en) * 1995-06-07 1996-12-19 Warner-Lambert Company Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
WO2008117305A2 (en) * 2007-03-28 2008-10-02 Glenmark Pharmaceuticals Limited A novel process for preparing pregabalin and its acid addition salts
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARVIN S. HOEKSTRA: "Chemical Development of CI-1008, an Enantiomerically Pure Anticonvulsant", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348124A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以氧代吡咯烷为中间体合成普瑞巴林的方法
CN108456144A (zh) * 2017-11-03 2018-08-28 乳源东阳光药业有限公司 一种小粒径晶状普瑞巴林、组合物及其制备工艺

Also Published As

Publication number Publication date
NZ588894A (en) 2012-12-21
EP2262761A1 (en) 2010-12-22
CA2719892A1 (en) 2009-10-08
WO2009122215A1 (en) 2009-10-08
AU2009233536A1 (en) 2009-10-08
US20110124909A1 (en) 2011-05-26
JP2011516459A (ja) 2011-05-26

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110608