CN102083463B - 编码甲病毒属复制酶的表达载体及其作为免疫佐剂的用途 - Google Patents

编码甲病毒属复制酶的表达载体及其作为免疫佐剂的用途 Download PDF

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CN102083463B
CN102083463B CN200980118773.7A CN200980118773A CN102083463B CN 102083463 B CN102083463 B CN 102083463B CN 200980118773 A CN200980118773 A CN 200980118773A CN 102083463 B CN102083463 B CN 102083463B
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replicase
adjuvant
purposes according
expression vector
seq
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CN102083463A (zh
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K·克伊沃
R·斯库特
U·托茨
T·默尔多
A·门尼克
M·乌斯塔夫
K·卡尔德玛
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Finnish Immunotechnology Ltd
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
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    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
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  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980118773.7A 2008-05-23 2009-05-22 编码甲病毒属复制酶的表达载体及其作为免疫佐剂的用途 Expired - Fee Related CN102083463B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7189808P 2008-05-23 2008-05-23
US61/071,898 2008-05-23
PCT/EP2009/056240 WO2009141434A1 (en) 2008-05-23 2009-05-22 Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant

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CN102083463A CN102083463A (zh) 2011-06-01
CN102083463B true CN102083463B (zh) 2017-04-05

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CN200980118773.7A Expired - Fee Related CN102083463B (zh) 2008-05-23 2009-05-22 编码甲病毒属复制酶的表达载体及其作为免疫佐剂的用途

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US (1) US9474800B2 (enExample)
EP (1) EP2296702A1 (enExample)
JP (1) JP5663474B2 (enExample)
KR (1) KR20110044836A (enExample)
CN (1) CN102083463B (enExample)
AU (1) AU2009248735B2 (enExample)
BR (1) BRPI0913045A2 (enExample)
CA (1) CA2724570A1 (enExample)
IL (1) IL209077A0 (enExample)
MX (1) MX2010012587A (enExample)
NZ (1) NZ589495A (enExample)
RU (1) RU2010152562A (enExample)
SG (1) SG191600A1 (enExample)
WO (1) WO2009141434A1 (enExample)
ZA (1) ZA201007880B (enExample)

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GB201220119D0 (en) * 2012-11-08 2012-12-26 Univ Cork Vector
CN111304201B (zh) * 2020-02-21 2022-10-21 华南农业大学 一种降低乙型脑炎脑病毒感染的siRNA及其应用
AU2021233816A1 (en) 2020-03-09 2022-10-06 Arcturus Therapeutics, Inc. Coronavirus vaccine compositions and methods
BR112023002642A2 (pt) 2020-08-14 2023-04-04 Arcturus Therapeutics Inc Método para liofilizar nanopartículas lipídicas
CN113846113B (zh) * 2021-09-09 2022-09-13 臻赫医药(杭州)有限公司 一种有限自我复制mRNA分子系统、制备方法及应用
WO2023133509A2 (en) * 2022-01-08 2023-07-13 Carogen Corporation Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection
KR20240049429A (ko) 2022-10-08 2024-04-16 최주언 황금비율 계량컵

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US5763584A (en) * 1992-05-18 1998-06-09 Genentech, Inc. Receptor activation with hepatocyte growth factor agonists
SE9401091D0 (sv) * 1994-03-31 1994-03-31 Bioption Ab Alphavirus cDNA vectors
SE9401709D0 (sv) * 1994-05-18 1994-05-18 Mathilda Sjoeberg Improved alphavirus vectors for expression of heterologous DNA
JP2002521461A (ja) * 1998-07-29 2002-07-16 インビトロゲン・コーポレーション Ｒｎａウイルスを用いる組換えタンパク質の調節発現
EP1226238A2 (en) * 1999-10-27 2002-07-31 Cytos Biotechnology AG Method for creating divergent populations of nucleic acid molecules and proteins
US7592005B2 (en) * 2000-12-28 2009-09-22 Kirin Beer Kabushiki Kaisha Monoclonal antibody
FI116851B (fi) * 2001-05-03 2006-03-15 Fit Biotech Oyj Plc Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita
AU2003266301A1 (en) * 2002-08-22 2004-03-11 Cytos Biotechnology Ag Inducible alphaviral/orip based gene expression system
ES2222095B1 (es) * 2003-07-02 2005-11-16 Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria Inia Virus adn recombinantes que comprenden un adn complementario de un replicon de un virus arn y sus aplicaciones.
WO2006085983A2 (en) * 2004-07-09 2006-08-17 University Of North Carolina At Chapel Hill Viral adjuvants
WO2008085557A2 (en) * 2006-09-12 2008-07-17 Alphavax, Inc. Alphavirus replicon particles encoding il- 12 as immunological adjuvants
HRP20100638T2 (hr) * 2006-11-28 2011-03-31 Proyecto De Biomedicina Cima Viralni vektori i njihova uporaba
WO2008119827A1 (en) * 2007-04-02 2008-10-09 Fit Biotech Oy Transreplicase constructs

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AU2009248735A1 (en) 2009-11-26
JP2011523642A (ja) 2011-08-18
CN102083463A (zh) 2011-06-01
RU2010152562A (ru) 2012-06-27
IL209077A0 (en) 2011-01-31
BRPI0913045A2 (pt) 2017-05-23
WO2009141434A1 (en) 2009-11-26
JP5663474B2 (ja) 2015-02-04
EP2296702A1 (en) 2011-03-23
MX2010012587A (es) 2011-05-25
SG191600A1 (en) 2013-07-31
CA2724570A1 (en) 2009-11-26
AU2009248735B2 (en) 2015-08-20
US20110171255A1 (en) 2011-07-14
WO2009141434A4 (en) 2010-01-14
NZ589495A (en) 2012-06-29
ZA201007880B (en) 2012-02-29
US9474800B2 (en) 2016-10-25
KR20110044836A (ko) 2011-05-02

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