CN102083443B - 调节肌动蛋白细胞骨架重排和细胞间间隙形成的方法 - Google Patents

调节肌动蛋白细胞骨架重排和细胞间间隙形成的方法 Download PDF

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CN102083443B
CN102083443B CN200980121482.3A CN200980121482A CN102083443B CN 102083443 B CN102083443 B CN 102083443B CN 200980121482 A CN200980121482 A CN 200980121482A CN 102083443 B CN102083443 B CN 102083443B
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cells
compound
ischemia
organ
alkyl
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CN102083443A (zh
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T·M·埃甘
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University of North Carolina at Chapel Hill
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Molecular Biology (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980121482.3A 2008-04-09 2009-04-09 调节肌动蛋白细胞骨架重排和细胞间间隙形成的方法 Expired - Fee Related CN102083443B (zh)

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Application Number Priority Date Filing Date Title
US4358608P 2008-04-09 2008-04-09
US61/043,586 2008-04-09
PCT/US2009/040098 WO2009126822A2 (en) 2008-04-09 2009-04-09 Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation

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CN102083443A CN102083443A (zh) 2011-06-01
CN102083443B true CN102083443B (zh) 2014-01-15

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US (1) US8809303B2 (enExample)
EP (1) EP2268286B1 (enExample)
JP (1) JP5562939B2 (enExample)
KR (1) KR20100135886A (enExample)
CN (1) CN102083443B (enExample)
AU (1) AU2009234156A1 (enExample)
BR (1) BRPI0911195A2 (enExample)
CA (1) CA2721082A1 (enExample)
EA (1) EA201001450A1 (enExample)
ES (1) ES2569608T3 (enExample)
IL (1) IL208565A0 (enExample)
MX (1) MX2010011050A (enExample)
WO (1) WO2009126822A2 (enExample)
ZA (1) ZA201007735B (enExample)

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JP5562939B2 (ja) 2008-04-09 2014-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル アクチン細胞骨格再編成及び細胞間ギャップ形成調節の方法
EA201101349A1 (ru) * 2009-04-09 2012-05-30 Университет Северной Каролины В Чапел-Хилл Методы лечения отека, связанного с ишемией-реперфузией
CN103160570A (zh) * 2011-12-09 2013-06-19 彩虹天健康科技研究(北京)有限责任公司 Unc-51激酶和pp1磷酸酶相互作用机制的发现
EP3752182B1 (en) * 2018-02-12 2024-05-15 Inimmune Corporation Toll-like receptor ligands
CN108836971B (zh) * 2018-08-16 2020-10-30 青岛大学 Ws6对小梁网细胞肌动蛋白形成的影响

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070209A2 (en) * 2000-03-17 2001-09-27 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders

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US5628984A (en) 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6013640A (en) * 1998-08-21 2000-01-11 Ribi Immunochem Research, Inc. Phosphoglycolipid and methods for its use
PT1252293E (pt) * 2000-01-19 2013-01-23 Univ North Carolina Fonte de tecido de fígado
WO2003105909A1 (ja) * 2002-06-13 2003-12-24 三菱ウェルファーマ株式会社 肝虚血再灌流傷害の予防及び／又は治療のための医薬並びに移植肝臓の保護剤
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
JP2007514648A (ja) 2003-10-24 2007-06-07 エーザイ株式会社 Ｔｏｌｌ−ｌｉｋｅｒｅｃｅｐｔｏｒ２に関連する疾患及び状態を治療するための化合物及び方法
US7928132B2 (en) 2004-08-06 2011-04-19 Ohio University Methods for the amelioration of episodes of acute or chronic ulcerative colitis
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
JP2007534775A (ja) * 2004-05-28 2007-11-29 セダーズ−シナイ メディカル センター 脈管の疾患を処置するための方法
ITMI20060530A1 (it) * 2006-03-22 2007-09-23 Univ Milano Bicocca Antinfiammatori a struttura monosaccaridica
EP2170366B1 (en) 2007-08-03 2013-11-06 Opsona Therapeutics Limited Use of tlr-2 antagonists for treatment of reperfusion injury and tissue damage
JP5562939B2 (ja) 2008-04-09 2014-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル アクチン細胞骨格再編成及び細胞間ギャップ形成調節の方法
EA201101349A1 (ru) 2009-04-09 2012-05-30 Университет Северной Каролины В Чапел-Хилл Методы лечения отека, связанного с ишемией-реперфузией

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070209A2 (en) * 2000-03-17 2001-09-27 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CASIRAGHI ET AL.427: Toll-Like Receptor-4 (TLR4) Inhibition Reduces Actin Cytoskeletal Re-Arrangement and Gap Formation in Cultured Human Pulmonary Microvascular Endothelial Cells (HMVECs) Subjected to Simulated Warm Ischemia-Reperfusion Injury (IRI).《JOURNAL OF HEART AND LUNG TRANSPLANTATION》.2008,第27卷(第2期),s214-5. *

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Publication number Publication date
US8809303B2 (en) 2014-08-19
WO2009126822A2 (en) 2009-10-15
CN102083443A (zh) 2011-06-01
KR20100135886A (ko) 2010-12-27
MX2010011050A (es) 2010-11-01
EP2268286A4 (en) 2011-10-12
JP5562939B2 (ja) 2014-07-30
US20110053871A1 (en) 2011-03-03
JP2011516572A (ja) 2011-05-26
AU2009234156A1 (en) 2009-10-15
EP2268286A1 (en) 2011-01-05
CA2721082A1 (en) 2009-10-15
WO2009126822A9 (en) 2009-12-17
IL208565A0 (en) 2010-12-30
ES2569608T3 (es) 2016-05-11
ZA201007735B (en) 2013-04-24
BRPI0911195A2 (pt) 2017-06-20
EP2268286B1 (en) 2016-04-06
EA201001450A1 (ru) 2011-08-30

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