CN102066559B - 藻青素二肽的生物技术制备 - Google Patents

藻青素二肽的生物技术制备 Download PDF

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Publication number
CN102066559B
CN102066559B CN200980122099XA CN200980122099A CN102066559B CN 102066559 B CN102066559 B CN 102066559B CN 200980122099X A CN200980122099X A CN 200980122099XA CN 200980122099 A CN200980122099 A CN 200980122099A CN 102066559 B CN102066559 B CN 102066559B
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China
Prior art keywords
cgp
cphe
arginine
dipeptide
degradation
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CN200980122099XA
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Chinese (zh)
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CN102066559A (zh
Inventor
A·萨拉姆
A·施泰因比歇尔
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Symrise AG
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Westfaelische Wilhelms Universitaet Muenster
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/15—Peptidyl-dipeptidases (3.4.15)
    • C12Y304/15006—Cyanophycinase (3.4.15.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Husbandry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN200980122099XA 2008-06-13 2009-06-15 藻青素二肽的生物技术制备 Active - Reinstated CN102066559B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310343230.3A CN103520700B (zh) 2008-06-13 2009-06-15 藻青素二肽的生物技术制备

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08158205.8 2008-06-13
EP08158205.8A EP2133419B1 (en) 2008-06-13 2008-06-13 Uses of cyanophycin beta-dipeptides
PCT/EP2009/057382 WO2009150252A2 (en) 2008-06-13 2009-06-15 Biotechnological production of cyanophycin dipeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310343230.3A Division CN103520700B (zh) 2008-06-13 2009-06-15 藻青素二肽的生物技术制备

Publications (2)

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CN102066559A CN102066559A (zh) 2011-05-18
CN102066559B true CN102066559B (zh) 2013-11-06

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CN200980122099XA Active - Reinstated CN102066559B (zh) 2008-06-13 2009-06-15 藻青素二肽的生物技术制备
CN201310343230.3A Active CN103520700B (zh) 2008-06-13 2009-06-15 藻青素二肽的生物技术制备

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Country Status (8)

Country Link
US (2) US8980845B2 (https=)
EP (2) EP2133419B1 (https=)
JP (2) JP5785075B2 (https=)
CN (2) CN102066559B (https=)
DK (2) DK2133419T3 (https=)
ES (2) ES2701727T3 (https=)
PL (1) PL2133419T3 (https=)
WO (1) WO2009150252A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133419B1 (en) * 2008-06-13 2018-09-19 Westfälische Wilhelms-Universität Münster Uses of cyanophycin beta-dipeptides
WO2017068149A1 (en) * 2015-10-21 2017-04-27 Cysal Gmbh Aspartyl-dipeptides for aquaculture
KR102700159B1 (ko) * 2015-12-09 2024-08-30 씨제이제일제당 주식회사 반추위 보호 펩타이드 유도체 및 그 용도
WO2017162879A1 (en) * 2016-03-24 2017-09-28 Cysal Gmbh Aspartyl-dipeptides for skin care and cosmetic use
WO2017174398A1 (en) 2016-04-07 2017-10-12 Cysal Gmbh Cyanophycin for slow feeding aquatic organisms
CN107488210B (zh) * 2016-06-13 2021-03-30 首都医科大学 华法林-4-o-乙酰-二肽,其合成,活性和应用
US20210188905A1 (en) * 2018-08-01 2021-06-24 Cysal Gmbh Combining beta-dipeptides and amino acids for optimal nutritional supplementation
WO2021037383A1 (en) * 2019-08-30 2021-03-04 Symrise Ag COSMETIC USE OF β-L-ASPARTYL-L-ARGININE
CN113373077B (zh) * 2021-02-07 2023-02-07 南宁海关技术中心 一种氯霉素高效降解菌、高效降解菌剂及其应用
CN113683661B (zh) * 2021-09-01 2022-03-11 济宁医学院 一种双重响应二肽超分子聚合物及其制备方法和应用
CN115746292B (zh) * 2022-05-03 2023-12-22 湘潭大学 一种活性污泥中藻青素的提取方法
CN116948939B (zh) * 2023-09-18 2023-12-12 四川厌氧生物科技有限责任公司 一种提高粪便样本挑菌多样性的方法和培养基及其用途

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US4225579A (en) 1979-02-27 1980-09-30 Israel Kleinberg Means and method for improving defenses against caries
JP3146251B2 (ja) 1993-09-10 2001-03-12 宮城化学工業株式会社 ペプチド組成物とその製造法
JP3851656B2 (ja) 1994-05-04 2006-11-29 ジェネンコア インターナショナル インコーポレーテッド 改善された界面活性剤耐性を有するリパーゼ
DE19813692A1 (de) * 1998-03-27 1999-09-30 Norddeutsche Pflanzenzucht Han Cyanophycinsynthetasegene zur Erzeugung von Cyanophycin oder Cyanophycinderivaten, und ihre Verwendung
US20040137081A1 (en) 2003-01-13 2004-07-15 Peter Rohdewald Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins
AU2001283962A1 (en) * 2000-08-09 2002-02-18 Bayer Aktiengesellschaft Method for improved production of cyanophycin and the secondary products thereof
US7091001B2 (en) 2004-07-30 2006-08-15 Council Of Scientific & Industrial Research Process for the preparation of high arginine peptides
EP2133419B1 (en) * 2008-06-13 2018-09-19 Westfälische Wilhelms-Universität Münster Uses of cyanophycin beta-dipeptides
WO2017068149A1 (en) 2015-10-21 2017-04-27 Cysal Gmbh Aspartyl-dipeptides for aquaculture

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Ahmed Sallam.Anaerobic and Aerobic Degradation of Cyanophycin by the Denitrifying Bacterium Pseudomonas alcaligenes Strain DIP1 and Role of Three Other Coisolates in a Mixed Bacterial Consortium.《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》.2008,第74卷(第11期),3434–3443. *
OBST,M.ISOLATION OF CYANOPHYCIN-DEGRADING BACTERIA,CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CYANOPHYCINASE GENE FROM PSEUDOMONAS ANGUILLISEPTICA STRAIN B1.《THE JOURNAL OF BIOLOGICAL CHEMISTRY》.2002,第277卷(第281期),25096-25105. *

Also Published As

Publication number Publication date
CN103520700A (zh) 2014-01-22
US9877996B2 (en) 2018-01-30
EP2283128A2 (en) 2011-02-16
JP6244336B2 (ja) 2017-12-06
ES2619952T3 (es) 2017-06-27
EP2133419B1 (en) 2018-09-19
WO2009150252A3 (en) 2010-02-18
CN102066559A (zh) 2011-05-18
PL2133419T3 (pl) 2019-02-28
ES2701727T3 (es) 2019-02-25
US8980845B2 (en) 2015-03-17
JP2016028024A (ja) 2016-02-25
CN103520700B (zh) 2016-03-09
JP5785075B2 (ja) 2015-09-24
EP2283128B1 (en) 2017-01-04
DK2283128T3 (en) 2017-04-24
EP2133419A1 (en) 2009-12-16
US20150231194A1 (en) 2015-08-20
WO2009150252A2 (en) 2009-12-17
HK1193357A1 (zh) 2014-09-19
JP2011522557A (ja) 2011-08-04
DK2133419T3 (en) 2019-01-14
US20110118177A1 (en) 2011-05-19

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