CN102065868A - 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 - Google Patents
诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 Download PDFInfo
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- CN102065868A CN102065868A CN2009801237219A CN200980123721A CN102065868A CN 102065868 A CN102065868 A CN 102065868A CN 2009801237219 A CN2009801237219 A CN 2009801237219A CN 200980123721 A CN200980123721 A CN 200980123721A CN 102065868 A CN102065868 A CN 102065868A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001173—Globo-H
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6196808P | 2008-06-16 | 2008-06-16 | |
| US61/061,968 | 2008-06-16 | ||
| PCT/US2009/047537 WO2010005735A2 (en) | 2008-06-16 | 2009-06-16 | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102065868A true CN102065868A (zh) | 2011-05-18 |
Family
ID=41431519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801237219A Pending CN102065868A (zh) | 2008-06-16 | 2009-06-16 | 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20090317411A1 (enExample) |
| EP (2) | EP2303286A4 (enExample) |
| JP (4) | JP2011524375A (enExample) |
| KR (1) | KR20110031949A (enExample) |
| CN (1) | CN102065868A (enExample) |
| AU (2) | AU2009268937A1 (enExample) |
| CA (2) | CA2728344A1 (enExample) |
| ES (1) | ES2570630T3 (enExample) |
| MX (2) | MX2010013932A (enExample) |
| NZ (1) | NZ590140A (enExample) |
| WO (2) | WO2010005735A2 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105026413A (zh) * | 2013-01-04 | 2015-11-04 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| CN106573962A (zh) * | 2014-08-22 | 2017-04-19 | 中央研究院 | 新颖的聚糖共轭物及其用途 |
| CN107407673A (zh) * | 2015-01-24 | 2017-11-28 | 中央研究院 | 新颖聚醣结合物及其使用方法 |
| CN107430127A (zh) * | 2015-01-24 | 2017-12-01 | 中央研究院 | 癌症标记及其使用方法 |
| CN107427564A (zh) * | 2014-09-15 | 2017-12-01 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性糖缀合物组合物及其用途 |
| CN107407673B (zh) * | 2015-01-24 | 2019-07-16 | 中央研究院 | 新颖聚醣结合物及其使用方法 |
| CN110062767A (zh) * | 2016-07-29 | 2019-07-26 | 台湾浩鼎生技股份有限公司 | 人抗体、药物组合物和方法 |
| CN110072545A (zh) * | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性聚糖组合物及其用途 |
| CN112513635A (zh) * | 2018-05-11 | 2021-03-16 | 台湾浩鼎生技股份有限公司 | 预测人体免疫反应的方法 |
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| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| PL2282773T3 (pl) | 2008-05-02 | 2014-08-29 | Seattle Genetics Inc | Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej |
| AU2009271411B2 (en) * | 2008-06-16 | 2013-02-07 | Academia Sinica | Cancer diagnosis based on levels of antibodies against Globo H and its fragments |
| CA2728344A1 (en) * | 2008-06-16 | 2010-01-14 | Academia Sinica | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカAcademia Sinica | Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| WO2012023008A2 (en) | 2010-05-03 | 2012-02-23 | Dcb-Usa Llc | Polysaccharide conjugation with detoxified e. coli heat labile enterotoxin (lt) used as vaccine |
| AU2011265184B2 (en) * | 2010-06-11 | 2016-08-04 | Sloan-Kettering Institute For Cancer Research | Multivalent glycopeptide constructs and uses thereof |
| EP2608796B1 (en) * | 2010-08-05 | 2018-11-21 | Seattle Genetics, Inc. | Inhibition of protein fucosylation in vivo using fucose analogs |
| GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
| US20120288525A1 (en) | 2011-05-11 | 2012-11-15 | Chakravarty Sumana | Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants |
| WO2013133220A1 (ja) * | 2012-03-08 | 2013-09-12 | 学校法人産業医科大学 | がんの悪性度の試験方法、ならびに多能性を有する造腫瘍細胞およびその調製方法 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| JP6302909B2 (ja) | 2012-08-18 | 2018-03-28 | アカデミア シニカAcademia Sinica | シアリダーゼの同定および画像化のための細胞透過性プローブ |
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| WO2014178195A1 (ja) | 2013-05-02 | 2014-11-06 | 独立行政法人産業技術総合研究所 | 糖鎖抗原の免疫誘導剤 |
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| SG11201510740YA (en) | 2013-09-17 | 2016-01-28 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
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| JP2017507118A (ja) * | 2014-01-16 | 2017-03-16 | アカデミア シニカAcademia Sinica | がんの処置および検出のための組成物および方法 |
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| CN107073088A (zh) | 2014-03-19 | 2017-08-18 | 台湾基督长老教会马偕医疗财团法人马偕纪念医院 | 免疫原性糖肽、包含所述糖肽的组合物及其用途 |
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| CN105067813A (zh) * | 2015-07-23 | 2015-11-18 | 丁晓昆 | 一种快速检测t-合酶活性的方法 |
| EP3344806A4 (en) * | 2015-09-04 | 2019-03-20 | OBI Pharma, Inc. | GLYCAN NETWORKS AND METHODS OF USE |
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| US8383767B2 (en) * | 2008-06-27 | 2013-02-26 | Academia Sinica | Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
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2009
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- 2009-06-16 US US12/485,546 patent/US20090317411A1/en not_active Abandoned
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- 2009-06-16 CN CN2009801237219A patent/CN102065868A/zh active Pending
- 2009-06-16 KR KR1020117001004A patent/KR20110031949A/ko not_active Withdrawn
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- 2015-04-01 US US14/675,838 patent/US9603913B2/en active Active
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111499679B (zh) * | 2013-01-04 | 2021-07-06 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| CN105026413A (zh) * | 2013-01-04 | 2015-11-04 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| CN111499679A (zh) * | 2013-01-04 | 2020-08-07 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| CN106573962B (zh) * | 2014-08-22 | 2020-06-05 | 中央研究院 | 新颖的聚糖共轭物及其用途 |
| CN106573962A (zh) * | 2014-08-22 | 2017-04-19 | 中央研究院 | 新颖的聚糖共轭物及其用途 |
| CN107427564A (zh) * | 2014-09-15 | 2017-12-01 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性糖缀合物组合物及其用途 |
| TWI726850B (zh) * | 2014-09-15 | 2021-05-11 | 台灣浩鼎生技股份有限公司 | 免疫/治療性醣共軛物組合物及其用途 |
| CN107430127A (zh) * | 2015-01-24 | 2017-12-01 | 中央研究院 | 癌症标记及其使用方法 |
| CN107407673B (zh) * | 2015-01-24 | 2019-07-16 | 中央研究院 | 新颖聚醣结合物及其使用方法 |
| CN107407673A (zh) * | 2015-01-24 | 2017-11-28 | 中央研究院 | 新颖聚醣结合物及其使用方法 |
| CN110072545A (zh) * | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性聚糖组合物及其用途 |
| CN110062767A (zh) * | 2016-07-29 | 2019-07-26 | 台湾浩鼎生技股份有限公司 | 人抗体、药物组合物和方法 |
| CN110062767B (zh) * | 2016-07-29 | 2023-07-11 | 台湾浩鼎生技股份有限公司 | 人抗体、药物组合物和方法 |
| CN112513635A (zh) * | 2018-05-11 | 2021-03-16 | 台湾浩鼎生技股份有限公司 | 预测人体免疫反应的方法 |
| CN112513635B (zh) * | 2018-05-11 | 2024-04-16 | 台湾浩鼎生技股份有限公司 | 预测人体免疫反应的方法 |
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| AU2009268937A1 (en) | 2010-01-14 |
| AU2009269127B2 (en) | 2013-12-05 |
| ES2570630T3 (es) | 2016-05-19 |
| CA2728344A1 (en) | 2010-01-14 |
| WO2010005598A1 (en) | 2010-01-14 |
| US20090317411A1 (en) | 2009-12-24 |
| US9028836B2 (en) | 2015-05-12 |
| US8268969B2 (en) | 2012-09-18 |
| JP2011524417A (ja) | 2011-09-01 |
| EP2303286A4 (en) | 2011-12-28 |
| EP2310047A1 (en) | 2011-04-20 |
| MX350230B (es) | 2017-08-30 |
| NZ590140A (en) | 2012-07-27 |
| WO2010005735A3 (en) | 2010-03-18 |
| WO2010005735A2 (en) | 2010-01-14 |
| EP2310047B1 (en) | 2016-03-30 |
| JP2014144958A (ja) | 2014-08-14 |
| US20100136042A1 (en) | 2010-06-03 |
| MX2010013932A (es) | 2013-03-01 |
| US20120328646A1 (en) | 2012-12-27 |
| US20150273034A1 (en) | 2015-10-01 |
| AU2009269127A1 (en) | 2010-01-14 |
| JP2016020363A (ja) | 2016-02-04 |
| KR20110031949A (ko) | 2011-03-29 |
| JP5628158B2 (ja) | 2014-11-19 |
| JP6151319B2 (ja) | 2017-06-21 |
| CA2728341A1 (en) | 2010-01-14 |
| CA2728341C (en) | 2019-07-02 |
| JP2011524375A (ja) | 2011-09-01 |
| US9603913B2 (en) | 2017-03-28 |
| EP2303286A2 (en) | 2011-04-06 |
| JP5795655B2 (ja) | 2015-10-14 |
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