CN102056485A - 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 - Google Patents
用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 Download PDFInfo
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- CN102056485A CN102056485A CN2009801216301A CN200980121630A CN102056485A CN 102056485 A CN102056485 A CN 102056485A CN 2009801216301 A CN2009801216301 A CN 2009801216301A CN 200980121630 A CN200980121630 A CN 200980121630A CN 102056485 A CN102056485 A CN 102056485A
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- lfa
- antagonist
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610115732.4A CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4524008P | 2008-04-15 | 2008-04-15 | |
| US61/045,240 | 2008-04-15 | ||
| PCT/US2009/002389 WO2009128934A1 (en) | 2008-04-15 | 2009-04-15 | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610115732.4A Division CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102056485A true CN102056485A (zh) | 2011-05-11 |
Family
ID=41164200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801216301A Pending CN102056485A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090258070A1 (enExample) |
| EP (2) | EP3632444A3 (enExample) |
| JP (2) | JP2011521896A (enExample) |
| CN (1) | CN102056485A (enExample) |
| ES (1) | ES2763703T3 (enExample) |
| WO (1) | WO2009128934A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
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| CA2544678C (en) | 2003-11-05 | 2013-12-31 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
| AU2006247136C1 (en) | 2005-05-17 | 2020-01-16 | Bausch + Lomb Ireland Limited | Compositions and methods for treatment of eye disorders |
| DK1915620T3 (da) | 2005-08-02 | 2010-10-04 | Xbiotech Inc | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer |
| MX2010004281A (es) | 2007-10-19 | 2010-09-10 | Sarcode Corp | Composiciones y metodos para el tratamiento de la retinopatia diabetica. |
| US20090257957A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders |
| CN102065893A (zh) * | 2008-04-15 | 2011-05-18 | 萨可德公司 | Lfa-1拮抗剂向胃肠系统的递送 |
| PL3085773T3 (pl) | 2008-05-30 | 2021-01-11 | Xbiotech, Inc | Zastosowanie przeciwciał il-1 alfa |
| JP5976319B2 (ja) | 2008-09-12 | 2016-08-23 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 病原性単球の標的化 |
| AU2009296458A1 (en) * | 2008-09-26 | 2010-04-01 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
| WO2010093992A1 (en) * | 2009-02-13 | 2010-08-19 | Topica Pharmaceuticals, Inc | Anti-fungal formulation |
| US20120022102A1 (en) * | 2010-01-20 | 2012-01-26 | Cadila Healthcare Limited | Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof |
| US20110311547A1 (en) | 2010-06-18 | 2011-12-22 | Xbiotech, Inc. | Arthritis Treatment |
| KR20210128021A (ko) | 2010-08-23 | 2021-10-25 | 얀센 바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| ES2695102T3 (es) | 2011-09-23 | 2019-01-02 | Xbiotech Inc | Tratamiento para la caquexia |
| WO2013108644A1 (ja) * | 2012-01-20 | 2013-07-25 | 京都府公立大学法人 | レバミピドのアレルギー性結膜炎治療剤 |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| CN104955453B (zh) | 2012-12-19 | 2018-09-18 | 原生质生物科学股份有限公司 | Lfa-1抑制剂制剂 |
| US9688943B2 (en) | 2015-05-29 | 2017-06-27 | beauty Avenues LLC | Candle containing non-ionic emulsifer |
| CN110087636A (zh) * | 2016-12-16 | 2019-08-02 | 萨可德生物科学公司 | 利非斯特制剂的眼部分布和药代动力学 |
| MX2019009798A (es) | 2017-02-16 | 2020-01-30 | Xbiotech Inc | Tratamiento de la hidradenitis supurativa. |
| CN106920239B (zh) * | 2017-03-08 | 2019-10-18 | 福建师范大学 | 一种基于改进sift算法的图像关键点检测方法 |
| TW201920956A (zh) * | 2017-09-29 | 2019-06-01 | 日商參天製藥股份有限公司 | 淚液中之muc5ac量之測定方法 |
| CN111787918A (zh) * | 2017-11-29 | 2020-10-16 | 洛克菲勒大学 | 用于皮肤病学病况增强治疗的局部和全身性治疗的组合 |
| EP3955926A4 (en) * | 2019-04-18 | 2022-11-30 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
| CA3147431A1 (en) | 2019-07-16 | 2021-01-21 | Donaghys Limited | Transdermal solvent system and methods of use |
| EP3797771B1 (en) * | 2019-09-03 | 2022-02-23 | Square Power Ltd | Rebamipide for use in prophylaxis and treatment of celiac disease |
| CN112494488B (zh) * | 2020-06-17 | 2022-01-18 | 中国药科大学 | 瑞巴派特的防脱发和生发用途 |
| US12393057B2 (en) * | 2020-12-15 | 2025-08-19 | Coopervision International Limited | Oleic acid-releasing contact lens |
| CA3204617A1 (en) * | 2020-12-29 | 2022-07-07 | Next Science IP Holdings Pty Ltd | Cancer treatment composition and method |
| CA3216947A1 (en) * | 2021-06-14 | 2022-12-22 | Protransit Nanotherapy Llc | Cyclosporine compositions and methods of use thereof |
| EP4589369A1 (en) * | 2022-09-15 | 2025-07-23 | NOF Corporation | Solution for contact lenses |
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| US20020045582A1 (en) * | 1997-12-31 | 2002-04-18 | Alexey L. Margolin | Stabilized protein crystals formulations containing them and methods of making them |
| CN1592746A (zh) * | 2000-11-28 | 2005-03-09 | 杰南技术公司 | Lfa-1拮抗剂化合物 |
| US20060281739A1 (en) * | 2005-05-17 | 2006-12-14 | Thomas Gadek | Compositions and methods for treatment of eye disorders |
| CN1902195A (zh) * | 2003-11-05 | 2007-01-24 | 苏内西斯制药公司 | 细胞粘着调节剂 |
| US20070142317A1 (en) * | 2003-12-29 | 2007-06-21 | Qlt Usa, Inc. | Topical composition for treatment of skin disorders |
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| US4557934A (en) | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| US4524008A (en) | 1983-12-16 | 1985-06-18 | E. I. Du Pont De Nemours And Company | Controlled initiation chromium dioxide synthesis |
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2013
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| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3632444A3 (en) | 2020-08-26 |
| EP2265125A4 (en) | 2011-12-28 |
| EP2265125A1 (en) | 2010-12-29 |
| JP2014132032A (ja) | 2014-07-17 |
| ES2763703T3 (es) | 2020-05-29 |
| WO2009128934A1 (en) | 2009-10-22 |
| EP3632444A2 (en) | 2020-04-08 |
| JP2011521896A (ja) | 2011-07-28 |
| EP2265125B1 (en) | 2019-08-14 |
| US20090258070A1 (en) | 2009-10-15 |
| US20140051722A1 (en) | 2014-02-20 |
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