CN102053023A - Analysis pre-treatment method and equipment for medical laboratory samples - Google Patents
Analysis pre-treatment method and equipment for medical laboratory samples Download PDFInfo
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- CN102053023A CN102053023A CN2009101977751A CN200910197775A CN102053023A CN 102053023 A CN102053023 A CN 102053023A CN 2009101977751 A CN2009101977751 A CN 2009101977751A CN 200910197775 A CN200910197775 A CN 200910197775A CN 102053023 A CN102053023 A CN 102053023A
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Abstract
The invention relates to an analysis and treatment method and equipment for medical laboratory samples, belonging to the field of laboratory medicine. The analysis pre-treatment method for the medical laboratory samples comprises the following steps: collecting samples, and marking the samples on a sample container; reading marking content of the samples; extracting the samples and the diluted samples according to the marking content, and adding the samples into an appropriate amount of diluent; uniformly mixing the samples with the diluent; extracting sample solution from the uniformly mixed samples, and dropping the sample solution on a reagent strip on an analytical instrument; and feeding back information of completing pretreatment of the samples to a sample analysis control center. The analysis pre-treatment equipment for the medical laboratory samples, which is manufactured according to the method, comprises a part for extracting the diluent, a part for inputting collected sample information, a part for extracting the samples, a part for mixing the samples with the diluent, a part for dropping the mixed sample solution and a part for control and communication, and the part for dropping the mixed sample solution comprises a sample dropping needle tube and a positioning structure for the sample dropping needle tube.
Description
Technical field
The present invention relates to the sample analysis disposal route and the equipment of laboratory medicine, relate in particular to the method and apparatus of in medical test, sample being analyzed pre-treatment.
Background technology
Facts have proved, for guaranteeing the clinical examination quality, must accomplish whole process quality control, comprising: the quality control of three phases before the sample analysis, in the sample analysis and after the sample analysis, wherein quality control is even more important before the sample analysis.Report is all arranged both at home and abroad, and 60～70% from before the check analysis in the verify error.Therefore, in clinical examination, must be noted that the quality management of carrying out before analyzing.And basic dependence manually-operated before analyzing now, automaticity is very low, present real-time test is that POCT (POINT OF CARETESTING) is the operation near the patient scene, link such as reduced the storage of the sample specimen before analyzing and transport, but in the collection of sample specimen with handle and still need manually-operated to finish, quality depends on reviewer's professional training degree and gimmick, therefore has unavoidable error for the quality control before the sample analysis.
Along with the progress of science and technology and the development of laboratory medicine, various testing instruments all tend to miniaturization and universalization, but the stage before sample analysis, because specimen types is many, if any various blood samples such as tip blood, venous blood, also have form kind such as various just samples of picture many, dilution that uses during check and dose container etc. are all had nothing in common with each other, and therefore are difficult to search out a kind of method in common or make a kind of general instrument and equipment and handle sample to be analyzed.
And today, people more paid attention to health, also all wish to know as early as possible the result of check to examination in hospital, and the increase of various measuring means and inspection machine and renewal, also make the doctor wish to obtain faster and more accurate data, therefore sample check and analysis are had higher requirement to provide more accurate to patient and therapeutic scheme hommization.
Summary of the invention
Technical matters to be solved by this invention provides medical test samples and analyzes pre-treating method and equipment, solves the preceding processing of present sample analysis and relies on artificial fully and the unavoidable defective of error that cause.
Technical scheme
Medical test samples is analyzed pre-treating method, comprises the steps:
1. gather sample, on sample container, sample is indicated, indicate content and comprise sample number, sample type and processing type;
2. read the sign content of sample;
3. according to indicating content, extract sample and dilution, sample is added in the into an amount of dilution then;
4. with sample and dilution mixing;
5. from the sample of mixing, extract sample liquid, according to indicate content drip sample liquid analytical instrument with reagent strip on; Differentiate sample type before the application of sample, if be the tip blood sample this, dripping the sample needle tubing must position by earlier relative reagent strip, locatees sample drop to be analyzed to be added on the reagent strip after finishing;
6. this sample pre-treatment is finished information feedback and given sample analysis control center.
Further, described step is denoted as sample in 1. and adopts bar code to indicate, and the sign content that step reads sample in 2. adopts the bar decoding apparatus to read.
Further, described step 5. in, drip the relative reagent strip of sample needle tubing location, drip distance between sample needle tubing bottom and the reagent strip top smaller or equal to 5mm.
Further, the distance between described sample needle tubing bottom and the reagent strip top is smaller or equal to 2mm, and the angle between a sample needle tubing and reagent strip is an acute angle.
Angle between described sample needle tubing and reagent strip is between 85 to 90 degree.
Medical test samples is analyzed pre-processing device, it is characterized in that: comprise the parts that extract dilution, the parts of the sample information input of gathering, extract the parts of sample, the parts of mixing sample and dilution, dropping mixes parts and the control and the communication component of back sample liquid, and the parts that described dropping mixes back sample liquid comprise a sample needle tubing and drip a sample needle tubing location structure.
Further, the parts of the sample information of described collection input are bar-code reading device, and described bar-code reading device is connected with control and communication component, and described control and communication component are connected with sample analysis control center.
Further, the parts of described extraction dilution comprise that dilution enters conduit, the stepper motor of dilution lift suction pump and drive dilution lift suction pump; The parts of described extraction sample comprise the suction needle pipe, the stepper motor of sample suction pump and drive sample suction pump; The stepper motor of the stepper motor of wherein said drive dilution lift suction pump and drive sample suction pump can adopt the combination of a stepper motor and several switches; Described sample needle tubing drips sample needle tubing location structure and uses stepper motor and suction needle pipe to do counter motion for using the suction needle pipe, and described sample needle tubing is oblique fixing down.
Further, the parts of described mixing sample and dilution are for there being the glass mixer under the suction needle pipe, and described dilution lift suction pump below has pipeline to be communicated with the suction needle pipe.
Comprise that also waste liquid discharges parts, described waste liquid is discharged parts and is comprised with the pipeline of the members of mixing sample and dilution and liquid waste discharge pump and waste liquid and discharge conduit.
Beneficial effect
The inventive method and equipment have been realized the robotization and the informationization of medical test samples pre-treatment, having eliminated the sample analysis forefathers is to carry out the error that sample process produces, significantly reduced reviewer's the preceding operation steps of analysis simultaneously, the reviewer only need gather to indicate behind the sample and clearly can directly use equipment of the present invention to operate, and the present invention is with sample classification, go for dissimilar samples, whole blood, serum, urine, body fluid etc., can also adopt multiple dilution ratio, realize universalization and from the specimen sampling to the dilution, the full-automation of mixing and application of sample.
Description of drawings
Fig. 1 is the front schematic view of equipment of the present invention.
Fig. 2 is the left side diagrammatic cross-section of equipment of the present invention.
Fig. 3 is the schematic rear view of equipment of the present invention.
Wherein: 1-extracts the parts of dilution, and the 2-dilution enters conduit, 3-suction needle pipe, and the 4-stepper motor, the 5-switch, 6-glass mixer, the 7-liquid waste discharge pump, the 8-waste liquid is discharged conduit, 9-bar-code reading device.
Embodiment
Below in conjunction with specific embodiment, further set forth the present invention.
In the present medical test, the analysis pre-treatment of sample is generally by artificial treatment, so error is unavoidable, for the degree of accuracy that improves check and fast, by improving the sample analysis pre-treating method, developed at present first analysis pre-processing device in the world about test samples.Can carry out the analysis pre-treatment of various test samples.
Medical test samples is analyzed pre-treating method, comprises the steps:
1. gather sample, on sample container, sample is indicated, indicate content and comprise sample number, sample type and processing type;
2. read the sign content of sample;
3. according to indicating content, extract sample and dilution, sample is added in the into an amount of dilution then;
4. with sample and dilution mixing;
5. from the sample of mixing, extract sample liquid, according to indicate content drip sample liquid analytical instrument with reagent strip on; Differentiate sample type before the application of sample, if be the tip blood sample this, dripping the sample needle tubing must position by earlier relative reagent strip, locatees sample drop to be analyzed to be added on the reagent strip after finishing;
6. this sample pre-treatment is finished information feedback and given sample analysis control center.
Described step is denoted as sample in 1. and adopts bar code to indicate, and the sign content that step reads sample in 2. adopts the bar decoding apparatus to read.
Described step 5. in, drip the relative reagent strip of sample needle tubing location, drip distance between sample needle tubing bottom and the reagent strip top smaller or equal to 5mm.
Distance between described sample needle tubing bottom and the reagent strip top is smaller or equal to 2mm, and the angle between a sample needle tubing and reagent strip is an acute angle.
Angle between described sample needle tubing and reagent strip is between 85 to 90 degree.
Above method is divided into tip blood and other sample with sample, because tip blood general quantity is very little, is difficult for adopting machinery to carry out application of sample, needs to handle especially, just the analyzing liquid sample that can obtain.
Analyze pre-processing device according to the medical test samples that said method is made, comprise the parts that extract dilution, the parts of the sample information input of gathering, extract the parts of sample, the parts of mixing sample and dilution, dropping mixes parts and the control and the communication component of back sample liquid, and the parts that described dropping mixes back sample liquid comprise a sample needle tubing and drip a sample needle tubing location structure.
The input mode that the parts of the sample information input of described collection can adopt has a variety of, similar personnel as contact directly import, contactless adopts frequency emission and reception etc. as data, wherein comparatively economic and accurate, uses more widely for adopting the mode of bar code.Therefore input block can adopt bar-code reading device, and described bar-code reading device is connected with control and communication component, and described control and communication component are connected with sample analysis control center.
The parts of described extraction dilution comprise that dilution enters conduit, the stepper motor of dilution lift suction pump and drive dilution lift suction pump; The parts of described extraction sample comprise the suction needle pipe, the stepper motor of sample suction pump and drive sample suction pump; The stepper motor of the stepper motor of wherein said drive dilution lift suction pump and drive sample suction pump adopts the combination of a stepper motor and a switch to reach the effect of the stepper motor of two drivings; Described sample needle tubing promptly is directly to utilize the suction needle pipe to replace, and drips sample needle tubing location structure and uses stepper motor and suction needle pipe to do counter motion.Drive motor adopts stepper motor, makes the distance of motion accurate, is beneficial to the ratio of calculating sample and dilution.Described suction needle pipe is oblique fixing down, is not to overlap with the vertical curve of vertical-horizontal, but acutangulates angle with horizontal line, and between 90 degree, preferred 87 spend this angle at 85 degree; When the suction needle pipe is used for dripping sample, when tip blood pattern application of sample, move to apart from the reagent strip of application of sample above position, 2-3mm place be the best.
The parts of described mixing sample and dilution are for there being the glass mixer under the suction needle pipe, described dilution lift suction pump below has pipeline to be communicated with the suction needle pipe, and dilution splashes in the glass mixer by the suction needle pipe from this pipeline during mixing.
Also comprise waste liquid discharge parts, described waste liquid is discharged parts and is comprised that with the parts of mixing sample and dilution be pipeline and liquid waste discharge pump and the waste liquid discharge conduit that is communicated with under the glass mixer.
Described control and communication component are the inner single-chip microcomputer circuit controls of using, pattern and dilution ratio with various samples sets in advance, the height that drives its motion according to the concrete size and the stepper motor of temporary place before the dilution lift suction pump and suction needle pipe, calculate the absorption and the combined amount of dilution and sample respectively, thereby obtain meeting the mixed liquor of ratio.Use serial communication that this sample information is passed to the sample analysis controlling computer in the communication and count and be communicated to the subsequent analysis instrument.
This sample analysis pre-processing device as shown in drawings, 1 for extracting the parts of dilution among the figure, 2 enter conduit for dilution, 3 is the suction needle pipe, and 4 is stepper motor, and 5 is switch, 6 are the glass mixer under the suction needle pipe, 7 is liquid waste discharge pump, and 8 are waste liquid discharge conduit, and 9 is bar-code reading device.
The inventive method and equipment have been realized the robotization and the informationization of medical test samples pre-treatment, having eliminated the sample analysis forefathers is to carry out the error that sample process produces, significantly reduced reviewer's the preceding operation steps of analysis simultaneously, the reviewer only need gather to indicate behind the sample and clearly can directly use equipment of the present invention to operate, and the present invention is with sample classification, go for dissimilar samples, whole blood, serum, urine, body fluid etc., can also adopt multiple dilution ratio, can be from 1 to 1 to 1: 1000, realized universalization and from the specimen sampling to the dilution, the full-automation of mixing and application of sample.Small and exquisite after this treatment facility is finished, portable and automaticity is high, can use in various check occasions, be well to replenish especially to existing P OCT equipment, can improve the scope of application of POCT equipment and the degree of accuracy of POCT greatly.
Claims (10)
1. medical test samples is analyzed pre-treating method, comprises the steps:
1. gather sample, on sample container, sample is indicated, indicate content and comprise sample number, sample type and processing type;
2. read the sign content of sample;
3. according to indicating content, extract sample and dilution, sample is added in the into an amount of dilution then;
4. with sample and dilution mixing;
5. from the sample of mixing, extract sample liquid, according to indicate content drip sample liquid analytical instrument with reagent strip on; Differentiate sample type before the application of sample, if be the tip blood sample this, dripping the sample needle tubing must position by earlier relative reagent strip, locatees sample drop to be analyzed to be added on the reagent strip after finishing;
6. this sample pre-treatment is finished information feedback and given sample analysis control center.
2. medical test samples as claimed in claim 1 is analyzed pre-treating method, it is characterized in that: described step is denoted as sample in 1. and adopts bar code to indicate, and the sign content that step reads sample in 2. adopts the bar decoding apparatus to read.
3. medical test samples as claimed in claim 1 is analyzed pre-treating method, it is characterized in that: described step 5. in, drip the relative reagent strip of sample needle tubing location, drip distance between sample needle tubing bottom and the reagent strip top smaller or equal to 5mm.
4. medical test samples as claimed in claim 3 is analyzed pre-treating method, it is characterized in that: the distance between described sample needle tubing bottom and the reagent strip top is smaller or equal to 2mm, and the angle between a sample needle tubing and reagent strip is an acute angle.
5. medical test samples as claimed in claim 4 is analyzed pre-treating method, it is characterized in that: the angle between described sample needle tubing and reagent strip is between 85 to 90 degree.
6. medical test samples is analyzed pre-processing device, it is characterized in that: comprise the parts that extract dilution, the parts of the sample information input of gathering, extract the parts of sample, the parts of mixing sample and dilution, dropping mixes parts and the control and the communication component of back sample liquid, and the parts that described dropping mixes back sample liquid comprise a sample needle tubing and drip a sample needle tubing location structure.
7. medical test samples as claimed in claim 6 is analyzed pre-processing device, it is characterized in that: the parts of the sample information input of described collection are bar-code reading device, described bar-code reading device is connected with control and communication component, and described control and communication component are connected with sample analysis control center.
8. medical test samples as claimed in claim 6 is analyzed pre-processing device, and it is characterized in that: the parts of described extraction dilution comprise that dilution enters conduit, the stepper motor of dilution lift suction pump and drive dilution lift suction pump; The parts of described extraction sample comprise the suction needle pipe, the stepper motor of sample suction pump and drive sample suction pump; The stepper motor of the stepper motor of wherein said drive dilution lift suction pump and drive sample suction pump can adopt the combination of a stepper motor and several switches; Described sample needle tubing drips sample needle tubing location structure and uses stepper motor and suction needle pipe to do counter motion for using the suction needle pipe, and described sample needle tubing is oblique fixing down.
9. medical test samples as claimed in claim 8 is analyzed pre-processing device, it is characterized in that: the parts of described mixing sample and dilution are for there being the glass mixer under the suction needle pipe, described dilution lift suction pump below has pipeline to be communicated with the suction needle pipe.
10. medical test samples as claimed in claim 6 is analyzed pre-processing device, it is characterized in that: comprise that also waste liquid discharges parts, described waste liquid is discharged parts and is comprised with the pipeline of the members of mixing sample and dilution and liquid waste discharge pump and waste liquid and discharge conduit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910197775A CN102053023B (en) | 2009-10-27 | 2009-10-27 | Analysis pre-treatment method and equipment for medical laboratory samples |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910197775A CN102053023B (en) | 2009-10-27 | 2009-10-27 | Analysis pre-treatment method and equipment for medical laboratory samples |
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| CN102053023A true CN102053023A (en) | 2011-05-11 |
| CN102053023B CN102053023B (en) | 2012-10-10 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104807714A (en) * | 2014-09-09 | 2015-07-29 | 长沙协大生物科技有限公司 | Medical examination method based on sample weight |
| CN106599954A (en) * | 2016-12-22 | 2017-04-26 | 丁治伟 | Pre-sample-analysis processing equipment and method for medical examination |
| CN107153763A (en) * | 2017-05-08 | 2017-09-12 | 孙鹏 | Medical test samples analyze pre-treating method and equipment |
| WO2018223539A1 (en) * | 2017-06-10 | 2018-12-13 | 深圳市前海安测信息技术有限公司 | Clinical test information processing system and method |
-
2009
- 2009-10-27 CN CN200910197775A patent/CN102053023B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104807714A (en) * | 2014-09-09 | 2015-07-29 | 长沙协大生物科技有限公司 | Medical examination method based on sample weight |
| CN106599954A (en) * | 2016-12-22 | 2017-04-26 | 丁治伟 | Pre-sample-analysis processing equipment and method for medical examination |
| CN107153763A (en) * | 2017-05-08 | 2017-09-12 | 孙鹏 | Medical test samples analyze pre-treating method and equipment |
| WO2018223539A1 (en) * | 2017-06-10 | 2018-12-13 | 深圳市前海安测信息技术有限公司 | Clinical test information processing system and method |
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| Publication number | Publication date |
|---|---|
| CN102053023B (en) | 2012-10-10 |
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Effective date of registration: 20210607 Address after: B3 / F, 9 Changyang Road, West Taihu science and Technology Industrial Park, Changzhou, Jiangsu Province, 213000 Patentee after: Changzhou Guoyao medical laboratory Co.,Ltd. Address before: Room 2007, 768 Xietu Road, Luwan District, Shanghai 200023 (block g) Patentee before: SHANGHAI KUAIDEXING BIOTECHNOLOGY Co.,Ltd. |
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