CN110836794A - Sample manufacturing method - Google Patents
Sample manufacturing method Download PDFInfo
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- CN110836794A CN110836794A CN201810935339.9A CN201810935339A CN110836794A CN 110836794 A CN110836794 A CN 110836794A CN 201810935339 A CN201810935339 A CN 201810935339A CN 110836794 A CN110836794 A CN 110836794A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
Abstract
The invention discloses a sample manufacturing method, which is based on sample manufacturing equipment and comprises the following steps: s1: the sample conveying device conveys the sample conveying containers along the conveying direction from the first station to the second station, and when the Nth sample conveying container filled with the sample to be detected is conveyed to the first station of the stirring device, the stirring device stirs the sample in the sample conveying container to manufacture a sample suspension, wherein N is a natural number not less than 1; s2: the sample conveying device conveys the Nth sample conveying container which is stirred to the second station of the sample sucking device, and simultaneously conveys the (N + 1) th sample conveying container to be stirred to the first station of the stirring device; and S3, sucking the sample suspension from the Nth sample sending container by the sample sucking device at the second station and adding the sample suspension into the external detection carrier, and stirring the sample in the (N + 1) th sample sending container by the stirring device at the first station to manufacture the sample suspension. The invention can greatly shorten the detection time.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a sample manufacturing method.
Background
The clinical examination is to detect the body fluid, secretion, excrement, fallen matter and other samples of the patient through visual observation, physical, chemical, instrument or molecular biological method and to emphasize the strict quality control measures taken to ensure the quality of the examination in the whole examination process (before, during and after analysis), so as to provide valuable experimental data for the patient in clinic. In clinical examination, in order to obtain certain physiological data of a patient body, some samples of the human body are often collected to perform various index detection.
In actual operation, before each index data of a sample is detected, the collected sample generally needs to be diluted and stirred, firstly, a diluent is added into a sample conveying container, then, the sample is stirred by a stirring device to prepare a sample suspension, and after stirring is finished, the sample suspension in the sample conveying container is sucked by a sample sucking needle of a sampling device and added into a sample carrier or a counting cell. In the sample manufacturing method in the prior art, each sampling must be finished by waiting for the stirring work in the preamble, the time for each detection is at least the sum of the time spent on stirring and the time spent on sampling, the total time consumption is very long, and the detection speed of the whole machine is greatly influenced.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a sample manufacturing method, and the sample manufacturing method can realize synchronous stirring and sampling through the structural design, so that the time required by detection is greatly reduced.
A sample preparation method is based on a sample preparation device, the sample preparation device comprises a sample conveying device for conveying a sample conveying container, a stirring device arranged at a first station, and a sample sucking device arranged at a second station, and the sample preparation method comprises the following steps:
s1: the sample conveying device conveys the sample conveying containers along the conveying direction from the first station to the second station, and when the Nth sample conveying container filled with the sample to be detected is conveyed to the first station of the stirring device, the stirring device stirs the sample in the sample conveying container to manufacture a sample suspension, wherein N is a natural number not less than 1;
s2: the sample conveying device conveys the Nth sample conveying container which is stirred to the second station of the sample sucking device, and simultaneously conveys the (N + 1) th sample conveying container to be stirred to the first station of the stirring device;
and S3, sucking the sample suspension from the Nth sample sending container by the sample sucking device at the second station and adding the sample suspension into the external detection carrier, and stirring the sample in the (N + 1) th sample sending container by the stirring device at the first station to manufacture the sample suspension.
Preferably, in step S1, the dilution liquid is injected before the stirring device stirs the sample in the sample container, and the injection of the dilution liquid and the stirring are performed at the first station.
Preferably, in step S1, the method includes:
s101: a stirring head of the stirring device vertically moves downwards, and the stirring head simultaneously drives a puncture needle to vertically downwards puncture a sealing membrane which is preset on the sample sending container;
s102: inputting a diluent into the sample feeding container, and simultaneously stirring the sample in the sample feeding container by the stirring head;
s103: and after stirring is finished, the stirring head vertically moves upwards until the stirring head and the puncture needle are separated from the sample sending container.
Preferably, in step S3, the method includes:
s301: a sampling needle of the sample sucking device vertically moves downwards until the sampling needle extends into a sample sending container to suck sample suspension;
s302: after the sampling needle finishes sampling, the sampling needle of the sample sucking device vertically moves upwards until the sampling needle is separated from the sample sending container;
s303: the sample sucking device drives the sampling needle to move to a specified station along the horizontal direction, and the sampling needle adds the sucked sample suspension into an external detection carrier.
Preferably, in step S3, the method includes:
s301': a sampling needle of the sample suction device vertically moves downwards until the sampling needle extends into the sample sending container, and the sampling needle sucks the sample suspension and outputs the sample suspension to the detection carrier through a conduit;
s302': after the sampling needle finishes sampling, the sample sucking device drives the sampling needle to vertically move upwards until the sampling needle is separated from the sample container.
Preferably, after step S3, the sampling needle of the sample aspirating apparatus is subjected to a cleaning operation.
The invention has the beneficial effects that: according to the sample manufacturing method provided by the invention, when the sample is stirred by the previous sample sending container and pushed to the position of the sample sucking device for sampling, the stirring device can continue to stir the sample of the next sample sending container, and the pipeline operation is performed by analogy, so that the synchronous stirring and sampling can be realized, and the time required by detection is greatly reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Fig. 1 is a schematic diagram of an overall structure of a sample preparation apparatus according to an embodiment of the present invention.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
In the description of the present invention, it is to be understood that the terms "upper", "lower", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
Referring to fig. 1, fig. 1 provides a sample preparation apparatus on which the present invention is based, wherein fig. 1 is a schematic diagram of an overall structure of the sample preparation apparatus disclosed in the embodiment of the present invention.
As shown in fig. 1, the present embodiment provides a sample preparation apparatus, which can perform stirring and sampling synchronously, and effectively reduce the time required for sample detection.
In this scheme, this sample preparation equipment includes base 1, sample conveyer 2, send appearance container 3, agitating unit 4, inhales appearance device 5.
In this embodiment, the base 1 is used for supporting. The actual shape of the base 1 is chosen and designed according to specific needs.
A sample conveying device 2 is arranged above the base 1, and a sample conveying container 3 used for bearing samples is arranged on the sample conveying device 2. The sample sending container 3 is used for bearing a sample to be made, and the sample transporting device 2 is used for transporting the sample sending container 3. Specifically, the transmission direction of the sample transportation device 2 is from the first station below the stirring device 4 to the second station below the sample suction device 5.
In the sample preparation device, a stirring device 4 is arranged at the upstream of a sample conveying device 2, and a sample sucking device 5 is arranged at the downstream of the sample conveying device 2. The stirring device 4 is used for stirring the sample in the sample feeding container 3. The sample sucking device 5 is used for sucking the sample from the sample sending container 3 after the stirring is finished and for subsequently adding the sample to the detection carrier.
The invention provides a sample preparation method, which is based on sample preparation equipment similar to the sample preparation method, and by the sample preparation method, efficient detection of a sample can be effectively realized.
Specifically, the present invention provides a sample preparation method, which is based on a sample preparation apparatus similar to the above sample preparation apparatus of the present embodiment, and the sample preparation apparatus of the present embodiment includes a sample transport device 2 for transporting a sample sending container 3, a stirring device 4 disposed at a first station, and a sample suction device 5 disposed at a second station.
The sample manufacturing method comprises the following steps:
s1: the sample conveying device 2 conveys the sample conveying container 3 along the conveying direction from the first station to the second station, and when the Nth sample conveying container 3 filled with the sample to be detected is conveyed to the first station of the stirring device 4, the stirring device 4 stirs the sample in the sample conveying container 3 to manufacture a sample suspension, wherein N is a natural number not less than 1;
s2: the sample conveying device 2 conveys the Nth sample conveying container 3 which is stirred to the second station of the sample sucking device 5, and simultaneously conveys the (N + 1) th sample conveying container 3 to be stirred to the first station of the stirring device 4;
s3, the sample sucking device 5 sucks the sample suspension from the nth sample sending container 3 at the second station and adds the sample suspension to the external detection carrier, and at the same time, the stirring device 4 stirs the sample in the (N + 1) th sample sending container at the first station to make the sample suspension.
In this embodiment, in order to further improve the quality of the mixed liquid, it is preferable that the dilution be injected before the stirring device 4 stirs the sample in the sample feeding container 3 in step S1, and the injection of the dilution be performed at the first station together with the stirring.
In this embodiment, to further facilitate the stirring of the sample, it is preferable that, in step S1, the method includes:
s101: the stirring head of the stirring device 4 vertically moves downwards, and the stirring head simultaneously drives the puncture needle to vertically downwards puncture a sealing membrane which is preset on the sample sending container 3;
s102: inputting a diluent into the sample feeding container 3, and stirring the sample in the sample feeding container 3 by a stirring head;
s103: after stirring, the stirring head vertically moves upwards until the stirring head and the puncture needle are separated from the sample sending container 3.
In this embodiment, to further facilitate the sucking and transferring of the sample, it is preferable that, in step S3, the method includes:
s301: the sampling needle of the sample sucking device 5 vertically moves downwards until the sampling needle extends into the sample conveying container 3 to suck the sample suspension;
s302: after the sampling needle finishes sampling, the sampling needle of the sample sucking device 5 vertically moves upwards until the sampling needle is separated from the sample sending container 3;
s303: the sample sucking device 5 drives the sampling needle to move to a specified station along the horizontal direction, and the sampling needle adds the sucked sample suspension into an external detection carrier.
Specifically, the present embodiment may add the aspirated sample suspension to the external counting plate through a sampling needle.
In this embodiment, the following method steps may also be adopted to achieve the sucking and transferring of the sample, and the step S3 includes:
s301': a sampling needle of the sample sucking device 5 vertically moves downwards until the sampling needle extends into the sample sending container 3, and the sampling needle sucks the sample suspension and outputs the sample suspension to the detection carrier through a conduit;
s302': after the sampling needle finishes sampling, the sample sucking device 5 drives the sampling needle to vertically move upwards until the sampling needle is separated from the sample container 3.
Specifically, the sampling needle of the present embodiment can aspirate the sample suspension and output the sample suspension to the external counting chamber through the catheter.
In this embodiment, in order to prevent the cross between the samples from affecting the accuracy of the detection result, it is preferable that the sampling needle of the sample suction device 5 is subjected to a cleaning operation after step S3.
The sample preparation method provided by the invention is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (7)
1. A sample preparation method is based on a sample preparation device, the sample preparation device comprises a sample conveying device for conveying a sample conveying container, a stirring device arranged at a first station, and a sample sucking device arranged at a second station, and the sample preparation method is characterized by comprising the following steps:
s1: the sample conveying device conveys the sample conveying containers along the conveying direction from the first station to the second station, and when the Nth sample conveying container filled with the sample to be detected is conveyed to the first station of the stirring device, the stirring device stirs the sample in the sample conveying container to manufacture a sample suspension, wherein N is a natural number not less than 1;
s2: the sample conveying device conveys the Nth sample conveying container which is stirred to the second station of the sample sucking device, and simultaneously conveys the (N + 1) th sample conveying container to be stirred to the first station of the stirring device;
and S3, sucking the sample suspension from the Nth sample sending container by the sample sucking device at the second station and adding the sample suspension into the external detection carrier, and stirring the sample in the (N + 1) th sample sending container by the stirring device at the first station to manufacture the sample suspension.
2. The method for preparing a specimen according to claim 1, wherein in step S1, the diluting solution is injected before the stirring device stirs the specimen in the sample container, and the injecting of the diluting solution and the stirring are performed at the first station.
3. The sample preparation method according to claim 1, wherein the step S1 includes:
s101: a stirring head of the stirring device vertically moves downwards, and the stirring head simultaneously drives a puncture needle to vertically downwards puncture a sealing membrane which is preset on the sample sending container;
s102: inputting a diluent into the sample feeding container, and stirring the sample in the sample feeding container by a stirring head;
s103: and after stirring is finished, the stirring head vertically moves upwards until the stirring head and the puncture needle are separated from the sample sending container.
4. The sample preparation method according to any one of claims 1 to 3, wherein the step S3 includes:
s301: a sampling needle of the sample sucking device vertically moves downwards until the sampling needle extends into a sample sending container to suck sample suspension;
s302: after the sampling needle finishes sampling, the sampling needle of the sample sucking device vertically moves upwards until the sampling needle is separated from the sample sending container;
s303: the sample sucking device drives the sampling needle to move to a specified station along the horizontal direction, and the sampling needle adds the sucked sample suspension into an external detection carrier.
5. The sample preparation method according to any one of claims 1 to 3, wherein the step S3 includes:
s301': a sampling needle of the sample suction device vertically moves downwards until the sampling needle extends into the sample sending container, and the sampling needle sucks the sample suspension and outputs the sample suspension to the detection carrier through a conduit;
s302': after the sampling needle finishes sampling, the sample sucking device drives the sampling needle to vertically move upwards until the sampling needle is separated from the sample container.
6. The method for preparing a specimen according to claim 4, wherein after the step S3, the sampling needle of the sample aspirating apparatus is subjected to a cleaning operation.
7. The method for preparing a specimen according to claim 5, wherein after the step S3, the sampling needle of the sample aspirating apparatus is subjected to a cleaning operation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810935339.9A CN110836794A (en) | 2018-08-16 | 2018-08-16 | Sample manufacturing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810935339.9A CN110836794A (en) | 2018-08-16 | 2018-08-16 | Sample manufacturing method |
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| CN110836794A true CN110836794A (en) | 2020-02-25 |
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| CN201810935339.9A Pending CN110836794A (en) | 2018-08-16 | 2018-08-16 | Sample manufacturing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112067414A (en) * | 2020-08-31 | 2020-12-11 | 李顺兰 | Cosmetic detection device |
| CN114062101A (en) * | 2020-07-30 | 2022-02-18 | 爱威科技股份有限公司 | Sample processing method and device |
-
2018
- 2018-08-16 CN CN201810935339.9A patent/CN110836794A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114062101A (en) * | 2020-07-30 | 2022-02-18 | 爱威科技股份有限公司 | Sample processing method and device |
| CN112067414A (en) * | 2020-08-31 | 2020-12-11 | 李顺兰 | Cosmetic detection device |
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