CN102046639A - 新类别的GABAA/BzR配体 - Google Patents
新类别的GABAA/BzR配体 Download PDFInfo
- Publication number
- CN102046639A CN102046639A CN2009801206121A CN200980120612A CN102046639A CN 102046639 A CN102046639 A CN 102046639A CN 2009801206121 A CN2009801206121 A CN 2009801206121A CN 200980120612 A CN200980120612 A CN 200980120612A CN 102046639 A CN102046639 A CN 102046639A
- Authority
- CN
- China
- Prior art keywords
- methyl
- quinoline
- ketone
- isothiazole
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (28)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0800758 | 2008-04-04 | ||
SE0800758-5 | 2008-04-04 | ||
PCT/SE2009/000175 WO2009123536A1 (en) | 2008-04-04 | 2009-04-02 | NEW CLASSES OF GABAa/BZR LIGANDS |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102046639A true CN102046639A (zh) | 2011-05-04 |
CN102046639B CN102046639B (zh) | 2013-05-15 |
Family
ID=41135803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801206121A Active CN102046639B (zh) | 2008-04-04 | 2009-04-02 | GABAA/BzR配体 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8481561B2 (zh) |
EP (1) | EP2291383B1 (zh) |
CN (1) | CN102046639B (zh) |
CA (1) | CA2720461C (zh) |
DK (1) | DK2291383T3 (zh) |
ES (1) | ES2546877T3 (zh) |
WO (1) | WO2009123536A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110177796A (zh) * | 2017-01-06 | 2019-08-27 | 高丽大学校世宗产学协力团 | 新的喹啉酮衍生物和包含所述喹啉酮衍生物作为活性成分用于预防或治疗变应性疾病例如哮喘或特应性的药物组合物 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102146068A (zh) * | 2011-01-20 | 2011-08-10 | 南开大学 | 3-苯甲酰基-4-羟基香豆素衍生物及其类似物与在除草方面的应用 |
ES2899988T3 (es) * | 2016-07-29 | 2022-03-15 | Nat Cancer Ct | Compuesto que inhibe la formación del complejo c-Myc/Max/ADN |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5182290A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain oxazoloquinolinones; a new class of GABA brain receptor ligands |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268496B1 (en) | 1990-10-31 | 2001-07-31 | Neurogen Corporation | Certain imidazoquinoxalines: a new class of GABA brain receptor ligands |
-
2009
- 2009-04-02 CN CN2009801206121A patent/CN102046639B/zh active Active
- 2009-04-02 ES ES09727437.7T patent/ES2546877T3/es active Active
- 2009-04-02 DK DK09727437.7T patent/DK2291383T3/en active
- 2009-04-02 EP EP09727437.7A patent/EP2291383B1/en active Active
- 2009-04-02 US US12/936,045 patent/US8481561B2/en active Active
- 2009-04-02 CA CA2720461A patent/CA2720461C/en active Active
- 2009-04-02 WO PCT/SE2009/000175 patent/WO2009123536A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5182290A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain oxazoloquinolinones; a new class of GABA brain receptor ligands |
Non-Patent Citations (3)
Title |
---|
ERIK LAGER"ET AL: "4-quinolone derivatives: High-affinity ligands at the benzodiazepine site of brain GABAA receptors. Synthesis, Pharmacology and Pharmacophoren Modeling", 《J.MED.CHEM.》 * |
POVL KROGSGAARD-LARSEN,ET AL: "GABAA agonists and partial agonists: THIP (Gaboxadol) as a non-opiod analgesic and a novel type of hypnotic", 《BIOCHEMICAL PHARMACOLOGY》 * |
VITTORIA COLOTTA,ET AL: "Tricyclic Heteroaromatic Systems.[1Benzopyranopyrrol-4-ones and [1Benzopyrano-1,2,3-triazol-4-ones as Benzodiazepine Receptor Ligands.Synthesis and Structure-activity Relationships", 《J. MED. CHEM.》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110177796A (zh) * | 2017-01-06 | 2019-08-27 | 高丽大学校世宗产学协力团 | 新的喹啉酮衍生物和包含所述喹啉酮衍生物作为活性成分用于预防或治疗变应性疾病例如哮喘或特应性的药物组合物 |
US11168094B2 (en) | 2017-01-06 | 2021-11-09 | Azcuris Co., Ltd. | Quinolinone derivative and pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopic dermatitis including the quinolinone derivative as active ingredient |
CN110177796B (zh) * | 2017-01-06 | 2022-04-08 | 阿斯克里斯有限公司 | 喹啉酮衍生物及其用于预防或治疗变应性疾病的药物组合物 |
Also Published As
Publication number | Publication date |
---|---|
EP2291383B1 (en) | 2015-07-01 |
US8481561B2 (en) | 2013-07-09 |
CA2720461C (en) | 2016-03-29 |
EP2291383A4 (en) | 2011-11-16 |
EP2291383A1 (en) | 2011-03-09 |
US20110105553A1 (en) | 2011-05-05 |
CA2720461A1 (en) | 2009-10-08 |
ES2546877T3 (es) | 2015-09-29 |
WO2009123536A1 (en) | 2009-10-08 |
DK2291383T3 (en) | 2015-09-21 |
CN102046639B (zh) | 2013-05-15 |
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PB01 | Publication | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SWEDEN INNOVATION PATENT CORP. Free format text: FORMER OWNER: FORSKARPATENT I SYD AB Effective date: 20130517 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20130517 Address after: Longde, Sweden Patentee after: FORSKARPATENT I SYD AB Address before: Longde, Sweden Patentee before: Forskarpatent I. Syd AB |
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ASS | Succession or assignment of patent right |
Owner name: GOBAT CO., LTD. Free format text: FORMER OWNER: SWEDEN INNOVATION PATENT CORP. Effective date: 20141203 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20141203 Address after: Swedish Mamo Patentee after: Gaobate Co., Ltd. Address before: Longde, Sweden Patentee before: FORSKARPATENT I SYD AB |