CN102016579B - Vegf多态性和抗血管发生疗法 - Google Patents

Vegf多态性和抗血管发生疗法 Download PDF

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Publication number
CN102016579B
CN102016579B CN200880125826.3A CN200880125826A CN102016579B CN 102016579 B CN102016579 B CN 102016579B CN 200880125826 A CN200880125826 A CN 200880125826A CN 102016579 B CN102016579 B CN 102016579B
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vegf
cancer
patient
purposes
genotype
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Expired - Fee Related
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CN102016579A (zh
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布赖恩·P·施奈德
米兰·拉多维科
乔治·W·斯莱奇
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Genentech Inc
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Genentech Inc
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  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN200880125826.3A 2007-11-30 2008-11-26 Vegf多态性和抗血管发生疗法 Expired - Fee Related CN102016579B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510199713.XA CN104805203A (zh) 2007-11-30 2008-11-26 Vegf多态性和抗血管发生疗法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99161607P 2007-11-30 2007-11-30
US60/991,616 2007-11-30
US3869908P 2008-03-21 2008-03-21
US61/038,699 2008-03-21
PCT/US2008/084933 WO2009073540A2 (en) 2007-11-30 2008-11-26 Vegf polymorphisms and anti-angiogenesis therapy

Related Child Applications (1)

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CN201510199713.XA Division CN104805203A (zh) 2007-11-30 2008-11-26 Vegf多态性和抗血管发生疗法

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CN102016579A CN102016579A (zh) 2011-04-13
CN102016579B true CN102016579B (zh) 2015-04-08

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CN201510199713.XA Pending CN104805203A (zh) 2007-11-30 2008-11-26 Vegf多态性和抗血管发生疗法

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ598791A (en) 2009-10-23 2014-05-30 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
WO2011146406A1 (en) * 2010-05-17 2011-11-24 University Of Southern California Germline polymorphisms in vegf predict clinical outcomes in cancer patients treated with sorafenib
BR112013001423A2 (pt) * 2010-07-19 2016-05-24 Hoffmann La Roche método, método in vitro, uso e kit útil para realizar o método
AR085301A1 (es) * 2011-02-23 2013-09-18 Sanofi Sa Polimorfismos de un solo nucleotido en el promotor del gen vegfa y su uso como marcadores predictivos para tratamientos anti-vegf
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
MX2014002311A (es) * 2011-08-31 2014-08-26 Hoffmann La Roche Capacidad de respuesta a inhibidores de angiogenesis.
EP2751280B1 (en) * 2011-08-31 2016-06-29 F.Hoffmann-La Roche Ag Method for predicting risk of hypertension associated with anti-angiogenesis therapy
UA117910C2 (uk) * 2012-04-27 2018-10-25 Мілленніум Фармасьютікалз, Інк. Молекула анти-gcc антитіла і її використання для тестування на чутливість до gcc-націленої терапії
US10456470B2 (en) * 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
CN111926080B (zh) 2014-06-18 2024-07-12 东丽株式会社 肺癌的检测试剂盒或装置以及检测方法
ES2732925T3 (es) 2014-07-18 2019-11-26 Sanofi Sa Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer
BR112017016307B1 (pt) * 2015-01-29 2024-02-15 Huawei Technologies Co., Ltd Método de reconfiguração de portador de rádio e equipamento de usuário
EP4520842A3 (en) * 2018-05-18 2025-09-10 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
CN108913772B (zh) * 2018-06-15 2020-04-03 上海思路迪生物医学科技有限公司 基于捕获测序的bMSI检测技术
GR1009959B (el) * 2019-06-21 2021-03-18 ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." Οι πολυμορφισμοι σαν προβλεπτικοι παραγοντες στην ανταποκριση στη θεραπεια και τη συνολικη επιβιωση

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207486A1 (en) * 2006-03-03 2007-09-06 University Of Southern California Angiogenesis pathway gene polymorphisms for therapy selection

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4998617A (en) 1986-09-15 1991-03-12 Laura Lupton Inc Facial cosmetic liquid make up kit
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5256775A (en) 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
EP1012342A4 (en) 1997-09-10 2004-07-21 Univ Maryland METHOD FOR THE AMPLIFICATION OF DNA AND RNA PRODUCTS, STARTING FROM SPLIT PIECES DUE TO MISSING BASE PAIRINGS
AU2006213856B2 (en) 2005-02-11 2011-03-17 Regeneron Pharmaceuticals, Inc. Therapeutic combination of a VEGF antagonist (VEGF trap) and an anti-hypertensive agent
JP2007020563A (ja) * 2005-06-13 2007-02-01 Sutaagen:Kk 糖尿病網膜症発症及び／又は進展リスクの診断方法
RU2287158C1 (ru) * 2005-07-07 2006-11-10 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" (ГОУ ВПО БГМУ РОСЗДРАВА РОССИИ) Способ прогнозирования развития гипертонической болезни по генетическим факторам риска
RU2414924C2 (ru) * 2005-08-12 2011-03-27 Ридженерон Фармасьютикалз, Инк. Способы лечения заболеваний антагонистами vegf
US20070218487A1 (en) * 2006-03-03 2007-09-20 University Of Southern California Genetic markers for predicting disease and treatment outcome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207486A1 (en) * 2006-03-03 2007-09-06 University Of Southern California Angiogenesis pathway gene polymorphisms for therapy selection

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A Common Polymorphism in the5’-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathyin Type 2 Diabetes Diabetes;Awata等;《Brief Genetics Report》;20020531(第51期);1635-1639 *
Association of polymorphisms of angiogenesis genes with breast cancer;Schneider等;《Breast Cancer Res Treat.》;20070920;第111卷(第1期);157-163 *
Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy.;Suganthalakshmi等;《Molecular Vision》;20060411(第12期);336-341 *
Hypertension Secondary to Anti-angiogenic Therapy:Experience with Bevacizumab.;Pande等;《ANTICANCER RESEARCH》;20071031(第27期);3465-3470 *

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