CN102015728A - 噻唑基-二氢-吲唑 - Google Patents
噻唑基-二氢-吲唑 Download PDFInfo
- Publication number
- CN102015728A CN102015728A CN2009801164824A CN200980116482A CN102015728A CN 102015728 A CN102015728 A CN 102015728A CN 2009801164824 A CN2009801164824 A CN 2009801164824A CN 200980116482 A CN200980116482 A CN 200980116482A CN 102015728 A CN102015728 A CN 102015728A
- Authority
- CN
- China
- Prior art keywords
- mmol
- alkyl
- reaction mixture
- yield
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(NC1=CC=C(CNOCC*2CCOCC2)CC1)=O Chemical compound CC(NC1=CC=C(CNOCC*2CCOCC2)CC1)=O 0.000 description 4
- BSORILXIRFEMBF-UHFFFAOYSA-N CC(Nc1nc(CCC(C(c2ccc(NCC=C)nc2)=O)=C2O)c2[s]1)=O Chemical compound CC(Nc1nc(CCC(C(c2ccc(NCC=C)nc2)=O)=C2O)c2[s]1)=O BSORILXIRFEMBF-UHFFFAOYSA-N 0.000 description 1
- ICOWVTRJWSEJKF-UHFFFAOYSA-N CC(Nc1nc(CCc2c-3[n](-c(c(Cl)c4)ccc4C(N(C)C)=O)nc2-c(cn2)ccc2Cl)c-3[s]1)=O Chemical compound CC(Nc1nc(CCc2c-3[n](-c(c(Cl)c4)ccc4C(N(C)C)=O)nc2-c(cn2)ccc2Cl)c-3[s]1)=O ICOWVTRJWSEJKF-UHFFFAOYSA-N 0.000 description 1
- IAQGSJWRLWSCNY-UHFFFAOYSA-N CCC(Nc1nc(CCC(C(c2ccc(C)nc2)=O)=C2O)c2[s]1)=O Chemical compound CCC(Nc1nc(CCC(C(c2ccc(C)nc2)=O)=C2O)c2[s]1)=O IAQGSJWRLWSCNY-UHFFFAOYSA-N 0.000 description 1
- PVDRBDYPECKUAT-UHFFFAOYSA-N CCNc(nc1)ccc1C(C(CCc1c2[s]c(CCCC(CCc3ncc[n]3C)=O)n1)=C2O)=O Chemical compound CCNc(nc1)ccc1C(C(CCc1c2[s]c(CCCC(CCc3ncc[n]3C)=O)n1)=C2O)=O PVDRBDYPECKUAT-UHFFFAOYSA-N 0.000 description 1
- OJJCSVDCNOOHPV-UHFFFAOYSA-N CCNc(nc1)ccc1C(C(CCc1c2[s]c(NC(N(C)CCCOC)=O)n1)=C2O)=O Chemical compound CCNc(nc1)ccc1C(C(CCc1c2[s]c(NC(N(C)CCCOC)=O)n1)=C2O)=O OJJCSVDCNOOHPV-UHFFFAOYSA-N 0.000 description 1
- YSXGIFZEOCWUDZ-UHFFFAOYSA-N CN(C)Cc(cc1)ccc1NN Chemical compound CN(C)Cc(cc1)ccc1NN YSXGIFZEOCWUDZ-UHFFFAOYSA-N 0.000 description 1
- SCAKLYATGYVZOU-UXBLZVDNSA-N CO/N=C/c(cc1)ccc1NN Chemical compound CO/N=C/c(cc1)ccc1NN SCAKLYATGYVZOU-UXBLZVDNSA-N 0.000 description 1
- OTMCKWOZCACCAE-MKMNVTDBSA-N COCCO/N=C/c(c(F)cc(NN)c1)c1F Chemical compound COCCO/N=C/c(c(F)cc(NN)c1)c1F OTMCKWOZCACCAE-MKMNVTDBSA-N 0.000 description 1
- KBDOSPRHPUXJSY-UHFFFAOYSA-N Cc(nc1)ccc1-c(c(CC1)c2-c3c1nc(NC(OC)=O)[s]3)n[n]2-c(cc1)ccc1Br Chemical compound Cc(nc1)ccc1-c(c(CC1)c2-c3c1nc(NC(OC)=O)[s]3)n[n]2-c(cc1)ccc1Br KBDOSPRHPUXJSY-UHFFFAOYSA-N 0.000 description 1
- GOARYCMMYKPDHC-UHFFFAOYSA-N Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(NCCCN(C)C)=O)n1)=C2O)=O Chemical compound Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(NCCCN(C)C)=O)n1)=C2O)=O GOARYCMMYKPDHC-UHFFFAOYSA-N 0.000 description 1
- QXEUWRPAODPBMH-UHFFFAOYSA-N Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(OC)=O)n1)=C2O)=O Chemical compound Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(OC)=O)n1)=C2O)=O QXEUWRPAODPBMH-UHFFFAOYSA-N 0.000 description 1
- CDEIZYZUYIFTNG-UHFFFAOYSA-N Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(OCCCOC)=O)n1)=C2O)=N Chemical compound Cc(nc1)ccc1C(C(CCc1c2[s]c(NC(OCCCOC)=O)n1)=C2O)=N CDEIZYZUYIFTNG-UHFFFAOYSA-N 0.000 description 1
- WCCDMVZNXNVVQM-UHFFFAOYSA-N NNC1CCNCC1 Chemical compound NNC1CCNCC1 WCCDMVZNXNVVQM-UHFFFAOYSA-N 0.000 description 1
- IANKJSSNODTBCL-UHFFFAOYSA-N Nc1nc(CCC(C(c2ccc(N)nc2)=O)=C2O)c2[s]1 Chemical compound Nc1nc(CCC(C(c2ccc(N)nc2)=O)=C2O)c2[s]1 IANKJSSNODTBCL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152721.0 | 2008-03-13 | ||
| EP08152721 | 2008-03-13 | ||
| PCT/EP2009/052959 WO2009112565A1 (en) | 2008-03-13 | 2009-03-13 | Thiazolyl-dihydro-indazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102015728A true CN102015728A (zh) | 2011-04-13 |
Family
ID=39591172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801164824A Pending CN102015728A (zh) | 2008-03-13 | 2009-03-13 | 噻唑基-二氢-吲唑 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20110118208A1 (enExample) |
| EP (1) | EP2280982A1 (enExample) |
| JP (1) | JP2011513471A (enExample) |
| KR (1) | KR20100135743A (enExample) |
| CN (1) | CN102015728A (enExample) |
| AR (1) | AR070877A1 (enExample) |
| AU (1) | AU2009224659A1 (enExample) |
| BR (1) | BRPI0908583A2 (enExample) |
| CA (1) | CA2717488A1 (enExample) |
| CL (1) | CL2009000599A1 (enExample) |
| CO (1) | CO6290768A2 (enExample) |
| EA (1) | EA201001427A1 (enExample) |
| EC (1) | ECSP10010532A (enExample) |
| IL (1) | IL207776A0 (enExample) |
| MA (1) | MA32158B1 (enExample) |
| MX (1) | MX2010009837A (enExample) |
| PE (1) | PE20091617A1 (enExample) |
| TW (1) | TW200942548A (enExample) |
| UY (1) | UY31700A (enExample) |
| WO (1) | WO2009112565A1 (enExample) |
| ZA (1) | ZA201006023B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| EP3444242A3 (en) | 2009-11-05 | 2019-03-20 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| US8466162B2 (en) | 2011-01-26 | 2013-06-18 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyridines |
| EP2546249A1 (en) | 2011-07-15 | 2013-01-16 | Boehringer Ingelheim International Gmbh | 5-Alkynyl-pyridines |
| TW201245176A (en) * | 2011-01-26 | 2012-11-16 | Boehringer Ingelheim Int | New 5-alkynyl-pyridines |
| PT2705029T (pt) | 2011-05-04 | 2019-02-01 | Rhizen Pharmaceuticals S A | Novos compostos como moduladores de proteína quinases |
| HRP20171610T1 (hr) | 2012-07-04 | 2018-03-23 | Rhizen Pharmaceuticals S.A. | Selektivni inhibitori pi3k delta |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2403258C2 (ru) * | 2004-10-07 | 2010-11-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Тиазолилдигидроиндазолы |
| DE102004048877A1 (de) * | 2004-10-07 | 2006-04-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | PI3-Kinasen |
| UY29149A1 (es) | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| BRPI0710843A2 (pt) | 2006-04-06 | 2011-08-23 | Boehringer Ingelheim Int | tiazolil-di-hidro-indazóis |
| US20070238718A1 (en) * | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
| JP2009532426A (ja) * | 2006-04-06 | 2009-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チアゾリル−ジヒドロ−インダゾール |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
-
2009
- 2009-03-11 PE PE2009000361A patent/PE20091617A1/es not_active Application Discontinuation
- 2009-03-11 UY UY0001031700A patent/UY31700A/es not_active Application Discontinuation
- 2009-03-12 TW TW098108096A patent/TW200942548A/zh unknown
- 2009-03-12 AR ARP090100892A patent/AR070877A1/es unknown
- 2009-03-12 CL CL2009000599A patent/CL2009000599A1/es unknown
- 2009-03-13 US US12/921,588 patent/US20110118208A1/en not_active Abandoned
- 2009-03-13 MX MX2010009837A patent/MX2010009837A/es not_active Application Discontinuation
- 2009-03-13 WO PCT/EP2009/052959 patent/WO2009112565A1/en not_active Ceased
- 2009-03-13 JP JP2010550206A patent/JP2011513471A/ja active Pending
- 2009-03-13 CN CN2009801164824A patent/CN102015728A/zh active Pending
- 2009-03-13 EA EA201001427A patent/EA201001427A1/ru unknown
- 2009-03-13 KR KR1020107020481A patent/KR20100135743A/ko not_active Withdrawn
- 2009-03-13 AU AU2009224659A patent/AU2009224659A1/en not_active Abandoned
- 2009-03-13 BR BRPI0908583A patent/BRPI0908583A2/pt not_active IP Right Cessation
- 2009-03-13 CA CA2717488A patent/CA2717488A1/en not_active Abandoned
- 2009-03-13 EP EP09719604A patent/EP2280982A1/en not_active Ceased
-
2010
- 2010-08-24 IL IL207776A patent/IL207776A0/en unknown
- 2010-08-24 ZA ZA2010/06023A patent/ZA201006023B/en unknown
- 2010-09-01 CO CO10108096A patent/CO6290768A2/es not_active Application Discontinuation
- 2010-09-09 MA MA33164A patent/MA32158B1/fr unknown
- 2010-10-08 EC EC2010010532A patent/ECSP10010532A/es unknown
-
2012
- 2012-01-11 US US13/347,797 patent/US8304556B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW200942548A (en) | 2009-10-16 |
| US20110118208A1 (en) | 2011-05-19 |
| IL207776A0 (en) | 2010-12-30 |
| KR20100135743A (ko) | 2010-12-27 |
| EA201001427A1 (ru) | 2011-04-29 |
| US8304556B2 (en) | 2012-11-06 |
| CO6290768A2 (es) | 2011-06-20 |
| AR070877A1 (es) | 2010-05-12 |
| MA32158B1 (fr) | 2011-03-01 |
| JP2011513471A (ja) | 2011-04-28 |
| CA2717488A1 (en) | 2009-09-17 |
| ECSP10010532A (es) | 2010-11-30 |
| AU2009224659A1 (en) | 2009-09-17 |
| BRPI0908583A2 (pt) | 2019-09-24 |
| MX2010009837A (es) | 2010-09-28 |
| PE20091617A1 (es) | 2009-11-12 |
| CL2009000599A1 (es) | 2011-01-07 |
| EP2280982A1 (en) | 2011-02-09 |
| UY31700A (es) | 2009-11-10 |
| US20120108567A1 (en) | 2012-05-03 |
| WO2009112565A1 (en) | 2009-09-17 |
| ZA201006023B (en) | 2011-10-26 |
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| REG | Reference to a national code |
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