CN102014923A - 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124 - Google Patents

用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124 Download PDF

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Publication number
CN102014923A
CN102014923A CN2009801149788A CN200980114978A CN102014923A CN 102014923 A CN102014923 A CN 102014923A CN 2009801149788 A CN2009801149788 A CN 2009801149788A CN 200980114978 A CN200980114978 A CN 200980114978A CN 102014923 A CN102014923 A CN 102014923A
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cdb
compound
progesterone
estrogen
dose
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Pending
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CN2009801149788A
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Chinese (zh)
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J·S·波多尔斯基
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Repros Therapeutics Inc
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Repros Therapeutics Inc
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Priority to CN201610029200.9A priority Critical patent/CN105616427A/zh
Publication of CN102014923A publication Critical patent/CN102014923A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN2009801149788A 2008-04-28 2009-04-27 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124 Pending CN102014923A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610029200.9A CN105616427A (zh) 2008-04-28 2009-04-27 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4847208P 2008-04-28 2008-04-28
US61/048472 2008-04-28
PCT/US2009/041826 WO2009134718A1 (en) 2008-04-28 2009-04-27 Pregesteron antagonists such as cdb-4124 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610029200.9A Division CN105616427A (zh) 2008-04-28 2009-04-27 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124

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CN102014923A true CN102014923A (zh) 2011-04-13

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CN2009801149788A Pending CN102014923A (zh) 2008-04-28 2009-04-27 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124
CN201610029200.9A Pending CN105616427A (zh) 2008-04-28 2009-04-27 用于治疗子宫内膜异位症、子宫肌瘤、痛经、乳腺癌的孕酮拮抗剂，例如cdb-4124

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US (2) US8426394B2 (https=)
EP (1) EP2293797B1 (https=)
JP (1) JP5791499B2 (https=)
KR (2) KR20110014162A (https=)
CN (2) CN102014923A (https=)
AR (1) AR071516A1 (https=)
AU (1) AU2009241355B2 (https=)
BR (1) BRPI0911563A2 (https=)
CA (1) CA2722753C (https=)
CL (1) CL2009001010A1 (https=)
DK (1) DK2293797T3 (https=)
EA (3) EA032646B1 (https=)
ES (1) ES2561810T3 (https=)
IL (1) IL208844A0 (https=)
ME (1) ME01123B (https=)
MX (1) MX2010011272A (https=)
MY (1) MY161059A (https=)
NI (1) NI201000183A (https=)
NZ (1) NZ589533A (https=)
SG (1) SG10201408483QA (https=)
TW (1) TWI477276B (https=)
UA (1) UA102849C2 (https=)
WO (1) WO2009134718A1 (https=)
ZA (1) ZA201007529B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104334158A (zh) * 2012-05-31 2015-02-04 利普生物药剂公司 经阴道递送抗孕素的调配物和方法
CN104755087A (zh) * 2012-11-02 2015-07-01 利普生物药剂公司 治疗孕酮依赖性病况的方法和组合物

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TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
HUP0900487A2 (hu) * 2009-08-05 2011-03-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására
UA113283C2 (xx) * 2010-12-23 2017-01-10 19-норстероїди і їх застосування для лікування прогестеронзалежних станів
EP2471537A1 (en) 2010-12-30 2012-07-04 PregLem S.A. Treatment of pain associated with dislocation of basal endometrium
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
HU230381B1 (hu) * 2014-02-17 2016-03-29 Richter Gedeon Nyrt Ipari eljárás szteroid intermedier előállítására
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104334158A (zh) * 2012-05-31 2015-02-04 利普生物药剂公司 经阴道递送抗孕素的调配物和方法
CN104334158B (zh) * 2012-05-31 2018-08-10 利普生物药剂公司 经阴道递送抗孕素的调配物和方法
US10328022B2 (en) 2012-05-31 2019-06-25 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
CN104755087A (zh) * 2012-11-02 2015-07-01 利普生物药剂公司 治疗孕酮依赖性病况的方法和组合物

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EP2293797B1 (en) 2015-11-11
JP5791499B2 (ja) 2015-10-07
TW200950786A (en) 2009-12-16
EA201990835A3 (ru) 2019-12-30
US20130289008A1 (en) 2013-10-31
DK2293797T3 (en) 2016-01-11
JP2011518845A (ja) 2011-06-30
WO2009134718A8 (en) 2010-09-23
EA032646B1 (ru) 2019-06-28
BRPI0911563A2 (pt) 2016-07-12
MY161059A (en) 2017-04-14
MX2010011272A (es) 2010-12-21
EA201071249A1 (ru) 2011-08-30
CN105616427A (zh) 2016-06-01
AU2009241355B2 (en) 2013-11-14
ME01123B (me) 2013-03-20
ZA201007529B (en) 2011-07-27
NZ589533A (en) 2012-06-29
CA2722753A1 (en) 2009-11-05
EA201990835A2 (ru) 2019-08-30
SG10201408483QA (en) 2015-02-27
AU2009241355A1 (en) 2009-11-05
TWI477276B (zh) 2015-03-21
US20110046098A1 (en) 2011-02-24
EA201401347A1 (ru) 2015-07-30
US8735381B2 (en) 2014-05-27
AR071516A1 (es) 2010-06-23
KR20130059442A (ko) 2013-06-05
UA102849C2 (ru) 2013-08-27
CA2722753C (en) 2018-07-03
IL208844A0 (en) 2011-01-31
EP2293797A1 (en) 2011-03-16
KR20110014162A (ko) 2011-02-10
WO2009134718A1 (en) 2009-11-05
US8426394B2 (en) 2013-04-23
NI201000183A (es) 2012-06-06
CL2009001010A1 (es) 2009-06-19
ES2561810T3 (es) 2016-03-01

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