CN102007223B - 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 - Google Patents
用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 Download PDFInfo
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- CN102007223B CN102007223B CN200980112966.1A CN200980112966A CN102007223B CN 102007223 B CN102007223 B CN 102007223B CN 200980112966 A CN200980112966 A CN 200980112966A CN 102007223 B CN102007223 B CN 102007223B
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6744508P | 2008-02-28 | 2008-02-28 | |
| US61/067,445 | 2008-02-28 | ||
| PCT/US2009/035458 WO2009108853A1 (en) | 2008-02-28 | 2009-02-27 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF GASTRIC CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102007223A CN102007223A (zh) | 2011-04-06 |
| CN102007223B true CN102007223B (zh) | 2014-06-18 |
Family
ID=41016479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980112966.1A Expired - Fee Related CN102007223B (zh) | 2008-02-28 | 2009-02-27 | 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110034538A1 (enExample) |
| EP (2) | EP3064584A3 (enExample) |
| JP (1) | JP5662166B2 (enExample) |
| CN (1) | CN102007223B (enExample) |
| AU (1) | AU2009219190A1 (enExample) |
| CA (1) | CA2716906A1 (enExample) |
| WO (1) | WO2009108853A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103866018B (zh) | 2005-08-01 | 2016-05-25 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| EP2487260B1 (en) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2007081720A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| ES2524018T3 (es) | 2006-01-05 | 2014-12-03 | The Ohio State University Research Foundation | Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| JP5501766B2 (ja) | 2006-11-01 | 2014-05-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 肝細胞癌における生存および転移を予測するためのマイクロrna発現サイン |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| CA2690144A1 (en) | 2007-06-08 | 2008-12-18 | The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services | Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| AU2008283997B2 (en) | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| CN101836112A (zh) | 2007-08-22 | 2010-09-15 | 俄亥俄州立大学研究基金会 | 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物 |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
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| JP5960060B2 (ja) | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| WO2012010584A1 (en) * | 2010-07-20 | 2012-01-26 | Febit Holding Gmbh | Complex mirna sets as novel biomarkers for gastric cancer |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| SG182016A1 (en) * | 2010-12-14 | 2012-07-30 | Univ Singapore | Method of detecting resistance to cancer therapy |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| JP6211511B2 (ja) * | 2011-04-18 | 2017-10-11 | ディアミール, エルエルシーDiamir, Llc | miRNAに基づくユニバーサルスクリーニングテスト(UST) |
| US8703425B2 (en) * | 2011-09-12 | 2014-04-22 | The Chinese University Of Hong Kong | Biomarker for gastric cancer |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| CN104619353A (zh) | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| US9845465B2 (en) | 2012-08-15 | 2017-12-19 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| JPWO2014097875A1 (ja) * | 2012-12-20 | 2017-01-12 | 国立大学法人鳥取大学 | 新規の脱分化誘導方法を用いた多能性幹細胞化 |
| CN104013975A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌治疗药物中的应用 |
| CN106460068B (zh) * | 2014-06-16 | 2024-08-23 | 东丽株式会社 | 胃癌的检测试剂盒或装置以及检测方法 |
| EP4137586A1 (en) * | 2014-08-07 | 2023-02-22 | Agency for Science, Technology and Research | Microrna biomarker for the diagnosis of gastric cancer |
| CN104293923A (zh) * | 2014-09-19 | 2015-01-21 | 浙江大学 | 荧光定量PCR检测组织中miR-100含量的试剂盒及其应用 |
| CN106591428B (zh) * | 2016-09-23 | 2021-06-11 | 宁波大学 | 一种胃癌新型分子标记物hsa_circ_0001017的检测及应用 |
| CN106636334B (zh) * | 2016-10-09 | 2020-07-03 | 山东大学 | microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用 |
| CN106755513B (zh) * | 2017-02-08 | 2018-10-19 | 泰山医学院 | 一种胃癌的lncRNA标志物 |
| RU2019134769A (ru) * | 2017-03-31 | 2021-04-30 | Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури | Композиции для лечения резистентных к лекарственным средствам опухолей и способы их применения |
| CN107217055B (zh) * | 2017-06-26 | 2019-01-18 | 生工生物工程(上海)股份有限公司 | 一种癌症诊断芯片及其试剂盒 |
| CN107641653B (zh) * | 2017-10-20 | 2021-02-19 | 南方医科大学南方医院 | Macc1-as1探针在制备用于预测胃癌临床预后的诊断试剂中的应用 |
| CN108546757B (zh) * | 2018-03-05 | 2021-09-07 | 上海长海医院 | Zfpm2-as1在制备胃癌诊断试剂或试剂盒中的应用 |
| KR102100124B1 (ko) * | 2018-08-31 | 2020-05-15 | 한국표준과학연구원 | 질량 분석법을 이용한 생체 분자의 고감도 및 고특이적 검출 방법 |
| JP7512285B2 (ja) * | 2018-12-19 | 2024-07-08 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | マイクロrnaを用いた胃癌の診断方法 |
| CN117683885A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| CN111139299B (zh) * | 2020-01-08 | 2021-12-17 | 浙江大学 | Josd2蛋白在制备治疗恶性肿瘤药物中的应用 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| CN114678121B (zh) * | 2022-05-30 | 2022-09-09 | 上海芯超生物科技有限公司 | 一种hp球形变诊断模型的构建方法及系统 |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3064584A3 (en) | 2016-12-07 |
| WO2009108853A1 (en) | 2009-09-03 |
| JP2011516032A (ja) | 2011-05-26 |
| CN102007223A (zh) | 2011-04-06 |
| EP2257647A4 (en) | 2011-08-03 |
| US20110034538A1 (en) | 2011-02-10 |
| CA2716906A1 (en) | 2009-09-03 |
| EP2257647B1 (en) | 2016-09-14 |
| EP2257647A1 (en) | 2010-12-08 |
| AU2009219190A1 (en) | 2009-09-03 |
| JP5662166B2 (ja) | 2015-01-28 |
| EP3064584A2 (en) | 2016-09-07 |
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