CN102002020A - 一种精制哌嗪的方法 - Google Patents
一种精制哌嗪的方法 Download PDFInfo
- Publication number
- CN102002020A CN102002020A CN 201010557195 CN201010557195A CN102002020A CN 102002020 A CN102002020 A CN 102002020A CN 201010557195 CN201010557195 CN 201010557195 CN 201010557195 A CN201010557195 A CN 201010557195A CN 102002020 A CN102002020 A CN 102002020A
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- CN
- China
- Prior art keywords
- piperazine
- extraction agent
- rectifying column
- reflux ratio
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title claims abstract description 105
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000007670 refining Methods 0.000 title claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 47
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 40
- 238000010992 reflux Methods 0.000 claims abstract description 23
- 238000000926 separation method Methods 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000006243 chemical reaction Methods 0.000 claims description 17
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 150000004885 piperazines Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 238000010438 heat treatment Methods 0.000 abstract description 4
- 239000012295 chemical reaction liquid Substances 0.000 abstract 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 description 11
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- KGWDUNBJIMUFAP-KVVVOXFISA-N Ethanolamine Oleate Chemical compound NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O KGWDUNBJIMUFAP-KVVVOXFISA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000001577 simple distillation Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical group OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- -1 hydrogen piperazines Chemical class 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- NQQWFVUVBGSGQN-UHFFFAOYSA-N phosphoric acid;piperazine Chemical compound OP(O)(O)=O.C1CNCCN1 NQQWFVUVBGSGQN-UHFFFAOYSA-N 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
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Abstract
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Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010105571951A CN102002020B (zh) | 2010-11-24 | 2010-11-24 | 一种精制哌嗪的方法 |
Applications Claiming Priority (1)
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CN2010105571951A CN102002020B (zh) | 2010-11-24 | 2010-11-24 | 一种精制哌嗪的方法 |
Publications (2)
Publication Number | Publication Date |
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CN102002020A true CN102002020A (zh) | 2011-04-06 |
CN102002020B CN102002020B (zh) | 2012-05-30 |
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CN2010105571951A Active CN102002020B (zh) | 2010-11-24 | 2010-11-24 | 一种精制哌嗪的方法 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977055A (zh) * | 2012-11-21 | 2013-03-20 | 西安近代化学研究所 | 一种哌嗪的分离方法 |
CN103319350A (zh) * | 2013-05-14 | 2013-09-25 | 西安近代化学研究所 | 一种提纯1,2-丙二胺的方法 |
CN104119297A (zh) * | 2014-08-04 | 2014-10-29 | 西安近代化学研究所 | 一种精制哌嗪的方法 |
CN104130209A (zh) * | 2014-08-04 | 2014-11-05 | 西安近代化学研究所 | 一种分离n-甲基哌嗪与n-乙基哌嗪的方法 |
CN105175357A (zh) * | 2015-08-11 | 2015-12-23 | 无锡桥阳机械制造有限公司 | 组合式提取哌嗪的方法 |
CN105198836A (zh) * | 2015-08-11 | 2015-12-30 | 无锡桥阳机械制造有限公司 | 膜分离精制哌嗪的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234730A (en) * | 1979-09-24 | 1980-11-18 | Texaco Development Corp. | Process of preparing selective mixtures of piperazine and ethylenediamine |
US20070043217A1 (en) * | 2003-10-17 | 2007-02-22 | Basf Aklengesellschaft | Method for the distillative separation of mixtures containing ethyleneamines |
CN101177419A (zh) * | 2007-12-05 | 2008-05-14 | 天津大学 | 共沸精馏间歇操作分离n-乙基哌嗪-乙醇胺共沸混合物的方法 |
-
2010
- 2010-11-24 CN CN2010105571951A patent/CN102002020B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234730A (en) * | 1979-09-24 | 1980-11-18 | Texaco Development Corp. | Process of preparing selective mixtures of piperazine and ethylenediamine |
US20070043217A1 (en) * | 2003-10-17 | 2007-02-22 | Basf Aklengesellschaft | Method for the distillative separation of mixtures containing ethyleneamines |
CN101177419A (zh) * | 2007-12-05 | 2008-05-14 | 天津大学 | 共沸精馏间歇操作分离n-乙基哌嗪-乙醇胺共沸混合物的方法 |
Non-Patent Citations (2)
Title |
---|
《川化》 20021231 朱亚丽 哌嗪合成和精制综述 第14-16页 1-2 , 第1期 2 * |
《现代化工》 20080831 郝妙莉等 基于Aspen模拟的乙醇胺催化胺化产物的精馏分离 第79-83页 1-2 第28卷, 第8期 2 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977055A (zh) * | 2012-11-21 | 2013-03-20 | 西安近代化学研究所 | 一种哌嗪的分离方法 |
CN102977055B (zh) * | 2012-11-21 | 2015-10-28 | 西安近代化学研究所 | 一种哌嗪的分离方法 |
CN103319350A (zh) * | 2013-05-14 | 2013-09-25 | 西安近代化学研究所 | 一种提纯1,2-丙二胺的方法 |
CN103319350B (zh) * | 2013-05-14 | 2014-10-15 | 西安近代化学研究所 | 一种提纯1,2-丙二胺的方法 |
CN104119297A (zh) * | 2014-08-04 | 2014-10-29 | 西安近代化学研究所 | 一种精制哌嗪的方法 |
CN104130209A (zh) * | 2014-08-04 | 2014-11-05 | 西安近代化学研究所 | 一种分离n-甲基哌嗪与n-乙基哌嗪的方法 |
CN104119297B (zh) * | 2014-08-04 | 2017-01-18 | 西安近代化学研究所 | 一种精制哌嗪的方法 |
CN105175357A (zh) * | 2015-08-11 | 2015-12-23 | 无锡桥阳机械制造有限公司 | 组合式提取哌嗪的方法 |
CN105198836A (zh) * | 2015-08-11 | 2015-12-30 | 无锡桥阳机械制造有限公司 | 膜分离精制哌嗪的方法 |
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Publication number | Publication date |
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CN102002020B (zh) | 2012-05-30 |
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Owner name: SHANXI YULONG CHEMICAL CO., LTD. Free format text: FORMER OWNER: XI'AN INST. OF MODERN CHEMISTRY Effective date: 20121023 |
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Free format text: CORRECT: ADDRESS; FROM: 710065 XI'AN, SHAANXI PROVINCE TO: 038300 SHUOZHOU, SHAANXI PROVINCE |
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Effective date of registration: 20121023 Address after: 038300 East Economic Development Zone, Huairen, Shanxi, Shuozhou Patentee after: SHANXI YULONG CHEMICAL CO.,LTD. Address before: 710065 Shaanxi province Xi'an Yanta District Zhang eight road No. 168 Patentee before: XI'AN MODERN CHEMISTRY Research Institute |
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Effective date of registration: 20180212 Address after: 038300 East Economic Development Zone, Huairen, Shanxi, Shuozhou Patentee after: Shanxi ERON Grant Chemical Co.,Ltd. Address before: 038300 Yundong Economic Development Zone, Huaihua County, Shuozhou, Shanxi Patentee before: SHANXI YULONG CHEMICAL CO.,LTD. |
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Effective date of registration: 20240410 Address after: 038300 pharmaceutical Park, Huairen economic and Technological Development Zone, Shuozhou City, Shanxi Province Patentee after: SHANXI YULONG CHEMICAL CO.,LTD. Country or region after: China Address before: 038300 Yundong Economic Development Zone, Huairen County, Shuozhou City, Shanxi Province Patentee before: Shanxi ERON Grant Chemical Co.,Ltd. Country or region before: China |
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