CN101991599A - 可使病变组织及病原体溶解消除的药物 - Google Patents

可使病变组织及病原体溶解消除的药物 Download PDF

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CN101991599A
CN101991599A CN2009100420308A CN200910042030A CN101991599A CN 101991599 A CN101991599 A CN 101991599A CN 2009100420308 A CN2009100420308 A CN 2009100420308A CN 200910042030 A CN200910042030 A CN 200910042030A CN 101991599 A CN101991599 A CN 101991599A
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medicine
pathogen
sodium hydroxide
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谭国梁
谭晓雯
谭晓晴
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Priority to CN201510358361.8A priority Critical patent/CN104940225A/zh
Priority to CN2009100420308A priority patent/CN101991599A/zh
Priority to CN202110427188.8A priority patent/CN113082046A/zh
Priority to EP10811173.3A priority patent/EP2471541B1/en
Priority to JP2012525865A priority patent/JP2013502443A/ja
Priority to PCT/CN2010/073628 priority patent/WO2011023013A1/zh
Priority to US13/392,267 priority patent/US10251925B2/en
Publication of CN101991599A publication Critical patent/CN101991599A/zh
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Abstract

本发明涉及可使病变组织及病原体溶解消除的药物，按重量计量，总份量设为100.0，其中包括氢氧化钠1.0-60.0，其余加水至100.0；或以氢氧化钾取代氢氧化钠，份量不变；或以氢氧化钠与氢氧化钾的混合物取代氢氧化钠，份量不变；还可以加入有局部麻醉作用的化合物，如丁卡因1.0；或蟾酥灵0.25-0.5；或蟾酥0.5-1.0；或薄荷醇0.5-1.0，成为复方制剂。本发明建基于民间和传统中医药，结合现代医药科学技术，对民间和传统医药中利用生石灰碱性化学性质的药理作用和临床经验进一步挖掘和发展，可使病变组织及病原体实时溶解消除，疗效快、效果显著、副作用小，具有较好的推广应用前景。

Description

可使病变组织及病原体溶解消除的药物
技术领域
本发明属于药物技术领域，具体属于外治赘生物、恶肉、疽疮、瘿瘤疣子、痛疥瘙癣的药物，涉及可使病变组织及病原体溶解消除的药物。
背景技术
生石灰又称石灰或氧化钙，在我国现存最早药物学专著《神农本草经》中记载：“主疽疡疥瘙，热气恶性疮，癞疾死肌堕眉，杀痔虫，去黑子息肉。”汉末《名医别录》：“疗髓骨疽。”唐代甄权《药性论》：“治痛疥，蚀恶肉，不入汤服，止金疮血，和鸡子白，败船茹甚良。”宋初《日华子本草》：“生肌长肉，止血，并主白癜、疬疡、瘢疵等，疗冷气、痔瘘疽疮，瘿瘤疣子”。生石灰历代广泛用于燥湿、杀虫、止血、定痛、蚀恶肉、治疥癣、湿闪、创伤出血、汤火烫伤、痔疮、脱肛、赘疣，具有较好的疗效。
发明内容
本发明建基于民间和传统中医药，并对民间和传统医药中利用生石灰之碱性化学性质的药理作用和临床经验继承和发展，提供一种可使病变组织及病原体实时溶解消除的药物。
本发明的目的是通过采用以下技术方案来实现的：
可使病变组织及病原体溶解消除的药物，所述药物按重量计量，总份量设为100.0，其中包括氢氧化钠1.0-60.0，其余加水至100.0；
或以氢氧化钾取代氢氧化钠，份量不变；
或以氢氧化钠与氢氧化钾的混合物取代氢氧化钠，份量不变。
本发明所述药物可以加入有局部麻醉作用的化合物，例如丁卡因1.0；
或，蟾酥灵0.25-0.5；
或，蟾酥0.5-1.0；
或，薄荷醇0.5-1.0；
或，赋形剂卡波姆(941)0-0.5，成为复方制剂。
本发明所述药物可以加入：薄荷醇0-1.0、异甘草素0-0.5、黄芩素0-0.5、小檗碱0-0.5、大黄素0-0.5、赋形剂卡波姆(941)0-0.5，成为复方制剂。
本发明所述药物可以加入磨成微粉的如下中药或中药材的热水抽提物：
薄荷0-1.0、甘草0-3.0、黄芩0-3.0、黄柏0-3.0、大黄0-3.0、赋形剂卡波姆(941)0-0.5，成为复方制剂。
本发明的有益效果是：本发明建基于民间和传统中医药，结合现代医药科学技术，对民间和传统医药中利用生石灰之碱性化学性质的药理作用和临床经验进一步挖掘和发展；本发明可使病变组织及病原体实时溶解消除，疗效快、效果显著、副作用小，具有较好的推广应用前景。
具体实施方式
可使病变组织及病原体溶解消除的药物，按重量计量，总份量设为100.0，其中包括氢氧化钠1.0-60.0，其余加水至100.0；
或以氢氧化钾取代氢氧化钠，份量不变；
或以氢氧化钠与氢氧化钾的混合物取代氢氧化钠，份量不变。
氢氧化钠、氢氧化钾能够溶解蛋白质，其适当的浓度可以实时溶解消除由蛋白质组成的各种病变组织及病原体，这是本发明的根据。
本发明药物制剂，也可以加入有局部麻醉作用的化合物，例如丁卡因1.0；或蟾酥灵0.5；或蟾酥0.75；或薄荷醇1.0；制成为复方制剂。使其用于治疗疾病时，可以在无痛或轻痛中实施。本发明也可以加赋形剂卡波姆(941)0-0.5，使其成为复方制剂。
本发明药物制剂，也可加入中药等有效成分，例如：薄荷醇0-1.0、异甘草素0-0.5、黄芩素0-0.5、小檗碱0-0.5、大黄素0-0.5、赋形剂卡波姆(941)0-0.5，使其成为复方制剂。
本发明也可加入磨成微粉的中药或热水抽提物，例如：薄荷0-1.0、甘草0-3.0、黄芩0-3.0、黄柏0-3.0、大黄0-3.0，以及赋形剂卡波姆(941)0-0.5，使其成为复方制剂。
甘草(甘草酸、异甘草素)有抗菌、抗病毒、抗肿瘤、抗炎、及免疫调节作用；大黄(大黄素)有抗菌抗病毒消炎及抗肿瘤作用；黄芩(黄芩素)抗菌抗病毒抗过敏抗癌作用；黄柏(小檗碱)有抗菌抗癌作用。以上这些中药或其有效成份与氢氧化钠或氢氧化钾组成复方制剂，可以增强药物的疗效。
实施例1
称为“可使病变组织及病原体溶解消除的药物1号制剂”，又名溶疣消赘膏。
其配方配比是(重量份)：氢氧化钠20.0、丁卡因1.0，余量加水至100.0。
本品特征为具有超卓的立即溶解消除病变组织及病原体之作用，适用于尖锐湿疣(CA)、传染性软疣、皮肤癌、各种组织和器官之息肉、癌前病变、结节性痒疹、墨痣、鸡眼、寻常疣、皮赘的治疗。
治疗尖锐湿疣，鬼臼毒素Podophyllotoxin，为世界卫生组织及中国国家卫生部推荐的首选药物。美国施泰福药厂产品称WARTREC疣敌，中国贵州汉方制药称疣迪，其主要成分都是鬼臼毒素。药品说明书：局部外用，涂搽于患处：早晚各二次，连用3天至疣体发白，停药观察4天，共7天为一疗程。疣体未消退者进行第二疗程。总计不超过三疗程(21天)。
应用本发明“可使病变组织及病原体溶解消除的药物1号制剂”，在治疗男性包皮内板(包括尿道)、肛门、女阴(包括官颈、阴道)等部位湿润多汁的尖锐湿疣，以棉签涂药，其效果如烈火溶冰，花生米大之疣粒，十数分钟之内，迅速溶化成半透明的胶汁，剩余相当于疣体三分一大之黑色内核(血根团)，此内核实乃CA组织之真皮内增生、扩张的毛细血管球团，受药物之作用，变黑并缩细。抹净半透明胶汁，再搽药数次，黑色的血根团继续被溶化、萎缩，或脱除，整个过程不过三十分钟左右，伤口实时缩细，数日可愈合，细小疣粒，以竹制牙签搽药，较为准确，二、三分钟可溶化根除。
实施例2
称为“可使病变组织及病原体溶解消除的药物2号制剂”，又称疱疹疮毒立消膏。
其配方组成：甘草3.0、黄芩3.0、黄柏3.0、大黄1.0、薄荷脑1.0、氢氧化钠2.5、蟾酥1.0，加赋形剂卡波姆(941)0.25、加水至100.0。
成份中之甘草、黄芩、黄柏、大黄、蟾酥、薄荷脑，乃磨成200目之粉末。
本品可用于尖锐湿疣，在应用“可使病变组织及病原体溶解消除的药物1号制剂”，化除肉眼所见的大小疣粒后，应用本品“可使病变组织及病原体溶解消除的药物2号制剂”，广泛涂搽患区及周围区域，处理CA之「亚临床」病区，溶解消除细微的病灶及病原体HPV病毒，减少再发机会。五至二十分钟后，以蒸馏水棉球抹去药物，结束治疗。
可使病变组织及病原体溶解消除的药物1号制剂及2号制剂联合应用，以这样的药物制剂，如此快速的实时溶解消除尖锐湿疣(包含疣内HPV病毒)，国内外文献未有同样记载。
每次复诊，以数码相机照相，输入计算机检查，放大10-50倍，观察是否仍存「亚临床」病变，以便继续处理。
“可使病变组织及病原体溶解消除的药物2号制剂”，适用于性病疱疹、带状庖疹、各期酒渣鼻、炎性痤疮、各期慢性子宫颈炎、化脓性汗腺炎、脓肿、痈疖、炎性肉芽肿、环状肉芽肿、疥疮、孢子丝菌病。此方剂的特征在于：若掌握恰当的搽药次数和持续时间，可对患病组织有高度选择作用而不伤及正常组织。
例如治疗性病生殖器疱疹，带状疱疹，于涂搽本品后数分钟，疼痛即减，患处毒液渐被吸出，十数分钟疼痛消失。疱疹消失时间：最快5分钟，最慢48分钟，平均18.77分钟。结痂愈合时间：最快17小时，最慢38小时，平均26.11小时。这样好的疗效，国内外文献未见记载。
例如治疗各期酒渣鼻、炎性脓肿痤疮，把药剂涂布患区，数分钟后即见病变组织开始溶解、脓液毒汁渗出、病变缩细、抹去溶解渗液。如此再搽药1-2次，病损实时消除，渗出停止。翌日结痂，10-14天痂脱，重现粉红细嫩新皮。严重的酒渣鼻如鼻赘期，可分区、多次用药，由表及里，溶化、清除赘生物。目前国内外文献尚未有用这种药物方剂和方法，治疗酒渣鼻和颜面炎性痤疮；其它的治疗酒渣鼻和炎性脓肿痤疮的药物和方法，也未取得如此快速疗效。
实施例3
称为“可使病变组织及病原体溶解消除的药物3号制剂”，其配方：甘草酸1.0、黄芩素1.0、小檗碱1.0、大黄素1.0、薄荷脑1.0、氢氧化钠(或氢氧化钾)4.0、蟾酥0.5，加赋形剂卡波姆(941)0.25、加水至100.0。
本品适用于扁平疣、皮肤结核、结核样型麻风、老人斑、毛囊炎。
治扁平疣、传染性软疣、老人斑、毛囊炎，宜用牙签或小棉花签准确涂药，见皮疹变焦黑，即可抹去药液。对于用抗生素治疗数月开始见效的皮肤结核、结核样型麻风，把本品涂布于皮疹上，数分钟毒汁渗出，抹去药物，即见皮损萎缩，一周后视情况再次涂药治疗，可明显缩短疗程；也适用于治疗神经性皮炎、玫瑰糠疹、体癣、足癣。
本品以蒸馏水或矿泉水稀释1-10倍外用，洗、涂布于小面积I-II度烧伤或烫伤，能迅速止痛、去热毒、消水疱、防感染。
实施例4
称为“可使病变组织及病原体溶解消除的药物4号制剂”，其配方：
氢氧化钠(或氢氧化钾)30.0，加蒸馏水至100.0。
本品外搽，可用于溶解灰指(趾)甲，也可用溶解硬皮、死皮。
本制剂也可于患者局部病变组织相对细小、长在疼痛较不敏感部位；在患者已作全身麻醉或其病变组织已在局部麻醉的情况下，本制剂可用于局部涂布溶解范围较广深、疼痛较敏感的病变组织，作快速、深彻的溶解。其用途用法可参考实施例1“可使病变组织及病原体溶解消除的药物1号制剂”的用途用法。
本发明还可以有其它的实施例，在此不一一列举。本发明的内容不仅仅限于实施例，凡属于本发明权利要求保护内容，均落入本发明的保护范围内。

Claims (4)

1.一种可使病变组织及病原体溶解消除的药物，其特征是：所述药物按重量计量，总份量设为100.0，其中包括氢氧化钠1.0-60.0，其余加水至100.0；
或以氢氧化钾取代氢氧化钠，份量不变；
或以氢氧化钠与氢氧化钾的混合物取代氢氧化钠，份量不变。
2.根据权利要求1所述的可使病变组织及病原体溶解消除的药物，其特征是：所述药物可以加入有局部麻醉作用的化合物，例如丁卡因1.0；
或，蟾酥灵0.25-0.5；
或，蟾酥0.5-1.0；
或，薄荷醇0.5-1.0；
或，赋形剂卡波姆(941)0-0.5，成为复方制剂。
3.根据权利要求1所述的可使病变组织及病原体溶解消除的药物，其特征是：所述药物可以加入：薄荷醇0-1.0、异甘草素0-0.5、黄芩素0-0.5、小檗碱0-0.5、大黄素0-0.5、赋形剂卡波姆(941)0-0.5，成为复方制剂。
4.根据权利要求1所述的可使病变组织及病原体溶解消除的药物，其特征是：所述药物可以加入磨成微粉的如下中药或中药材的热水抽提物：
薄荷0-1.0、甘草0-3.0、黄芩0-3.0、黄柏0-3.0、大黄0-3.0、赋形剂卡波姆(941)0-0.5，成为复方制剂。
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