CN101980723A - 艰难梭菌芽孢的抗体及其用途 - Google Patents

艰难梭菌芽孢的抗体及其用途 Download PDF

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Publication number
CN101980723A
CN101980723A CN2009801113555A CN200980111355A CN101980723A CN 101980723 A CN101980723 A CN 101980723A CN 2009801113555 A CN2009801113555 A CN 2009801113555A CN 200980111355 A CN200980111355 A CN 200980111355A CN 101980723 A CN101980723 A CN 101980723A
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China
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seq
antibody
isolated antibody
clostridium difficile
fragment
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CN2009801113555A
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Chinese (zh)
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拉伊·拉贾戈帕尔
魏爱平
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3M Innovative Properties Co
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3M Innovative Properties Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2009801113555A 2008-02-28 2009-02-25 艰难梭菌芽孢的抗体及其用途 Pending CN101980723A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3227008P 2008-02-28 2008-02-28
US61/032,270 2008-02-28
PCT/US2009/035050 WO2009108652A1 (en) 2008-02-28 2009-02-25 Antibodies to clostridium difficile spores and uses thereof

Publications (1)

Publication Number Publication Date
CN101980723A true CN101980723A (zh) 2011-02-23

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CN2009801113555A Pending CN101980723A (zh) 2008-02-28 2009-02-25 艰难梭菌芽孢的抗体及其用途

Country Status (9)

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US (2) US8697374B2 (https=)
EP (1) EP2271366A4 (https=)
JP (1) JP2011512817A (https=)
KR (1) KR20100126760A (https=)
CN (1) CN101980723A (https=)
AU (1) AU2009219358A1 (https=)
BR (1) BRPI0906060A2 (https=)
CA (1) CA2714720A1 (https=)
WO (1) WO2009108652A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
CN105555309A (zh) * 2013-04-19 2016-05-04 英穆伦有限公司 治疗和/或预防艰难梭菌相关疾病的方法和组合物
CN108424449A (zh) * 2011-09-16 2018-08-21 Ucb医药有限公司 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体
CN111948388A (zh) * 2020-08-18 2020-11-17 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用
CN114585740A (zh) * 2019-06-05 2022-06-03 利夫加工有限公司 针对艰难梭菌的适配体

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WO2010126670A2 (en) * 2009-03-27 2010-11-04 Gojo Industries, Inc. Compositions and methods for screening and using compounds antagonizing spore-surface interactions
US20120276059A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease
US10295535B2 (en) * 2011-04-29 2019-05-21 Techlab, Inc. Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease
JP2014528715A (ja) * 2011-09-15 2014-10-30 ロサンゼルス バイオメディカル リサーチ インスティテュート アットハーバー− ユーシーエルエー メディカル センター ＣｏｔＨを用いたムコール菌症の免疫療法および診断法
US10364298B2 (en) 2011-11-18 2019-07-30 National Research Council Of Canada Clostridium difficile lipoteichoic acid and uses thereof
CN102590515B (zh) * 2012-01-13 2014-07-30 张春华 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体
AR090219A1 (es) 2012-03-02 2014-10-29 Regeneron Pharma Anticuerpos humanos frente a toxinas de clostridium difficile
US9133527B2 (en) * 2012-05-11 2015-09-15 Techlab, Inc. Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
CA2882620A1 (en) * 2012-09-19 2014-03-27 Novartis Ag Clostridium difficile polypeptides as vaccine
CN109776676A (zh) * 2012-11-28 2019-05-21 Cnj控股公司 针对艰难梭菌的抗体
US10890583B2 (en) * 2014-04-01 2021-01-12 Institut Pasteur Predictive value of Clostridium difficile-specific immune response for recurrence and disease outcome
JP6397939B2 (ja) 2014-06-09 2018-09-26 スリーエム イノベイティブ プロパティズ カンパニー アッセイ装置及び標的分析種の検出方法
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
WO2017051413A1 (en) * 2015-09-21 2017-03-30 4C Diagnostics Ltd. Stool specimen collecting, sampling and diagnosing means and methods thereof
WO2023039159A2 (en) 2021-09-09 2023-03-16 Abel Santos Ernesto Inhibitors of c. difficile spore germination
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

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WO1999002188A1 (en) * 1997-07-11 1999-01-21 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hen egg yolk antibodies to clostridium difficile antigens and use in therapy for pseudomembranous colitis
US20040033546A1 (en) * 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
US20050220783A1 (en) * 1999-11-01 2005-10-06 Mucovax Holding B.V. Antibody production in farm animals

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
CN108424449A (zh) * 2011-09-16 2018-08-21 Ucb医药有限公司 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体
CN105555309A (zh) * 2013-04-19 2016-05-04 英穆伦有限公司 治疗和/或预防艰难梭菌相关疾病的方法和组合物
CN114585740A (zh) * 2019-06-05 2022-06-03 利夫加工有限公司 针对艰难梭菌的适配体
CN111948388A (zh) * 2020-08-18 2020-11-17 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用

Also Published As

Publication number Publication date
EP2271366A4 (en) 2012-06-20
CA2714720A1 (en) 2009-09-03
KR20100126760A (ko) 2010-12-02
WO2009108652A1 (en) 2009-09-03
JP2011512817A (ja) 2011-04-28
US20110183360A1 (en) 2011-07-28
EP2271366A1 (en) 2011-01-12
BRPI0906060A2 (pt) 2015-12-01
US8697374B2 (en) 2014-04-15
US20140335543A1 (en) 2014-11-13
AU2009219358A1 (en) 2009-09-03

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Application publication date: 20110223