KR20100126760A - 클로스트리듐 디피실레 포자에 대한 항체 및 그 용도 - Google Patents

클로스트리듐 디피실레 포자에 대한 항체 및 그 용도 Download PDF

Info

Publication number
KR20100126760A
KR20100126760A KR1020107021314A KR20107021314A KR20100126760A KR 20100126760 A KR20100126760 A KR 20100126760A KR 1020107021314 A KR1020107021314 A KR 1020107021314A KR 20107021314 A KR20107021314 A KR 20107021314A KR 20100126760 A KR20100126760 A KR 20100126760A
Authority
KR
South Korea
Prior art keywords
ser
lys
asn
seq
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107021314A
Other languages
English (en)
Korean (ko)
Inventor
라지 라자고팔
아이-핑 웨이
Original Assignee
쓰리엠 이노베이티브 프로퍼티즈 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쓰리엠 이노베이티브 프로퍼티즈 캄파니 filed Critical 쓰리엠 이노베이티브 프로퍼티즈 캄파니
Publication of KR20100126760A publication Critical patent/KR20100126760A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020107021314A 2008-02-28 2009-02-25 클로스트리듐 디피실레 포자에 대한 항체 및 그 용도 Withdrawn KR20100126760A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3227008P 2008-02-28 2008-02-28
US61/032,270 2008-02-28

Publications (1)

Publication Number Publication Date
KR20100126760A true KR20100126760A (ko) 2010-12-02

Family

ID=41016450

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107021314A Withdrawn KR20100126760A (ko) 2008-02-28 2009-02-25 클로스트리듐 디피실레 포자에 대한 항체 및 그 용도

Country Status (9)

Country Link
US (2) US8697374B2 (https=)
EP (1) EP2271366A4 (https=)
JP (1) JP2011512817A (https=)
KR (1) KR20100126760A (https=)
CN (1) CN101980723A (https=)
AU (1) AU2009219358A1 (https=)
BR (1) BRPI0906060A2 (https=)
CA (1) CA2714720A1 (https=)
WO (1) WO2009108652A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126670A2 (en) * 2009-03-27 2010-11-04 Gojo Industries, Inc. Compositions and methods for screening and using compounds antagonizing spore-surface interactions
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
US20120276059A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease
US10295535B2 (en) * 2011-04-29 2019-05-21 Techlab, Inc. Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease
JP2014528715A (ja) * 2011-09-15 2014-10-30 ロサンゼルス バイオメディカル リサーチ インスティテュート アットハーバー− ユーシーエルエー メディカル センター ＣｏｔＨを用いたムコール菌症の免疫療法および診断法
PL2758432T3 (pl) * 2011-09-16 2019-08-30 Ucb Biopharma Sprl Przeciwciała neutralizujące przeciw głównym egzotoksynom tcda i tcdb z clostridium difficile
US10364298B2 (en) 2011-11-18 2019-07-30 National Research Council Of Canada Clostridium difficile lipoteichoic acid and uses thereof
CN102590515B (zh) * 2012-01-13 2014-07-30 张春华 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体
AR090219A1 (es) 2012-03-02 2014-10-29 Regeneron Pharma Anticuerpos humanos frente a toxinas de clostridium difficile
US9133527B2 (en) * 2012-05-11 2015-09-15 Techlab, Inc. Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
CA2882620A1 (en) * 2012-09-19 2014-03-27 Novartis Ag Clostridium difficile polypeptides as vaccine
CN109776676A (zh) * 2012-11-28 2019-05-21 Cnj控股公司 针对艰难梭菌的抗体
CA2909636C (en) * 2013-04-19 2023-08-22 Dena Lyras Methods and compositions for the treatment and/or prophylaxis of clostridium difficile associated disease
US10890583B2 (en) * 2014-04-01 2021-01-12 Institut Pasteur Predictive value of Clostridium difficile-specific immune response for recurrence and disease outcome
JP6397939B2 (ja) 2014-06-09 2018-09-26 スリーエム イノベイティブ プロパティズ カンパニー アッセイ装置及び標的分析種の検出方法
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
WO2017051413A1 (en) * 2015-09-21 2017-03-30 4C Diagnostics Ltd. Stool specimen collecting, sampling and diagnosing means and methods thereof
KR20220041072A (ko) * 2019-06-05 2022-03-31 엘아이브이 프로세스, 인크. 클로스트리듐 디피실에 대한 앱타머
CN111948388B (zh) * 2020-08-18 2022-03-22 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用
WO2023039159A2 (en) 2021-09-09 2023-03-16 Abel Santos Ernesto Inhibitors of c. difficile spore germination
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879218A (en) 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
US4530833A (en) 1982-09-13 1985-07-23 Wilkins Tracy D Toxins and antibodies of C. difficile
US4533630A (en) 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8426464D0 (en) 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
US4863852A (en) 1985-07-03 1989-09-05 Virginia Tech Intellectual Properties, Inc. Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors
US4956302A (en) 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5231003A (en) 1990-05-11 1993-07-27 Cambridge Bioscience Corporation Monoclonal antibodies specific for toxin b of clostridium difficile
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5610023A (en) 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US5753517A (en) 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
US7179611B2 (en) 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
AU8395498A (en) * 1997-07-11 1999-02-08 Regents of The University of Arizona, The Hen egg yolk antibodies to (clostridium difficile) antigens and use in therapy for pseudomembranous colitis
US5876960A (en) 1997-08-11 1999-03-02 The United States Of America As Represented By The Secretary Of The Army Bacterial spore detection and quantification methods
US6733760B1 (en) 1999-04-09 2004-05-11 Techlab, Inc. Recombinant toxin A/toxin B vaccine against Clostridium difficile
US7074454B1 (en) 1999-11-01 2006-07-11 Mucovax Holding B.V. Production of mammary secretion antibodies in farm animals
DE60025945T2 (de) 1999-11-01 2006-09-28 Mucovax Holding B.V. Herstellung von antikörpern in mammarsekreten von zuchttieren
US6974573B2 (en) * 1999-11-01 2005-12-13 Mucovax Holdings, B.V. Antibody production in farm animals
US6509196B1 (en) 2000-01-04 2003-01-21 Response Biomedical Corp. Compensation for non-specific signals in quantitative immunoassays
GB0007263D0 (en) 2000-03-24 2000-05-17 Imperial College Peptides
US6498041B1 (en) 2000-08-18 2002-12-24 Echo Technologies, Inc. Optical sensors for rapid, sensitive detection and quantitation of bacterial spores
US6815178B1 (en) 2001-11-19 2004-11-09 Antony R. Shoaf Endospore detection method
US7306930B2 (en) 2001-11-30 2007-12-11 California Institute Of Technology Method bacterial endospore quantification using lanthanide dipicolinate luminescence
US7428045B2 (en) 2002-01-10 2008-09-23 Chemimage Corporation Raman spectral analysis of pathogens
WO2003065009A2 (en) 2002-02-01 2003-08-07 California Institute Of Technology Methods and apparatus for assays of bacterial spores
US20030175318A1 (en) 2002-03-06 2003-09-18 Schilling Amanda S. Application of germination solution improved efficacy of biological decontamination
US20040033546A1 (en) 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
US7608419B2 (en) 2003-11-13 2009-10-27 California Institute Of Technology Method and apparatus for detecting and quantifying bacterial spores on a surface
WO2004069848A2 (en) 2003-01-28 2004-08-19 Diversa Corporation Amidases, nucleic acids encoding them and methods for making and using them
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US20060275920A1 (en) 2005-06-01 2006-12-07 Petrilla John F Apparatus and method for discriminating among lateral flow assay test indicators

Also Published As

Publication number Publication date
EP2271366A4 (en) 2012-06-20
CA2714720A1 (en) 2009-09-03
WO2009108652A1 (en) 2009-09-03
CN101980723A (zh) 2011-02-23
JP2011512817A (ja) 2011-04-28
US20110183360A1 (en) 2011-07-28
EP2271366A1 (en) 2011-01-12
BRPI0906060A2 (pt) 2015-12-01
US8697374B2 (en) 2014-04-15
US20140335543A1 (en) 2014-11-13
AU2009219358A1 (en) 2009-09-03

Similar Documents

Publication Publication Date Title
KR20100126760A (ko) 클로스트리듐 디피실레 포자에 대한 항체 및 그 용도
KR101707291B1 (ko) 항리포아라비노만난 항체 및 당해 항체를 사용한 항산균증의 이뮤노어세이
US8529910B2 (en) Enterococcus antigens
AU2014216127B2 (en) Methods to protect against and treat multiple sclerosis
CA2792956C (en) Bacterial vaccine components from staphylococcus aureus and uses thereof
AU2010206800A1 (en) Methods and compositions based on Shiga toxin type 2 protein
US20190144527A1 (en) Monoclonal Antibodies that Neutralize Anthrax Protective Antigen (PA) Toxin
JP2009536818A (ja) 志賀毒性１型タンパク質に基づく方法および組成物
Lee et al. Characterization of chicken-derived antibody against Alpha-Enolase of Streptococcus pneumoniae
US8663940B2 (en) Ex-vivo passive protection bacteremia assay
Ansari et al. Selection and characterization of two monoclonal antibodies specific for the Aspergillus flavus major antigenic cell wall protein Aflmp1
Wang et al. Identification of a conserved linear B-cell epitope in the Staphylococcus aureus GapC protein
Kumar et al. Production of monoclonal antibodies specific to major outer membrane protein of Edwardsiella tarda
US20220221455A1 (en) Antigen binding proteins and assays
Kaukabayeva et al. Development and validation of a regionally adapted sandwich enzyme-linked immunosorbent assay targeting recombinant p60 antigen for rapid detection of Listeria monocytogenes in food samples
RU2588480C2 (ru) Антитело против липоарабиноманнана и иммунологический анализ инфекции, вызываемой кислотоустойчивыми бактериями, с использованием антитела
Kim Development of the rapid immunoassay methods for the screening of Listerial contamination
Turnbough Jr et al. Monoclonal Antibodies for
WO2003013601A1 (en) Toxin associated with sudden infant death syndrome, and uses thereof
Buys Development of a flow cytometric bead immunoassay as an aid to potency evaluation of enterotoxaemia vaccines
WO2014188763A1 (en) An antibody that binds to leptospiral antigen
AU2011236092A1 (en) Enterococcus Antigens

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100924

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid