CA2714720A1 - Antibodies to clostridium difficile spores and uses thereof - Google Patents

Antibodies to clostridium difficile spores and uses thereof Download PDF

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Publication number
CA2714720A1
CA2714720A1 CA2714720A CA2714720A CA2714720A1 CA 2714720 A1 CA2714720 A1 CA 2714720A1 CA 2714720 A CA2714720 A CA 2714720A CA 2714720 A CA2714720 A CA 2714720A CA 2714720 A1 CA2714720 A1 CA 2714720A1
Authority
CA
Canada
Prior art keywords
seq
isolated antibody
difficile
antibody
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2714720A
Other languages
English (en)
French (fr)
Inventor
Raj Rajagopal
Ai-Ping Wei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CA2714720A1 publication Critical patent/CA2714720A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2714720A 2008-02-28 2009-02-25 Antibodies to clostridium difficile spores and uses thereof Abandoned CA2714720A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3227008P 2008-02-28 2008-02-28
US61/032,270 2008-02-28
PCT/US2009/035050 WO2009108652A1 (en) 2008-02-28 2009-02-25 Antibodies to clostridium difficile spores and uses thereof

Publications (1)

Publication Number Publication Date
CA2714720A1 true CA2714720A1 (en) 2009-09-03

Family

ID=41016450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2714720A Abandoned CA2714720A1 (en) 2008-02-28 2009-02-25 Antibodies to clostridium difficile spores and uses thereof

Country Status (9)

Country Link
US (2) US8697374B2 (https=)
EP (1) EP2271366A4 (https=)
JP (1) JP2011512817A (https=)
KR (1) KR20100126760A (https=)
CN (1) CN101980723A (https=)
AU (1) AU2009219358A1 (https=)
BR (1) BRPI0906060A2 (https=)
CA (1) CA2714720A1 (https=)
WO (1) WO2009108652A1 (https=)

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PT2411410E (pt) * 2009-03-27 2015-10-09 Gojo Ind Inc Composições e métodos para screening e utilização de compostos que antagonizam interações esporo-superfície
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
US10295535B2 (en) 2011-04-29 2019-05-21 Techlab, Inc. Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease
US20120276060A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for treating infection in patients with clostridium difficile disease
WO2013040517A2 (en) * 2011-09-15 2013-03-21 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH
SG10201701055WA (en) * 2011-09-16 2017-03-30 Ucb Pharma Sa Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile
US10364298B2 (en) 2011-11-18 2019-07-30 National Research Council Of Canada Clostridium difficile lipoteichoic acid and uses thereof
CN102590515B (zh) * 2012-01-13 2014-07-30 张春华 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体
HK1200463A1 (en) 2012-03-02 2015-08-07 瑞泽恩制药公司 Human antibodies to clostridium difficile toxins
US9133527B2 (en) * 2012-05-11 2015-09-15 Techlab, Inc. Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
SG11201500980WA (en) * 2012-09-19 2015-04-29 Novartis Ag Clostridium difficile polypeptides as vaccine
CN109776676A (zh) * 2012-11-28 2019-05-21 Cnj控股公司 针对艰难梭菌的抗体
EP2986316B1 (en) * 2013-04-19 2023-01-25 Immuron Limited Methods and compositions for the treatment and/or prophylaxis of clostridium difficile associated disease
EP3126840B1 (en) * 2014-04-01 2020-05-06 Institut Pasteur Predictive value of clostridium difficile-specific immune response for recurrence and disease outcome
CN106662529B (zh) 2014-06-09 2019-08-30 3M创新有限公司 检测目标分析物的测定装置和方法
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
WO2017051413A1 (en) * 2015-09-21 2017-03-30 4C Diagnostics Ltd. Stool specimen collecting, sampling and diagnosing means and methods thereof
KR20220041072A (ko) 2019-06-05 2022-03-31 엘아이브이 프로세스, 인크. 클로스트리듐 디피실에 대한 앱타머
CN111948388B (zh) * 2020-08-18 2022-03-22 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用
EP4398890A4 (en) 2021-09-09 2025-07-30 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve C. Difficile Spore Germination Inhibitors
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

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Also Published As

Publication number Publication date
US20140335543A1 (en) 2014-11-13
US8697374B2 (en) 2014-04-15
US20110183360A1 (en) 2011-07-28
EP2271366A4 (en) 2012-06-20
JP2011512817A (ja) 2011-04-28
WO2009108652A1 (en) 2009-09-03
CN101980723A (zh) 2011-02-23
BRPI0906060A2 (pt) 2015-12-01
EP2271366A1 (en) 2011-01-12
AU2009219358A1 (en) 2009-09-03
KR20100126760A (ko) 2010-12-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140225