CN101970491A - 树突状细胞标记物及其用途 - Google Patents

树突状细胞标记物及其用途 Download PDF

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Publication number
CN101970491A
CN101970491A CN2008801106595A CN200880110659A CN101970491A CN 101970491 A CN101970491 A CN 101970491A CN 2008801106595 A CN2008801106595 A CN 2008801106595A CN 200880110659 A CN200880110659 A CN 200880110659A CN 101970491 A CN101970491 A CN 101970491A
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polypeptide
cell
polynucleotide
compound
seq
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Chinese (zh)
Inventor
M·H·拉霍德
A·I·普罗耶托
I·卡明斯基
K·肖特曼
A·M·卢
L·吴
M·D·赖特
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Inst Medical W & E Hall
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BURNET INST
Walter and Eliza Hall Institute of Medical Research
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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CN2008801106595A 2007-08-30 2008-08-29 树突状细胞标记物及其用途 Pending CN101970491A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96911807P 2007-08-30 2007-08-30
US60/969,118 2007-08-30
US5286508P 2008-05-13 2008-05-13
US61/052,865 2008-05-13
PCT/AU2008/001294 WO2009026660A1 (en) 2007-08-30 2008-08-29 Dendritic cell marker and uses thereof

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CN101970491A true CN101970491A (zh) 2011-02-09

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US (2) US8426565B2 (cg-RX-API-DMAC7.html)
EP (1) EP2195346B1 (cg-RX-API-DMAC7.html)
JP (3) JP2010536388A (cg-RX-API-DMAC7.html)
CN (1) CN101970491A (cg-RX-API-DMAC7.html)
AU (1) AU2008294074B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0815848A2 (cg-RX-API-DMAC7.html)
CA (1) CA2697448C (cg-RX-API-DMAC7.html)
IL (1) IL204157A (cg-RX-API-DMAC7.html)
WO (1) WO2009026660A1 (cg-RX-API-DMAC7.html)

Cited By (10)

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CN103720719A (zh) * 2013-10-11 2014-04-16 长沙赢润生物技术有限公司 一项DC和Treg细胞治疗红斑狼疮的技术
CN104202971A (zh) * 2012-02-01 2014-12-10 瑞泽恩制药公司 表达包含vl结构域的重链的人源化啮齿动物
CN104387453A (zh) * 2014-12-08 2015-03-04 深圳市同康生物医药有限公司 树突状细胞靶向肽及编码基因及应用
CN108779175A (zh) * 2015-12-28 2018-11-09 依奈特制药公司 NKp46结合蛋白的可变区
US10130081B2 (en) 2011-08-05 2018-11-20 Regeneron Pharmaceuticals, Inc. Humanized universal light chain mice
CN110418802A (zh) * 2017-01-20 2019-11-05 朱诺治疗学有限公司 细胞表面缀合物及相关的细胞组合物和方法
CN112601811A (zh) * 2018-06-19 2021-04-02 泰莱托恩基金会 工程改造的细胞的产生及其用途
CN114563574A (zh) * 2020-11-27 2022-05-31 中国科学院北京基因组研究所(国家生物信息中心) 分子标记物组合及其用途
CN115298219A (zh) * 2020-01-22 2022-11-04 耶达研究及发展有限公司 多特异性抗体在治疗数个疾病方面的用途
CN119661686A (zh) * 2024-09-30 2025-03-21 中国农业大学 一种重组clec9a基因及其在提高动物的免疫和抗病能力中的应用

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WO2009026660A1 (en) 2007-08-30 2009-03-05 Walter And Eliza Hall Institute Of Medical Research Dendritic cell marker and uses thereof
US20110110861A1 (en) * 2008-05-13 2011-05-12 Mireille Hanna Lahoud Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells
JP2012521199A (ja) * 2009-03-23 2012-09-13 ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ 免疫応答を調節するための化合物および方法
CN102741288B (zh) 2009-08-29 2015-08-19 Abbvie公司 治疗用dll4结合蛋白
KR101853278B1 (ko) * 2010-03-02 2018-05-02 애브비 인코포레이티드 치료학적 ｄｌｌ４ 결합 단백질
RS55495B1 (sr) 2010-08-02 2017-04-28 Regeneron Pharma Miševi koji stvaraju vezujuće proteine koji sadrže vl domene
EP2568051A1 (en) 2011-09-07 2013-03-13 Stallergenes S.A. Methods for identifying dendritic cell subsets, for determining if a patient is developing a regulatory or an effector immune response, and for determining response to immunotherapy
CN103483441A (zh) * 2012-06-10 2014-01-01 复旦大学 恒河猴ny-eso-1蛋白、其编码基因及应用
ES2872475T3 (es) 2014-03-21 2021-11-02 Regeneron Pharma Animales no humanos que producen proteínas de unión de dominio único
WO2015143406A2 (en) 2014-03-21 2015-09-24 Regeneron Pharmaceuticals, Inc. Vl antigen binding proteins exhibiting distinct binding characteristics
JP2018508224A (ja) 2015-03-19 2018-03-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 抗原を結合する軽鎖可変領域を選択する非ヒト動物
EP3841112A1 (en) 2018-08-24 2021-06-30 Codiak BioSciences, Inc. Extracellular vesicles targeting dendritic cells and uses thereof
US12233356B2 (en) 2019-03-21 2025-02-25 Lonza Sales Ag Process for preparing extracellular vesicles
AU2020240135A1 (en) 2019-03-21 2021-10-14 Lonza Sales Ag Extracellular vesicles for vaccine delivery
CN114008069A (zh) 2019-04-17 2022-02-01 科迪亚克生物科学公司 外来体和aav的组合物
WO2021184017A1 (en) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Extracellular vesicles for treating neurological disorders
AU2021236763A1 (en) 2020-03-20 2022-10-06 Lonza Sales Ag Extracellular vesicles for therapy
US20240082389A1 (en) 2020-09-23 2024-03-14 Lonza Sales Ag Methods of producing extracellular vesicles
WO2022066883A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Extracellular vesicles comprising kras antigens and uses thereof
EP4225795A4 (en) * 2020-10-05 2025-03-26 Monash University Clec9a antibodies
IL286430A (en) 2021-09-14 2023-04-01 Yeda Res & Dev Multispecific antibodies for use in the treatment of diseases
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same
WO2025079599A1 (ja) * 2023-10-11 2025-04-17 国立大学法人金沢大学 サブセットレベルで細胞を標的化可能な担体およびその製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042386A1 (en) * 2000-01-31 2002-04-11 Rosen Craig A. Nucleic acids, proteins, and antibodies

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542225A (en) 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5118606A (en) 1988-09-02 1992-06-02 The Regents Of The University Of California Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
US5536642A (en) * 1993-09-09 1996-07-16 Barbera-Guillem; Emilio Diagnostic and prognostic methods for solid non-lymphoid tumors and their metastases
US5597569A (en) 1993-10-25 1997-01-28 Bristol-Myers Squibb Company Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica
DE69536091D1 (de) 1994-01-27 2010-09-09 Univ Massachusetts Medical Immunisierung durch Impfung von DNS Transkriptionseinheit
US6117985A (en) * 1995-06-16 2000-09-12 Stemcell Technologies Inc. Antibody compositions for preparing enriched cell preparations
US5939400A (en) 1996-02-26 1999-08-17 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for induction of suppressive T cell response
AU3210997A (en) 1996-05-24 1997-12-09 University Of Maryland At Baltimore Dna vaccines for eliciting a mucosal immune response
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CA2323726C (en) 1998-03-20 2005-02-08 Benitec Australia Ltd. Control of gene expression
DK1068311T3 (da) 1998-04-08 2011-08-08 Commw Scient Ind Res Org Fremgangsmåder og midler til opnåelse af modificerede fænotyper
EP1046651A1 (en) 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
AUPQ002399A0 (en) 1999-04-28 1999-05-20 Australian National University, The Model membrane systems
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
CA2380443C (en) * 2000-05-26 2013-03-12 Ginette Dubuc Single-domain antigen-binding antibody fragments derived from llama antibodies
WO2003025130A2 (en) * 2001-09-14 2003-03-27 Incyte Genomics, Inc. Receptors and membrane-associated proteins
EP1504099A4 (en) * 2001-12-10 2006-05-10 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
AU2003235099A1 (en) * 2002-04-23 2003-11-10 K. K. Dnaform Novel proteins and dnas encoding the same
US6813008B2 (en) 2002-06-10 2004-11-02 Palantyr Research, Llc Microdissection optical system
US9259459B2 (en) * 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
WO2004108079A2 (en) 2003-05-30 2004-12-16 University Of Massachusetts Parkin-interacting proteins
JP4970035B2 (ja) 2003-08-21 2012-07-04 リポテック・プロプライエタリー・リミテッド ｉｎｖｉｖｏにおける樹状細胞の標的化
PL1691837T3 (pl) * 2003-12-10 2012-11-30 Squibb & Sons Llc IP-10 przeciwciała i ich zastosowanie
NZ560737A (en) 2005-02-11 2010-01-29 Cambridge Scient Pty Ltd Analgesic and anti-inflammatory composition
WO2007002183A2 (en) 2005-06-21 2007-01-04 Bausch & Lomb Incorporated Drug delivery device for implanting in the eye comprising a drug core and a preformed permeable crystalline polymeric disc
EP1938104A2 (en) 2005-10-17 2008-07-02 Institute for Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
GB0805159D0 (en) * 2008-03-19 2008-04-23 Sancho Madrid David Immune modulation via C-type lectin
WO2009026660A1 (en) 2007-08-30 2009-03-05 Walter And Eliza Hall Institute Of Medical Research Dendritic cell marker and uses thereof
US20110110861A1 (en) 2008-05-13 2011-05-12 Mireille Hanna Lahoud Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells
JP2012521199A (ja) 2009-03-23 2012-09-13 ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ 免疫応答を調節するための化合物および方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042386A1 (en) * 2000-01-31 2002-04-11 Rosen Craig A. Nucleic acids, proteins, and antibodies

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11357217B2 (en) 2011-08-05 2022-06-14 Regeneron Pharmaceuticals, Inc. Humanized universal light chain mice
US10130081B2 (en) 2011-08-05 2018-11-20 Regeneron Pharmaceuticals, Inc. Humanized universal light chain mice
CN104202971B (zh) * 2012-02-01 2016-07-06 瑞泽恩制药公司 表达包含vl结构域的重链的人源化啮齿动物的制备方法
CN104202971A (zh) * 2012-02-01 2014-12-10 瑞泽恩制药公司 表达包含vl结构域的重链的人源化啮齿动物
CN103720719B (zh) * 2013-10-11 2016-07-06 长沙赢润生物技术有限公司 一项DC和Treg细胞治疗红斑狼疮的技术
CN103720719A (zh) * 2013-10-11 2014-04-16 长沙赢润生物技术有限公司 一项DC和Treg细胞治疗红斑狼疮的技术
CN104387453A (zh) * 2014-12-08 2015-03-04 深圳市同康生物医药有限公司 树突状细胞靶向肽及编码基因及应用
CN108779175A (zh) * 2015-12-28 2018-11-09 依奈特制药公司 NKp46结合蛋白的可变区
CN108779175B (zh) * 2015-12-28 2022-07-08 依奈特制药公司 NKp46结合蛋白的可变区
CN110418802A (zh) * 2017-01-20 2019-11-05 朱诺治疗学有限公司 细胞表面缀合物及相关的细胞组合物和方法
CN112601811A (zh) * 2018-06-19 2021-04-02 泰莱托恩基金会 工程改造的细胞的产生及其用途
CN115298219A (zh) * 2020-01-22 2022-11-04 耶达研究及发展有限公司 多特异性抗体在治疗数个疾病方面的用途
CN114563574A (zh) * 2020-11-27 2022-05-31 中国科学院北京基因组研究所(国家生物信息中心) 分子标记物组合及其用途
CN114563574B (zh) * 2020-11-27 2025-03-04 中国科学院北京基因组研究所(国家生物信息中心) 分子标记物组合及其用途
CN119661686A (zh) * 2024-09-30 2025-03-21 中国农业大学 一种重组clec9a基因及其在提高动物的免疫和抗病能力中的应用

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