CN101970051A - 用于治疗心力衰竭的rna干扰 - Google Patents

用于治疗心力衰竭的rna干扰 Download PDF

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CN101970051A
CN101970051A CN2008801252341A CN200880125234A CN101970051A CN 101970051 A CN101970051 A CN 101970051A CN 2008801252341 A CN2008801252341 A CN 2008801252341A CN 200880125234 A CN200880125234 A CN 200880125234A CN 101970051 A CN101970051 A CN 101970051A
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rnai
aav
vector
expression
plb
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罗杰·J·哈贾
沃尔夫冈·Ch.·波尔
亨利·费克纳
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Nanocor Therapeutics Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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CN2008801252341A 2007-12-31 2008-12-23 用于治疗心力衰竭的rna干扰 Pending CN101970051A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1832607P 2007-12-31 2007-12-31
US61/018,326 2007-12-31
PCT/US2008/088248 WO2009088786A1 (en) 2007-12-31 2008-12-23 Rna interference for the treatment of heart failure

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CN101970051A true CN101970051A (zh) 2011-02-09

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US (2) US8404658B2 (https=)
EP (1) EP2225002A4 (https=)
JP (1) JP2011512326A (https=)
CN (1) CN101970051A (https=)
AU (1) AU2008346801A1 (https=)
CA (1) CA2711179A1 (https=)
NZ (1) NZ587060A (https=)
WO (1) WO2009088786A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN116286820A (zh) * 2023-02-17 2023-06-23 华中科技大学同济医学院附属同济医院 一种shRNA、其重组表达载体、转化体、抗心衰药物及制备方法和制药用途

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