WO2021152181A1 - Virus therapy - Google Patents

Abstract

In brief, a recombinant CRISPR type protein in complex with an RNA guide strand (protein-RNA complex) that targets the CRISPR type protein to the DNA or the RNA of a pathogen is used for treating an infection in a patient. The protein-RNA complex specifically cuts polynucleotides of the pathogen that causes the infection. In a preferred embodiment the patient is a human.

Description

Virus Therapy

FIELD OF TECHNOLOGY This invention relates to CRISPR-related type therapies of infections, for example a virus infection, in particular a SARS-CoV-2 infection.

BACKGROUND

Endonucleases are enzymes that cleave polynucleotides. Clustered regular interspaced short palin- dromic repeat (CRISPR)-type proteins are endonucleases that use an RNA guide strand to cut DNA or RNA at specific sites. CRISPR-type proteins can be used for editing of DNA or for RNA knock down. Cpfl and Casl3 are two recently identified CRISPR type proteins. The use of Cpfl for ge nome editing is described in Zetsche et al (Zetsche et al., 2015, Cell 163, 759-771). The use of Casl3 for knockdown has been reported in Abudayyeh et al (Abudayyeh et al (2017) Nature, 550280-284.

Pathogens, such as virus, bacteria and eukaryotic parasites are still a major cause of suffering and death. There is a need for improved therapies for infections in particular SARS-CoV-2 which is the virus that causes Covid-19. SUMMARY OF INVENTION

In a first aspect of the intervention there is provided a protein-RNA complex where here the pro tein is CAS13 and where and the RNA is an RNA guide strand that comprises a sequence that is complimentary to one of the sequences: SEQ ID NO 3029, OR ONE OF SEQ ID NO 1- SEQ ID NO 3028 or ONE OF SEQ ID NO 3030 to SEQ ID NO 3103.

These sequences are suitable for selectively targeting of Covid-19, i.e. SARS-CoV-2 infection and for treating covid-19 in patients. The use of Casl3 causes the destruction of virus RNA (such as mRNA) in virus infected cells. The selected sequences are highly conserved and stable regions that do not mutate in the virus and hence and have flanking sequences that enable binding of CAS13. In a preferred embodiment the sequence is SEQ ID NO 3029. This sequence targets the spike pro tein gene of SARS-CoV-2.

In a second aspect of the invention there is provided a protein-RNA complex according to the first aspect of the invention for use in therapy, in particular in the treatment of a corona virus infection, in particular for treatment of Covid-19, i.e. SARS-CoV-2 infection.

In a third aspect of the invention there is provided a plasmid encoding the protein is CAS13 and an RNA guide strand that comprises a sequence that is complimentary to one of the sequences SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, where the plasmid is adapted for expres sion of the protein and the transcription of the RNA guide strand in a mammalian cell.

In a fourth aspect of the invention there is provided a pharmaceutical composition comprising a. a protein -RNA complex according to the first aspect of the invention or b. a plasmid according to the third aspect of the invention; or c. two separate plasmids of which one encodes the protein is CAS13 and the other encodes an RNA guide strand that comprises a sequence that is complimentary to one of the sequences SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, where the plasmids are adapted for expression of the protein and transcription of the RNA guide strand in a mammalian cell, or d. an RNA guide strand for Casl3 comprising a sequence that is complimentary to one of SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, and a plasmid that encodes the protein Casl3 where the plasmid is adapted for expression of the protein in a mammalian cell.

In a fifth aspect of the invention, there is provided a method of treatment of a virus infection, in particular covid-19 i.e. SARS-CoV-2 infection, comprising administering a protein-RNA complex or a plasmid or a pharmaceutical to a patient in need thereof.

In a sixths aspect of the invention there is provided a method for RNA knock-down of virus RNA in a virus-infected cell comprising using a protein-RNA complex comprising a Cas 13 protein and an RNA guide strand that comprises a sequence that is complimentary to one of sequences SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, and where the method comprises introducing the protein-RNA complex, or means for expression of these, in a cell. BRIEF DESCRIPTION OF DRAWINGS

Fig. 1 is a schematic diagram showing an RNA guide strand for Cpfl which comprises a handle se quence and a guide sequence.

DETAILED DESCRIPTION

In brief, a recombinant CRISPR type protein in complex with an RNA guide strand (protein-RNA complex) that targets the CRISPR type protein to the DNA or the RNA of a pathogen is used for treating an infection in a patient. The protein-RNA complex specifically cuts polynucleotides of the pathogen that causes the infection. The patient may be a human or an animal, preferably a mam malian animal. In a preferred embodiment the patient is a human.

In a more general sense, the protein-RNA complex may be used to cause double strand breaks in the DNA of pathogen-infected cells, or to knock down RNA in a pathogen-infected cell. The pro tein-RNA complex may be directed to target a genomic locus of interest of the pathogen.

In a preferred embodiment the disease being treated is an infection caused by a pathogen such as a virus, a bacteria or a eukaryotic parasite, such as a fungus. In a preferred embodiment the infec tion is caused by a bacteria or a virus, most preferably a corona virus, preferably SARS-CoV-2 infec tion. SARS-CoV-2 is the virus that causes covid-19.

CRISPR -type proteins use an RNA guide strand to cut DNA or RNA. A guide strand is an RNA mole cule that binds to the CRISPR-type protein and guides the CRISPR type protein to a certain polynu cleotide target sequence. The guide strand is able to hybridize with the target strand (Watson- Crick base pairing). A complex between a CRISPR-type protein and an RNA guide strand is referred to as a protein-RNA complex herein.

As used herein "handle motif" and "handle sequence" refers to a RNA sequence that interacts with a CRISPR type protein for example by mediating binding between an RNA guide strand and a CRISPR type protein. Examples of handle sequences for Cpfl and CAS13 are given below. There are many different useful CRISPR-type proteins. Preferably the CRISPR-type protein has en donuclease activity that causes a double strand breaks. The most studied CRISPR protein is CRISPR/Cas9 which cuts DNA, leaving blunt ends. CRISPR/Cas9 has been used for editing of eukary otic genomes (Cong et al, Science 339, (2013) 819-823, Mali et al, Science (2013) 823-826).

CRISPR/Cas9 uses a 42-nucleotide RNA guide strand and in addition a second strand (so called tra- crRNA strand) which may be 89 nucleotides long.

In a preferred embodiment, one of the CRISPR-type proteins Cpfl or Casl3 is used. The use of Cpfl for genome editing is described in Zetsche et al (Zetsche et al., 2015, Cell 163, 759-771). The use of Casl3 for RNA knockdown has been reported in Abudayyeh et al (Abudayyeh et al (2017) Na ture, 550280-284).

In contrast to CRISPR/Cas 9, Cpfl (Zetsche et al., 2015, Cell 163, 759-771) cuts DNA in a staggered manner, leaving sticky ends with a 4 or 5 nucleotide 5'- overhang. This makes it difficult for DNA- repair system to repair the cut, compared to if a blunt end is created. The unligated DNA may in hibit the pathogen in different ways including but not limited to: 1) triggering apoptosis of a virus- infected cell, 2) causing the death of a pathogen, for example a bacterium. The pathogen is prefer ably a pathogen that has its genomic material in the form of DNA during at least some part of its life cycle. Many virus genomes become integrated into the host genomic DNA.

The Cpfl protein may be a Cpfl protein from Francisella novicida, Adamiococcus sp BV3L6 or Lach- nospiracea bacterium ND2006 in particular Adamiococcus sp BV3L6 or Lachnospiracea bacterium ND2006. A useful variant of Cpfl is Alt-R Casl2a.

CRISPR/Cas 13 cuts RNA and can be used for knockdown of pathogen RNA. This may limit patho gen survival, replication or activation, or may cause the death of the pathogen. The Casl3 protein may be Casl3 from Leptotrichia wadei (Abudayyeh et al (2017) Nature, 550 280-284. Useful vari ants of Casl3 include PspCasl3b, LwaCasl3a, LbuCasl3a and LshCasl3a, LwaCAS13 and PsmCAS13. For example PspCasl3b from Prevotella sp. may be used.

Other useful CRISPR type proteins edit polynucleotides by inserting an extra base in the polynucle otides, for example mRNA, leading to a frameshift and premature stop of translation.

When it is referred to CRISPR/Cas 9, Cpfl and CAS13 it also includes functional equivalents and homologues of these proteins. Thus, modified or truncated proteins are included, provided that they have the same or comparable nuclease activity as the endogenous CRISPR/Cas 9 Cpfl and CAS13 proteins. A homologue may have an amino acid identify with the original protein sequence of at least 70% more preferably at least 80%, even more preferably at least 90%, even more pref erably at least 95% and most preferably at least 99%, using amino acid sequence alignment in BLAST (for example BLAST2 sequences) using the following settings: word size: 3, gapcosts: 11, 1, Matrix: BLOSUM62, Filter string: F, Window Size 40, Threshold 11.

With reference to Fig. 1, the guide strand for Cpfl preferably has a length of from 40 to 44, more preferably 41 to 44 nucleotides and comprises a 5' constant motif (handle sequence) which may be 5' - AAUUUCUACUCUUGUAGAU-3' or 5'-UAAUUUCUACUCUUGUAGAU-3'. The handle se quence interacts with Cpfl and may be important for complexing with Cpfl or Cpfl activity. The guide sequence is 21- 24 nucleotides long and is located at the 3' -terminal off the handle se quence. The RNA is provided as single stranded RNA but parts, in particular parts of the handle se quence, may form a secondary structure. The guide strand hybridizes with a target strand of dou ble stranded DNA. The opposite strand is referred to as the "displaced strand".

In addition, the guide strand for Cpfl may have a unspecific 5' extension of from 3 to 59 or more nucleotides as described in Park et al., Nature Communications, (2018) 9:3313 DOI: 10.1038/s41467-018-05641-3 in order to increase the efficacy. The 5' extension is preferably not homologous to the human genome. For example, it may be a scrambled sequence. It has been hy pothesized that such a 5' extension increases efficacy by providing a negative charge.

Some CRISPR type proteins, including Cpfl, uses a PAM (Protospacer Adjacent Motif) motif to rec ognise target sequences. The minimal PAM motif for Cpfl is TTN. The TTN motif for Cpfl is prefer ably TTT, even more preferably TTTV where V is any nucleotide except T. The PAM motif is local ized on the displaced strand and is not recognized by the guide strand of the RNA -protein complex but by the interaction between the TTN nucleotides and amino acid residues of the Cpfl protein. Cpfl cuts the displaced strand with a 4-5 nucleotide overhang approximately 18-19 nucleotides from the PAM TTTN motif and cuts the target strand approximately 24- 25 nucleotides from the TTTN motif.

Examples of suitable target RNA sequences for targeting CAS13 to corona virus RNA, include the sequences SEQ ID NO 1 to SEQ ID NO 3103. The sequences are described in the attached provi sional sequence list, which is an integral part of the description of this patent application. The pro visional sequence listing also provides a reference to the number of the sequence in the priority application (SE 2050090-6). The identified sequences are conserved over a large number of SARS- CoV-2 stains.

The target sequence may be a part of SEQ ID NO 1 to SEQ ID NO 3103. The part may be from 25 to 30, more preferably from 28-39 consecutive nucleotides from any one of SEQ ID NO 1 to SEQ ID NO 3103.

The targeted sequence may be flanked by a protospacer flanking site (PFS), se for example Abudayyeh et al (2017) Nature, 550280-284 where the PFS for Leptotrichia shahii Casl3a is dis cussed. The PFS may be a preference for FI (=not G). It is referred to (Smargon, Cox, Pyzocha et al., Molecular cell 2017;Cox, Gootenberg, Abudayyeh et al., Science 2017). The PFS may be for exam- pie UGG- target sequence- GGA. Flence for the SEQ ID 3029 the target sequence with flanking PFS motifs will be UGGGUGUUUAUUACCACAAAAACAACAAAAGUUGGA (PFS underlined). Typically the PFS interacts with the CAS13 protein and not the guide strand.

The guide strand will comprise a sequence that is the reverse complement of one of the sequences SEQ ID NO 1 to SEQ ID NO 3103. The sequence 5'- CACAAU U U U AAAAG AAAAGGGGGG AU UGGG -3'will be used as an example:

The guide sequence will be the reverse complement of this sequence, which is 5'- CCCAAUCCCCCCUUUUCUUUUAAAAUUGUG - 3'

The guide strand should also comprise a so called "direct repeat sequence" (DRS) ("handle se quence") that is specific for the CAS13 protein used, and which interacts with the CAS13 protein, and may mediate binding of the guide strand to the CAS13 protein. For some CAS13 proteins, the DRS is located 5' of the guide sequence and for others the DRS is located 3' of the guide sequence.

Below are some examples of DRS for CAS 13 proteins:

PspCasl3b: 5'- GUUGUGGAAGGUCCAGUUUUGAGGGGCUAUUACAAC -3^' (located 3^' of guide se quence) LwaCasl3a: 5'- GAUUUAGACUACCCCAAAAACGAAGGGGACUAAAAC -3^' (located 5' of the guide se quence) (Freije et al, 2019, Molecular Cell 76, 826-837).

PsmCasl3b: 5'- GUUGUAGAAGCUUAUCGUUUGGAUAGGUAUGACAAC -3^' (Freije et al, 2019, Mo lecular Cell 76, 826-837). PspCasl3b from Prevotella sp: 5' - GUUGUGGAAGGUCCAGUUUUGAGGGGCUAUUACAAC - 3'.

The guide strand for CAS13 preferably has a length of from 40 - 100 nucleotides more preferably from 60 to 80 nucleotides and comprises a handle sequence and a targeting sequence which is complimentary to a targeted sequence.

In a preferred embodiment the targeted sequence is SEQ ID NO 3029

(G U G U U U AU U ACCACAAAAAC AACAAAAG U U ) . This targets the spike protein gene in SARS-CoV-2.

In a preferred embodiment the guide strand is 5'

AACUUUUGUUGUUUUUGUGGUAAUAAACACGUUGUGGAAGGUCCAGUUUUGAGGGGCUAUUACAA C-3' for targeting SEQ ID NO 3029 with the use of PspCasl3b from Prevotella sp. This sequence comprises the 5' reverse complement of SEQ ID 3029 followed by the handle sequence GUUGUGGAAGGUCCAGUUUUGAGGGGCUAUUACAAC located in the 3' end of the guide strand.

Other preferred sequences for targeting in SARS-CoV-2 includes SEQ ID NO 480 (spike protein RNA), SEQ ID NO 2077 (spike protein RNA), SEQ ID NO 2177 (ORF AB RNA) and SEQ ID NO 2719 (EndoRNAase RNA).

The protein-RNA complexes, or the plasmids or the virus are preferably administered to the pa tient in the form of a pharmaceutical composition. Such a pharmaceutical composition comprises an effective amount of the protein-RNA complexes, plasmids or virus, ("active component"), and a pharmaceutically acceptable carrier, which typically is an aqueous solution optionally comprising a variety of different pharmacologically acceptable compounds. The formulation is made to suit the mode of administration. There is a wide variety of possible formulations. The formulation may be adapted to increase the uptake or stability of the active component or to improve the pharmacoki netics or pharmacodynamics of the active component, or to enhance other desirable properties of the formulation. The pharmaceutical composition, the complexes and the virus and plasmids de scribed herein are preferably non-naturally occurring or engineered. The protein-RNA complex, the plasmid, or a virus may be an isolated protein-RNA complex, plasmid or virus.

In certain embodiments a protein-RNA complex is delivered. Delivery of the protein-RNA complex can be made in any suitable way. Two reviews that describe useful methods of delivery are: Glass, Lee, LI and Xu; Trends in Biotechnology, 2017, and Liu, Zhang, Liu and Cheng, Journal of Controlled Disease, 266 (2017) 17-26. Suitable methods include nanoparticles for example gold particles, or polymeric carriers, such as polymers obtained from chitosan or poly-caprolactone or poly-lactic/glycolic acid-copolymers. The use of gold particles is a preferred method of delivery (Mout et al (2017) ACS Nano 11, 2452-2458) and Lee et al Nature Biomedical Engineering volume 1, pages 889-901 (2017). Another preferred method of delivery is lipid nanoparticles, for example as described in Wang et al., PNAS March 15, 2016 vol. 113 no. 112868-2873, and Li et al., Biomaterials 178 (2018) 652 - 662.

In other embodiments a plasmid or plasmids encoding the protein and/or the guide RNA is admin istered to the patient, as is known in the art. The plasmids are preferably adapted for expression of the protein and transcription of the RNA in the cell type of interest which may be a mammalian cell, preferably a human cell. For example, the protein gene and the guide strand gene is prefera bly under control of suitable promotors that induce expression in these cells. A skilled person knows how to achieve expression in mammalian cells. For plasmid delivery, the route of admin istration, formulation and dose can be as in US Patent No 5,846,946 and as in clinical studies in volving plasmids. In some embodiments, the guide strand is delivered (as RNA) together with a plasmid that encodes the CRISPR-type protein, or the other way around. A suitable promotor for expression in humans is chosen when the pathogen is a virus. When the plasmid or plasmids are delivered to pathogens that are bacterial or eukaryotes for expression in the pathogen, the pro motor is preferably chosen to suit the internal transcription system of the pathogen.

In other embodiments delivery of the CRISPR type protein or the RNA guide strand is carried out with the use of a virus. The CRISPR-type protein and the guide RNA can be delivered using adeno associated virus (AAV), lentivirus, adenovirus or other plasmid or viral vector types, in particular, using formulations and doses from, for example, US Patents Nos. 8,454,972 (formulations, doses for adenovirus), 8,404,658 (formulations, doses for AAV) and 5,846,946 (formulations, doses for DNA plasmids) and from clinical trials and publications regarding the clinical trials involving lentivi rus, AAV and adenovirus. For examples, for AAV, the route of administration, formulation and dose can be as in US Patent No. 8,454,972 and as in clinical trials involving AAV. For adenovirus, the route of administration, formulation and dose can be as in US Patent No. 8,404,658 and as in clinical trials involving adenovirus.

When a virus or a plasmid is used, each of the sequences encoding the CRISPR-type protein and the guide strand is adapted for expression of the protein in the cell, and adapted for transcription of RNA. Thus, the coding sequences are preferably under control of a regulatory element, which typically is a DNA sequence that controls the transcription of the gene of interest. The regulatory element may comprise one more promotors, enhancers or the like. The regulatory element is cho sen to suit the cell in which expression is to be achieved. The regulatory element may be operably linked to the sequences. Each of the CRISPR-type protein and the sequence encoding the guide stand may be operably linked to a separate regulatory element. The genes for the CRISPR-type protein may be codon-optimized for expression in the cells of the interest, for example human cells. The CRISPR-type protein and/or the guide strand may be targeted to the nucleus with the ad dition of nucleus targeting sequences. Multiple guide strands that each target one separate se quence may be deliver simultaneously, for example with the use of a plasmid that encodes for sep arate guide strands or for one long RNA that is broken up into a plurality of guide strands with the use of a nuclease activity.

Formulation for parenteral administration such as for example intraarticular, intravenous, intra- dermal, intraperitoneal, or subcutaneous administration include aqueous and non-aqueous injec tion solutions. Formulations for injection may be in unit dosage forms, for example ampules or in multidosage forms. The formulation can be for administration topically, systemically or locally. The formulation can also be provided as an aerosol.

The formulations may contain nuclease inhibitors (such as RNase inhibitors) antioxidants, buffers, antibiotics, salts, solutes that renders the formulation isotonic, lipids, carriers, diluents emulsifiers, chelating agents, excipients, fillers, drying agents, antioxidants, binding agents, solubilizers, stabi lizers, antimicrobial agents, preservatives and the like.

The protein-RNA complex, the plasmids or the virus may be administered to the subject in any suitable manner. The protein-RNA complexes, the plasmids or the virus can be administered by a number of routes including intravenous injection, intraperitoneal, intramuscular, transdermal, subcutaneous, topical, sublingual, or rectal means. Suitable modes of administration include injec tion or infusion. Intravenous administration is a preferred mode of administration.

Preferably an effective amount of the protein-RNA complex, the plasmids or the virus is adminis tered to the subject. An effective amount is an amount that is able to treat one or more symptoms of a disease, halt or reverse the progression of a disease.

Administration may be carried out at a single time point or repeatedly over a time period or from an implanted slow-release matrix. Other delivery systems include bolus injections, time-release, delayed release, sustained release or controlled release systems. Dosage and administration regimens may be determined by methods known in the art, for exam ple with testing in appropriate in vitro or in vivo models, such as animal models to analyse efficacy, pharmacokinetics, pharmacodynamics, excretion, tissue uptake and the like by methods known in the art. A suitable way of finding a suitable dose is starting with a low amount and gradually in creasing the amount.

The CRISPR type protein for use in protein-RNA complexes are preferably produced in a suitable expression system. Production of protein with the use of expression systems is well known in the art. In general, Current protocols in Molecular Biology (John Wiley & sons) provides guidance for polynucleotide handling and manipulation, and protein expression and handling. CRISPR type pro tein, in particular Cpfl and CAS13 can be produced in any suitable manner. Suitable expression systems include eukaryotic cells such as CHO cells, insect cells or bacteria. Often, E. coli is the pre ferred expression system because of its ease of use, and because the CRISPR-type proteins are of bacterial origin. Typically, the production of protein involves cloning of the coding sequence for the protein into a plasmid suitable for expression. The plasmid preferably has a promotor that drives expression. For expression in E. coli the T7 promotor may be useful. For expression in mam malian cells, the CMV promotor may be useful. The plasmid is introduced into the cells with the use of well-known transfection protocols, and stable or transient expressing cells are generated. Suitable transfection techniques may be the use of electroporation or the use of liposomes, such as Lipofectamine^® or virus-based methods. Clones stably expression the protein may be selected, expanded and propagated. Expression plasmids for Cpfl are described in Zetsche et al and expres sion plasmids for CAS13 are described in Abudayyeh et al (see above). The proteins may be ex pressed with a suitable tag for purification of the protein, such as poly-His tag.

Purification of protein may be carried out as is known in the art and may include steps such as: cell lysis, centrifugation, gel filtration, affinity chromatography and dialysis. The protein is preferably purified and endotoxin-free. Useful plasmids for expression of Cpfl include pTE4396, pTE4396, pAsCpfl(TYCV)(BB) (pY211) and pYOlO (pcDNA3.1-hAsCpfl). Useful plasmids for expression of Casl3 include: pC0046-EFla-PspCasl3b-NES-HIV and pC0056 - LwCasl3a-msfGFP-NES (eukaryotic expression) and p2CT-Flis-MBP-Lwa_Casl3a_WT (expression in bacteria).

The RNA guide strand can be produced in any suitable way. A preferred way is chemical synthesis. Methods for synthesis of RNA are well known to a person skilled in the art. RNA synthesis is prefer able done in a controlled environment to avoid degradation of RNA by for example RNAses. The conditions for complexing guide RNA with protein are known. Typically, the protein is incu bated with the guide RNA in a suitable buffer. Incubation time may be 10 minutes to 30 minutes.

The above-mentioned methods for administration of protein-RNA complexes, plasmids and virus can be used to introduce double strand breaks with the use of Cpfl pathogenic virus-infected cells, or to knock down pathogenic virus RNA in infected cells, in vivo, ex vivo or in vitro. In one embodi ment this is done in vitro. The virus-infected cells may be a subpopulation of a larger population of cells, where not all cells are infected with the pathogenic virus.

There are known in vitro methods for assessing the efficacy of treatment and delivery. Examples include the methods used in Ueda et at, Microbiology and Immunology Volume60, Issue7, July 2016, 483-496

EXAMPLE 1

Genomes for a large number of corona virus subtypes where downloaded from www.hiv.lanl.gov.

Data was imported into a table in a relational database. An algorithm was used to search in the da tabase of sequences that are likely to be transcribed to RNA, as being suitable targets for CAS13. The most conserved sequences were selected for further processing. It was checked that none of the selected sequences were present in the consensus human genome. The sequences were then selected based on that they should be present in sequences that are important for virus survival, replication or activation. The results are shown in the appended provisional sequence listing de scribing the sequences SEQ ID NO 1 to SEQ ID NO 3103.

EXAMPLE 2

PspCasl3b from Prevotella sp was expressed and purified and crRNA oligos synthesized. Protein was expressed and purified by method as follows.

Day 1: Inoculation of overnight cultures from fresh transformants in the afternoon. The cultures were grown at 30°C, 175 RPM overnight in the presence of 0.4% glucose.

Day 2: Cultures were grown in the LEX system with start in the morning Cultivation temperature before induction: 37°C. Protein expression temperature: 18°C At different times, the OD was measured for the cultures and the temperature was set to 18°C at OD 2. The protein expression was induced at approximately OD 3 (IPTG, final concentration 0.5 mM). Protein expression continued overnight before the cells were harvested by centrifugation (10 min at 4500 x g). IMAC lysis buffer (1.5 ml buffer per gram cell pellet) and the complete stock solution (1 ml per 1.5 I culture) were added and the cell pellets were re-suspended on a shaker table (cold room). The re suspended cell pellets were frozen at -80°C.

Complete stock solution: 1 tablet Complete EDTA-free (protease inhibitor cocktail, Roche) and 50 pi benzonase nuclease cell resuspension (PSF) per 1 ml. Purification Buffers:

IMAC lysis buffer: 20 mM Tris-HCI, 500 mM NaCI, 1 mM DTT, pH 8.0

IMAC wash 1 buffer: 20 mM HEPES, 500 mM NaCI, 10% glycerol, 10 mM imidazole, 0.5 mM TCEP, pH 7.5 IMAC wash 2 buffer: 20 mM HEPES, 1000 mM NaCI, 10% glycerol, 50 mM imidazole, 0.5 mM TCEP, pH 7.5 IMAC elution buffer: 20 mM HEPES, 500 mM NaCI, 10% glycerol, 500 mM imidaz ole, 0.5 mM TCEP, pH 7.5 Gel filtration buffer: 20 mM HEPES, 300 mM NaCI, 10% glycerol, 0.5 mM TCEP, pH 7.5

Final Storage buffer: 20 mM HEPES, 300 mM NaCI, 10% glycerol, 2 mM TCEP, pH 7.5 Sample preparation The resuspended cells were disrupted by pulsed sonication (4s/4s 4 min, 80% amplitude). The sonicated lysate was centrifuged (20 min at 49000 ^c g) and the supernatant was filtered through 0.45 pm filters and loaded onto the AKTA Xpress and purified.

IMAC Column: 5 ml HisTrap HP (GE Healthcare) Gel Filtration Column: HiLoad 16/60 Superdex 200 Pooling and concentration Fractions were examined on SDS-PAGE gel before pooling. The pooled fractions were concentrated on an Amicon Ultra-15 centrifugation filter (molecular weight cutoff = 100 kDa). The protein sam ples were aliquoted (50* or 100 mI per tube), flash-frozen in liquid Nitrogen and stored at -80°C.

Experimental method. Target concentration is 2.6 nM. Total 50 ng per condition, 10 pL of 5 ng/pL in final eluate.

CRISPR protein concentration used evaluated between 31 to 250 nM.

Protein -RNA complexes were formed by combining guide strand RNA and CAS13 protein, pipette mixing and letting them incubate for 10 minutes.

Sequence in priority

SEQ ID NO document Sequence

1 8 GCUACAACUUCCUCAAGGAACAACAUUGCC

2 28 GCGUACUGCUGCAAUAUUGUUAACGUGAGU

3 31 GUGCGUACUGCUGCAAUAUUGUUAACGUGA

4 51 UGUGACCGAAAGGUAAGAUGGAGAGCCUUG

5 52 GUGUGACCGAAAGGUAAGAUGGAGAGCCUU

6 64 CCGGGUGUGACCGAAAGGUAAGAUGGAGAG

7 95 GUGACCGAAAGGUAAGAUGGAGAGCCUUGU

8 104 ACAUAAUCAGGAUGUAAACUUACAUAGCUC 9 122 AACAACAUUGCCAAAAGGCUUCUACGCAGA

10 129 UACGUUAAUAGUUAAUAGCGUACUUCUUUU

11 131 UUCGUCCGGGUGUGACCGAAAGGUAAGAUG

12 132 UGCUUUUCAAACUGUCAAACCCGGUAAUUU

13 137 UUUCGUCCGGGUGUGACCGAAAGGUAAGAU

14 142 AUGCCAUUAGUGCAAAGAAUAGAGCUCGCA

15 160 ACGAACUUAUGUACUCAUUCGUUUCGGAAG

16 165 UUUACCCAAUAAUACUGCGUCUUGGUUCAC

17 177 UAACUUUAAUCUCACAUAGCAAUCUUUAAU

18 183 AGUUAACUUUAAUCUCACAUAGCAAUCUUU

19 195 GUUUGCGGUGUAAGUGCAGCCCGUCUUACA

20 196 UUGCGGUGU A AG UGCAGCCCGUCUUACACC 21 197 UUUUAAACGGGUUUGCGGUGUAAGUGCAGC 22 199 U UUGCGGUGU AAGUGCAGCCCGUCUUACAC

23 216 AGAGCUGCCUAUAUGGAAGAGCCCUAAUGU

24 219 A A AG G CCA AC A AC A AC A AG G CCA A AC U G U C

25 226 GUAAGUGCAGCCCGUCUUACACCGUGCGGC

26 236 GAGAGCUGCCUAUAUGGAAGAGCCCUAAUG

27 237 GUGUAACAUUAGGGAGGACUUGAAAGAGCC

28 239 AACAUUAGGGAGGACUUGAAAGAGCCACCA

29 240 GUAACAUUAGGGAGGACUUGAAAGAGCCAC

30 246 U G U A AG UGCAGCCCGUCUUACACCGUGCGG

31 254 U A A AG G CCA AC A AC A AC A AG G CCA A AC U G U

32 265 AAGUGCAGCCCGUCUUACACCGUGCGGCAC

33 266 AAG AGCCCU AAUG UG U AAAAU U AAU U U U AG

34 276 CCA AC A AC A AC A AG G CCA A AC U G U C AC U A A

35 284 C U G G U A A AG G CC A AC AAC A AC A AG G CCA A A

36 296 GCAGCCCGUCUUACACCGUGCGGCACAGGC

37 321 CCAAACUGUCACUAAGAAAUCUGCUGCUGA

38 324 ACGUUAAUAGUUAAUAGCGUACUUCUUUUU

39 352 AACCACCU UG U AGG U U UG U U ACAG ACACAC

40 358 AGAGUACACCUUUGAAAAAGGUGACUAUGG

41 362 CCCCAAGGUUUACCCAAUAAUACUGCGUCU

42 367 UGGACUGAGACUGACCUUACUAAAGGACCU

43 374 ACUUUGAUUGUUACGAUGGUGGCUGUAUUA

44 385 AGCUGGUGUCUCUAUCUGUAGUACUAUGAC

45 389 ACACCUUUGAAAAAGGUGACUAUGGUGAUG Sequence in priority

SEQ ID NO document Sequence

46 411 AGAUCUGUUCUCUAAACGAACUUUAAAAUC

47 413 CUCUGAAGAAGUAGUGGAAAAUCCUACCAU

48 422 UAAUAGUUAAUAGCGUACUUCUUUUUCUUG

49 432 CAUCCCUACUAUAACUCAAAUGAAUCUUAA

50 453 ACUUCUUUUUCUUGCUUUCGUGGUAUUCUU

51 458 AAUGUCAUCCCUACUAUAACUCAAAUGAAU

52 460 UAAUAGCGUACUUCUUUUUCUUGCUUUCGU

53 489 GCAAAGAAUAGAGCUCGCACCGUAGCUGGU

54 495 CCAGAUGACCAAAUUGGCUACUACCGAAGA

55 514 CUACUCUUGUGCAGAAUGAAUUCUCGUAAC

56 518 GCUUUUUAGCCUUUCUGCUAUUCCUUGUUU

57 530 A AC U G A U U AC A A AC A U U G G CCG C A A A U U G C

58 540 ACCACCUGGUACUGGUAAGAGUCAUUUUGC

59 543 GACCACCUGGUACUGGUAAGAGUCAUUUUG

60 554 UUUCUAGCAAUGUUGCAAAUUAUCAAAAGG 61 558 UCUGAUAAAGGAGUUGCACCAGGUACAGCU 62 577 GUAGAGUGUUUUGAUAAAUUCAAAGUGAAU

63 579 AGAGUGUUUUGAUAAAUUCAAAGUGAAUUC

64 580 CAAAU U ACAU U ACACAU AAACG AACU U AUG

65 593 CUUACACCGUGCGGCACAGGCACUAGUACU

66 596 GAACCUGAGUUUUAUGAGGCUAUGUACACA

67 600 AACCUGAGUUUUAUGAGGCUAUGUACACAC

68 611 UGUCCUGCUGAAAUUGUUGACACUGUGAGU

69 616 CCUGCUGAAAUUGUUGACACUGUGAGUGCU

70 622 CGUUGUCCUGCUGAAAUUGUUGACACUGUG

71 646 AAAAUUAAUUUUAGUAGUGCUAUCCCCAUG

72 655 GUAAAAUUAAUUUUAGUAGUGCUAUCCCCA

73 660 AGUGCUAUCCCCAUGUGAUUUUAAUAGCUU

74 668 GCUAUCCCCAUGUGAUUUUAAUAGCUUCUU

75 680 GAUUUUAAUAGCUUCUUAGGAGAAUGACAA

76 700 UAUGGCUGUAGUUGUGAUCAACUCCGCGAA

77 701 UUAUGGCUGUAGUUGUGAUCAACUCCGCGA

78 707 GGAAAGGUUAUGGCUGUAGUUGUGAUCAAC

79 708 AAAGGUUAUGGCUGUAGUUGUGAUCAACUC

80 713 AUGUGGAAAGGUUAUGGCUGUAGUUGUGAU 81 716 AG A A U G AC A A A A A A A AAA A A A A A A A A A A A A 82 719 CUGUAGUUGUGAUCAACUCCGCGAACCCAU

83 723 GUUGUACAUAAUCAGGAUGUAAACUUACAU

84 726 UGUACAUAAUCAGGAUGUAAACUUACAUAG

85 729 G AGG ACU UG AAAG AGCCACCACAU U U UCAC

86 737 AG G AC U U G AAAG AGCCACCACAU UUUCACC

87 738 ACU UG AAAG AGCCACCACAU U U UCACCG AG

88 794 CACAUACAAUUGUUGUGAUGAUGAUUAUUU

89 811 GAGCAGAGGCGGCAGUCAAGCCUCUUCUCG

90 822 CUCUAUCUGUAGUACUAUGACCAAUAGACA Sequence in priority

SEQ ID NO document Sequence

91 825 GUCUCUAUCUGUAGUACUAUGACCAAUAGA

92 832 UGUCUCUAUCUGUAGUACUAUGACCAAUAG

93 840 UGACAUGGUACCACAUAUAUCACGUCAACG

94 841 GACAUGGUACCACAUAUAUCACGUCAACGU

95 854 AG UCAAAU U ACAU UACACAUAAACGAACU U

96 859 U UCGG AAG AG ACAGG U ACG U U AAU AG U U AA

97 882 ACUCAUUCGUUUCGGAAGAGACAGGUACGU

98 884 AAG AG ACAGG U ACG U U AAU AG U U AAU AGCG

99 896 CACACCGUUUCUAUAGAUUAGCUAAUGAGU 100 906 UCUGUUGAAUUAAAACACUUCUUCUUUGCU 101 907 UGAAUUAAAACACUUCUUCUUUGCUCAGGA 102 919 GCUCAAAGGAGUCAAAUUACAUUACACAUA

103 929 AAGUUCUGUUGAAUUAAAACACUUCUUCUU

104 935 AAGGAAGUUCUGUUGAAUUAAAACACUUCU

105 952 UUCUUUAAGGAAGGAAGUUCUGUUGAAUUA

106 971 UCUCUAAACGAACUUUAAAAUCUGUGUGGC

107 982 UACACUAGCCAUCCUUACUGCGCUUCGAUU

108 990 UAUUCUUGCUAGUUACACUAGCCAUCCUUA

109 999 AUUCUUGCUAGUUACACUAGCCAUCCUUAC

110 1009 GGUAUUCUUGCUAGUUACACUAGCCAUCCU 111 1031 UACUAUCUAUACAGAACUGGAACCACCUUG 112 1036 AUGGCUUAUUGUUGGCGUUGCACUUCUUGC

113 1048 CUUAUUGUUGGCGUUGCACUUCUUGCUGUU

114 1062 AACUAAUCAGACAAGGAACUGAUUACAAAC

115 1080 UACCCUAACAUGUUUAUCACCCGCGAAGAA

116 1085 U U ACCCU AACAUG U U U AUCACCCGCG AAG A

117 1092 CGGCCCCAAGGUUUACCCAAUAAUACUGCG

118 1128 CUUCUACGCAGAAGGGAGCAGAGGCGGCAG

119 1176 UGUUGAUAAGUACUUUGAUUGUUACGAUGG

120 1180 UACGAUGGUGGCUGUAUUAAUGCUAACCAA 121 1190 UGAAGUUGUUGAUAAGUACUUUGAUUGUUA 122 1191 UGAUAAGUACUUUGAUUGUUACGAUGGUGG

123 1207 GCCACAAGAGCACUAUGUUAGAAUUACUGG

124 1211 ACAGUAAGUGACAACAGAUGUUUCAUCUCG

125 1225 AGUUGAAGUUGUUGAUAAGUACUUUGAUUG

126 1232 AAGUGACAACAGAUGUUUCAUCUCGUUGAC

127 1240 GACAACAGAUGUUUCAUCUCGUUGACUUUC

128 1247 AGCUACUGUAGUAAUUGGAACAAGCAAAUU

129 1257 GCACACUAGAACCAGAAUAUUUCAAUUCAG

130 1264 ACUGAGACUGACCUUACUAAAGGACCUCAU

131 1270 CACACUAGAACCAGAAUAUUUCAAUUCAGU

132 1305 UAAACAACUUAGCUCCAAUUUUGGUGCAAU

133 1325 CUAGACUUUAUUAUGAUUCAAUGAGUUAUG

134 1331 ACAUACAGCUAAUAAAUGGGAUCUCAUUAU

135 1337 CUUUAUUUCACCUUAUAAUUCACAGAAUGC Sequence in priority

SEQ ID NO document Sequence

136 1356 CCUCUUUUGUUUACUCAACCGCUACUUUAG

137 1357 AAGGCUAGACUUUAUUAUGAUUCAAUGAGU

138 1358 GGUAAGGCUAGACUUUAUUAUGAUUCAAUG

139 1365 GUAAGGCUAGACUUUAUUAUGAUUCAAUGA

140 1371 AUGUUUGCAAUGCUCCAGGUUGUGAUGUCA

141 1388 UAAUGGUUACCCUAACAUGUUUAUCACCCG

142 1389 GUUUUGAUAAAUUCAAAGUGAAUUCAACAU

143 1392 UAUACAUUUUGGUGCUGGUUCUGAUAAAGG

144 1397 UACUUUGGCCUCUUUUGUUUACUCAACCGC

145 1399 UUUGAUAAAUUCAAAGUGAAUUCAACAUUA

146 1401 UAAGGCUAGACUUUAUUAUGAUUCAAUGAG

147 1404 UUUGCAGAGUGGUUUUAGAAAAAUGGCAUU

148 1413 U CC A A A A ACCC A UUACUUUAUGAU G CCA AC

149 1417 UGGAGCUAAACUUAAAGCCUUGAAUUUAGG

150 1422 GUUUCUUUAAGGAAGGAAGUUCUGUUGAAU

151 1441 UAAGAUGGAGAGCCUUGUCCCUGGUUUCAA

152 1442 UAUGAGGAUCAAGAUGCACUUUUCGCAUAU

153 1444 UUUCGUCCGUGUUGCAGCCGAUCAUCAGCA

154 1450 UUUCUUUAAGGAAGGAAGUUCUGUUGAAUU

155 1454 UUACGAUAUAUAGUCUACUCUUGUGCAGAA

156 1468 AGCUAAACUUAAAGCCUUGAAUUUAGGUGA

157 1473 AGAGCCUUGUCCCUGGUUUCAACGAGAAAA

158 1485 AUUGAUAAAGUACUUAAUGAGAAGUGCUCU

159 1503 CAUCAUAUGGGUUGCAACUGAGGGAGCCUU

160 1522 AAGAUGGAGAGCCUUGUCCCUGGUUUCAAC 161 1524 GGAGCUAAACUUAAAGCCUUGAAUUUAGGU 162 1532 ACAAGAGGGCAAAAGUUACUAGUGCUAUGC

163 1594 G AG AAACACU UCCCACAG AAG UG U U A AC AG

164 1601 ACUUGGAUUGGCUGCAAUCAUGCAAUUGUU

165 1611 CAAUUCACCAUUUCAUCCUCUAGCUGAUAA

166 1622 CUUCAUUUAAUUAUUUGAAGUCACCUAAUU

167 1637 GAUACAUUCUGUGCUGGUAGUACAUUUAUU

168 1652 GUAGUGCUUUAUUAGAAGAUGAAUUUACAC

169 1665 CUAUGCUAAUGGAGGUAAAGGCUUUUGCAA

170 1701 GGUUUUAGAAAAAUGGCAUUCCCAUCUGGU

171 1713 AGCUUCGCAGCGUGUAGCAGGUGACUCAGG

172 1751 AGUUACAACUGUCAUGUUUUUGGCCAGAGG

173 1772 CCUUUUAUGUCUAUGCUAAUGGAGGUAAAG

174 1791 ACUGUGCCCUUGCACCUAAUAUGAUGGUAA

175 1794 CAAAAGACUUAUGAAAGACAUUCUCUCUCU

176 1796 AUUGGCUGCAAUCAUGCAAUUGUUUUUCAG

177 1802 CACCCGCAAUCCUGCUAACAAUGCUGCAAU

178 1816 ACAACUAUUGUUAAUGGUGUUAGAAGGUCC

179 1820 CAUGUUUUUGGCCAGAGGUAUUGUUUUUAU

180 1845 AUACAAGGCUAUUGAUGGUGGUGUCACUCG Sequence in priority

SEQ ID NO document Sequence

181 1852 AGCAGGUGACUCAGGUUUUGCUGCAUACAG

182 1865 AAUGGAACCAAUUUAUGAUGAACCGACGAC

183 1888 CUUGGUUCACCGCUCUCACUCAACAUGGCA

184 1891 AAAUAAAUUUUUGGCUUUGUGUGCUGACUC

185 1898 AUGAAUGGACGUACCAUAUUGGGUAGUGCU

186 1901 GCAGAAUGAAUUCUCGUAACUACAUAGCAC

187 1907 CUUGUAAAACCUUCUUUUUACGUUUACUCU

188 1915 C A A AG AC AG U G C U U A A A A AG U G U A A A AG U G

189 1916 CGUUGCACUUCUUGCUGUUUUUCAGAGCGC

190 1926 CACUUGUGGCUUAGUAGAAGUUGAAAAAGG

191 1938 AGCUGGUGGCCAUAGUUACGGCGCCGAUCU

192 1954 GUAGCAGGUGACUCAGGUUUUGCUGCAUAC

193 1959 AACUACAUAGCACAAGUAGAUGUAGUUAAC

194 1975 AG AAACAC U U CCCACAGAAG U G U U AAC AG A

195 1982 ACCAUAUUGGGUAGUGCUUUAUUAGAAGAU

196 1986 AGCAGUGACAAUAUUGCUUUGCUUGUACAG

197 1989 CACUACAGUUUAAAAGACCAAUAAAUCCUA

198 1990 AGCUGUGAUCCUUCGUGGACAUCUUCGUAU

199 1991 CGUUGACAGGACACGAGUAACUCGUCUAUC

200 1995 GACAAUAUUGCUUUGCUUGUACAGUAAGUG 201 2001 CAUGCAUGCAAAUUACAUAUUUUGGAGGAA 202 2002 CACGUCAACAUCUUAAAGAUGGCACUUGUG

203 2033 ACUGCUGCAAUAUUGUUAACGUGAGUCUUG

204 2056 GUAAUGUGAAAACUACCGAAGUUGUAGGAG

205 2058 AUGGAGCUGAUGUUACUAAAAUAAAACCUC

206 2059 CUCUUAUAAUCUCUGUUACUUCUAACUACU

207 2078 ACGUACCAUAUUGGGUAGUGCUUUAUUAGA

208 2089 CUGCGGUAUGUGGAAAGGUUAUGGCUGUAG

209 2121 AACAUACGAGGGCAAUUCACCAUUUCAUCC

210 2122 CAACAUCUUAAAGAUGGCACUUGUGGCUUA 211 2131 GGAACUUCUCCUGCUAGAAUGGCUGGCAAU 212 2147 AGAGUUUCUUAGAGACGGUUGGGAAAUUGU

213 2165 CC AG A AC A A ACCC A AG G AAA U UUUGGGGAC

214 2171 GCCUUUGUAAGCACAAGCUGAUGAGUACGA

215 2174 GGGCUCUUAUAAUCUCUGUUACUUCUAACU

216 2182 CCAGAAGCUGGACUUCCCUAUGGUGCUAAC

217 2213 G G U CC AG A AC A A ACCC A AG G AAA U U U U G G G

218 2214 ACAUUUUAUUAGUAAUUCUUGGCUUAUGUG

219 2217 GAGUCUUGUAAAACCUUCUUUUUACGUUUA

220 2218 GUAGUUACAACUGUCAUGUUUUUGGCCAGA 221 2220 AGAGUGUUCAGACAUUCUUUAAGCUUGUAA 222 2221 AGGGGAACUUCUCCUGCUAGAAUGGCUGGC

223 2247 CAUUGUCUGAACAACUACGAAAACAAAUAC

224 2267 CCAGAGGUAUUGUUUUUAUGUGUGUUGAGU

225 2280 GAACAGAAAUCAAUACUGAGUCCUCUUUAU Sequence in priority

SEQ ID NO document Sequence

226 2281 AAGAACGGUAAUAAAGGAGCUGGUGGCCAU

227 2285 GCAAUUCACCAUUUCAUCCUCUAGCUGAUA

228 2308 AACCAAUUUAUGAUGAACCGACGACGACUA

229 2314 AAAACCUUCUUUUUACGUUUACUCUCGUGU

230 2316 CUUAUGUGGUUAAUAAUUAAUCUUGUACAA

231 2326 AGUGCUUUAUUAGAAGAUGAAUUUACACCU

232 2337 GAACUUCUCCUGCUAGAAUGGCUGGCAAUG

233 2338 AAGCACAAGCUGAUGAGUACGAACUUAUGU

234 2351 ACUUUUAAAGUUUCCAUUUGGAAUCUUGAU

235 2373 ACUGGUUCUAUACCUUGUAGUGUUUGUCUU

236 2374 GCUCUUAUAAUCUCUGUUACUUCUAACUAC

237 2379 GGUUAAUAAUUAAUCUUGUACAAAUGGCCC

238 2388 CUGCAAUCAUGCAAUUGUUUUUCAGCUAUU

239 2411 AACUUCUCCUGCUAGAAUGGCUGGCAAUGG

240 2447 AAUAAAGGAGCUGGUGGCCAUAGUUACGGC

241 2459 GAGCUUCGCAGCGUGUAGCAGGUGACUCAG

242 2475 ACUUGACAUUUUAUCUUACUAAUGAUGUUU

243 2498 AAUGUGAAAACUACCGAAGUUGUAGGAGAC

244 2504 AAUUCUUGGCUUAUGUGGUUAAUAAUUAAU

245 2506 GACUCAGGUUUUGCUGCAUACAGUCGCUAC

246 2509 CAGCAGUAGGGGAACUUCUCCUGCUAGAAU

247 2545 G AAAACU ACCG AAG U UG U AGG AG ACAU U AU

248 2568 CUAUUGAUGGUGGUGUCACUCGUGACAUAG

249 2579 UUCUUAGAGACGGUUGGGAAAUUGUUAAAU

250 2585 UU AUG UCAUGCAUGCAAAUU ACAU AUUUUG

251 2587 UAUAGUUUUUGAUGGUAAAUCAAAAUGUGA

252 2591 UUUAGAAAAAUGGCAUUCCCAUCUGGUAAA

253 2593 UUAGAAGAGCUUUUGGUGAAUACAGUCAUG

254 2595 UUUUGAUGGUAAAUCAAAAUGUGAAGAAUC

255 2612 UUUAGAAGAGCUUUUGGUGAAUACAGUCAU

256 2618 UAGUGCUUUAUUAGAAGAUGAAUUUACACC

257 2620 UUCUUCUUCGUAAGAACGGUAAUAAAGGAG

258 2632 UCCUCAUCACGUAGUCG C A AC AG U U C A AG A

259 2643 UGACUUUCAGGUUACUAUAGCAGAGAUAUU

260 2659 UUCAUUCCUUAAUGGUUCAUGUGGUAGUGU 261 2662 U U U UAAAAUGAAU U AUCAAG UUAAUGGUUA 262 2665 UUCAUUGCCUAUUAAUGUUAUAGUUUUUGA

263 2668 U AAC AG AG G AAG U U G U C U UGAAAAC U GG U G

264 2672 UCUUUUGGUGGUGUCAGUGUUAUAACACCA

265 2691 UUAUUCUGUUAUUUACUUGUACUUGACAUU

266 2693 UUACUCUCGUGUUAAAAAUCUGAAUUCUUC

267 2695 UGACAGGACACGAGUAACUCGUCUAUCUUC

268 2708 UGGGUGAUGCGUAUUAUGACAUGGUUGGAU

269 2714 UAGAAGGUCCUUUUAUGUCUAUGCUAAUGG

270 2716 UAUGAAUGGACGUACCAUAUUGGGUAGUGC Sequence in priority

SEQ ID NO document Sequence

271 2717 GUUAACAGAGGAAGUUGUCUUGAAAACUGG

272 2721 UCAUUGCCUAUUAAUGUUAUAGUUUUUGAU

273 2726 UGACUCAGGUUUUGCUGCAUACAGUCGCUA

274 2741 GUUUUAAAAUGAAUUAUCAAGUUAAUGGUU

275 2746 UAUGUGGAAAGGUUAUGGCUGUAGUUGUGA

276 2747 UCAUUCCUUAAUGGUUCAUGUGGUAGUGUU

277 2753 UUUUCAGCUAUUUUGCAGUACAUUUUAUUA

278 2759 UGGCGUUGCACUUCUUGCUGUUUUUCAGAG

279 2767 UUAUAAAGUUUAUUAUGGUAAUGCUUUAGA

280 2783 UUAUACCUACUAAAAAGGCUGGUGGCACUA 281 2784 UACAAUGGUUCACCAUCUGGUGUUUACCAA 282 2793 GUUAGAAGGUCCUUUUAUGUCUAUGCUAAU

283 2795 UAAUAAAGGAGCUGGUGGCCAUAGUUACGG

284 2799 UUUCCAUUUAAUAAAUGGGGUAAGGCUAGA

285 2801 U U UAAAAUGAAU U AUCAAG UUAAUGGUUAC

286 2813 UUAAAAGACCAAUAAAUCCUACUGACCAGU

287 2829 UACAACUGUCAUGUUUUUGGCCAGAGGUAU

288 2830 UGUUAGAAGGUCCUUUUAUGUCUAUGCUAA

289 2841 UGAUAGUGUUACAGUGAAGAAUGGUUCCAU

290 2867 U CC AG A AC A A ACCC A AG G AAA UUUUGGGGA

291 2868 UUUUCCAUUUAAUAAAUGGGGUAAGGCUAG

292 2870 UGGUGUCAGUGUUAUAACACCAGGAACAAA

293 2876 UACUUCUAACUACUCAGGUGUAGUUACAAC

294 2899 UCCUUUUAUGUCUAUGCUAAUGGAGGUAAA

295 2906 UAAUGGUGUUAGAAGGUCCUUUUAUGUCUA

296 2917 UCUUCUUCGUAAGAACGGUAAUAAAGGAGC

297 2921 UUCACCGCUCUCACUCAACAUGGCAAGGAA

298 2929 UCUUGAGUGUAAUG U G AAAAC U ACCG AAG U

299 2931 UGGCCAUAGUUACGGCGCCGAUCUAAAGUC

300 2933 UAUGUCAUGCAUGCAAAUUACAUAUUUUGG

301 2935 GUUUAUUCUGUUAUUUACUUGUACUUGACA

302 2950 UAAUUGUGAUACAUUCUGUGCUGGUAGUAC

303 2956 UGACAUACUAGGACCUCUUUCUGCUCAAAC

304 2962 UUGUGUAUCUACUAGUGGUAGAUGGGUACU

305 2988 UCAAAAGACUUAUGAAAGACAUUCUCUCUC

306 2992 UAAAGAUUUCAUGUCAUUGUCUGAACAACU

307 2993 UGCAGAGUGGUUUUUGGCAUAUAUUCUUUU

308 3005 UAUACCUACUAAAAAGGCUGGUGGCACUAC

309 3006 UUCUAUACCUUGUAGUGUUUGUCUUAGUGG

310 3007 UAAAAAUCUGAAUUCUUCUAGAGUUCCUGA

311 3009 GUUAAAAAUCUGAAUUCUUCUAGAGUUCCU

312 3010 UUUUGCUGCAUACAGUCGCUACAGGAUUGG

313 3017 UAACGUGAGUCUUGUAAAACCUUCUUUUUA

314 3029 UUUUGGCCAGAGGUAUUGUUUUUAUGUGUG

315 3042 UUUUAGAAAAAUGGCAUUCCCAUCUGGUAA Sequence in priority 21

SEQ ID NO document Sequence

316 3055 UCUAUACCUUGUAGUGUUUGUCUUAGUGGU

317 3103 UUCAUCUCGUUGACUUUCAGGUUACUAUAG

318 3107 UGUAGUUACAACUGUCAUGUUUUUGGCCAG

319 3113 UGCACUUCUUGCUGUUUUUCAGAGCGCUUC

320 3115 UAUUUACUUGUACUUGACAUUUUAUCUUAC

321 3141 GUUCAUUCCUUAAUGGUUCAUGUGGUAGUG

322 3158 UGUUUAUUCUGUUAUUUACUUGUACUUGAC

323 3164 UGUGGACAUGUCAAUGACAUAUGGACAACA

324 3168 G U U U ACAACAG U AG ACAACAU U AACCUCCA

325 3169 U U C AACG AG AAAAC ACACG UCCAAC U CAG U

326 3177 UGAUGAGCCUGAAGAACAUGUCCAAAUUCA

327 3183 UAGCUUGUUACAAUGGUUCACCAUCUGGUG

328 3186 UUGAUUAUGGUGCUAGAUUUUACUUUUACA

329 3190 U U ACAACAG U AG ACAACAU U AACCUCCACA

330 3193 UGUGGUUGAUUAUGGUGCUAGAUUUUACUU

331 3210 UUUGUUGAUUCAGAUGUAGAAACUAAAGAU

332 3215 UUGUUGAUUCAGAUGUAGAAACUAAAGAUG

333 3225 UGAUUCAGAUGUAGAAACUAAAGAUGUUGU

334 3227 UGAUUAUGGUGCUAGAUUUUACUUUUACAC

335 3230 UAUUGGGAACCUGAGUUUUAUGAGGCUAUG

336 3244 UCAUUCAAUCCAGAAACUAACAUUCUUCUC

337 3247 UUGUAUUAACGGGCUUAUGUUGCUCGAAAU

338 3252 UGGUACACCAGUUUGUAUUAACGGGCUUAU

339 3261 U G G AC A A A UUGUCACCUGUG C A A AG G A A A U

340 3272 GUUACAGUGAAGAAUGGUUCCAUCCAUCUU

341 3277 GUUUGUUGAUUCAGAUGUAGAAACUAAAGA

342 3285 UGUAGAGUUUCUUAGAGACGGUUGGGAAAU

343 3308 UGUAUACUGCUGCCGUGAACAUGAGCAUGA

344 3310 UGAGGCUGAAGUGCAAAUUGAUAGGUUGAU

345 3315 UUUGUAGAUGAUAUCGUAAAAACAGAUGGU

346 3327 UCAGACAUUCUUUAAGCUUGUAAAUAAAUU

347 3329 UACAGUGAAGAAUGGUUCCAUCCAUCUUUA

348 3332 UCUGAAAAGAGCUAUGAAUUGCAGACACCU

349 3336 UUGGUACACCAGUUUGUAUUAACGGGCUUA

350 3345 GUGUGGUUGAUUAUGGUGCUAGAUUUUACU

351 3355 UG U U U ACAACAG U AG ACAACAU U AACCUCC

352 3358 GUUCAGACAUUCUUUAAGCUUGUAAAUAAA

353 3363 UUUCGCUUUUCCGUUUACGAUAUAUAGUCU

354 3367 U ACACCAG U U UG U AU U AACGGGCU U AUG U U

355 3404 U AC U A A A A U A A A ACC UCAUAAUUCACAUGA

356 3405 U U U C AACG AG AAAAC ACACG UCCAAC U CAG

357 3407 UGCCACAUAGAUCAUCCAAAUCCUAAAGGA

358 3428 GCUAUAUAAACGUUUUCGCUUUUCCGUUUA

359 3440 GGUGUAUACUGCUGCCGUGAACAUGAGCAU

360 3451 CAUUCAAUCCAGAAACUAACAUUCUUCUCA Sequence in priority

SEQ ID NO document Sequence

361 3453 GUAUACUGCUGCCGUGAACAUGAGCAUGAA

362 3475 AAUGCUGCUAUCAGCGAUUAUGACUACUAU

363 3489 GGUCAUUCAAUCCAGAAACUAACAUUCUUC

364 3508 CUGUACCGUCUGCGGUAUGUGGAAAGGUUA

365 3516 CGCAAAAUAUACUCAACUGUGUCAAUAUUU

366 3520 AAGGUGUAGAGUUUCUUAGAGACGGUUGGG

367 3537 GCUUGUGAAAUUGUCGGUGGACAAAUUGUC

368 3550 AAAUUAAGGAGAGUGUUCAGACAUUCUUUA

369 3551 GGUUGAUUAUGGUGCUAGAUUUUACUUUUA

370 3554 GGACAUGUCAAUGACAUAUGGACAACAGUU

371 3557 ACACCAGUUUGUAUUAACGGGCUUAUGUUG

372 3569 AGAUGUAGUUAACUUUAAUCUCACAUAGCA

373 3575 GUGUAUACUGCUGCCGUGAACAUGAGCAUG

374 3586 ACAUGUCAAUGACAUAUGGACAACAGUUUG

375 3619 CUGAAGCAAAAUGUUGGACUGAGACUGACC

376 3642 CAGAUGGGCUAUAUAAACGUUUUCGCUUUU

377 3655 CACCUGUGCAAAGGAAAUUAAGGAGAGUGU

378 3664 AAUUGUGACACAUUAAAAGAAAUACUUGUC

379 3667 CGGUGGACAAAUUGUCACCUGUGCAAAGGA

380 3673 CUAUAUAAACGUUUUCGCUUUUCCGUUUAC

381 3686 GACCGAAAGGUAAGAUGGAGAGCCUUGUCC

382 3694 AUUGGGAACCUGAGUUUUAUGAGGCUAUGU

383 3709 GACACAUUAAAAGAAAUACUUGUCACAUAC

384 3719 AGAAACUAAAGAUGUUGUUGAAUGUCUUAA

385 3720 GUAGAGUUUCUUAGAGACGGUUGGGAAAUU

386 3726 AUAAUGAUGCACUCAACAACAUUAUCAACA

387 3741 AC A A A UUGUCACCUGUG C A A AG G A A A U U A A

388 3775 CAAGGGUUUGUUGAUUCAGAUGUAGAAACU

389 3777 GAACAUGAGCAUGAAAUUGCUUGGUACACG

390 3786 AGAUGAUAUCGUAAAAACAGAUGGUACACU

391 3803 G G AC A A A UUGUCACCUGUG C A A AG G A A A U U

392 3804 GUGGUUGAUUAUGGUGCUAGAUUUUACUUU

393 3805 CCAACUUAUUUGGAUGGAGCUGAUGUUACU

394 3829 G C A A AG G A A A UUAAGGAGAGUGUUCAGACA

395 3833 AUACUGCUGCCGUGAACAUGAGCAUGAAAU

396 3841 GAAGAAUGGUUCCAUCCAUCUUUACUUUGA

397 3856 GACUCUUCUUCCUGCUGCAGAUUUGGAUGA

398 3858 ACCGUCUGCGGUAUGUGGAAAGGUUAUGGC

399 3866 GAAAUGGUCAUGUGUGGCGGUUCACUAUAU

400 3872 CACGCCUAAACGAACAUGAAAUUUCUUGUU

401 3899 CCCUGGUUU CAACG AG AAAACAC ACG U CCA

402 3900 AGACAACAUUAACCUCCACACGCAAGUUGU

403 3905 CUUGACAAAGUUGAGGCUGAAGUGCAAAUU

404 3914 CUGUUUUGUAGAUGAUAUCGUAAAAACAGA

405 3935 CUACCCUCUUGAGUGCAUUAAAGACCUUCU Sequence in priority

SEQ ID NO document Sequence

406 3936 AAUGCUGAUCUUUAUAAGCUCAUGGGACAC

407 3948 CAACAUCAAUAUUGUUGGUGACUUUAAACU

408 3950 CCUCUUUAUGCAUUUGCAUCAGAGGCUGCU

409 3954 AAGCCAAUAUGGAUCAAGAAUCCUUUGGUG

410 3979 CAUUCAGUACGGUCGUAGUGGUGAGACACU

411 3988 C A A AG A A A UUUGACACCUUCAAUGGGGAAU

412 3998 AGCUGAUGUUACUAAAAUAAAACCUCAUAA

413 4004 AACUGGUAUGAUUUCGGUGAUUUCAUACAA

414 4018 ACUGCCGUUGCCACAUAGAUCAUCCAAAUC

415 4019 GGCAACCGGGUGUUGCUAUGCCUAAUCUUU

416 4026 C U A A A A UGUCAGAUGU A A AG U G C AC A U C AG

417 4029 CACUUAUCAACACACUUAACGAUCUAAAUG

418 4032 GGUUAUACUGAAAAAUGGGAAUCUGGAGUA

419 4082 ACAAG UUUUUGGUU U AU AU AAAAAU ACAUG

420 4105 AGCAGAACUCGAAGGCAUUCAGUACGGUCG

421 4113 GAUGGCACAACAAGUCCUAUUUCUGAACAU

422 4116 CCAAUGUUAAUGCACUUUUAUCUACUGAUG

423 4135 GCAGAUAACAACUGUUAUCUUGCCACUGCA

424 4139 AAUUACCAACUGGAGUUCAUGCUGGCACAG

425 4168 AUAACACGUUGCAAUUUAGGUGGUGCUGUC

426 4170 ACUGCCACU A A AG CAU AC A A U G U A AC AC A A

427 4171 ACGCCAAGCU U UG U U AAAAACAG UACAAU U

428 4172 AUGAAAAUGCCUUUUUACCUUUUGCUAUGG

429 4186 AGGUUUGUUACAGACACACCUAAAGGUCCU

430 4190 CCAAUUCUGCUGUCAAAUUACAGAAUAAUG

431 4213 AGGUUUGUACUUGCACUGUUAUCCGAUUUA

432 4222 AAUUACCAGUGUGGUCACUAUAAACAUAUA

433 4229 GGUUAUACCUACUAAAAAGGCUGGUGGCAC

434 4237 G AC A A AG Cl) U AU AAAAU AG AAG AAU U AU UC

435 4249 GUCAACCUAUACUGUUACUAGAUCAGGCAU

436 4277 G U ACU U U U ACU AG AAG U ACAAAU UCU AG AA

437 4282 CCUUGAAGCCCCUUUUCUCUAUCUUUAUGC

438 4287 GCUGGUGAAGCUGCUAACUUUUGUGCACUU

439 4317 CCACAAAUAGGCGUGGUAAGAGAAUUCCUU

440 4319 CGUUUUGCCUCAACUUGAACAGCCCUAUGU

441 4324 AUUUAUACUUUAU U AAAGG AU U AAACAACC

442 4325 CCACAAAUUAUGAUUUGAGUGUUGUCAAUG

443 4333 ACGCGCAGGGAAUGGAUAAUCUUGCCUGCG

444 4337 GGGGCGCGAUCAAAACAACGUCGGCCCCAA

445 4346 CUGAAGUGCAAAUUGAUAGGUUGAUCACAG

446 4377 AAUUUCAAAAAUCUUAGGGAAUUUGUGUUU

447 4397 GGUCGCACUAUUGCCUUUGGAGGCUGUGUG

448 4408 ACGCGUUCCAUGUGGUCAUUCAAUCCAGAA

449 4426 GGUGCAUCGUGUUGUCUGUACUGCCGUUGC

450 4428 GCUUUUGACAUCUACAAUGAUAAAGUAGCU Sequence in priority

SEQ ID NO document Sequence

451 4430 CCACACAGAUCUAAUGGCUGCUUAUGUAGA

452 4438 GUGCCUAUUGGGUUCCACGUGCUAGCGCUA

453 4445 GGGGGACAACCAAUCACUAAUUGUGUUAAG

454 4463 CUUCUUACAUCGUUGAUAGUGUUACAGUGA

455 4472 GCAGAAAAUUCAGUUGCUUACUCUAAUAAC

456 4510 GCUGGUAGUACAUUUAUUAGUGAUGAAGUU

457 4515 AAU U ACCU AAAG AG ACG UG U AG UCU U UAAU

458 4526 A AC UUACACCAGUUGUUCAGACUAU U G A AG

459 4537 G AAUGUCCAAAU UUUGU AU UUCCCUU AAAU

460 4538 GUCUUUAGCUAUAGAUGCUUACCCACUUAC

461 4540 GCACUUGGAAAACUUCAAGAUGUGGUCAAC

462 4549 ACGCUGCUGUUAUAAAUGGAGACAGGUGGU

463 4554 ACGCUGCUUGUCGAUUCAGAUCUUAAUGAC

464 4557 GCACUUGACCCUCUCUCAG A A AC A A AG U G U

465 4565 AUGAACUUAAGCAUGGUACAUUUACUUGUG

466 4571 GAAAGG U U UGG AU U AU AAAGCAU UCAAACA

467 4573 ACGCUGUGACAUCAAGGACCUGCCUAAAGA

468 4585 AUGAAGAAGAAGGUGAUUGUGAAGAAGAAG

469 4593 GCACUUAUCUUAGCCUACUGUAAUAAGACA

470 4605 GGCAACUUUACAAGC U G A A A A U G U A AC AG G

471 4609 GUAGAAUUCGAUCUGUCUAUCCAGUUGCGU

472 4626 CUUCUUGCAUGUGACUUAUGUCCCUGCACA

473 4647 GAAUUUGUGUUUAAGAAUAUUGAUGGUUAU

474 4656 AAUUAUAAUUACCUGUAUAGAUUGUUUAGG

475 4674 GCUGGUAAAGCUUCAUGCACUUUGUCCGAA

476 4681 AGAACGCAGUGGGGCGCGAUCAAAACAACG

477 4685 ACGG ACACAACU AU UACAG UUAAUGUUUUA

478 4712 GAUGGUACAACAUUUACUUAUGCAUCAGCA

479 4734 CCU AAAG UGAAG UAUUUAUACUUUAU U AAA

480 4760 AC A A U C A A A A AG AGUUGAUUUUUGU G G A A A

481 4776 CCUACUCAUGCCUCU A A A AG CCCC A A A AG A

482 4794 CUUGAAAACCAUUCUUCGUAAGGGUGGUCG

483 4795 CUUGAAAACUGGUGAUUUACAACCAUUAGA

484 4796 ACUGAUGUCGUAUACAGGGCUUUUGACAUC

485 4804 AUAAUCUUGCCUGCGAAGAUCUAAAACCAG

486 4821 GAAUUUCAAUUUUGUAAUGAUCCAUUUUUG

487 4827 ACAAUCACUUCUGGUUGGACCUUUGGUGCA

488 4828 AC A A U C AG AC A AC U AC U A U U C A A AC A A U U G

489 4843 CUUGAAAUUCCACGUAGGAAUGUGGCAACU

490 4869 CUGCUUACGGUUUCGUCCGUGUUGCAGCCG

491 4872 CCACGAGUGCUUUGUUAAGCGUGUUGACUG

492 4877 CUUUCAUUUGUACU U ACAAU ACAU AAG AAA

493 4879 CUUGAACGUGGUGUGUAAAACUUGUGGACA

494 4896 CU UGAAG AG AAG U U U AAGG AAGG UG U AG AG

495 4899 GCACGUAGUGUAGCUAGUCAAUCCAUCAUU Sequence in priority

SEQ ID NO document Sequence

496 4902 CCACGCGGAGUACGAUCGAGUGUACAGUGA

497 4905 GUCUGGUAACUGUGAUGUUGUAAUAGGAAU

498 4909 AACAACUUUUGAUUCUGAGUACUGUAGGCA

499 4916 CACUUGGUGCAGAAAAUUCAGUUGCUUACU

500 4931 AACUGUUUCUUGGAAUUUGCGAGAAAUGCU

501 4936 AGUUUAGCUGCCACAGUACGUCUACAAGCU

502 4940 GUAGAAGCUGUUAUGUACAUGGGCACACUU

503 4963 AUUUAACUGCUUUUGGCUUAGUUGCAGAGU

504 4964 AGGUUCCGUGGCUAUAAAGAUAACAGAACA

505 4970 GCACCUUUUUGUUAAAUAAAGAAAUGUAUC

506 4971 CCUUGAUUGGCUUGAAGAGAAGUUUAAGGA

507 4978 AGUUUAGAUAUAUGAAUUCACAGGGACUAC

508 4987 CACUUGUGAAAGAUCAGAAGCUGGUGUUUG

509 5008 CUUGACACUCGUUUAUAAAGUUUAUUAUGG

510 5042 ACAAUCUACACAACUAGGUAUAGAAUUUCU

511 5043 GCACCUACACUAGUGCCACAAGAGCACUAU

512 5083 GAUGGUGGCAGUUUGUAUGUAAAUAAACAU

513 5092 AGAAUGGAAGUUCUAUGAUGCACAGCCUUG

514 5100 CUGCUUAUGUAGACAAUUCUAGUCUUACUA

515 5108 ACGGUCGUAGUGGUGAGACACUUGGUGUCC

516 5136 AUUGUUUUUAUGUGUGUUGAGUAUUGCCCU

517 5141 AUGAAUUCAUUGAACGGUAUAAAUUAGAAG

518 5155 GCACCACUCACUGUCUUUUUUGAUGGUAGA

519 5167 AGUUUACUGUCCAAGACAUGUGAUCUGCAC

520 5171 AGCAAUGGAUACAACUAGCUACAGAGAAGC

521 5177 AACAAGCAAAUUCUAUGGUGGUUGGCACAA

522 5211 GCACCAACAAAGGUUACUUUUGGUGAUGAC

523 5215 GCUUUUCAGUAGCUGCACUUACUAACAAUG

524 5217 GGUUGCCUACGGGUACGCUGCUUGUCGAUU

525 5225 AAUUUCACAGUAUUCACUGAGACUCAUUGA

526 5238 AUGGCUACAUACUACUUAUUUGAUGAGUCU

527 5257 AUG AC A A AG A U CCA A All U U C A A AG A U C A AG

528 5260 GCACAUGGCUUUGAGUUGACAUCUAUGAAG

529 5264 AUUAUAAAGCAUUCAAACAAAUUGUUGAAU

530 5266 GAGCUUAACGGAGGGGCAUACACUCGCUAU

531 5280 AAUUACUUGUGUAUGCUGCUGACCCUGCUA

532 5284 GCACAUCAGUAGUCUUACUCUCAGUUUUGC

533 5291 AUUGUUGGUGUACUGACAUUAGAUAAUCAA

534 5320 AG C AC A A A ACC AG U U G A A AC A U C A A A U U CG

535 5347 CUUGAUGACGUAGUUUACUGUCCAAGACAU

536 5371 AUUGUUCUUUCUACCCUCCAGAUGAGGAUG

537 5381 AGAAAACCCUCACCUUAUGGGUUGGGAUUA

538 5392 AUGACAGAUGCAUUCUGCAUUGUGCAAACU

539 5399 CGUUCCAAUUAACACCAAUAGCAGUCCAGA

540 5404 GCACACUUUCUUAUGAACAAUUUAAGAAAG Sequence in priority

SEQ ID NO document Sequence

541 5419 AGCACACCUUGUAAUGGUGUUGAAGGUUUU

542 5431 G AAU UCAACAUUAGAACAGU AUG UCU UUUG

543 5447 CUUGAUGUGGCUCAGCUACUUCAUUGCUUC

544 5449 AGGUGUUGCAGGAGCCUUAAAUAAGGCUAC

545 5453 AACUGUGAUGUUGUAAUAGGAAUUGUCAAC

546 5479 ACUGACAUUAGAUAAUCAAGAUCUCAAUGG

547 5497 AGUUUACAGUCAUGUACUCAACAUCAACCA

548 5517 CUUGAUUGCCAUAGUAAUGGUGACAAUUAU

549 5557 AUGCCUAUUUUGGAAUUGCAAUGUCGAUAG

550 5563 CGGGCACGUAGUGUAGCUAGUCAAUCCAUC

551 5565 AUAACAAUUGCUUAUAUCAUUUGUAUUUCC

552 5576 GCACAAAAGUUUAACGGCCUUACUGUUUUG

553 5577 AUGACCAGUUGCUGUAGUUGUCUCAAGGGC

554 5583 CCAGACAUGUUCCUCGGAACUUGUCGGCGU

555 5598 AAUCAUCACAACUGUAGCUGCAUUUCACCA

556 5599 GCAAUUUCAAGUGUUUUAAAUGAUAUCCUU

557 5637 CCAGAGUACUCAAUGGUCUUUGUUCUUUUU

558 5650 ACGUCUACAAGCUGGUAAUGCAACAGAAGU

559 5666 ACUGAAGUCAGAGGACGCGCAGGGAAUGGA

560 5687 GUCGGUAAAUUUUGUCUAGAGGCUUCAUUU

561 5698 GGUGAUUCAACUGAAUGCAGCAAUCUUUUG

562 5703 AGCUGGUUUUGCUAAAUUCCUAAAAACUAA

563 5719 A A A A AC U C A A A AC AC UAGUUGCAACUGCAG

564 5720 AAAAGUGCCUUUUACAUUCUACCAUCUAUU

565 5729 ACGUGAAGUGCUGUCUGACAGAGAAUUACA

566 5733 GAUGUAGAAAACCCUCACCUUAUGGGUUGG

567 5749 AAUUAGAGGUGAUGAAGUCAGACAAAUCGC

568 5756 ACUGAAGAUGAUUACCAAGGUAAACCUUUG

569 5783 ACGUGCAUGGAUUGGCUUCGAUGUCGAGGG

570 5792 CGCUUCCAAGAAAAGGACGAAGAUGACAAU

571 5803 CGUGUUUAUUCUACAGGUUCUAAUGUUUUU

572 5807 G G U A A AC A AG C U AC A AAA UAUCUAGUACAA

573 5809 CCGCAAAUUGCACAAUUUGCCCCCAGCGCU

574 5811 CCAGCAUGUCACAAUUCAGAAGUAGGACCU

575 5816 AAGUUGUCUUGAAAACUGGUGAUUUACAAC

576 5839 CUUGCCGAAUACCAUAAUGAAUCUGGCUUG

577 5847 AAAUAAACAUGCAUUCCACACACCAGCUUU

578 5868 ACGUGGCUUUGGAGACUCCGUGGAGGAGGU

579 5878 ACUGAAAGACUCAAGCUUUUUGCAGCAGAA

580 5909 AACGUUCUGAAAAGAGCUAUGAAUUGCAGA

581 5913 GGUAAAAUUGUUAAUAAUUGGUUGAAGCAG

582 5918 ACAAUGUACAUUUGUGGUGAUUCAACUGAA

583 5923 AUUGUCCAGCUGUUGCUAAACAUGACUUCU

584 5930 AACUGUAACUUUGAAG C A AG G U G AAA U C A A

585 5936 AGACAUCAUGCUAAUGAGUACAGAUUGUAU Sequence in priority

SEQ ID NO document Sequence

586 5942 CCAGCUGUUGCUAAACAUGACUUCUUUAAG

587 5944 CGAGGGGUGUCAUGCUACUAGAGAAGCUGU

588 5949 G AGG ACU AU U AAGG UG U U U ACAACAG U AG A

589 5960 ACGUGUGGUAAACAAGCUACAAAAUAUCUA

590 5964 GAUGUCACAGAUGUGACUCAACUUUACUUA

591 5968 C ACC A A A U G A A U G C A ACC A A A UGUGCCUUU

592 5970 GUACCUUCCUUACCCAGAUCCAUCAAGAAU

593 5974 AUUGUCAAGUCCAUGGUAAUGCACAUGUAG

594 5991 CUUUAUGGGUAGAAUUCGAUCUGUCUAUCC

595 5994 CUCAGCUACUUCAUUGCUUCUUUCAGACUG

596 6029 AAG UUGG U AAACCU AG ACCACCACU U AACC

597 6030 GGUAAUUAUAAUUACCUGUAUAGAUUGUUU

598 6061 AUUGUAGCUAUCGUAGUAACAUGCCUUGCC

599 6109 GCAAGGUUACAAGAGUGUGAAUAUCACUUU

600 6136 AUUGUACAG A A AG U G U G U U AAA U CC AG AG A 601 6150 AAGUUGGAAAAGAUGGCUGAUCAAGCUAUG 602 6165 ACG U U G AAA UCCUUCACUGUAG A A A A AG G A

603 6188 CGGUAAAUUUUGUCUAGAGGCUUCAUUUAA

604 6190 GGGUUUUGUCGUGCCUGGUUUGCCUGGCAC

605 6193 CCAGUAACUUUAGCUUGUUUUGUGCUUGCU

606 6211 AGGUGAGUUAGGUGAUGUUAGAGAAACAAU

607 6221 AAAACACGUCUAUCAGUUACGUGCCAGAUC

608 6224 CCUACCAUUUAAUGAUGGUGUUUAUUUUGC

609 6234 CUCUCAGCCUUUUCUUAUGGACCUUGAAGG

610 6290 AAGUUGCAGUUAAAAUGUUUGAUGCUUACG 611 6292 CUGCUUUUGCAAUGAUGUUUGUCAAACAUA 612 6297 AUGAGCAGUAUAUAAAAUGGCCAUGGUACA

613 6303 GGUUACUUACCCCAAAAUGCUGUUGUUAAA

614 6310 AACUGGUACUAUCUAUACAGAACUGGAACC

615 6344 GCAACUGUACAUACAGCUAAUAAAUGGGAU

616 6355 CCAGUUACACAAUGACAUUCUCUUAGCUAA

617 6357 AUACCUUACAAUAGUGUAACUUCUUCAAUU

618 6371 AACUCGUCUAUCUUCUGCAGGCUGCUUACG

619 6381 GUGCUCAAGUAUUGAGUGAAAUGGUCAUGU

620 6388 AUGAGCUAUUAUUGUAAAUCACAUAAACCA 621 6395 GCAACUACUAGACAAGUUGUUAAUGUUGUA 622 6402 CGUGGUAAGAGAAUUCCUUACACGUAACCC

623 6411 GAUGUGCUAUUACCUCUUACGCAAUAUAAU

624 6420 AGGUCUUAUCAGAGGCACGUCAACAUCUUA

625 6433 GCAACCU U ACAAGCU AU AGCCUCAG AG U U U

626 6444 ACAAUUAUGAACCUCUAACACAAGACCAUG

627 6448 AACUGGGCCAGAAGCUGGACUUCCCUAUGG

628 6484 ACAAU U AU U AU AAG AAAG ACAAU UCU U AU U

629 6486 AGGCUGUGUGUUCUCUUAUGUUGGUUGCCA

630 6504 GCAACAUUACCUAAAGGCAUAAUGAUGAAU Sequence in priority

SEQ ID NO document Sequence

631 6510 GGGUUUUACACUUAAAAACACAGUCUGUAC

632 6512 GUGAUGGUACAACAUUUACUUAUGCAUCAG

633 6520 AUUGGCUUCGAUGUCGAGGGGUGUCAUGCU

634 6533 GAUGUGGUGGCUAUUGAUUAUAAACACUAC

635 6535 ACAAUUCACCUAAUUUAGCAUGGCCUCUUA

636 6557 AUGAGGCUGGUUCUAAAUCACCCAUUCAGU

637 6572 AUGGUUAUGUUCACACCUUUAGUACCUUUC

638 6597 GCAAAUUGAUAGGUUGAUCACAGGCAGACU

639 6603 CCAUAGUUACGGCGCCGAUCUAAAGUCAUU

640 6605 AGGUCCCAAACAAGCUAGUCUUAAUGGAGU

641 6618 ACAAUUCUGUGAUGCCAUGCGAAAUGCUGG

642 6619 CGAAAUACCAGUGGCUUACCGCAAGGUUCU

643 6620 AUUAUUGCUAUGUCUGCUUUUGCAAUGAUG

644 6625 GAACAAUGCUAGGGAGAGCUGCCUAUAUGG

645 6630 CCUACAUUACAGGUGGUGUUGUUCAGUUGA

646 6634 AUUGGCAACUAUAAAUUAAACACAGACCAU

647 6635 ACUAAGAGGUUUGAUAACCCUGUCCUACCA

648 6649 GUAUAACACGUUGCAAUUUAGGUGGUGCUG

649 6662 CCU UGUCCCUCAUGUGGGCG AAAU ACCAGU

650 6673 AUUGGAGUUACACAGAAUGUUCUCUAUGAG

651 6674 AGAAGGUUCCGAAGGUCUUAAUGACAACCU

652 6682 CACAU U AAU UGG AG AAGCCG UAAAAACACA

653 6715 CUCAGAAUAUGACUAUGUCAUAUUCACUCA

654 6719 GAGCUUUAUCACUACCAAGAGUGUGUUAGA

655 6730 CGUGCCUGGUUUGCCUGGCACGAUAUUACG

656 6758 CACAUG U UG ACACUG ACU UAACAAAGCCU U

657 6802 GCAAACUUUAAUGUUUUAUUCUCUACAGUG

658 6820 GCAAACUGGAAAGAUUGCUGAUUAUAAUUA

659 6831 CCGAACAACUGGACUUUAUUGACACUAAGA

660 6839 AAGUUCUAUGAUGCACAGCCUUGUAGUGAC 661 6882 GAACUCAUGCGUGAGCUUAACGGAGGGGCA 662 6892 AGAAAACCCAGAUAUAUUACGCGUAUACGC

663 6897 ACUAAUUAUAUGCCUUAUUUCUUUACUUUA

664 6904 AUUGCUGGACACCAUCUAGGACGCUGUGAC

665 6908 GCUGCU AAAAAG AAU AACU UACCUUU UAAG

666 6913 CACAUGGCUUUGAGUUGACAUCUAUGAAGU

667 6923 GAUGUUAGAGAAACAAUGAGUUACUUGUUU

668 6940 GGUUUCUCAAUCGAUUUACCACAACUCUUA

669 6949 GGGUGAUGUUGUUCAAGAGGGUGUUUUAAC

670 6969 ACUACAAAAGAGAUGCUCCAGCACAUAUAU

671 6976 GCAAAAGUUACUAGUGCUAUGCAGACAAUG

672 6987 AGGUAUGAGCUAUUAUUGUAAAUCACAUAA

673 7002 AG U UG U U AAUCCAG U A A U G G A ACC A A U U U A

674 7009 AUUGCUACUGUACGUGAAGUGCUGUCUGAC

675 7010 AAUUGGAACAAGCAAAUUCUAUGGUGGUUG Sequence in priority

SEQ ID NO document Sequence

676 7029 ACUACACAAACUGCUUGCACUGAUGACAAU

677 7030 CCAUGGUAAUGCACAUGUAGCUAGUUGUGA

678 7036 CCAUGGUACAUUUGGCUAGGUUUUAUAGCU

679 7039 CUUUAGCUUGUGGGUUUACAAACAAUUUGA

680 7048 AGGCUUGAUGUGGCUCAGCUACUUCAUUGC 681 7050 CCAUG U AG AAACAU U U UACCCAAAAU U ACA 682 7056 AACACU U U U ACAAG ACU UCAG AG U U U AG AA

683 7057 AGUUGUGUUUUAAGCGGACACAAUCUUGCU

684 7068 GAUGUUCUUGUUAACAACU A A ACG A AC A A U

685 7070 CCAUGUGAGUCUCAUGGAAAACAAGUAGUG

686 7075 CUUUAGCUAUAGAUGCUUACCCACUUACUA

687 7076 GCUUUGUUAAGCGUGUUGACUGGACUAUUG

688 7094 AAUUGUCAACAACACAGUUUAUGAUCCUUU

689 7132 GGGUUUAUACAACAAAAGCUAGCUCUUGGA

690 7148 AUUGCCCUAUUUUCUUCAUAACUGGUAAUA

691 7150 ACUACCAACUCAAACUGUUGAUUCAUCACA

692 7155 GCUGCCGGUACUACACAAACUGCUUGCACU

693 7157 ACUACCACACAACUGAUCCUAGUUUUCUGG

694 7158 AACACAAAGG AAU U U U U AUG AACCACAAAU

695 7163 AAGGGUGGUCGCACUAUUGCCUUUGGAGGC

696 7177 AGGUAGGUUUGUACUUGCACUGUUAUCCGA

697 7198 CCCUUGGGAUACUAUAGCUAAUUAUGCUAA

698 7201 GAACUCGUAAUCGGAGCUGUGAUCCUUCGU

699 7223 CGGUGAUGCUGCUCUUGCUUUGCUGCUGCU

700 7224 AAGUUCAAGAACUUUACUCUCCAAUUUUUC

701 7230 ACAAUUUUUAAAGAUGCUUCUGGUAAGCCA

702 7232 AUUGCAUAGACGGUGCUUUACUUACAAAGU

703 7254 GGGUU U ACAAACAAU U UG AU ACU U AU AACC

704 7259 CGGUGCACCAACAAAGGUUACUUUUGGUGA

705 7268 CCUCUUAUUGUAACAGCUUUAAGGGCCAAU

706 7281 GUAAUUUCAAAAAUCUUAGGGAAUUUGUGU

707 7283 CUUGUAGAAAGGUUCAACACAUGGUUGUUA

708 7286 AAAACAAGUAGUGUCAGAUAUAGAUUAUGU

709 7292 GGUGAGACACUUGGUGUCCUUGUCCCUCAU

710 7311 CUUUAGAACCAUUGGUAGAUUUGCCAAUAG

711 7313 GAUGUUGUAAUAGGAAUUGUCAACAACACA

712 7325 CUUGUAGGCUUGAUGUGGCUCAGCUACUUC

713 7336 AGAAUCAUCAUCUAAAUUGUGGGCUCAAUG

714 7349 AAGACCUUAAAUUCCCUCGAGGACAAGGCG

715 7351 CUUGUAGUGCGUUGUUCGUUCUAUGAAGAC

716 7360 AACCAUUACAGAUGCUGUAGACUGUGCACU

717 7374 ACUACUCCCACCCAAGAAUAGCAUAGAUGC

718 7376 CUCUCAAUGACUUCAGUAACUCAGGUUCUG

719 7381 GGGUGGUAGUUGUGUUUUAAGCGGACACAA

720 7388 CACAUCAAUCUGACAUAGAAGUUACUGGCG Sequence in priority

SEQ ID NO document Sequence

721 7399 GAUUUGUUAAAAUAUGACUUCACGGAAGAG m 7412 AGUUGUGAUCAACUCCGCGAACCCAUGCUU

123 7419 GAUGUUGUUCAAGAGGGUGUUUUAACUGCU

724 7437 AGGUACAUGUCAGCAUUAAAUCACACUAAA

725 7459 CUUUACUGGUUAUCGUGUAACUAAAAACAG

726 7482 ACUACUUUAGAUUCGAAGACCCAGUCCCUA

727 7491 GCUGCAUUACAAAUACCAUUUGCUAUGCAA

728 7513 CCCUGUUGCUAUUCAUGCAGAUCAACUUAC

729 7515 AUGAUGAUGGUGCUAGGAGAGUGUGGACAC

730 7521 ACUAGAAGGUUCUGUUGCUUAUGAAAGUUU

731 7550 ACACAACUAU UACAG UUAAUGUUUUAGCUU

732 7555 AUGCAUCAGCUGUAGUGUUACUAAUCCUUA

733 7561 CCCAAACAAGCUAGUCUUAAUGGAGUCACA

734 7599 AGUUGUCUCAAGGGCUGUUGUUCUUGUGGA

735 7610 CCCAAAUGUUAACAAAGGUGAAGACAUUCA

736 7619 AUUGAGUGAAAUGGUCAUGUGUGGCGGUUC

737 7624 GGAUGGUUAUGUUCACACCUUUAGUACCUU

738 7642 ACUAGCUAAACG U U U U AAGG AAUCACCU U U

739 7663 AGGUAAAGGCUUUUGCAAACUACACAAUUG

740 7681 AAUGUCCAAAUUUUGUAUUUCCCUUAAAUU

741 7682 GAUUUCAUACAAACCACGCCAGGUAGUGGA

742 7685 GGUGACGGUAAAAUGAAAGAUCUCAGUCCA

743 7686 AUUGACUGUAGUGCGCGUCAUAUUAAUGCG

744 7687 CUUGUCUGUUAAUCCGUAUGUUUGCAAUGC

745 7700 CUUGUCUUGUAGGCUUGAUGUGGCUCAGCU

746 7708 AUGCUGCUGACCCUGCUAUGCACGCUGCUU

747 7716 GCUGCAGCUUAUUAUGUGGGUUAUCUUCAA

748 7748 AACACAUGGCUUAAAUUUGGAAGAAGCUGC

749 7749 CCCAAUUUCACUAUUAAGGGUUCAUUCCUU

750 7790 ACACAAUCUUGCUAAACACUGUCUUCAUGU

751 7822 GUAUUAUUGCUAUGUCUGCUUUUGCAAUGA

752 7827 AC AC A A U U A A ACCG UGCUUUAACUGGAAUA

753 7830 AUUCACUGAGACUCAUUGAUGCUAUGAUGU

754 7833 GCUUUGGUUUAUGAUAAUAAGCUUAAAGCA

755 7835 G AU U U ACAACCAU U AG AACAACCU ACU AG U

756 7844 C AG AC A A A UCGCUCCAGGG C A A AC U G G AAA

757 7852 CGUAUUUGUCUUAUGGGCACAUGGCUUUGA

758 7864 CGGUUCACUAUAUGUUAAACCAGGUGGAAC

759 7869 GAUUUAACUGCUUUUGGCUUAGUUGCAGAG

760 7870 GGCUAAAUCUGAAUUUGACCGUGAUGCAGC

761 7871 AUGAUGUGUU AC A A ACG U A A U AG AG C A AC A

762 7872 CUUGUGCUGCCGGUACUACACAAACUGCUU

763 7881 CCCUG C AC A AG A A A AG A AC UUCACAACUGC

764 7933 CCCUGAUGGCUACCCUCUUGAGUGCAUUAA

765 7944 ACACACACUGGUACUGGUCAGGCAAUAACA Sequence in priority

SEQ ID NO document Sequence

766 7963 AAAAGCACACUUUCCUCGUGAAGGUGUCUU

767 8002 AGACGGUUGUAAUUCAUCAACUUGUAUGAU

768 8011 GAUUGUGCAACUGUACAUACAGCUAAUAAA

769 8024 ACUAUCUAUACAGAACUGGAACCACCUUGU

770 8026 GAUUGUGAAGAAGAAGAGUUUGAGCCAUCA

771 8027 ACACACCACUGGUUGUUACUCACAAUUUUG

772 8057 AC U A U G ACC A A UAGACAGUUUCAU C A A A A A

773 8060 CUUGUGUUCUUUGCAAUUCACAGACUUCAU

774 8063 ACACACCGCAUACAGUCUUACAGGCUGUUG

775 8064 AGCUAGUCAAUCCAUCAUUGCCUACACUAU

776 8072 AAG U U AAGCCAU U U AU AACUG AAAG UAAAC 111 8077 GAUUGUACAGAAAGUGUGUUAAAUCCAGAG

778 8101 GAUUACAUUUUAGCUAACACCUGUACUGAA

779 8106 AUUCUGUUAUGCUUACUAAUGAUAACACUU

780 8136 GGCUAACUAACAUCUUUGGCACUGUUUAUG

781 8180 CGUAUACAGGGCUUUUGACAUCUACAAUGA

782 8192 GGGUUAUCUUCAACCUAGGACUUUUCUAUU

783 8204 AUG U U U UCU ACAAAG AAAACAG U UACACAA

784 8254 GAUUGCCUUGGUGAUAUUGCUGCUAGAGAC

785 8258 AUGAUUUCGGUGAUUUCAUACAAACCACGC

786 8267 CCCUCAUGUGGGCGAAAUACCAGUGGCUUA

787 8270 AUGAUUUC U CCA A AC A A U U G C A AC A A U CC A

788 8274 CGUAGUGGUGAGACACUUGGUGUCCUUGUC

789 8285 CACAGGUGUUCUUACUGAGUCUAACAAAAA

790 8295 ACU AU U AAGG UG U U U ACAACAG U AG ACAAC

791 8313 CGUAAAACACGUCUAUCAGUUACGUGCCAG

792 8325 ACUAUUACCGUUGAAGAGCUUAAAAAGCUC

793 8371 AGCUAAAUUGUUACAUAAACCUAUUGUUUG

794 8383 ACUUUUGAAGAAGCUGCGCUGUGCACCUUU

795 8391 GCUUUGGACAUAUCAGCAUCUAUAGUAGCU

796 8396 CUUUAAUGGUGUUUCCUUUAGUACUUUUGA

797 8397 AUGAUUUUGUAGAAAACCCAGAUAUAUUAC

798 8403 GAGGUAGGUUUGUACUUGCACUGUUAUCCG

799 8408 ACUAUUGAAUAUCCUAUAAUUGGUGAUGAA

800 8411 GAUUCUUCUUCAGGUUGGACAGCUGGUGCU 801 8413 GGUACUGCUGUUAUGUCUUUAAAAGAAGGU 802 8432 CCCCGAUUUCAGCUAUGGUUAGAAUGUACA

803 8437 AUUCUACACUCCAGGGACCACCUGGUACUG

804 8457 AUGCAAAAGUAUUCUACACUCCAGGGACCA

805 8467 GAUUCUGAAGUUGUUCUUAAAAAGUUGAAG

806 8498 AAUGUCGCGCAUUGGCAUGGAAGUCACACC

807 8500 CAGACCUCGUCUAUGCUUUAAGGCAUUUUG

808 8505 AG AC A U A A AC A AG C U U U G U G A AG A A A U G C U

809 8506 GAGUCUCAUGGAAAACAAGUAGUGUCAGAU

810 8511 AGGGGCAUACACUCGCUAUGUCGAUAACAA Sequence in priority

SEQ ID NO document Sequence

811 8531 GAGUUAGGUGAUGUUAGAGAAACAAUGAGU

812 8557 CACAGGCACUAGUACUGAUGUCGUAUACAG

813 8572 ACUUUUCUAUUAAAAUAUAAUGAAAAUGGA

814 8583 GAUUAUCCUAAAUGUGAUAGAGCCAUGCCU

815 8584 ACUCAACAUCAACCAUAUGUAGUUGAUGAC

816 8586 GUGUACCUCAAGCUGAUGUAGAAUGGAAGU

817 8611 ACUCAACUCAAUUGAGUACAGACACUGGUG

818 8617 CAGACGGGCGAUUUUGUUAAAGCCACUUGC

819 8640 CCCUACUUAUUGUUAAUAACGCUACUAAUG

820 8642 AACACUAAACAUAGCAGUGGUGUUACCCGU 821 8657 CAGACGUGGUCCAGAACAAACCCAAGGAAA 822 8673 CUUUAAAAGAAGGUCAAAUCAAUGAUAUGA

823 8679 ACUCAAUGGUCUUUGUUCUUUUUUUUGUAU

824 8708 GAUUCAACUGAAUGCAGCAAUCUUUUGUUG

825 8720 GAGGACAAUCAGACAACUACUAUUCAAACA

826 8724 GUAUUAAAAUACAAGAGGGUGUGGUUGAUU

827 8726 GAUUAUUUUGUGCUGACAUCACAUACAGUA

828 8734 AAGUCUAAUCAUAAUUUCUUGGUACAGGCU

829 8736 GGUGAAACUUCAUGGCAGACGGGCGAUUUU

830 8737 CUCUAUUAUUCAAUUUCCUAACACCUACCU

831 8756 AUGCUGAUGUCUUUCAUUUGUACUUACAAU

832 8763 AAGUCUAAUCUCAAACCUUUUGAGAGAGAU

833 8797 CUUUAACUGCAGAGUCACAUGUUGACACUG

834 8837 AAUCACUGGGUUACAUCCUACACAGGCACC

835 8849 CAGACUUCAAAGUUUGCAGACAUAUGUGAC

836 8865 CUCAAUGUGUCCAGUUACACAAUGACAUUC

837 8876 CGACCCUGCUCAAUUACCUGCACCACGCAC

838 8890 AUACGCCAACUUAGGUGAACGUGUACGCCA

839 8898 CAGAGACAUUGCUGACACUACUGAUGCUGU

840 8904 CACAGAUGUGACUCAACUUUACUUAGGAGG

841 8909 AAUGCCAUUAAGUGCACCUACACUAGUGCC

842 8921 G U ACG U U G A A A UCCUUCACUGU AG A A A A AG

843 8924 GCUGACUCUAUCAUUAUUGGUGGAGCUAAA

844 8926 GCUGACUCAACUCAGGCCUAAACUCAUGCA

845 8929 CUGGAUUUUUGGUACUACUUUAGAUUCGAA

846 8932 GAGUUCAGAGUUUAUUCUAGUGCGAAUAAU

847 8936 GUCUGAUGUUGGUGAUAGUGCGGAAGUUGC

848 8937 AUGGCUCUAUUAUUCAAUUUCCUAACACCU

849 8945 ACACAUGUUAGACAUGUAUUCUGUUAUGCU

850 8950 GCUGACCCUAUACAUUCUUUAAGAGUUUGU

851 8954 CACAGACU U AG AAGG UAACU U U U AUGG ACC

852 8974 GCUGACAUCACAUACAGUAAUGCCAUUAAG

853 8982 AUAUAAAAUGGCCAUGGUACAUUUGGCUAG

854 8987 CUGGCAAUGGCGGUGAUGCUGCUCUUGCUU

855 8990 AAAU G AAG AG UGAAAAG CAAG U U G AAC AAA Sequence in priority

SEQ ID NO document Sequence

856 9006 AAUCACCUUUUGAAUUAGAAGAUUUUAUUC

857 9007 CAGAGGACGCGCAGGGAAUGGAUAAUCUUG

858 9009 CACACUUUCU U AUG AACAAU U UAAGAAAGG

859 9015 ACU U U U ACU AG AAG U ACAAAU UCU AG AAU U

860 9032 AACCAUACAGGUGUUGUUGGAGAAGGUUCC 861 9042 AGUUGCCUUUAAUACUUUACUAUUCCUUAU 862 9055 AGCUAGUUGUGAUGCAAUCAUGACUAGGUG

863 9056 AAAGG U AG ACU U AU AAU U AG AG AAAACAAC

864 9074 GCUGAACAUGUCAACAACUCAUAUGAGUGU

865 9078 CUCAAGGGCUGUUGUUCUUGUGGAUCCUGC

866 9122 CAGAGUGUGUACUUGGACAAUCAAAAAGAG

867 9125 ACACCAUCUAGGACGCUGUGACAUCAAGGA

868 9133 AUAAAUUAGAAGGCUAUGCCUUCGAACAUA

869 9142 ACUUUUAAAAGAACCUUGCUCUUCUGGAAC

870 9150 AAUUUGCGAGAAAUGCUUGCACAUGCAGAA

871 9154 CACACCUUCGGGAACGUGGUUGACCUACAC

872 9162 AG U UGCACCAGG U ACAGCUG U U U U AAG ACA

873 9175 AAAACAACUGUAGCGUCACUUAUCAACACA

874 9178 CAGAUAACAACUGUUAUCUUGCCACUGCAU

875 9179 GAAAAUAGGACCUGAGCGCACCUGUUGUCU

876 9186 GAAAAUACUCAAUAAUUUGGGUGUGGACAU

877 9203 AGACUCCGUGGAGGAGGUCUUAUCAGAGGC

878 9248 CAGAUAUAGAUUAUGUACCACUAAAGUCUG

879 9256 AUAUAAUUAAGUUAAUUUUCCUCUGGCUGU

880 9279 AGUUGAUGACCCGUGUCCUAUUCACUUCUA 881 9283 CACACACUGG U U UG U AACACAAAGG AAU U U 882 9309 CCGUGAUCCACAGACACUUGAGAUUCUUGA

883 9316 AAAAGUUAUGUGCAUGUUGUAGACGGUUGU

884 9328 GCUCUGCCUAUACAGUUGAACUCGGUACAG

885 9344 CUCUAUAGAAAUAGAGAUGUUGACACAGAC

886 9362 CACAAUUCAGAAGUAGGACCUGAGCAUAGU

887 9369 GGCUAGCAUAAAGAACUUUAAGUCAGUUCU

888 9378 CAGAUGCUGUCAUAAAAACUUUGCAACCAG

889 9391 GGCACUACUGAAAUGCUAGCGAAAGCUUUG

890 9402 AAAUGAGUUCGCCUGUGUUGUGGCAGAUGC

891 9418 CAGAUGUAAAGUGCACAUCAGUAGUCUUAC

892 9424 AGACAGGUGGUUUCUCAAUCGAUUUACCAC

893 9432 GUGGUCGCACUAUUGCCUUUGGAGGCUGUG

894 9434 GAGACACUUGGUGUCCUUGUCCCUCAUGUG

895 9443 CUCUAGUCAGUGUGUUAAUCUUACAACCAG

896 9446 ACACGAGUAACUCGUCUAUCUUCUGCAGGC

897 9476 AGAAAAGCUGUCUUUAUUUCACCUUAUAAU

898 9496 ACACGGAACGUUCUGAAAAGAGCUAUGAAU

899 9501 GAGUUUAAAUUGGCUUCACAUAUGUAUUGU

900 9503 GCUCGUGUAGAGUGUUUUGAUAAAUUCAAA Sequence in priority

SEQ ID NO document Sequence

901 9510 AAUUUGGUGCCACUUCUGCUGCUCUUCAAC

902 9516 GGCUAUAAAGAUAACAGAACAUUCUUGGAA

903 9522 CAG AU UCCAACGG U ACU AU U ACCG U UG AAG

904 9535 GCUCGUACGUGGCUUUGGAGACUCCGUGGA

905 9544 AAAAUUGUUCAACUUAGUGAAAUUAGUAUG

906 9565 GGCACUGAGAAUUUGACUAAAGAAGGUGCC

907 9572 G A AG A A A UGCUGGACAACAGGG C A ACC U U A

908 9584 GUGAUGAUUAUGUGUACCUUCCUUACCCAG

909 9589 CUAUUUUUGUACUUGUUACUUUGGCCUCUU

910 9593 GUGAUAUCAGACAACUACUAUUUGUAGUUG

911 9613 AGAAGCUGUUAUGUACAUGGGCACACUUUC

912 9622 AGACUGUGCACUUGACCCUCUCUCAGAAAC

913 9623 AAAAUUGUUAAUAAUUGGUUGAAGCAGUUA

914 9629 AAUGCACAUGUAGCUAGUUGUGAUGCAAUC

915 9652 CCGGUAGCACACCUUGUAAUGGUGUUGAAG

916 9653 C AC A AC A U G U U A A A A AC UGUUUAUAGUGAU

917 9671 CACAACAAGUCCUAUUUCUGAACAUGACUA

918 9681 GUCCU UGUCCCUCAUGUGGGCGAAAUACCA

919 9706 G A A A AG C A AG U U G A AC A A A AG AUCGCUGAG

920 9707 G AAG AAG AAG AG U U UG AGCCAU C A AC U C A A

921 9713 AAGUAUGUACAAAUACCUACAACUUGUGCU

922 9731 CGGCAGUCAAGCCUCUUCUCGUUCCUCAUC

923 9732 GGCUAUGAAGUACAAUUAUGAACCUCUAAC

924 9740 AG ACU U AU AAU U AG AG AAAACAACAG AG U U

925 9741 GCUUUAUUAGAAGAUGAAUUUACACCUUUU

926 9759 AGACUUAUGAAAACUAUAGGUCCAGACAUG

927 9760 CAGCACCACCUGCUCAGUAUGAACUUAAGC

928 9767 AAAGCUUCAUGCACUUUGUCCGAACAACUG

929 9775 CAGCACCUCAUGGUGUAGUCUUCUUGCAUG

930 9787 AGACUUAUUUAGAAAUGCCCGUAAUGGUGU

931 9812 A A U G C A AC AG A AG UGCCUGCCAAUU C A AC U

932 9818 AUGUUAACUGCACAGAAGUCCCUGUUGCUA

933 9820 GUGGACACUUAUGAAUGUCUUGACACUCGU

934 9822 AAACCUUUGGAAUUUGGUGCCACUUCUGCU

935 9846 GCUCAUGGAUGGCUCUAUUAUUCAAUUUCC

936 9857 AAUUUGUGUUUAAGAAUAUUGAUGGUUAUU

937 9858 GAAAAGAACAAUCAAGGGUACACACCACUG

938 9864 CUGGUAACUGUGAUGUUGUAAUAGGAAUUG

939 9881 AUACGUUGUCUUUGGAG C AC A A A ACC AG U U

940 9882 CUAUUUGAACUCUACUAAUGUCACUAUUGC

941 9891 GUCCUUAGACAAUGUCUUAUCUACUUUUAU

942 9895 CUGGUAAUGUUCAACUCAGGGUUAUUGGAC

943 9907 AGUUCCUGUUGUAGAUUCUUAUUAUUCAUU

944 9911 ACUUUCUUUUGAACUUCUACAUGCACCAGC

945 9912 GAGAAGGCAUUAAAAUAUUUGCCUAUAGAU Sequence in priority

SEQ ID NO document Sequence

946 9924 GUACAUUGGCGACCCUGCUCAAUUACCUGC

947 9956 AGCGUCACUUAUCAACACACUUAACGAUCU

948 9957 CAAUUUCAACUUCAAUGGUUUAACAGGCAC

949 9959 ACACUGGUAAUUACCAGUGUGGUCACUAUA

950 9969 GCUCAGAAUAUGACUAUGUCAUAUUCACUC

951 9984 AAAUGCAUUGCCUGAGACGACAGCAGAUAU

952 9999 C AG C A U U AAA U C AC AC U A A A A AG U G G AAA U

953 10042 GCUCAAUGUGUCCAGUUACACAAUGACAUU

954 10050 AAUUU UAAAG U U AC A A A AG G A A A AG C U AAA

955 10067 AGUUCAUGCUGGCACAGACUUAGAAGGUAA

956 10071 GAAGAAUCAUCUGCAAAAUCAGCGUCUGUU

957 10076 GCUCAAGUAUUGAGUGAAAUGGUCAUGUGU

958 10095 AAUUUUAACAAAGACUUCUAUGACUUUGCU

959 10096 ACACUUAUGAAUGUCUUGACACUCGUUUAU

960 10101 ACACUUAUGAUUGAACGGUUCGUGUCUUUA

961 10115 GGCAGAUGCUGUCAUAAAAACUUUGCAACC

962 10129 AAAUGCCG U UCCAAAAACCCAU U ACU U U AU

963 10130 ACACUUCGCAUGGUGGACAGCCUUUGUUAC

964 10141 AAAACAUUUUAUGUUUUACCUAAUGAUGAC

965 10166 GAUAAAAGUGUAUAUUACACUAGUAAUCCU

966 10185 GUACCUCAAGCUGAUGUAGAAUGGAAGUUC

967 10204 GGCUAUUGAUUAUAAACACUACACACCCUC

968 10216 CUAUUGAUUAUAAACACUACACACCCUCUU

969 10223 GCUAUUGGCAAAAUUCAAGACUCACUUUCU

970 10226 CGCAACAGUUCAAGAAAUUCAACUCCAGGC

971 10229 ACACUUUGAUGGACAACAGGGUGAAGUACC

972 10246 GUCUAUGACCAAGACAUCAGUAGAUUGUAC

973 10247 GGUGUUUAUUACCCUGACAAAGUUUUCAGA

974 10286 GAAGACAUUCAACUUCUUAAGAGUGCUUAU

975 10291 ACAGAAAGUGUGUUAAAUCCAGAGAAGAAA

976 10292 GGAAUGUCCAAAUUUUGUAUUUCCCUUAAA

977 10293 GCUUUACUU AC A A AG U CC U C AG A A U AC A A A

978 10303 ACAG AAAU UG ACCCU AAG UUGGACAAU U AU

979 10322 ACUUUAUUGACACUAAGAGGGGUGUAUACU

980 10324 CUGGUGAAGCUGCUAACUUUUGUGCACUUA

981 10327 GGAGUUCCUGUUGUAGAUUCUUAUUAUUCA

982 10331 GCUAUUACCUCUUACGCAAUAUAAUAGAUA

983 10334 AUACAUUAAAAAUGCAGACAUUGUGGAAGA

984 10337 GAGUGCUUUGGUUUAUGAUAAUAAGCUUAA

985 10351 ACAGAAGUAAAUGAGUUCGCCUGUGUUGUG

986 10375 CUGGUGAGUUUAAAUUGGCUUCACAUAUGU

987 10400 GAGAAAAAUAUUUGUUGAUGGUGUUCCAUU

988 10401 AAAAACACAG U UCAAU U AU U AU AAG AAAG U

989 10408 GACUUUUUGCAUUUCUUACCUAGAGUUUUU

990 10416 AUUAAAAUACAAGAGGGUGUGGUUGAUUAU Sequence in priority

SEQ ID NO document Sequence

991 10456 ACAGACACUGGUGUUGAACAUGUUACCUUC

992 10481 AAUAUUGGUGAACAGAAAUCAAUACUGAGU

993 10483 GUACGCUGCUUGUCGAUUCAGAUCUUAAUG

994 10487 CUGGUGGCACUACUGAAAUGCUAGCGAAAG

995 10509 AUAUGAGAUCUCUCAAAGUGCCAGCUACAG

996 10521 GCUAUGCAGACAAUGCUUUUCACUAUGCUU

997 10534 GGUGUUGUUCAGUUGACUUCGCAGUGGCUA

998 10544 ACAGACUUUUUCAGUGUUAGCUUGUUACAA

999 10558 AAUGAUCCAUUUUUGGGUGUUUAUUACCAC 1000 10562 AGCUGCAUUUCACCAAGAAUGUAGUUUACA 1001 10563 GCUAUGAGGCCCAAUUUCACUAUUAAGGGU 1002 10567 GCUUUAACUGGAAUAGCUGUUGAACAAGAC

1003 10568 GCUUUAACUGCAGAGUCACAUGUUGACACU

1004 10582 AAAGGGCUAUCAUCUUAUGUCCUUCCCUCA

1005 10591 GGUUUUAAUUU U UCACAAAU AU UACCAGAU

1006 10601 CAGCUGAUGCACAAUCGUUUUUAAACGGGU

1007 10606 GUCCUAUUCACUUCUAUUCUAAAUGGUAUA

1008 10607 GCUAUCUAACCUUAACUUGCCUGGUUGUGA

1009 10610 AAAUGCUGUUACGACCAUGUCAUAUCAACA

1010 10616 AGUUAUACUAAUGACAAAGCUUGCCCAUUG 1011 10631 GG U U U U ACAGG U A ACC U AC A A AG C A ACC A U 1012 10642 GGCUCAGCUACUUCAUUGCUUCUUUCAGAC

1013 10652 GCUAUCAUCUUAUGUCCUUCCCUCAGUCAG

1014 10713 GUCUUUGUUUCAAAUGGCACACACUGGUUU

1015 10730 AUUAAACAACCUAAAUAGAGGUAUGGUACU

1016 10732 CAGCUUAUGUGUCAACCUAUACUGUUACUA

1017 10749 GUGAAGUACCAGUUUCUAUCAUUAAUAACA

1018 10789 ACAGAUUGUAUCUCGAUGCUUAUAACAUGA

1019 10825 GACUUUAAACUUAAUGAAGAGAUCGCCAUU

1020 10845 AG U U AG AU AAAU AU U U U AAG AAUCAU ACAU 1021 10852 AUAUGCGCUAGUUAUCAGACUCAGACUAAU 1022 10857 AG A A AG G U U C A AC AC AU G G U U G U U A A AG C U

1023 10869 GGUUGUUAAUGCAGCCAAUGUUUACCUUAA

1024 10879 CAAUGGCGGUGAUGCUGCUCUUGCUUUGCU

1025 10899 CUGGUUCUAAAUCACCCAUUCAGUACAUCG

1026 10909 AAUUGUGUUAAUUGUGAUACAUUCUGUGCU

1027 10922 AGCUAUCGUAGUAACAUGCCUUGCCUACUA

1028 10924 AAUGUGGCAACUUUACAAGCUGAAAAUGUA

1029 10926 GCUAGUGAGUACACUGGUAAUUACCAGUGU

1030 10939 AUACUAUAGCUAAUUAUGCUAAGCCUUUUC

1031 10962 AAUGUAAACAGAUUUAAUGUUGCUAUUACC

1032 10994 GCUAGGAGAGUGUGGACACUUAUGAAUGUC

1033 10996 G A A AC A UUUGUCACGCACU C A A AG G G A U U G

1034 11003 AAAUAAGGGACACUUUGAUGGACAACAGGG

1035 11006 ACAGCCUUUGUUACUAAUGUGAAUGCGUCA Sequence in priority

SEQ ID NO document Sequence

1036 11020 GCUAGCGCUAACAUAGGUUGUAACCAUACA

1037 11026 GUAGUCUUGUAGUGCGUUGUUCGUUCUAUG

1038 11028 GAAAUUAGUAUGGACAAUUCACCUAAUUUA

1039 11029 CAAUGCCAGAUUACGUGCUAAGCACUAUGU

1040 11032 GGCAGUUUGUAUGUAAAUAAACAUGCAUUC

1041 11042 CUGGUUUUAAGCUAAAAGACUGUGUUAUGU

1042 11050 GCUAGAUUUUACUUU U ACACCAG U AAAACA

1043 11054 GUAGUCUUUAAUGGUGUUUCCUUUAGUACU

1044 11061 GCUAGAUUCCCUAAGAGUGAUGGAACUGGU

1045 11069 AGUUACACAGAAUGUUCUCUAUGAGAACCA

1046 11103 GCUUGUGUUCUUUGCAAUUCACAGACUUCA

1047 11116 CUUUUUUGAUGGUAGAGUUGAUGGUCAAGU

1048 11138 A A AG G C U U U U G C A A AC U AC AC A A U U G G A A U

1049 11149 CUAUGUGAUAGACGUGCCACAUGCUUUUCC

1050 11157 CAAUGACAUAUGGACAACAGUUUGGUCCAA

1051 11159 CAGGCAAUAACAGUUACACCGGAAGCCAAU

1052 11174 AACAUGCCUUGCCUACUAUUUUAUGAGGUU

1053 11176 ACAGCUGGUGCUGCAGCUUAUUAUGUGGGU

1054 11182 GGAUCCUGCUGCAAAUUUGAUGAAGACGAC

1055 11187 ACAGCUGUUUUAAGACAGUGGUUGCCUACG

1056 11196 GAUAAUAUCAAAUUUGCUGAUGAUUUAAAC

1057 11206 AUAUGGUUGAUACUAGUUUGUCUGGUUUUA

1058 11209 AAUUGCUAUCGCAAUGGCUUGUCUUGUAGG

1059 11227 ACUUGUUCUUACCUUUCUUUUCCAAUGUUA

1060 11228 GGCAUACACUCGCUAUGUCGAUAACAACUU 1061 11230 CAAUCUUCAUCCAGAUUCUGCCACUCUUGU 1062 11254 AG G A A U AC A A A UCCAAUUCAGUUGUCUUCC

1063 11273 ACUUGUUACUUUGGCCUCUUUUGUUUACUC

1064 11282 AGUUAAGAGACACACUUUCUCUAACUACCA

1065 11287 GACUUAUGUCCCUGCACAAGAAAAGAACUU

1066 11294 AACGUGGUUGACCUACACAGGUGCCAUCAA

1067 11317 CUAUGUACACACCGCAUACAGUCUUACAGG

1068 11322 GGUUGACCUACACAGGUGCCAUCAAAUUGG

1069 11333 CUAUGUAACACAUGGCUUAAAUUUGGAAGA

1070 11393 GUCCCUUGGGAUACUAUAGCUAAUUAUGCU

1071 11411 CAAUCCAUCAUUGCCUACACUAUGUCACUU

1072 11426 AAGAAUAAUAAUGAGGCUUUGGCUUUGCUG

1073 11452 GGAAUUGCUAUCGCAAUGGCUUGUCUUGUA

1074 11466 GUCUCUAUAGAAAUAGAGAUGUUGACACAG

1075 11470 GUGAAUAUCACUUUUGAACUUGAUGAAAGG

1076 11479 GACUUAAAAGGUAAGUAUGUACAAAUACCU

1077 11481 ACAGGCUGGUAAUGUUCAACUCAGGGUUAU

1078 11488 AGGAAUGUGGCAACUUUACAAGCUGAAAAU

1079 11496 CUGUACUGCCGUUGCCACAUAGAUCAUCCA

1080 11516 AAU U U U U AUG AACCACAAAUCAU U ACU ACA Sequence in priority

SEQ ID NO document Sequence

1081 11517 AGUGUUUGUCUUAGUGGUUUAGAUUCUUUA

1082 11530 CUCUGGGACCAAUGGUACUAAGAGGUUUGA

1083 11542 CUGUAGACAUCAUGCUAAUGAGUACAGAUU

1084 11550 GCUUGUAUUGACUGUAGUGCGCGUCAUAUU

1085 11554 CAAUAU U U A A AC AC A U U A AC A U UAGCUGUA

1086 11571 CAGGGUUUAAAUGGUUACACUGUAGAGGAG

1087 11598 GGCUGAACAUGUCAACAACUCAUAUGAGUG

1088 11606 GUCUAGCUGUCCACGAGUGCUUUGUUAAGC

1089 11624 CUAUGCUUUAAGGCAUUUUGAUGAAGGUAA

1090 11639 GUAUAUUACACUAGUAAUCCUACCACAUUC

1091 11650 CAAUAGUGUUUAUAACACUUUGCUUCACAC

1092 11656 CGAUUUUGUUAAAGCCACUUGCGAAUUUUG

1093 11667 AGUGUUGGUUUUAACAUAGAUUAUGACUGU

1094 11676 GCUAAUGGACAAGUUUUUGGUUUAUAUAAA

1095 11677 AUAAAGAUUGUACAAAUGUUAAGUGACACA

1096 11682 GUGGACAUUGCUGCUAAUACUGUGAUCUGG

1097 11683 AAAUAUAAGGGUAUUAAAAUACAAGAGGGU

1098 11713 AUAUUACACUAGUAAUCCUACCACAUUCCA

1099 11716 AUUAGGUUUGAAAACCCUUGCUACUCAUGG

1100 11720 GCUAAUGACCCUGUGGGUUUUACACUUAAA 1101 11728 CUAUGCCUUCGAACAUAUCGUUUAUGGAGA 1102 11761 ACAGUACAG U U AAAAACU AU U UCAU AACAG

1103 11766 AUAUUAGAGUAGGAGCUAGAAAAUCAGCAC

1104 11790 CCGGCUGUUUUGUAGAUGAUAUCGUAAAAA

1105 11808 CUAUGCAGAUUCAUUUGUAAUUAGAGGUGA

1106 11843 AACCCUAAAGCUAUUAAGUGUGUACCUCAA

1107 11857 GACUGGACAAAUGCUGGUGAUUACAUUUUA

1108 11861 AAUGGUGACAAUUAUGCUUUGCUGUAUGAC

1109 11865 CAAUAACAGUUACACCGGAAGCCAAUAUGG

1110 11880 AUGGACAAUUCACCUAAUUUAGCAUGGCCU 1111 11882 GGUGUUACCCGUGAACUCAUGCGUGAGCUU 1112 11896 ACUUGGUAGUUUAGCUGCCACAGUACGUCU

1113 11904 ACAGUCUAAAAUGUCAGAUGUAAAGUGCAC

1114 11910 AAUGGCCUACAUUACAGGUGGUGUUGUUCA

1115 11921 GCUAAGCGCAACAUUAAACCAGUACCAGAG

1116 11935 AGUGUUACUAAUCCUUAUGACAGCAAGAAC

1117 11940 ACAGUGAACAAUGCUAGGGAGAGCUGCCUA

1118 11941 GCUAAGCACUAUGUGUACAUUGGCGACCCU

1119 11945 CUGUAUUAAUGCUAACCAAGUCAUCGUCAA

1120 11976 GUAGGUACAUGUCAGCAUUAAAUCACACUA 1121 11981 CAGUAACCAGAAUGGAGAACGCAGUGGGGC 1122 11987 AGUGUUAAAGGUUUACAACCAUCUGUAGGU

1123 11990 AGCGAUAAUGUUACUGACUUUAAUGCAAUU

1124 11991 CCUCAGAAUACAAAGGUCCUAUUACGGAUG

1125 12015 AC A A A A AG A AG A AG G CU G A U G A A AC U C A AG Sequence in priority

SEQ ID NO document Sequence

1126 12046 GUAUACAGCUUGCUCUCAUGCCGCUGUUGA

1127 12047 ACUUGGACAAUCAAAAAGAGUUGAUUUUUG

1128 12056 ACAGUUAAAAACUAUUUCAUAACAGAUGCG

1129 12061 CG G CCC A A A U G U U A AC A A AG GUGAAGACAU

1130 12067 GCUAACAAAGACGGCAUCAUAUGGGUUGCA

1131 12068 AAACUGUGAAAGGUUUGGAUUAUAAAGCAU

1132 12081 GAUACUAUAGCUAAUUAUGCUAAGCCUUUU

1133 12082 AAGCCAG U ACCAU AU UG U U AUG AU ACCAAU

1134 12097 AAUUCUAACAAUCUUGAUUCUAAGGUUGGU

1135 12108 GUGAUGCGUAUUAUGACAUGGUUGGAUAUG

1136 12114 AAACAGAUUUAAUGUUGCUAUUACCAGAGC

1137 12120 CUAUGACCAAGACAUCAGUAGAUUGUACAA

1138 12128 CCUCACUUGUUCUUGCUCGCAAACAUACAA

1139 12151 CUAUGAAGUACAAUUAUGAACCUCUAACAC

1140 12167 AUAAACUUUGUAAGAAUAAUAAUGAGGCUU

1141 12171 G C U A A ACC ACCG CCUGGAGAUCAAUUU AAA

1142 12199 AAACCU AG ACCACCACU U AACCG AAAU U AU

1143 12207 CUAUCUUCUGCAGGCUGCUUACGGUUUCGU

1144 12229 CAAGUCCAUGGUAAUGCACAUGUAGCUAGU

1145 12240 GG AAAU ACCCACAAG UUAAUGGUU UAACU U

1146 12262 CAGUCAAGCCUCUUCUCGUUCCUCAUCACG

1147 12268 GUCCAGUUACACAAUGACAUUCUCUUAGCU

1148 12269 GGAGUAUGGCUACAUACUACUUAUUUGAUG

1149 12299 GCGUUGUUCGUUCUAUGAAGACUUUUUAGA

1150 12315 CGCGAUCAAAACAACGUCGGCCCCAAGGUU

1151 12322 CAAGUAGACUUAUUUAGAAAUGCCCGUAAU

1152 12339 AGAGGAGG C A A AG ACAGUGCUU A A A A AG U G

1153 12342 G AU AG AAG UGCAAGG U U ACAAG AG UG UG AA

1154 12355 GAUAGACGUGCCACAUGCUUUUCCACUGCU

1155 12368 G G A AG A AG C U A A A A AG G U A A A ACC A AC AG U

1156 12392 GAUAGAGCCAUGCCUAACAUGCUUAGAAUU

1157 12394 GAAACUUCAUGGCAGACGGGCGAUUUUGUU

1158 12400 AGGACCUGAGCAUAGUCUUGCCGAAUACCA

1159 12401 AGUGUCUCCUACUAAAUUAAAUGAUCUCUG

1160 12433 G G U G U G U A A A AC UUGUGGACAACAGCAGAC 1161 12437 GCUUGCUGCUGUUUACAGAAUAAAUUGGAU 1162 12439 ACUUGCACUGUUAUCCGAUUUACAGGAUUU

1163 12446 AAACCUUCAGUUGAACAGAGAAAACAAGAU

1164 12459 G U ACGCCAAGCU U UG U U A A A A AC AG U AC A A

1165 12462 GCGUGUUUUACAGAAGGCCGCUAUAACAAU

1166 12482 AACAUCUGUUACACACCAUCAAAACUUAUA

1167 12493 GGACAACAGCAGACAACCCUUAAGGGUGUA

1168 12494 CUAUCCAGUUGCGUCACCAAAUGAAUGCAA

1169 12498 GGUUUUUGGCAUAUAUUCUUUUCACUAGGU

1170 12505 CAGUGAGGACAAUCAGACAACUACUAUUCA Sequence in priority

SEQ ID NO document Sequence

1171 12519 AACCCUGCUUGGAGAAAAGCUGUCUUUAUU

1172 12520 AGUGUCAGAUAUAGAUUAUGUACCACUAAA

1173 12536 ACAUAUCAGCAUCUAUAGUAGCUGGUGGUA

1174 12540 CUGUGAAUUUCAAUUUUGUAAUGAUCCAUU

1175 12551 CUGAUAGAGACCUUUAUGACAAGUUGCAAU

1176 12556 CUAUCAUCUUAUGUCCUUCCCUCAGUCAGC

1177 12557 GACUCAACUUUACUUAGGAGGUAUGAGCUA

1178 12561 GACUCAACAAUUAAUUAGAGCUGCAGAAAU

1179 12566 GGACAACCAAUCACUAAUUGUGUUAAGAUG

1180 12576 CUAUCAGUUACGUGCCAGAUCAGUUUCACC 1181 12584 AAGAAGCUGCUCGGUAUAUGAGAUCUCUCA 1182 12602 GGAUGAGGCUGGUUCUAAAUCACCCAUUCA

1183 12610 GCGUGGAUGAGGCUGGUUCUAAAUCACCCA

1184 12627 GACUAUUGACUAUACAGAAAUUUCAUUUAU

1185 12646 GGUCACUAUAAACAUAUAACUUCUAAAGAA

1186 12653 AGUGUAGCUAGUCAAUCCAUCAUUGCCUAC

1187 12654 A AG A AG C U A A A A AG G U A A A ACC A AC AG U G G

1188 12675 AGCUGCACUUACUAACAAUGUUGCUUUUCA

1189 12680 GCGUGAUCUCCCUCAGGGUUUUUCGGCUUU

1190 12686 AGCCUUGAAUACACCAAAAGAUCACAUUGG

1191 12711 CAAGGAAGACCUUAAAUUCCCUCGAGGACA

1192 12725 AUAAACCAAAUACCUGGUGUAUACGUUGUC

1193 12729 CAGUGUGUUAAUCUUACAACCAGAACUCAA

1194 12730 GACUAUGGUGAUGCUGUUGUUUACCGAGGU

1195 12737 GCUUGCAUACGUAGACCAUUCUUAUGUUGU

1196 12745 CAGUGUUAU A AC ACC AG G A AC A A A U AC U U C

1197 12746 AAUCUUGAUUACAUCAUAAACCUCAUAAUU

1198 12765 CUUUUGUACUGUAAAUGCAUUGCCUGAGAC

1199 12770 CAAGCUGUCACGGCCAAUGUUAAUGCACUU

1200 12786 ACAUCGAUAUCGGUAAUUAUACAGUUUCCU 1201 12813 CUAUAUGCCUGCUAGUUGGGUGAUGCGUAU 1202 12822 AGCCUUAAAUAAGGCUACUAACAAUGCCAU

1203 12858 CAGUUAGGUGGUUUACAUCUACUGAUUGGA

1204 12865 AUAAACAGGCUAGAUCUGAGGACAAGAGGG

1205 12873 GCGUAUAAAGAUUGUACAAAUGUUAAGUGA

1206 12878 CAAGCGUGGCAACCGGGUGUUGCUAUGCCU

1207 12897 CGCGCAUUGGCAUGGAAGUCACACCUUCGG

1208 12903 AUGGUGUUGUUUGUACAGAAAUUGACCCUA

1209 12904 GAUAGUGCAACAUUACCUAAAGGCAUAAUG

1210 12907 GAUAGUGCGGAAGUUGCAGUUAAAAUGUUU 1211 12916 AGACAAUUCUAGUCUUACUAUUAAGAAACC 1212 12918 A A AC U A A AG CCA U AG U U U C A AC U A U AC AG C

1213 12920 GGAAAGGGCUAUCAUCUUAUGUCCUUCCCU

1214 12925 AG AAGCCG U AAAAACACAG UUCAAU U AU U A

1215 12932 CAAGCCUCUUCUCGUUCCUCAUCACGUAGU Sequence in priority

SEQ ID NO document Sequence

1216 12944 AUUAACAUCACUAGGUUUCAAACUUUACUU

1217 12946 CAGUUCUUUAUUAUCAAAACAAUGUUUUUA

1218 12947 ACAUCUUCGUAUUGCUGGACACCAUCUAGG

1219 12954 ACAUCUUCUUUGCAUCAUUUUAUUAUGUAU

1220 12984 AGUGGUGAGACACUUGGUGUCCUUGUCCCU 1221 13005 GUACAGUGAACAAUGCUAGGGAGAGCUGCC 1222 13009 GAAGCUGCUAACUUUUGUGCACUUAUCUUA

1223 13022 ACAUGACCUAUAGAAGACUCAUCUCUAUGA

1224 13039 CCGUGUUGCAGCCGAUCAUCAGCACAUCUA

1225 13066 AUCAAAGUAGCCACUGUACAGUCUAAAAUG

1226 13067 GGUAGAUGGGUACUUAACAAUGAUUAUUAC

1227 13098 GACUACUCCCACCCAAGAAUAGCAUAGAUG

1228 13107 G U AAAACU UG UGG ACAACAGCAG ACAACCC

1229 13131 GGCCAUAGUUACGGCGCCGAUCUAAAGUCA

1230 13146 GAAGCUGUUGAAGCUCCAUUGGUUGGUACA

1231 13167 CUGAUCAAGCUAUGACCCAAAUGUAUAAAC

1232 13196 G U G G U A A AC A AG C U AC A A A A UAUCUAGUAC

1233 13208 CUGUGUGGAAACUAAAGCCAUAGUUUCAAC

1234 13216 CAGUUUGUAUGUAAAUAAACAUGCAUUCCA

1235 13230 GUAAAAGUGCCUUUUACAUUCUACCAUCUA

1236 13243 GACUACCAACUCAAACUGUUGAUUCAUCAC

1237 13245 GGCUGUAUUAAUGCUAACCAAGUCAUCGUC

1238 13251 CGAUUCAGAUCUUAAUGACUUUGUCUCUGA

1239 13252 CUGUGUGUUCUCUUAUGUUGGUUGCCAUAA

1240 13279 CAG U U U U UG U ACACAAU UAAACCGUGCU U U

1241 13283 AAUCUGGAGUAAAAGACUGUGUUGUAUUAC

1242 13287 CAUAAAAACUUUGCAACCAGUAUCUGAAUU

1243 13292 ACAUGGGCACACUUUCUUAUGAACAAUUUA

1244 13293 AGGAGACAUUAUACUUAAACCAGCAAAUAA

1245 13296 AUCAAGAAUCCUUUGGUGGUGCAUCGUGUU

1246 13302 GCGGCACAGGCACUAGUACUGAUGUCGUAU

1247 13320 GGUUGGCACAACAUGUUAAAAACUGUUUAU

1248 13321 GUGGUAAAAUUGUUAAUAAUUGGUUGAAGC

1249 13339 AUCAAGAUGCACUUUUCGCAUAUACAAAAC

1250 13352 GACUACAAAAGAGAUGCUCCAGCACAUAUA

1251 13371 GGUGUCAUGCUACUAGAGAAGCUGUUGGUA

1252 13383 CAUAACAAGAGAAGUGGGUUUUGUCGUGCC

1253 13385 ACAUGUCAGCAUUAAAUCACACUAAAAAGU

1254 13386 GCGGAAGUUGCAGUUAAAAUGUUUGAUGCU

1255 13394 CU U U UGCAAACU ACACAAU UGGAAUUGUGU

1256 13412 GAUAUCAGACAACUACUAUUUGUAGUUGAA

1257 13420 CUAUAAUCCGUUUAUGAUUGAUGUUCAACA

1258 13438 AAUGGUGUUCUUAUUACAGAAGGUAGUGUU

1259 13441 AUUAACGGGCUUAUGUUGCUCGAAAUCAAA

1260 13448 CUCUUUUUGUUACAUGCACCAUAUGGAAUU Sequence in priority

SEQ ID NO document Sequence

1261 13465 GGUGUCAGUGUUAUAACACCAGGAACAAAU

1262 13486 ACAAAGGACUUCCUUGGAAUGUAGUGCGUA

1263 13497 CUGUUAAUCCGUAUGUUUGCAAUGCUCCAG

1264 13501 AGUGGAGUUCCUGUUGUAGAUUCUUAUUAU

1265 13540 GGUGUCACUCGUGACAUAGCAUCUACAGAU

1266 13546 CAUAAUGAUGAAUGUCGCAAAAUAUACUCA

1267 13556 CUAUAAAGAUAACAGAACAUUCUUGGAAUG

1268 13578 ACUUCCUUGGAAUGUAGUGCGUAUAAAGAU

1269 13608 AGUGGAAAAUCCUACCAUACAGAAAGACGU

1270 13616 AAAAGACUGUGUUGUAUUACACAGUUACUU

1271 13622 GGCCCUGAUGGCUACCCUCUUGAGUGCAUU

1272 13648 CAUACACUCGCUAUGUCGAUAACAACUUCU

1273 13649 AGCCUCAAAGAUUUUGGGACUACCAACUCA

1274 13651 GCGCGUCAUAUUAAUGCGCAGGUAGCAAAA

1275 13657 CUUUUGAGUACUACCACACAACUGAUCCUA

1276 13662 GGAAACUGUGAAAGGUUUGGAUUAUAAAGC

1277 13693 CAACUUUACAAGCUGAAAAUGUAACAGGAC

1278 13698 G CG CG A U C A A A AC A ACG U CG G CCCC A AG G U

1279 13701 CAUACCAGACUAUAACACAUAUAAAAAUAC

1280 13717 AUACCACUUCAGAGAGCUAGGUGUUGUACA 1281 13719 ACUUCCCUAUGGUGCUAACAAAGACGGCAU 1282 13729 CAUACCUAAGGACAUGACCUAUAGAAGACU

1283 13738 CCUAUUUCUGAACAUGACUACCAGAUUGGU

1284 13743 CUGUUAUGGCCAGUAACUUUAGCUUGUUUU

1285 13745 CUUUUGACAUCUACAAUGAUAAAGUAGCUG

1286 13771 AGUGCUGCUAAAAAGAAUAACUUACCUUUU

1287 13776 CAUACUAAUUGUUACGACUAUUGUAUACCU

1288 13781 GUAUACGUUGUCUUUGGAGCACAAAACCAG

1289 13806 AAGAGUCAUUUUGCUAUUGGCCUAGCUCUC

1290 13807 AAUCUAUUACUAGAUAAACGCACUACGUGC

1291 13819 GAUAUGUACGACCCUAAGACUAAAAAUGUU

1292 13822 ACAUUCUAUGCAAAAUUGUGUACUUAAGCU

1293 13825 GGCCGGCUGUUUUGUAGAUGAUAUCGUAAA

1294 13856 AAUCUAUCAAACUUCUAACUUUAGAGUCCA

1295 13857 CUAGUGGCUAGCAUAAAGAACUUUAAGUCA

1296 13861 GUGGUAGUUGUGUUUUAAGCGGACACAAUC

1297 13862 CAUACUUUGCAUAAUGUCUGAUAGAGACCU

1298 13870 GGACACUUAUGAAUGUCUUGACACUCGUUU

1299 13876 ACAAAUACCUACAACUUGUGCUAAUGACCC

1300 13921 AUCACCGGUGGAAUUGCUAUCGCAAUGGCU

1301 13926 AGUGCGUUGUUCGUUCUAUGAAGACUUUUU

1302 13946 ACAAAU AGG AG AG U ACACCU U UG AAAAAGG

1303 13964 ACAUUGCUGCUAAUACUGUGAUCUGGGACU

1304 13975 AGGAGCUAGAAAAUCAGCACCUUUAAUUGA

1305 13977 AGUGCGUAUAAAGAUUGUACAAAUGUUAAG Sequence in priority

SEQ ID NO document Sequence

1306 13986 AAAGUGAGUUCAGAGUUUAUUCUAGUGCGA

1307 13998 AGUGCGCGUCAUAUUAAUGCGCAGGUAGCA

1308 14001 ACAUUGGCGACCCUGCUCAAUUACCUGCAC

1309 14009 AAUGUUCAACUCAGGGUUAUUGGACAUUCU

1310 14012 G G A A AC U A A AG CCA U AG U U U C A AC U A U AC A

1311 14017 AGCUUAUUUUAAUAUGGUCUAUAUGCCUGC

1312 14019 GCGAUUUUGUUAAAGCCACUUGCGAAUUUU

1313 14022 CAUAGUCAGUUAGGUGGUUUACAUCUACUG

1314 14035 GUAGUCUUCUUGCAUGUGACUUAUGUCCCU

1315 14084 GGCUUACCGCAAGGUUCUUCUUCGUAAGAA

1316 14085 AUGUACAAAUACCUACAACUUGUGCUAAUG

1317 14110 CAACU All AAAU U AAACACAG ACCAU UCCAG

1318 14119 CAACUAGCACUCUCCAAGGGUGUUCACUUU

1319 14122 CCUGACGGCGUAAAACACGUCUAUCAGUUA

1320 14135 AUAAUUAAUAACUAAUUACUGUCGUUGACA

1321 14144 ACAUUUACUUGUGCUAGUGAGUACACUGGU

1322 14145 GGCUUAGUAGAAGUUGAAAAAGGCGUUUUG

1323 14153 GAUAUUGCUGCUAGAGACCUCAUUUGUGCA

1324 14165 ACAUUUAUUAGUGAUGAAGUUGCGAGAGAC

1325 14166 CAUAUAUUCUUUUCACUAGGUUUUUCUAUG

1326 14169 CAUAUCAACAUCACAUAAAUUAGUCUUGUC

1327 14189 CCUGUUGCACUACGACAGAUGUCUUGUGCU

1328 14197 AGAGUGUGGACACUUAUGAAUGUCUUGACA

1329 14200 ACAAAUGCUGGUGAUUACAUUUUAGCUAAC

1330 14203 G ACG G U A A A A U G A A AG A U CUCAGUCCAAGA

1331 14212 AUGGAAAGUGAGUUCAGAGUUUAUUCUAGU

1332 14221 CAACGUCUUACUAAAUACACAAUGGCAGAC

1333 14233 ACAUUUGGCUAGGUUUUAUAGCUGGCUUGA

1334 14240 CUGUUGCUAAUGGUGAUUCUGAAGUUGUUC

1335 14250 ACAAAUGGCCCCGAUUUCAGCUAUGGUUAG

1336 14260 CUAGGUUUUAUAGCUGGCUUGAUUGCCAUA

1337 14267 AUUAUCCUAAAUGUGAUAGAGCCAUGCCUA

1338 14271 ACAUUUGUGGUGAUUCAACUGAAUGCAGCA

1339 14280 AAUUGCCGUUUUAGAUAUGUGUGCUUCAUU

1340 14283 AUCAGACAUACCACCCAAAUUGUGUUAACU

1341 14310 GUCUAAGGGUUUCUUUAAGGAAGGAAGUUC

1342 14318 CUGUUGGGGCUUGUGUUCUUUGCAAUUCAC

1343 14320 GUCAUGCUACUAGAGAAGCUGUUGGUACCA

1344 14322 GGACAGCCUUUGUUACUAAUGUGAAUGCGU

1345 14341 GCUUCAUUAAAAGAAUUACUGCAAAAUGGU

1346 14343 GGUGUAGAUGCUGUAAAUUUACUUACUAAU

1347 14345 AC A A A UGUUAAGUGACACACUU A A A A A U C U

1348 14346 AAGAGAGGUUAAAACUCUUUGACCGUUAUU

1349 14358 CAUAUUAAUGCGCAGGUAGCAAAAAGUCAC

1350 14360 CAACCUUACAAGCUAUAGCCUCAGAGUUUA Sequence in priority

SEQ ID NO document Sequence

1351 14366 AAUGGAUAAUCUUGCCUGCGAAGAUCUAAA

1352 14395 GCGAAUAAUUGCACUUUUGAAUAUGUCUCU

1353 14401 AAUUCAUCAACUUGUAUGAUGUGUUACAAA

1354 14403 CAUAUUCACUCAAACCACUGAAACAGCUCA

1355 14405 GAGCCUUGAAU AC ACC A A A AG AUCACAUUG

1356 14417 AGGAGGUCUUAUCAGAGGCACGUCAACAUC

1357 14431 ACCAAACCAACCAUAUCCAAACGCAAGCUU

1358 14441 AGCUAGAAAAUCAGCACCUUUAAUUGAAUU

1359 14442 CAACCUAUACUGUUACUAGAUCAGGCAUUA

1360 14444 AGGAGGUGUUGCAGGAGCCUUAAAUAAGGC

1361 14456 GAUCAACUCCGCGAACCCAUGCUUCAGUCA

1362 14469 GCGAAAUACCAGUGGCUUACCGCAAGGUUC

1363 14483 AGAGUUGAUGGUCAAGUAGACUUAUUUAGA

1364 14492 CAACCGGGUGUUGCUAUGCCUAAUCUUUAC

1365 14499 AAUAGGUUUUUGUAUAUAAUUAAGUUAAUU

1366 14507 CUGUUGUUCUUGUGGAUCCUGCUGCAAAUU

1367 14509 GUAUCUACUAGUGGUAGAUGGGUACUUAAC

1368 14514 ACAAAUUCUAGAAUUAAAGCAUCUAUGCCG

1369 14528 GUACUGACAUUAGAUAAUCAAGAUCUCAAU

1370 14537 CUAGCUGUCCACGAGUGCUUUGUUAAGCGU

1371 14543 AAUAGGUUUCCUAUUCCUUACAUGGAUUUG

1372 14547 GCCUUUUACAUUCUACCAUCUAUUAUCUCU

1373 14550 AUGGAAAAGUUAUGUGCAUGUUGUAGACGG

1374 14559 CUGUUUAAUAGGGGCUGAACAUGUCAACAA

1375 14579 CUGUUUACUACAGUCAGCUUAUGUGUCAAC

1376 14582 AGUGAUGUGCUAUUACCUCUUACGCAAUAU

1377 14590 AAUCGGAGCUGUGAUCCUUCGUGGACAUCU

1378 14603 GGUAACAACUUUUGAUUCUGAGUACUGUAG

1379 14609 CCUAUUCUGGACAAUCUACACAACUAGGUA

1380 14625 GCCUUUCAACUCUCAUGAAGUGUGAUCAUU

1381 14630 AAAGUACAAAUAGGAGAGUACACCUUUGAA

1382 14691 GAAGGUGUCUUUGUUUCAAAUGGCACACAC

1383 14699 G U AAAG AUGGCCAUG U AG AAACAU U U U ACC

1384 14731 GUGGCGGUUCACUAUAUGUUAAACCAGGUG

1385 14750 GUAGCUAGUCAAUCCAUCAUUGCCUACACU

1386 14754 CCU AU UCACUUCU AU UCU AAAUGGU AU AU U

1387 14761 CAUCAUCUGAAGCAUUUUUAAUUGGAUGUA

1388 14767 CUAGCAUAAAGAACUUUAAGUCAGUUCUUU

1389 14777 GAUCAGACAUACCACCCAAAUUGUGUUAAC

1390 14787 CAACCAAAAUGCACAAGCUUUAAACACGCU

1391 14803 CAUCAUUCUAUUGGAUUUGAUUACGUCUAU

1392 14805 GGUUAUUUAAAACUUACUGACAAUGUAUAC

1393 14835 ACC A A U G G A A A A AC U C A A A AC AC U AG U U G C

1394 14843 ACCAAUGGUACUAAGAGGUUUGAUAACCCU

1395 14879 AGGAGUUAGAUAAAUAUUUUAAGAAUCAUA Sequence in priority

SEQ ID NO document Sequence

1396 14881 CUAGAUUCCCUAAGAGUGAUGGAACUGGUA

1397 14887 AUAGAAUUUCUUAAGAGAGGUGAUAAAAGU

1398 14907 AAAGUAUGAGCAGUAUAUAAAAUGGCCAUG

1399 14909 ACCAAUUUACCUUUACAGCUAGGUUUUUCU

1400 14921 CUAGAUCUGAGGACAAGAGGGCAAAAGUUA

1401 14942 AAUAGGAAUUGUCAACAACACAGUUUAUGA

1402 14983 AC A AC A AC U U AC A A A U U AAA UGUUGGUGAU

1403 14991 CUAGAGGCUUCAUUUAAUUAUUUGAAGUCA

1404 14998 AACCUAAAUUGGGUAGUCUUGUAGUGCGUU

1405 15016 AAUAGCUGUUGAACAAGACAAAAACACCCA

1406 15028 GCCUGGUUUGCCUGGCACGAUAUUACGCAC

1407 15050 ACCACAUAUAUCACGUCAACGUCUUACUAA

1408 15054 GAAGUACCAG UUUCUAUCAU UAAUAACACU

1409 15068 AG U G AC A A AG C U U A U A A A A U AG A AG A A U U A

1410 15078 C A U CG U C A AC A ACC U AG AC A A A U C AG C U G G

1411 15092 GCCUGGAAUAUUGGUGAACAGAAAUCAAUA

1412 15109 CCU AU U ACGG AUG U U U U C U AC A A AG A A A AC

1413 15119 GAUCAUUGUGGUGAAACUUCAUGGCAGACG

1414 15121 GUGUAGACUUAUGAAAACUAUAGGUCCAGA

1415 15138 GGACAUCUUCGUAUUGCUGGACACCAUCUA

1416 15145 GCCUGCCAAUUCAACUGUAUUAUCUUUCUG

1417 15148 A A AC A AG C U AC A A A A UAUCUAGU AC A AC AG

1418 15150 AUCAUGACGUUCGUGUUGUUUUAGAUUUCA

1419 15174 GCUUAUGUUGCUCGAAAUCAAAGACACAGA

1420 15187 AACCUACAAAGCAACCAUGAUCUGUAUUGU

1421 15188 GAUCCACAGACACUUGAGAUUCUUGACAUU

1422 15195 GACCUUGGUGCUUGUAUUGACUGUAGUGCG

1423 15208 CAUCUCGCAAAGGCUCUCAAUGACUUCAGU

1424 15237 ACCACUAAAGUCUGCUACGUGUAUAACACG

1425 15245 GACCUUCAAAAUUAUGGUGAUAGUGCAACA

1426 15258 ACCACUAGUGAGAAAAAUAUUUGUUGAUGG

1427 15260 GAAGUAUUUAUACUUUAUUAAAGGAUUAAA

1428 15269 CAACAAGACGGCAGUGAGGACAAUCAGACA

1429 15285 A U G U AAA U A A AC A U G C A U U CC AC AC ACC AG

1430 15289 CAACAACUCAUAUGAGUGUGACAUACCCAU

1431 15308 GUAUAAUGCUAGUUUAUUGUUUCUUAGGCU

1432 15310 CAACAACCUAGACAAAUCAGCUGGUUUUCC

1433 15331 CAACAACACAG UUUAUGAUCCU U UGCAACC

1434 15335 CUUAAAUUGUCACAUCAAUCUGACAUAGAA

1435 15342 CUUAAAUUUGGAAGAAGCUGCUCGGUAUAU

1436 15358 CUCUGAUGCAGAUUCAACUUUGAUUGGUGA

1437 15362 AAAGUGCACAUCAGUAGUCUUACUCUCAGU

1438 15365 AUAAGUUUGUUCGCAUUCAACCAGGACAGA

1439 15367 ACCACUUAAAGUGGGUGGUAGUUGUGUUUU

1440 15378 C A AC A A AC U G U U G G U C A AC A AG ACGGCAGU Sequence in priority

SEQ ID NO document Sequence

1441 15382 GGCUUGUGUUCUUUGCAAUUCACAGACUUC

1442 15394 GUGACAUACCCAUUGGUGCAGGUAUAUGCG

1443 15445 AGUCUUUAAUGGUGUUUCCUUUAGUACUUU

1444 15460 ACAACAGCAGACAACCCUUAAGGGUGUAGA

1445 15477 AAUCCUACCACAUUCCACCUAGAUGGUGAA

1446 15478 GCCUAUUGGGUUCCACGUGCUAGCGCUAAC

1447 15479 AGUCUUGUAGUGCGUUGUUCGUUCUAUGAA

1448 15481 CUACUUCUUGCAGAGUAUAAACUUUGUAAG

1449 15490 CGAAUGUACAACUAUUGUUAAUGGUGUUAG

1450 15501 CAUCUUUUUCUGCUUCCACAAGUGCUUUUG

1451 15517 GGAAAAUCCUACCAUACAGAAAGACGUUCU

1452 15524 ACAACAGGAGUCACCUUUUGUUAUGAUGUC

1453 15527 AGUCUUCUUGCAUGUGACUUAUGUCCCUGC

1454 15535 ACCAGAGGUGAAAAUACUCAAUAAUUUGGG

1455 15541 ACAACAGGGCAACCUUACAAGCUAUAGCCU

1456 15547 CACUAACUGAGAAUAAAUAUUCUCAAUUAG

1457 15548 CUUUUAAUGUUGUAAAUAAGGGACACUUUG

1458 15549 GUCAGUGUUAUAACACCAGGAACAAAUACU

1459 15552 ACAACAGGGUGAAGUACCAGUUUCUAUCAU

1460 15558 GCUUAUGAAAAUUUUAAUCAGCACGAAGUU

1461 15571 CUACUUAGCUGUCUUUGAUAAAAAUCUCUA

1462 15581 ACAACAGUACUUUUAAAAGAACCUUGCUCU

1463 15598 CACUAAGAAAUCUGCUGCUGAGGCUUCUAA

1464 15600 CUGAUGUUGGUGAUAGUGCGGAAGUUGCAG

1465 15601 GGUAGUGUUGGUUUUAACAUAGAUUAUGAC

1466 15611 AGUCUUACUCUCAGUUUUGCAACAACUCAG

1467 15630 GAUCCUUCGUGGACAUCUUCGUAUUGCUGG

1468 15632 CAAAUUACAGAAUAAUGAGCUUAGUCCUGU

1469 15658 GGACAUUGCUGCUAAUACUGUGAUCUGGGA

1470 15666 ACAACAGUUUGGUCCAACUUAUUUGGAUGG

1471 15694 ACCAGGAACUAAUCAGACAAGGAACUGAUU

1472 15696 ACUUACAAUACAUAAGAAAGCUACAUGAUG

1473 15729 A A A AC AG G G U A A U U U C A A A A A UCUUAGGGA

1474 15744 CAAAUGGAAAUUGAUUUCUUAGAAUUAGCU

1475 15762 AAUAGAGCAACAAGAGUCGAAUGUACAACU

1476 15783 CUGCGUUAUAGCUUGGAAUUCUAACAAUCU

1477 15784 ACUUAAUGAGAAGUGCUCUGCCUAUACAGU

1478 15803 CAUGAUGGAAAAGCACACUUUCCUCGUGAA

1479 15809 AACAGUUUACUCACACCUUUUGCUCGUUGC

1480 15819 AUACAGCUUGCUCUCAUGCCGCUGUUGAUG

1481 15829 GAAGUGCUGUCUGACAGAGAAUUACAUCUU

1482 15830 AACCUAGUAAUAGGUUUCCUAUUCCUUACA

1483 15834 GAAAGAUCAGAAGCUGGUGUUUGUGUAUCU

1484 15863 GUGCUGACUCUAUCAUUAUUGGUGGAGCUA

1485 15871 CUUAAUGACAACCUUCUUGAAAUACUCCAA Sequence in priority

SEQ ID NO document Sequence

1486 15887 CAAAUCAAUGAUAUGAUUUUAUCUCUUCUU

1487 15888 ACUUAAGCUUAAGGUUGAUACAGCCAAUCC

1488 15894 GUCAGGGUUUAAAUGGUUACACUGUAGAGG

1489 15903 GUACUGCUGUUAUGUCUUUAAAAGAAGGUC

1490 15906 ACCAGUUUCUAUCAUUAAUAACACUGUUUA

1491 15909 AG AAAU U U ACAAG AAU U U AAACCCAGG AG U

1492 15912 A AG A A AC UAAGUUCCU C AC AG A A A AC U U G U

1493 15913 AAGAGAAUUCCUUACACGUAACCCUGCUUG

1494 15914 GUGCUUCAUUAAAAGAAUUACUGCAAAAUG

1495 15927 AAA U C A A A A UGUGAAGAAUCAUCUG C A A A A

1496 15939 CUUAAUGGAGUCACAUUAAUUGGAGAAGCC

1497 15963 ACUUAACAAUGAUUAUUACAGAUCUUUACC

1498 15968 GGUAGUUAUACUAAUGACAAAGCUUGCCCA

1499 15984 ACAACAUUUACUUAUGCAUCAGCAUUGUGG

1500 16000 GCCGGCUGUUUUGUAGAUGAUAUCGUAAAA

1501 16012 AGCCACUGUACAGUCUAAAAUGUCAGAUGU

1502 16018 GGCUUUGGAGACUCCGUGGAGGAGGUCUUA

1503 16019 CACGUAGUGUAGCUAGUCAAUCCAUCAUUG

1504 16021 CAUGCCUUCUUACUGUACUGGUUACAGAGA

1505 16024 AAAUUGAUUUCUUAGAAUUAGCUAUGGAUG

1506 16025 CUCCUACUAAAUUAAAUGAUCUCUGCUUUA

1507 16034 GGAGGAGGUCUUAUCAGAGGCACGUCAACA

1508 16050 ACAACCAAUCACUAAUUGUGUUAAGAUGUU

1509 16057 ACCAUAUUGUUAUGAUACCAAUGUACUAGA

1510 16073 GUGCUGUAGACAUAAACAAGCUUUGUGAAG

1511 16076 CUUUGUUUCAAAUGGCACACACUGGUUUGU

1512 16082 AAAAGAUGGCUGAUCAAGCUAUGACCCAAA

1513 16088 CGGCGUUGUCCUGCUGAAAUUGUUGACACU

1514 16096 AAAGUUGAGGGUUGUAUGGUACAAGUAACU

1515 16101 CUGAACAACUACGAAAACAAAUACGUAGUG

1516 16107 CAUGCUACUAGAGAAGCUGUUGGUACCAAU

1517 16114 GGUGGUGACGGUAAAAUGAAAGAUCUCAGU

1518 16123 AG A U C A A U U U A A AC ACC UCAUACCACUUAU

1519 16126 CAAAGUGACUAUUGACUAUACAGAAAUUUC

1520 16142 GAUCUCAUUAUUAGUGAUAUGUACGACCCU

1521 16164 GAUCUCCCUCAGGGUUUUUCGGCUUUAGAA

1522 16166 CUACUACCGAAGAGCUACCAGACGAAUUCG

1523 16172 GGCUUUUAAUGUUGUAAAUAAGGGACACUU

1524 16190 CUACUAAUUUGGUUAAAAACAAAUGUGUCA

1525 16204 GGCGCGAUCAAAACAACGUCGGCCCCAAGG

1526 16234 CUACUAACAAUGCCAUGCAAGUUGAAUCUG

1527 16236 CACUACUGAAAUGCUAGCGAAAGCUUUGAG

1528 16238 CUACUAACAAUCUAGUUGUAAUGGCCUACA

1529 16242 AAGAGAAUCAGCAACUGUGUUGCUGAUUAU

1530 16247 GCCCUUUUGGUGAAGUUUUUAACGCCACCA Sequence in priority

SEQ ID NO document Sequence

1531 16252 CUGAUAAUGGACCCCAAAAUCAGCGAAAUG

1532 16255 CAUGGAAGUCACACCUUCGGGAACGUGGUU

1533 16265 AUAAUGGUUAUCUUACUUCUUCUUCUAAAA

1534 16268 GCCCUUGCACCUAAUAUGAUGGUAACAAAC

1535 16271 AG U CG C A AC AG U U C A AG A A A U U C A AC U CC A

1536 16274 CUUACAGGCUGUUGGGGCUUGUGUUCUUUG

1537 16280 GAAGUUAUCACCUUUGACAAUCUUAAGACA

1538 16287 G G ACCAG G AAC U AAU CAG ACAAG G AAC U G A

1539 16290 CUUUGUUCUUUUUUUUGUAUGAAAAUGCCU

1540 16296 GAUCUGCACCUCUGAAGACAUGCUUAACCC

1541 16315 A AG UCACACCUUCG G G A ACG UGGUUGACCU

1542 16348 GAUCUGGGACUACAAAAGAGAUGCUCCAGC

1543 16403 AUGUAAACUUACAUAGCUCUAGACUUAGUU

1544 16428 GGUGGUAGUUAUACUAAUGACAAAGCUUGC

1545 16431 GUGUAGAAGCUGUUAUGUACAUGGGCACAC

1546 16433 CACGGCCAAUGUUAAUGCACUUUUAUCUAC

1547 16436 A A A ACC A AC AG UGGUUGUUAAUG CAG CCA A

1548 16449 AGUUUUCUGUGGUGUAGAUGCUGUAAAUUU

1549 16450 CACGGCACUUGUGAAAGAUCAGAAGCUGGU

1550 16471 CUUACCGCAAGGUUCUUCUUCGUAAGAACG

1551 16478 AUUAUCUUUCUGUGCUUUUGCUGUAGAUGC

1552 16501 GGGAAAUCCAACAGGUUGUAGAUGCAGAUA

1553 16530 GUCUCCU ACU AAAU UAAAUGAUCUCUGCUU

1554 16540 CACUAGUACUGAUGUCGUAUACAGGGCUUU

1555 16583 CAAACUGGAAAGAUUGCUGAUUAUAAUUAU

1556 16589 AGACAUUUAAACUGUCUUAUGGUAUUGCUA

1557 16591 CGCACUAUUGCCUUUGGAGGCUGUGUGUUC

1558 16594 CUUUGUGUGCUGACUCUAUCAUUAUUGGUG

1559 16608 CUUACUAAAUACACAAUGGCAGACCUCGUC

1560 16609 CAUGUACUCAACAUCAACCAUAUGUAGUUG

1561 16634 CAUGUAGUUGCCUUUAAUACUUUACUAUUC

1562 16645 GAAAUCCAACAGGUUGUAGAUGCAGAUAGU

1563 16649 GAAGUUGGUAAACCUAGACCACCACUUAAC

1564 16653 C AC U A U A A AC A UAU AAC U U C U A A AG A A AC U

1565 16675 CCUUACUGUUUUGCCACCUUUGCUCACAGA

1566 16681 CUUACUAUUAAGAAACCUAAUGAAUUAUCU

1567 16682 GACCAGGAACUAAUCAGACAAGGAACUGAU

1568 16697 GUCAGAUAUAGAUUAUGUACCACUAAAGUC

1569 16708 CAUGUCUAAACAUACUGACUUUUCAAGUGA

1570 16717 CUUACUCUCAGUUUUGCAACAACUCAGAGU

1571 16720 CAAACCUUGUAUCAAAGUAGCCACUGUACA

1572 16745 CCUUAGACAAUGUCUUAUCUACUUUUAUUU

1573 16769 CAAACCCGG U AAU U U U AACAAAG ACU UCU A

1574 16774 CUGAACAUGUCAACAACUCAUAUGAGUGUG

1575 16781 ACCCCAAAAUCAGCGAAAUGCACCCCGCAU Sequence in priority

SEQ ID NO document Sequence

1576 16794 CGACGAGCUUGGCACUGAUCCUUAUGAAGA

1577 16802 AACCUCAUCAGGAGAUGCCACAACUGCUUA

1578 16804 CAAACCACGCGAACAAAUAGAUGGUUAUGU

1579 16815 GGACCCUCAGAUUCAACUGGCAGUAACCAG

1580 16846 CAUGUGUGGCGGUUCACUAUAUGUUAAACC

1581 16849 AAAUCACAU AAACCACCCAU U AG U U U UCCA

1582 16864 GGUUUACAUCUACUGAUUGGACUAGCUAAA

1583 16866 CAUGUUAACAAUGCAACUAAUAAAGCCACG

1584 16868 CUGCUACGUGUAUAACACGUUGCAAUUUAG

1585 16869 CAAACAUAAGCAUGCAUUUCUCUGUUUGUU

1586 16873 GACCAAUGG U ACU AAG AGG U U UG AU AACCC

1587 16909 AUCCUGCUGCAAAUUUGAUGAAGACGACUC

1588 16914 CAAACAGCACAAGCAGCUGGUACGGACACA

1589 16921 CAUGUUAUGGUUGAGCUGGUAGCAGAACUC

1590 16926 AACGUUAAAGAUUUCAUGUCAUUGUCUGAA

1591 16934 AGCAUUUGAGCUUUGGGCUAAGCGCAACAU

1592 16943 GAUGAACUGAAGAUUAAUGCGGCUUGUAGA

1593 16956 ACAACUACACUUAACGGUCUUUGGCUUGAU

1594 16959 GUGACCUUCAAAAUUAUGGUGAUAGUGCAA

1595 16970 ACAACU ACU AACAU AG U U ACACGG UG U U U A

1596 16976 CAAACAAAU U U ACAAAACACCACCAAU U AA

1597 16985 AGUCACCUUUUGUUAUGAUGUCAGCACCAC

1598 16986 AAACUUACAUAGCUCUAGACUUAGUUUUAA

1599 16990 GGUAGUUGUGUUUUAAGCGGACACAAUCUU

1600 17003 AAAAUCCUACCAUACAGAAAGACGUUCUUG 1601 17008 AGUCACAUUAAUUGGAGAAGCCGU A A A A AC 1602 17014 G CC A U C A A A U U G G A U G AC A A AG A U CCA A A U

1603 17026 CAAAAUUCAAGACUCACUUUCUUCCACAGC

1604 17027 CACGCACUCAAAGGGAUUGUACAGAAAGUG

1605 17037 CACUAUUCUGACCAGACCGCUUCUAGAAAG

1606 17040 G AAG U U U U U AACGCCACCAG AU U UGCAUCU

1607 17063 CACUAUUGCAACCUACUGUACUGGUUCUAU

1608 17080 AUGCUACUCCUUCAGAUUUUGUUCGCGCUA

1609 17083 GAUGAAGUCAGACAAAUCGCUCCAGGGCAA

1610 17088 AAAUUGUUAAAUUUAUCUCAACCUGUGCUU 1611 17092 GGACCUAAAAAGUCUACUAAUUUGGUUAAA 1612 17118 CAUUAAAAUAUUUGCCUAUAGAUAAAUGUA

1613 17125 GGGACAACCAAUCACUAAUUGUGUUAAGAU

1614 17131 GAUGAAGUUGCGAGAGACUUGUCACUACAG

1615 17134 CUACAUACUACUUAUUUGAUGAGUCUGGUG

1616 17152 GGUGGCUAUUGAUUAUAAACACUACACACC

1617 17169 ACCCUAUAAUAUGAGAGUUAUACAUUUUGG

1618 17179 CAAAAGUUACUAGUGCUAUGCAGACAAUGC

1619 17206 AACUUUUAUGGACCUUUUGUUGACAGGCAA

1620 17208 ACCCUCAGAUUCAACUGGCAGUAACCAGAA Sequence in priority

SEQ ID NO document Sequence

1621 17211 CACGAUAUUACGCACAACUAAUGGUGACUU

1622 17228 AGUCAAAUGGAAAUUGAUUUCUUAGAAUUA

1623 17232 GCCAGCUACAGUUUCUGUUUCUUCACCUGA

1624 17237 G AACG UG U ACGCCAAGCU U UG U UAAAAACA

1625 17243 CUUAGUAGAAGUUGAAAAAGGCGUUUUGCC

1626 17250 CAUUAAUGCUUCAGUUGUAAACAUUCAAAA

1627 17269 AAAAGCUAAAAAAGGUGCCUGGAAUAUUGG

1628 17271 GACAUUGACAUCACUUUCUU A A AG A A AG A U

1629 17284 GCCAGAUCAGUUUCACCUAAACUGUUCAUC

1630 17289 AAGGUAAUCACUGGGUUACAUCCUACACAG

1631 17316 GCCAGAAGCUGGACUUCCCUAUGGUGCUAA

1632 17319 AG AUGCAG AU AG U AAAAU UG U UCAACU U AG

1633 17323 CUUAGUGGUUUAGAUUCUUUAGACACCUAU

1634 17343 GAUGACACUGUGAUAGAAGUGCAAGGUUAC

1635 17344 GCCACUUCUGCUGCUCUUCAACCUGAAGAA

1636 17364 CUUAGUUGCAGAGUGGUUUUUGGCAUAUAU

1637 17379 AGAUGCCACAACUGCUUAUGCUAAUAGUGU

1638 17393 CAUUACUUCAGGUGAUGGCACAACAAGUCC

1639 17415 GCCACUCCAUGGCACUAUUCUGACCAGACC

1640 17440 GCCACUACUUGUGGUUACUUACCCCAAAAU

1641 17450 GAAAUUGUCGGUGGACAAAUUGUCACCUGU

1642 17468 AUAGAUUGUUUAGGAAGUCUAAUCUCAAAC

1643 17471 GAAUACAGUCAUGUAGUUGCCUUUAAUACU

1644 17485 CAUUAGUGUCUGAUGUUGGUGAUAGUGCGG

1645 17503 GAAAUCAUAGGAUACAAGGCUAUUGAUGGU

1646 17504 A U U A A U G C U A ACC A AG U C A U CG U C A AC A AC

1647 17515 AG AAU UG U U UG AAAAU AAAACAACAU U ACC

1648 17536 GCCACAUGCUUUUCCACUGCUUCAGACACU

1649 17566 AAUGCUUUAGAUCAAGCCAUUUCCAUGUGG

1650 17567 CACCUUUUGUUAUGAUGUCAGCACCACCUG

1651 17568 CUUAUACCCAACACUCAAUAUCUCAGAUGA

1652 17570 CAAAAACGUACUGCCACUAAAGCAUACAAU

1653 17577 CUACAAGCUGGUAAUGCAACAGAAGUGCCU

1654 17579 AGAUGCUGCUAAAGCUUACAAAGAUUAUCU

1655 17580 AUUAUGACAUGGUUGGAUAUGGUUGAUACU

1656 17585 GCU U A A A A AG U G U A A A AG U G CC U U U U ACAU

1657 17604 GUCACUCGUGACAUAGCAUCUACAGAUACU

1658 17610 AGAUGCUGUAAAUUUACUUACUAAUAUGUU

1659 17612 AG G C A A AG AC AG U G C U U A A A A AG U G U A A A A

1660 17615 GCCAAUUCUGCUGUCAAAUUACAGAAUAAU 1661 17627 GUAUGAUGAUGGUGCUAGGAGAGUGUGGAC 1662 17635 AG AAACAU U U U ACCCAAAAU U ACAAUCU AG

1663 17656 AG ACAU U AU ACU U AAACCAGCAAAU AAU AG

1664 17671 AAAU UUACUUACUAAUAUGUU U ACACCACU

1665 17672 A AC U U U G A AG C A AG G U G AAA U C A AG G A U G C Sequence in priority

SEQ ID NO document Sequence

1666 17687 CUUAUAGGUUUAAUGGUAUUGGAGUUACAC

1667 17689 GUGAUGUUGUUCAAGAGGGUGUUUUAACUG

1668 17691 CAUUCACUGUACUCUGUUUAACACCAGUUU

1669 17753 AUUUUUGGUGCUGACCCUAUACAUUCUUUA

1670 17754 AUUUUUGGUACUACUUUAGAUUCGAAGACC

1671 17763 G U ACACACCACUGG U UG U U ACUCACAAU U U

1672 17789 GACAUCUCUGGCAUUAAUGCUUCAGUUGUA

1673 17795 CUUAUCAGAGGCACGUCAACAUCUU A A AG A

1674 17797 ACUGUAGGCACGGCACUUGUGAAAGAUCAG

1675 17802 AAUACACUUCAGUGUAUAAUGCUAGUUUAU

1676 17806 CAUUCCCAUCUGGUAAAGUUGAGGGUUGUA

1677 17816 GUGAUCAUUGUGGUGAAACUUCAUGGCAGA

1678 17817 CUAAUUUAGGCAUGCCUUCUUACUGUACUG

1679 17825 GUACUUAACAAUGAUUAUUACAGAUCUUUA

1680 17832 GCCAACAGACAAUUAUAUAACCACUUACCC 1681 17845 GUGUACUUGGACAAUCAAAAAGAGUUGAUU 1682 17846 GUACUUAAGCUUAAGGUUGAUACAGCCAAU

1683 17855 AGUAUGGCUACAUACUACUUAUUUGAUGAG

1684 17865 CCGCUAUAACAAUACUAGAUGGAAUUUCAC

1685 17869 GGUUUAGAUUCUUUAGACACCUAUCCUUCU

1686 17870 CUUUGGCUUUGCUGGAAAUGCCGUUCCAAA

1687 17879 GUACACACACUGGUACUGGUCAGGCAAUAA

1688 17880 CACUCGUGACAUAGCAUCUACAGAUACUUG

1689 17881 GAGUACACUGGUAAUUACCAGUGUGGUCAC

1690 17885 CUUUGGCUUGAUGACGUAGUUUACUGUCCA

1691 17893 AUGUGAUAAUAUCAAAUUUGCUGAUGAUUU

1692 17898 AUGGUAAUGCUGCUAUCAGCGAUUAUGACU

1693 17900 CCUAUAUAAUUCCGCAUCAUUUUCCACUUU

1694 17909 AGUAUGCUGAUGUCUUUCAUUUGUACUUAC

1695 17915 CUUAUCUACUUUUAUUUCAGCAGCUCGGCA

1696 17919 GCUGUUGUUCUUGUGGAUCCUGCUGCAAAU

1697 17945 G U G U A A A AC UUGUGGACAACAGCAG AC A AC

1698 17953 GACAUCAAGGACCUGCCU A A AG AAA U C AC U

1699 17965 AGAUGGGUACUUAACAAUGAUUAUUACAGA

1700 17977 CGCUACAGGAUUGGCAACUAUAAAUUAAAC

1701 17986 GAAUAGUUUUAGUGGUUAUU UAAAACU U AC

1702 18008 AAUACAAAUCCAAUUCAGUUGUCUUCCUAU

1703 18018 AAAAACAGAUGGUACACUUAUGAUUGAACG

1704 18021 AAAUUUCCCCUUAAAUUAAGGGGUACUGCU

1705 18027 GACAUAGCAUCUACAGAUACUUGUUUUGCU

1706 18042 AACUUUAGCUUGUUUUGUGCUUGCUGCUGU

1707 18048 ACC U A A A A AG UCUACUAAU UUGGU UAAAAA

1708 18085 G AAAU UGU U AAAU UUAUCUCAACCUGUGCU

1709 18088 GACAUACCCAUUGGUGCAGGUAUAUGCGCU

1710 18096 ACUGUAAAUGCAUUGCCUGAGACGACAGCA Sequence in priority

SEQ ID NO document Sequence

1711 18126 G U AGAUGCUG U AAAU UU ACU U ACU AAU AUG

1712 18146 AUUUUGUGACUUAAAAGGUAAGUAUGUACA

1713 18154 AUGGUACAAGUAACUUGUGGUACAACUACA

1714 18155 AUUUUGUGAAAAUAGGACCUGAGCGCACCU

1715 18157 AUCUAAAGUUGCGUAGUGAUGUGCUAUUAC

1716 18164 GAAUAUCACUUUUGAACUUGAUGAAAGGAU

1717 18184 CUUUGGAG C AC A A A ACC AG U U G A A AC A U C A

1718 18210 CAUUGAUUUAGAUGAGUGGAGUAUGGCUAC

1719 18214 CUUAUGGGCACAUGGCUUUGAGUUGACAUC

1720 18215 GAUGAUGAUUAUUUCAAUAAAAAGGACUGG

1721 18220 ACCUACAGGUUAUGUUGAUACACCUAAUAA

1722 18227 AUAAUGCUAGUUUAUUGUUUCUUAGGCUAU

1723 18230 CUUUGGAGACUCCGUGGAGGAGGUCUUAUC

1724 18234 AACUUUAAUUUUAGCCAUGGCAGAUUCCAA

1725 18248 CUUAUGGUAUUGCUACUGUACGUGAAGUGC

1726 18254 AAAAC U U G U G G AC AACAG CAG ACAACCC U U

1727 18292 AUGCUCGAACUGCACCUCAUGGUCAUGUUA

1728 18301 G U A AC U A A A A AC AG U A A AG U ACAAAU AGG A

1729 18311 AGGCACGGCACUUGUGAAAGAUCAGAAGCU

1730 18313 GCAUUGAUUUAGAUGAGUGGAGUAUGGCUA

1731 18330 GUGGUCACUAUAAACAUAUAACUUCUAAAG

1732 18349 ACUGGUUACAGAGAAGGCUAUUUGAACUCU

1733 18356 AUCUACUAGUGGUAGAUGGGUACUUAACAA

1734 18370 GAAAUCAAGGAUGCUACUCCUUCAGAUUUU

1735 18382 AG A AG U U G A A A A AG GCGUUUUGCCUCAACU

1736 18411 CUUUGCUGG AAA U G CCG U U CC A A A A ACCC A

1737 18427 CUUAUGUUGC U CG A A A U C A A AG AC AC AG A A

1738 18440 AAUGUAGUGCGUAUAAAGAUUGUACAAAUG

1739 18442 CUAAUCUCAAACCUUUUGAGAGAGAUAUUU

1740 18452 GGGAUUUGUUAAAAUAUGACUUCACGGAAG

1741 18476 GAUGAUUAUGUGUACCUUCCUUACCCAGAU

1742 18478 AGAAUUCGAUCUGUCUAUCCAGUUGCGUCA

1743 18523 CACUGAGAAUUUGACUAAAGAAGGUGCCAC

1744 18531 ACCUCAAGCUGAUGUAGAAUGGAAGUUCUA

1745 18536 CUAAUCAUAAUUUCUUGGUACAGGCUGGUA

1746 18555 AACUUGUGGUACAACUACACUUAACGGUCU

1747 18563 GCAUUAAAGACCUUCUAGCACGUGCUGGUA

1748 18570 AAAAUGAAAGAUCUCAGUCCAAGAUGGUAU

1749 18577 CACUGAUAACACUCGCUACUUGUGAGCUUU

1750 18579 CUGAUGAAACUCAAGCCUUACCGCAGAGAC

1751 18586 GCAUGUUGUAGACGGUUGUAAUUCAUCAAC

1752 18599 ACUGGUCAGGCAAU AACAG UUACACCGGAA

1753 18600 ACCUCAUGAAUUUUGCUCUCAACAUACAAU

1754 18639 ACUGGUAUGAUUUUGUAGAAAACCCAGAUA

1755 18647 GGUGCUUGCAUACGUAGACCAUUCUUAUGU Sequence in priority

SEQ ID NO document Sequence

1756 18650 CACUGAUCCUUAUGAAGAUUUUCAAGAAAA

1757 18652 AG U AGU ACU U UCU UUUGAACU UCU ACAUGC

1758 18660 AACUUGUCGGCGUUGUCCUGCUGAAAUUGU

1759 18663 GUAACUUCUUCAAUUGUCAUUACUUCAGGU

1760 18692 AAAUCCAACAGGUUGUAGAUGCAGAUAGUA

1761 18732 GAUGCAAUCAUGACUAGGUGUCUAGCUGUC

1762 18751 GAACGUGGUUGACCUACACAGGUGCCAUCA

1763 18764 GUACAAUCACUUCUGGUUGGACCUUUGGUG

1764 18765 AUUUUAGUGGAGCAAUGGAUACAACUAGCU

1765 18785 GCAUGGAUUGGCUUCGAUGUCGAGGGGUGU

1766 18798 GCUUUUGUUAAUU U AAAACAAU U ACCAU U U

1767 18809 AUCUCAUUAUUAGUGAUAUGUACGACCCUA

1768 18813 ACUGGUAAGAGUCAUUUUGCUAUUGGCCUA

1769 18818 ACCUCUUUCUGCUCAAACUGGAAUUGCCGU

1770 18828 AUACAACUAGCUACAGAGAAGCUGCUUGUU

1771 18830 GCUUUUGUGGAAACUGUGAAAGGUUUGGAU

1772 18836 GACACUUUGAUGGACAACAGGGUGAAGUAC

1773 18838 CAUUUAUUGAAGAUCUACUUUUCAACAAAG

1774 18850 GGUCAACCAAAAUGCACAAGCUUUAAACAC

1775 18864 GACACUUGCAGAUGCUGGCUUCAUCAAACA

1776 18871 AACUCAGGUUCUGAUGUUCUUUACCAACCA

1777 18882 ACCUGAGCAUAGUCU UGCCGAAU ACCAU AA

1778 18891 AUGGUACUGAAGAUGAUUACCAAGGUAAAC

1779 18893 ACCUGAGCGCACCUGUUGUCUAUGUGAUAG

1780 18894 AAUGGUGUUGAAGGUUUUAAUUGUUACUUU

1781 18899 AUCUCGAUGCUUAUAACAUGAUGAUCUCAG

1782 18902 AUGUCUUUUGUACUGUAAAUGCAUUGCCUG

1783 18908 GACACUUCGCAUGGUGGACAGCCUUUGUUA

1784 18925 AAUUGCAAUGUCGAUAGAUAUCCUGCUAAU

1785 18934 GAUGCAGCCAUG C A ACG U A AG U U G G A A A AG

1786 18985 GGUGCUGUCUGUAGACAUCAUGCUAAUGAG

1787 18989 CAUUUGACUUAGGCGACGAGCUUGGCACUG

1788 18990 ACCUGCCUAAAGAAAUCACUGUUGCUACAU

1789 19002 GGAGCAAUGGAUACAACUAGCUACAGAGAA

1790 19006 AGGCAUACUUUGCAUAAUGUCUGAUAGAGA

1791 19039 GGCAAACCUUGUAUCAAAGUAGCCACUGUA

1792 19049 AGUAGAAUUAUACCUGCACGUGCUCGUGUA

1793 19052 CGAUAGUUGUAAUAACUAUAUGCUCACCUA

1794 19059 AUGGUACUUGGUAGUUUAGCUGCCACAGUA

1795 19065 GCAUCGUGUUGUCUGUACUGCCGUUGCCAC

1796 19069 CUAAGGGUUUCUUUAAGGAAGGAAGUUCUG

1797 19075 CUGCUCGUGUUGUACGAUCAAUUUUCUCCC

1798 19085 AUACAGGGCUUUUGACAUCUACAAUGAUAA

1799 19104 GUAUGCCUAUUUUGGAAUUGCAAUGUCGAU

1800 19108 AUCUGAAUUACUUACACCACUGGGCAUUGA Sequence in priority

SEQ ID NO document Sequence

1801 19110 AAAGAUUGCUGAUUAUAAUUAUAAAUUACC

1802 19114 AGAAAAAGGAAUCUAUCAAACUUCUAACUU

1803 19117 AGUACUUUCUUUUGAACUUCUACAUGCACC

1804 19122 AAA UUUUGGGGACCAGGAACUAAUCAGACA

1805 19133 AUUUGUUUAUGAGAAUCUUCACAAUUGGAA

1806 19139 GAUGCCAUGCGAAAUGCUGGUAUUGUUGGU

1807 19151 AGAAUUAUACCUGCACGUGCUCGUGUAGAG

1808 19156 AAAUUUUGUCUAGAGGCUUCAUUUAAUUAU

1809 19175 CUUCACAUAUGUAUUGUUCUUUCUACCCUC

1810 19190 GUCAAUUUCAACUUCAAUGGUUUAACAGGC 1811 19192 GGCGGUUCACUAUAUGUUAAACCAGGUGGA 1812 19220 CACCUACACACCUCAGUGUUGACACUAAAU

1813 19223 AUUUGUUAAAAUAUGACUUCACGGAAGAGA

1814 19236 GAAUCUGGAGUAAAAGACUGUGUUGUAUUA

1815 19240 CACCUAAUUUUUCUAAACUGAUAAAUAUUA

1816 19256 CUAAGCGCAACAUUAAACCAGUACCAGAGG

1817 19300 AUUUGUCUUCUACAAUUUGCCUAUGCCAAC

1818 19302 AUUUGUCUUAUGGGCACAUGGCUUUGAGUU

1819 19318 CUUUGAUGAAAUUUCAAUGGCCACAAAUUA

1820 19329 AGUACUAUGACCAAUAGACAGUUUCAUCAA 1821 19333 GGUACAACUACACUUAACGGUCUUUGGCUU 1822 19340 CAUUUUGAUGAAGGUAAUUGUGACACAUUA

1823 19345 CGAUAGAUAUCCUGCUAAUUCCAUUGUUUG

1824 19349 CAUUUUGCUAUUGGCCUAGCUCUCUACUAC

1825 19350 AGCUGGUGGUAUUGUAGCUAUCGUAGUAAC

1826 19354 CAUUUUGCUGAAUAAGCAUAUUGACGCAUA

1827 19367 GGGCGAAAUACCAGUGGCUUACCGCAAGGU

1828 19380 GUCUCUUUUUGUUACAUGCACCAUAUGGAA

1829 19385 CCUUCCCUCAGUCAGCACCUCAUGGUGUAG

1830 19409 GAUGCGUAUUAUGACAUGGUUGGAUAUGGU

1831 19410 GCUGUCUGUAGACAUCAUGCUAAUGAGUAC

1832 19413 GCUGUCUGACAGAGAAUUACAUCUUUCAUG

1833 19417 AGUACGAUCGAGUGUACAGUGAACAAUGCU

1834 19425 GCAUACACUCGCUAUGUCGAUAACAACUUC

1835 19430 CUGCUGAAUGUACAAUUUUUAAAGAUGCUU

1836 19432 CUUUGAUAAAAAUCUCUAUGACAAACUUGU

1837 19436 ACAAGGCGUUCCAAUUAACACCAAUAGCAG

1838 19439 CUUUGAGUUGACAUCUAUGAAGUAUUUUGU

1839 19446 AGAUUCUUAUUAUUCAUUGUUAAUGCCUAU

1840 19449 A AC U A A A A AC AG U A A AG U AC A A A U AG G AG A

1841 19453 ACCUUCCUUACCCAGAUCCAUCAAGAAUCC

1842 19474 AAACAUUUCUCAAUGAUGAUACUCUCUGAC

1843 19492 CUUCAUCAAACAAUAUGGUGAUUGCCUUGG

1844 19504 ACCUUGAAGG A A A AC AG G G UAAU UUCAAAA

1845 19517 AAUAAGACAGUAGGUGAGUUAGGUGAUGUU Sequence in priority

SEQ ID NO document Sequence

1846 19538 GUGCUAAUGGACAAGUUUUUGGUUUAUAUA

1847 19563 CUUCAUGUUGUCGGCCCAAAUGUUAACAAA

1848 19564 AG AU UG AU U AAACG AACAUG AAAAU U AU UC

1849 19575 AGUACAUUUAUUAGUGAUGAAGUUGCGAGA

1850 19582 AACAAAAUUGCCGAUAAGUAUGUCCGCAAU

1851 19602 GACACACUUAAAAAUCUCUCUGACAGAGUC

1852 19608 GCAGUUGGUAACAUCUGUUACACACCAUCA

1853 19610 A AC A A AC A A UACCUUCACACU C A A AG G CG G

1854 19612 AACUUCUUCAAUUGUCAUUACUUCAGGUGA

1855 19625 GUACUUGGACAAUCAAAAAGAGUUGAUUUU

1856 19653 GUGGAAACUAAAGCCAUAGUUUCAACUAUA

1857 19667 GAAUGAGUUUUACGCAUAUUUGCGUAAACA

1858 19683 CUAACUAACAUCUUUGGCACUGUUUAUGAA

1859 19693 ACCUUUCUGGAUAACAAUUGCUUAUAUCAU

1860 19730 AAUAACUAUAUGCUCACCUAUAACAAAGUU 1861 19742 ACCUUUGGUGCAGGUGCUGCAUUACAAAUA 1862 19763 G UCAAU AU U U AAACACAU U AACAU U AGCUG

1863 19780 AAUUAUCUUGGCAAACCACGCGAACAAAUA

1864 19784 CUUUGAAUGUGGCUAAAUCUGAAUUUGACC

1865 19800 G C AG U G A A A AG A AC A A UCAAGGGUACACAC

1866 19802 GGGCUCAAUGUGUCCAGUUACACAAUGACA

1867 19803 GUAUGCUGCUGACCCUGCUAUGCACGCUGC

1868 19808 ACCUUUUGUUGACAGG C A A AC AG C AC A AG C

1869 19822 CUAACAUAAUAAGAGGCUGGAUUUUUGGUA

1870 19827 GGUAAGAGAAUUCCUUACACGUAACCCUGC

1871 19832 AGAUUGUACAAUGUACAUUUGUGGUGAUUC

1872 19834 ACAAGUAACUUGUGGUACAACUACACUUAA

1873 19839 GCUUUUGCUGUAGAUGCUGCUAAAGCUUAC

1874 19846 AGCUUGUCACACCGUUUCUAUAGAUUAGCU

1875 19851 AUUUGAUUACGUCUAUAAUCCGUUUAUGAU

1876 19856 AGUAAUUGGAACAAGCAAAUUCUAUGGUGG

1877 19863 A A A AC U U C A AG A U G U G G U C A ACC A A A A U G C

1878 19869 GGUAUUGUAGCUAUCGUAGUAACAUGCCUU

1879 19872 CCAAAUUCACACAAUCGACGGUUCAUCCGG

1880 19875 ACUGCUGUUAUGUCUUUAAAAGAAGGUCAA 1881 19879 AGUUUCUAAGGUUGUCAAAGUGACUAUUGA 1882 19892 GACAAUUAUGCUUUGCUGUAUGACCAGUUG

1883 19908 CUUCCUAUUCUUUAUUUGACAUGAGUAAAU

1884 19909 CCAAAU UUUGUAUUUCCCU U AAAU UCCAU A

1885 19916 C U A AC A A A A AG UUUCUGCCUUU CCA AC A A U

1886 19917 CCUAAACUCAUGCAGACCACACAAGGCAGA

1887 19921 GAUGCUGCUCUUGCUUUGCUGCUGCUUGAC

1888 19925 CUCAUGGAAAACAAGUAGUGUCAGAUAUAG

1889 19928 CCUAGCUCUCUACUACCCUUCUGCUCGCAU

1890 19935 CCAACAAUUACCUGAAACUUACUUUACUCA Sequence in priority

SEQ ID NO document Sequence

1891 19944 AACAGGAAGAGAAUCAGCAACUGUGUUGCU

1892 19948 ACGAAGAUGACAAUUUAAUUGAUUCUUACU

1893 20003 GCUGUAGACAU A A AC A AG CUUUGUGAAGAA

1894 20005 ACAAG U AU U U U AG UGG AGCAAUGG AU ACAA

1895 20009 CCAACCAACAGAAUCUAUUGUUAGAUUUCC

1896 20010 GGAACCUCAUCAGGAGAUGCCACAACUGCU

1897 20013 GCAGGUGCUGCAUUACAAAUACCAUUUGCU

1898 20046 AACAGCUUUAAGGGCCAAUUCUGCUGUCAA

1899 20047 GCAGGUAUAUGCGCUAGUUAUCAGACUCAG

1900 20060 AU UACACAG U U ACU UCACU UCAG ACU AU U A

1901 20063 AACAAAUACUUCUAACCAGGUUGCUGUUCU

1902 20071 GAUGCUGUUGUUUACCGAGGUACAACAACU

1903 20078 CUAAAUCUGAAUUUGACCGUGAUGCAGCCA

1904 20082 AUUUGAAAUGGGCUAGAUUCCCUAAGAGUG

1905 20085 ACGACCCUAAGACUAAAAAUGUUACAAAAG

1906 20094 CACUGUUUAUGAAAAACUCAAACCCGUCCU

1907 20097 GAAUGCGUCAUCAUCUGAAGCAUUUUUAAU

1908 20106 CUUCGAUGUCGAGGGGUGUCAUGCUACUAG

1909 20124 GCAGGCUGUUUAAUAGGGGCUGAACAUGUC

1910 20128 AGUAAGGUAAUCACUGGGUUACAUCCUACA

1911 20154 CGAUAACAACUUCUGUGGCCCUGAUGGCUA

1912 20155 CCAACUCAGUUUGCCUGUUUUACAGGUUCG

1913 20240 CCAAGACAUGUGAUCUGCACCUCUGAAGAC

1914 20253 CUGACAGAGAAUUACAUCUUUCAUGGGAAG

1915 20265 AUUUCUACUACCUAGGAACUGGGCCAGAAG

1916 20280 AGUAACAUGCCUUGCCUACUAUUUUAUGAG

1917 20283 CCAAGAUGGUAUUUCUACUACCUAGGAACU

1918 20288 AGAUUUGACACUAGAGUGCUAUCUAACCUU

1919 20319 CUUCUAAGAAGCCUCGGCAAAAACGUACUG

1920 20327 AGAUUUGCCAAUAGGUAUUAACAUCACUAG

1921 20337 AGACCAUUCUUAUGUUGUAAAUGCUGUUAC

1922 20340 ACGAUCAAUUUUCUCCCGCACUCUUGAAAC

1923 20342 GAUGGAACUGGUACUAUCUAUACAGAACUG

1924 20349 ACGAUCGAGUGUACAGUGAACAAUGCUAGG

1925 20360 CUUCUACAAUUUGCCUAUGCCAACAGGAAU

1926 20373 CGCCGAUCUAAAGUCAUUUGACUUAGGCGA

1927 20376 AUUUCCCUUAAAUUCCAUAAUCAAGACUAU

1928 20385 GUAGACUUAUGAAAACUAUAGGUCCAGACA

1929 20396 AUUUCCACAAAGCAUUUCUAUUGGUUCUUU

1930 20398 AAAGAUGGCCAUGUAGAAACAUUUUACCCA

1931 20403 AGCAGAGGCGGCAGUCAAGCCUCUUCUCGU

1932 20405 AAAU ACCCACAAG UUAAUGGUU UAACUUCU

1933 20416 GG U AAU U U UAAAG U U AC A A A AG G A A A AG C U

1934 20418 AACCAGAAUGGAGAACGCAGUGGGGCGCGA

1935 20421 GCUGGUUCUGAUAAAGGAGUUGCACCAGGU Sequence in priority

SEQ ID NO document Sequence

1936 20430 GAAUGGAUAAUCUUGCCUGCGAAGAUCUAA

1937 20435 AUGUAAUUAUCUUGGCAAACCACGCGAACA

1938 20458 C U A A ACG A AC U AAA UAU UAUAUUAGUUUUU

1939 20468 AACAACAAAG AU AGCACU UAAGGGUGG U AA

1940 20496 A A AC A U U C A A A A AG AAA UUGACCGCCU C A A

1941 20500 C U A A AC A UACUGACUUUU C A AG U G A A A U C A

1942 20504 AGUAAAAGACUGUGUUGUAUUACACAGUUA

1943 20505 AGUUUCAACUGGAUACCACUUCAGAGAGCU

1944 20506 GACAACCAAUCACUAAUUGUGUUAAGAUGU

1945 20514 AGAUUUUAGUCAUAGUCAGUUAGGUGGUUU

1946 20556 U A AC A A AC A A UACCUUCACACU C A A AG G CG

1947 20557 U U A A A A AC A A A U G U G U C A A U U U C A AC U U C A

1948 20558 U A AC A A A A UUGCCGAUAAGUAUGUCCGCAA

1949 20569 UAAAUUUUGUCUAGAGGCUUCAUUUAAUUA

1950 20577 UAUGGUACUUGGUAGUUUAGCUGCCACAGU

1951 20582 UUUUACUAUUAAGUGUUUGCCUAGGUUCUU

1952 20583 UG U U U ACCG AGG U ACAACAACU U ACAAAU U

1953 20587 UGUUUACCAAUGUGCUAUGAGGCCCAAUUU

1954 20593 UUGUCAUACCAGACUAUAACACAUAU A A A A

1955 20603 U AAAU UUAUCUCAACCUGUGCUUGUG AAAU

1956 20605 UAAGAGAAUUCCU UACACG U AACCCUGCU U

1957 20607 UAAGAGACACACUUUCUCUAACUACCAACA

1958 20613 UGGGAUUAUCCUAAAUGUGAUAGAGCCAUG

1959 20615 U UAAAAAU U ACAG AAG AGG U UGGCCACACA

1960 20618 UUUUUACUAUUAAGUGUUUGCCUAGGUUCU

1961 20650 GUUAGCUUGUUACAAUGGUUCACCAUCUGG

1962 20657 UUUCCAACCCACUAAUGGUGUUGGUUACCA

1963 20661 UGUUUAAACCGUGUUUGUACUAAUUAUAUG

1964 20662 UUAAAACUCUUUGACCGUUAUUUUAAAUAU

1965 20668 UAUGAUACCAAUGUACUAGAAGGUUCUGUU

1966 20683 UAAGAGUCAUUUUGCUAUUGGCCUAGCUCU

1967 20689 UG U UGU UUGU ACAG AAAU UGACCCUAAGUU

1968 20690 UGUUGUUUGUAACAGUUUACUCACACCUUU

1969 20700 UAAGAGUGUCGGUAAAUUUUGUCUAGAGGC

1970 20705 GUUACUAAUCCUUAUGACAGCAAGAACUGU

1971 20708 UAUGGUUGAGCUGGUAGCAGAACUCGAAGG

1972 20718 UCCUGUUGUAGAUUCUUAUUAUUCAUUGUU

1973 20732 UGUUGUUGGAGAAGGUUCCGAAGGUCUUAA

1974 20762 UGUUGUUCAGUUGACUUCGCAGUGGCUAAC

1975 20763 UAAGAUGUUGUGUACACACACUGGUACUGG

1976 20774 UACUUGGUUCCAUGCUAUACAUGUCUCUGG

1977 20779 UUGUCUGGUUUUAAGCUAAAAGACUGUGUU

1978 20781 G UGU UUCAAU AGCACU UAUGCAUCUCAAGG

1979 20789 UAUGAGCUAUUAUUGUAAAUCACAUAAACC

1980 20794 UAUGUACAUGGGCACACUUUCUUAUGAACA Sequence in priority

SEQ ID NO document Sequence

1981 20799 UUGUCUUAGUGGUUUAGAUUCUUUAGACAC

1982 20829 UACUUGGUAGUUUAGCUGCCACAGUACGUC

1983 20835 GUUGUCUGUACUGCCGUUGCCACAUAGAUC

1984 20840 UUUUAAGCUAAAAGACUGUGUUAUGUAUGC

1985 20856 UUGGGAUUAUCCUAAAUGUGAUAGAGCCAU

1986 20858 UAUGUAUGCAUCAGCUGUAGUGUUACUAAU

1987 20874 UAAAUCCAGAGAAGAAACUGGCCUACUCAU

1988 20879 UUAAACCGUGUUUGUACUAAUUAUAUGCCU

1989 20890 UAAAUCAAAAUGUGAAGAAUCAUCUGCAAA

1990 20914 UGUUGUCCAACAAUUACCUGAAACUUACUU

1991 20915 UUGGG AAAU UGU U AAAU UUAUCUCAACCUG

1992 20918 UUGUGAUGGUGGCAGUUUGUAUGUAAAUAA

1993 20921 UUGUGAUGUCACAGAUGUGACUCAACUUUA

1994 20927 UAAGCCAGUACCAUAUUGUUAUGAUACCAA

1995 20933 U A AG CCAUUUAU A AC U G A A AG U A A ACC U U C

1996 20971 UGUUGUACAUAAUCAGGAUGUAAACUUACA

1997 20987 UAAAUAAAGAAAUGUAUCUAAAGUUGCGUA

1998 21002 UAUGUCUUUAAAAGAAGGUCAAAUCAAUGA

1999 21007 GUUACCCGUGAACUCAUGCGUGAGCUUAAC

2000 21009 UG U UGG U U ACCAACCAU ACAG AG U AG U AG U 2001 21016 UAAAGUUGAGGGUUGUAUGGUACAAGUAAC 2002 21017 GUUCUUAUUACAGAAGGUAGUGUUAAAGGU

2003 21023 GUUGUUCAGUUGACUUCGCAGUGGCUAACU

2004 21025 UGUUGGUGGCAAACCUUGUAUCAAAGUAGC

2005 21028 U AAGCG UGU UGACUGGACU AU UGAAU AUCC

2006 21037 UUAUCUUACUUCUUCUUCUAAAACACCUGA

2007 21039 UUAUGUGUUGACAUACCUGGCAUACCUAAG

2008 21046 UUUCAUCAACUUUUAACGUACCAAUGGAAA

2009 21060 UAUGUGCAUGUUGUAGACGGUUGUAAUUCA

2010 21074 UAUGUGCUCAUGGAUGGCUCUAUUAUUCAA 2011 21083 UUGUGGACCUAAAAAGUCUACUAAUUUGGU 2012 21090 GUUACCACAGAAAUUCUACCAGUGUCUAUG

2013 21105 GUUGUCCAACAAUUACCUGAAACUUACUUU

2014 21109 U U C ACC U A A AC UGUUCAUCAGACAAGAGGA

2015 21117 UAAAGGUUUACAACCAUCUGUAGGUCCCAA

2016 21120 UGUUGGAGAAGGUUCCGAAGGUCUUAAUGA

2017 21122 UUUUAGUGCAGUUGGUAACAUCUGUUACAC

2018 21126 UUUUAACGCCACCAGAUUUGCAUCUGUUUA

2019 21159 U A A AG G C U U U U G C A A AC U AC AC A A U U G G A A

2020 21169 UUAUCUUCAACCUAGGACUUUUCUAUUAAA 2021 21176 UUGGCCACACAGAUCUAAUGGCUGCUUAUG 2022 21192 UUAUUUUGCUUCCACUGAGAAGUCUAACAU

2023 21193 UUGGCAUGUUAACAAUGCAACUAAUAAAGC

2024 21196 UGUUGCUAUGCCUAAUCUUUACAAAAUGCA

2025 21211 UAAAGCUUCAUGCACUUUGUCCGAACAACU Sequence in priority

SEQ ID NO document Sequence

2026 21220 UAAAGCUGCAUUAUUAGCAGACAAAUUCCC

2027 21221 UUUUAACAUUUGUCAAGCUGUCACGGCCAA

2028 21231 GUUACAUCCUACACAGGCACCUACACACCU

2029 21236 UAUGUUCACACCUUUAGUACCUUUCUGGAU

2030 21239 UAUCUUGCCACUGCAUUGUUAACACUCCAA

2031 21243 UAAAGCCACUUGCGAAUUUUGUGGCACUGA

2032 21256 UUUUAACAUAGAUUAUGACUGUGUCUCUUU

2033 21262 UAUGUUGAUACACCUAAUAAUACAGAUUUU

2034 21264 U U G G C AC A AC A U G U U A A A A AC UGUUUAUAG

2035 21265 UAUCUUCAACCUAGGACUUUUCUAUUAAAA

2036 21268 UGUUGCAGGAGCCUUAAAUAAGGCUACUAA

2037 21275 UAUCUUACUUCUUCUUCUAAAACACCUGAA

2038 21276 GUUGUCAAUGCCAGAUUACGUGCUAAGCAC

2039 21283 GUUGUUGGAGAAGGUUCCGAAGGUCUUAAU

2040 21314 UUGGAUUAUAAAGCAUUCAAACAAAUUGUU

2041 21316 UUGUGUUCCCUUGAACAUAAUACCUCUUAC

2042 21332 UUUUAUAGCUGGCUUGAUUGCCAUAGUAAU

2043 21333 UUAAAUGGUUACACUGUAGAGGAGGCAAAG

2044 21347 GUUAAGAUGUUGUGUACACACACUGGUACU

2045 21358 UGUUGAUGUAGAAUUGUUUGAAAAUAAAAC

2046 21364 UUGGAUGACAGAUGCAUUCUGCAUUGUGCA

2047 21377 UU AAAU UGGCUUCACAUAUGU AU UGUUCUU

2048 21378 U UG U U AAAGCUGCAU U AU U AGCAG ACAAAU

2049 21393 UUGGAUAUGGUUGAUACUAGUUUGUCUGGU

2050 21408 UUUCAGAUCCUCAGUUUUACAUUCAACUCA

2051 21416 UAUUAAAAUACAAGAGGGUGUGGUUGAUUA

2052 21437 G U UG U AU UACACAG U U ACU UCACU UCAG AC

2053 21442 UGAGCUGGUAGCAGAACUCGAAGGCAUUCA

2054 21454 UAUUAAAGUCUGUGAAUUUCAAUUUUGUAA

2055 21479 UUGUUAAUGCAGCCAAUGUUUACCUUAAAC

2056 21481 GUUGUAUGGUACAAGUAACUUGUGGUACAA

2057 21484 UAUUAACAUCACUAGGUUUCAAACUUUACU

2058 21516 UUAACAGGCACAGGUGUUCUUACUGAGUCU

2059 21518 UGUUGAAUGUCUUAAAUUGUCACAUCAAUC

2060 21523 G U U A U A AC ACC AG G A AC A A A UACUUCUAAC 2061 21524 UAUCGUGUAACU A A A A AC AG U A A AG U AC A A 2062 21535 UGUUGAAGGUUUUAAUUGUUACUUUCCUUU

2063 21545 UGAGGCUUUUGAGUACUACCACACAACUGA

2064 21548 U U U C U AC A A AG A A A ACAG U U ACACAACAAC

2065 21553 UAAGUAUGUACAAAUACCUACAACUUGUGC

2066 21554 UGUUGAACAUGUUACCUUCUUCAUCUACAA

2067 21567 U UG U U ACAG ACACACCU AAAGG UCCU AAAG

2068 21568 UGAGGGUUGUAUGGUACAAGUAACUUGUGG

2069 21575 U U AUG AAAAACUCAAACCCG UCCU UGAUUG

2070 21582 UUUCACUACUUUCUGUUUUGCUUUCCAUGC Sequence in priority

SEQ ID NO document Sequence

2071 21584 UGAGGUUCAACCUCAAUUAGAGAUGGAACU

2072 21592 UGUUCUUGUGGAUCCUGCUGCAAAUUUGAU 207B 21594 UUGGACCUUUGGUGCAGGUGCUGCAUUACA

2074 21598 GUUGUUUGUACAGAAAUUGACCCUAAGUUG

2075 21609 UGAGACACUUGGUGUCCUUGUCCCUCAUGU

2076 21612 UGUUCUUAUUACAGAAGGUAGUGUUAAAGG

2077 21618 UUGGACAGCUGGUGCUGCAGCUUAUUAUGU

2078 21623 UGUUCUUACUGAGUCUAACAAAAAGUUUCU

2079 21638 GUGUGUGUUCUGUUAUUGAUUUAUUACUUG

2080 21641 UGUUCUUAAAAAGUUGAAGAAGUCUUUGAA 2081 21657 U A AG UGACACACUU A A A A A UCUCUCUGACA 2082 21677 UUAACGGCCUUACUGUUUUGCCACCUUUGC

2083 21683 UGGGAAAUUGUUAAAUUUAUCUCAACCUGU

2084 21688 UGAGUAUUGCCCUAUUUUCUUCAUAACUGG

2085 21689 UUGUUACUCACAAUUUUGACUUCACUUUUA

2086 21695 GUUGUUUUAGAUUUCAUCUAAACGAACAAA

2087 21702 UGACUUUUUGCAUUUCUUACCUAGAGUUUU

2088 21720 UAAACCUUUGGAAUUUGGUGCCACUUCUGC

2089 21721 UGUUCGUUCUAUGAAGACUUUUUAGAGUAU

2090 21723 UUGGAACUUUAAUUUUAGCCAUGGCAGAUU

2091 21737 UGACUUUAAACUUAAUGAAGAGAUCGCCAU

2092 21738 UUUGCCACCUUUGCUCACAGAUGAAAUGAU

2093 21765 UGACUUCGCAGUGGCUAACUAACAUCUUUG

2094 21790 UUAACUUCUAUUAAAUGGGCAGAUAACAAC

2095 21795 UGAGUUAGGUGAUGUUAGAGAAACAAUGAG

2096 21808 UAUCCGAUUUACAGGAUUUGAAAUGGGCUA

2097 21820 UGUUCCAUUUGUAGUUUCAACUGGAUACCA

2098 21822 UGAGU UU AAAU UGGCUUCACAUAUGU AU UG

2099 21825 UGACUGGACUAUUGAAUAUCCUAUAAUUGG

2100 21828 UGGUCAACAAGACGGCAGUGAGGACAAUCA 2101 21845 UGAUAAAAGUGUAUAUUACACUAGUAAUCC 2102 21860 UUAAGAAUAUUGAUGGUUAUUUUAAAAUAU

2103 21862 UGUUCAGUUGACUUCGCAGUGGCUAACUAA

2104 21869 U AAACCU AG ACCACCACU U AACCG AAAU U A

2105 21880 GUUGUAGCUUGUCACACCGUUUCUAUAGAU

2106 21894 GUUUAAACCGUGUUUGUACUAAUUAUAUGC

2107 21901 UGACUAUGGUGAUGCUGUUGUUUACCGAGG

2108 21903 UGUUCAGAUACCUUGUACGUGUGGUAAACA

2109 21906 UGUUCAGACUAUUGAAGUGAAUAGUUUUAG

2110 21910 UGUUCACUUUGUUUGCAACUUGCUGUUGUU 2111 21937 GUGUUUUAACUGCUGUGGUUAUACCUACUA 2112 21943 UGUUCAAGAGGGUGUUUUAACUGCUGUGGU

2113 21952 GUUUAAAUGGUUACACUGUAGAGGAGGCAA

2114 21965 UG AU ACACCU AAU AAU ACAG AU U U U UCCAG

2115 21969 UGAUACAGCCAAUCCUAAGACACCUAAGUA Sequence in priority

SEQ ID NO document Sequence

2116 21979 U G ACG G U A A A A U G A A AG A U CUCAGUCCAAG

2117 21982 UG U U AU U UCU AG UGAUGU UCU UGUUAACAA

2118 21984 UUUUUCUAUGUACUUGGAUUGGCUGCAAUC

2119 21988 UACUCACAAUUUUGACUUCACUUUUAGUUU

2120 21989 GUUCUUACUGAGUCUAACAAAAAGUUUCUG 2121 21991 UGAUACUAGUUUGUCUGGUUUUAAGCUAAA 2122 22002 UUGCUGUUCUUUAUCAGGAUGUUAACUGCA

2123 22021 UAAACCAGGUGGAACCUCAUCAGGAGAUGC

2124 22022 GUUAACUGCACAGAAGUCCCUGUUGCUAUU

2125 22025 UAAUAACGCUACUAAUGUUGUUAUUAAAGU

2126 22028 GUUUAAGAAUAUUGAUGGUUAUUUUAAAAU

2127 22042 UGUUAUUAAAGUCUGUGAAUUUCAAUUUUG

2128 22045 UGAUAGUGCAACAUUACCUAAAGGCAUAAU

2129 22047 UGAUAGUGCGGAAGUUGCAGUUAAAAUGUU

2130 22088 UGACCUACACAGGUGCCAUCAAAUUGGAUG

2131 22089 UAUCAGACUCAGACUAAUUCUCCUCGGCGG

2132 22097 UUAAGGAAGGUGUAGAGUUUCUUAGAGACG

2133 22118 GUUGUACGAUCAAUUUUCUCCCGCACUCUU

2134 22128 UAUUAUUGCUAUGUCUGCUUUUGCAAUGAU

2135 22145 UGAUAUUGCUGCUAGAGACCUCAUUUGUGC

2136 22157 UGUUAUCACGCAUGAUGUUUCAUCUGCAAU

2137 22161 UAUCACGCAUGAUGUUUCAUCUGCAAUUAA

2138 22164 UAUCACCUUUGACAAUCUUAAGACACUUCU

2139 22169 GUGUGUUCUGUUAUUGAUUUAUUACUUGAU

2140 22181 UAAUAAUUAAUCUUGUACAAAUGGCCCCGA

2141 22182 UGAUCACAGGCAGACUUCAAAGUUUGCAGA

2142 22184 UUUUUCUACAGGUGUUAACCUAGUUGCUGU

2143 22190 U AAU AAU UGG U UG AAGCAG UUAAU UAAAG U

2144 22211 UAAUACACUUCAGUGUAUAAUGCUAGUUUA

2145 22218 UUUGGACCACUAGUGAGAAAAAUAUUUGUU

2146 22221 UGACAUGUGCAACUACUAGACAAGUUGUUA

2147 22245 UGACAUCUCUGGCAUUAAUGCUUCAGUUGU

2148 22247 UGACAUCUAUGAAGUAUUUUGUGAAAAUAG

2149 22264 GUUGACUGGACUAUUGAAUAUCCUAUAAUU

2150 22275 U AAU ACG U U U UCAUCAACU U U UAACG U ACC

2151 22278 UGACAUACCUGGCAUACCUAAGGACAUGAC

2152 22279 UG U U AG U ACAACU ACU AACAU AG U UACACG

2153 22287 UGGUAUUGUAGCUAUCGUAGUAACAUGCCU

2154 22296 GUUUACAAACAAUUUGAUACUUAUAACCUC

2155 22299 UAAACAGGGUGAUGAUUAUGUGUACCUUCC

2156 22307 UGACAGGCAAACAGCACAAGCAGCUGGUAC

2157 22318 UGAUGAACUGAAGAUUAAUGCGGCUUGUAG

2158 22333 UGAUGAAGUCAGACAAAUCGCUCCAGGGCA

2159 22338 U AG AGG U ACAACAG U ACU U U UAAAAGAACC

2160 22344 UGACACUGUGAGUGCUUUGGUUUAUGAUAA Sequence in priority

SEQ ID NO document Sequence

2161 22345 GUUAUCACGCAUGAUGUUUCAUCUGCAAUU

2162 22353 UGAUGACACUGUGAUAGAAGUGCAAGGUUA

2163 22355 UGACACUGACUUAACAAAGCCUUACAUUAA

2164 22359 UGAUGACCCGUGUCCUAUUCACUUCUAUUC

2165 22373 UUUCAAACUUUACUUGCUUUACAUAGAAGU

2166 22378 UUUCUCAAUCGAUUUACCACAACUCUUAAU

2167 22382 UGACACUAAAUUCAAAACUGAAGGUUUAUG

2168 22383 UGUUAGACAAUGCUCAGGUGUUACUUUCCA

2169 22395 UGUUACUU U CCA A AG U G C AG U G A A A AG A AC

2170 22417 UGACACAGACUUUGUGAAUGAGUUUUACGC

2171 22437 UG U U ACUCACAAU U U UG ACU UCACU U U U AG

2172 22443 UGACAAUUAUGCUUUGCUGUAUGACCAGUU

2173 22467 UGAUGAUUAUGUGUACCUUCCUUACCCAGA

2174 22478 UAAUAGUGUCCCUUGGGAUACUAUAGCUAA

2175 22492 UGAUGCACUAUGUGAGAAGGCAUUAAAAUA

2176 22504 UGUUACCCGUGAACUCAUGCGUGAGCUUAA

2177 22531 U A A AC A AG C U AC A A A A UAUCUAGUACAACA

2178 22541 UGAUGCGUAUUAUGACAUGGUUGGAUAUGG

2179 22547 UAUAUUAGAGUAGGAGCUAGAAAAUCAGCA

2180 22565 GUUGGUUUUAACAUAGAUUAUGACUGUGUC 2181 22566 GUUUACCAAUGUGCUAUGAGGCCCAAUUUC 2182 22567 GUUACAAACGUAAUAGAGCAACAAGAGUCG

2183 22577 UGAUGCUGCUCUUGCUUUGCUGCUGCUUGA

2184 22582 UGAUGCUGUUGUUUACCGAGGUACAACAAC

2185 22590 GUUAUCUUCAACCUAGGACUUUUCUAUUAA

2186 22597 UGUUAAUGUUGU A AC A AC A A AG A U AG C AC U

2187 22608 UUCAAACUUUACUUGCUUUACAUAGAAGUU

2188 22616 UGAUGGCACAACAAGUCCUAUUUCUGAACA

2189 22618 UAUUGAUUUAUUACUUGAUGAUUUUGUUGA

2190 22620 U ACU UCACU UCAGACUAUUACCAGCUGU AC

2191 22629 UUAAUAAUUAAUCUUGUACAAAUGGCCCCG

2192 22634 UGUUAAUGCAGCCAAUGUUUACCUUAAACA

2193 22638 UGAAUGUCUUAAAUUGUCACAUCAAUCUGA

2194 22639 UUGUUCGCAUUCAACCAGGACAGACUUUUU

2195 22645 UUUUGCUAAAUUCCUAAAAACUAAUUGUUG

2196 22648 UGUUAAUCCAGUAAUGGAACCAAUUUAUGA

2197 22651 UAAAAUUUAUUGUCCAGCAUGUCACAAUUC

2198 22658 UGAUGGUCAAGUAGACUUAUUUAGAAAUGC

2199 22662 UCCCUUCCAUCAUAUGCAGCUUUUGCUACU

2200 22672 UAAAAUUGUUAAUAAUUGGUUGAAGCAGUU 2201 22675 UUGCGCGUACGCGUUCCAUGUGGUCAUUCA 2202 22685 UGAUGGUGUUCCAUUUGUAGUUUCAACUGG

2203 22686 UGAUGGUGUUGAUGUAGAAUUGUUUGAAAA

2204 22687 UGAUGGUGUUGUCCAACAAUUACCUGAAAC

2205 22691 UAUAUGCGCUAGUUAUCAGACUCAGACUAA Sequence in priority

SEQ ID NO document Sequence

2206 22698 UAUUGCUACUGUACGUGAAGUGCUGUCUGA

2207 22705 UAAUCACUGGGUUACAUCCUACACAGGCAC

2208 22709 UGAUGUAGAAUUGUUUGAAAAUAAAACAAC

2209 22710 UUAAUAGGGGCUGAACAUGUCAACAACUCA

2210 22711 UGAAUCUGAUGAUUACAUAGCUACUAAUGG 2211 22712 G U UGG U U ACCAACCAU ACAG AG U AG U AG U A 2212 22718 UGAAUCCUGUGGUAAUUUUAAAGUUACAAA

2213 22723 UUGUUCUAUGACUGACAUAGCCAAGAAACC

2214 22731 UAUUGGACAUUCUAUGCAAAAUUGUGUACU

2215 22734 UAUAUGAGAUCUCUCAAAGUGCCAGCUACA

2216 22742 GUGUCAUGCUACUAGAGAAGCUGUUGGUAC

2217 22744 UAUUGGAGUUACACAGAAUGUUCUCUAUGA

2218 22761 UCCCUUGAACAUAAUACCUCUUACAACAGC

2219 22766 UGUUAACUGCACAGAAGUCCCUGUUGCUAU

2220 22769 UUGCCUGUUUUACAGGUUCGCGACGUGCUC 2221 22772 UAAUCCAGUAAUGGAACCAAUUUAUGAUGA 2222 22773 UGUUAACCUAGUUGCUGUACCUACAGGUUA

2223 22774 UGAAUACAGUCAUGUAGUUGCCUUUAAUAC

2224 22777 UGAUGUGGUGGCUAUUGAUUAUAAACACUA

2225 22780 UUGCCUGGCACGAUAUUACGCACAACUAAU

2226 22785 GUGUUCACUUUGUUUGCAACUUGCUGUUGU

2227 22788 UAAUCCGUAUGUUUGCAAUGCUCCAGGUUG

2228 22801 UGAAG U U U U U AACGCCACCAG AU U UGCAUC

2229 22802 UAAAAUGUUUGAUGCUUACGUUAAUACGUU

2230 22809 UGAAGUUUAAUCCACCUGCUCUACAAGAUG

2231 22811 UUUUUGUAUAUAAUUAAGUUAAUUUUCCUC

2232 22815 UGAUGUUAGAGAAACAAUGAGUUACUUGUU

2233 22823 UUAAUCCACCUGCUCUACAAGAUGCUUAUU

2234 22831 UUUUUCGGCUUUAGAACCAUUGGUAGAUUU

2235 22835 UGAAGUUAUCACCUUUGACAAUCUUAAGAC

2236 22845 UUGCCUACGGGUACGCUGCUUGUCGAUUCA

2237 22855 UG U U AAAGCUGCAU U AU U AGCAG ACAAAU U

2238 22868 UGAUGUUGUUCAAGAGGGUGUUUUAACUGC

2239 22870 UAAUCUAUUACUAGAUAAACGCACUACGUG

2240 22881 UAUUGUAGCUAUCGUAGUAACAUGCCUUGC

2241 22882 GUUGGUGGCAAACCUUGUAUCAAAGUAGCC

2242 22889 UG AAG U ACCAG UUUCUAUCAU U AAU AACAC

2243 22896 UGAAGGUUUUAAUUGUUACUUUCCUUUACA

2244 22910 UAAUCUUACAACCAGAACUCAAUUACCCCC

2245 22914 UGUUAAAAUUUAUUGUCCAGCAUGUCACAA

2246 22916 UAAAAUGAAAGAUCUCAGUCCAAGAUGGUA

2247 22920 GUUAAUUGUGAUACAUUCUGUGCUGGUAGU

2248 22930 UUUAUUGCCACUAGUCUCUAGUCAGUGUGU

2249 22931 UGAUUACAUUUUAGCUAACACCUGUACUGA

2250 22967 UUGCCAUAACAAGUGUGCCUAUUGGGUUCC Sequence in priority

SEQ ID NO document Sequence

2251 22969 UGUGUUUUAAGCGGACACAAUCUUGCUAAA

2252 22974 UGAAGCUGCUAACUUUUGUGCACUUAUCUU

2253 22978 UGAAGCUCCAUUGGUUGGUACACCAGUUUG

2254 22982 UUUAUUCUCUACAGUGUUCCCACCUACAAG

2255 23000 UGAUUAUUUUGUGCUGACAUCACAUACAGU

2256 23003 UGAUUCAACUGAAUGCAGCAAUCUUUUGUU

2257 23012 UGAAGCAGUUAAUUAAAGUUACACUUGUGU

2258 23017 UGAUUCAUCACAGGGCUCAGAAUAUGACUA

2259 23031 UAAAAUAUGACUUCACGGAAGAGAGGUUAA

2260 23034 UAUUGUUGGUGUACUGACAUUAGAUAAUCA 2261 23040 UUUCUGGGUAGGUACAUGUCAGCAUUAAAU 2262 23046 UUGCCAAGAAUUUAAAUGAAUCUCUCAUCG

2263 23054 UGAUUCUGAAGUUGUUCUUAAAAAGUUGAA

2264 23064 UAUUGUUUUUAUGUGUGUUGAGUAUUGCCC

2265 23065 UGAUUCUUCUUCAGGUUGGACAGCUGGUGC

2266 23070 UAUUUAAAACUUACUGACAAUGUAUACAUU

2267 23081 GUUAUGGAGUGUCUCCUACUAAAUUAAAUG

2268 23087 UGAUUGCCUUGGUGAUAUUGCUGCUAGAGA

2269 23092 UGAAGAGCUUAAAAAGCUCCUUGAACAAUG

2270 23097 GUUGAAGGUUUUAAUUGUUACUUUCCUUUA

2271 23110 UGAAGACAUUCAACUUCUUAAGAGUGCUUA

2272 23112 UUCAAAUGGCACACACUGGUUUGUAACACA

2273 23119 GUUGGUAGCGAUAAUGUUACUGACUUUAAU

2274 23126 U G A AG A AG U U AC A AC A AC U C U G G A AG A A AC

2275 23128 UGAUUGUGAAGAAGAAGAGUUUGAGCCAUC

2276 23130 UGAAGAAGUCUUUGAAUGUGGCUAAAUCUG

2277 23132 UGAUUGUGCAACUGUACAUACAGCUAAUAA

2278 23139 UGUGUUCCCUUGAACAUAAUACCUCUUACA

2279 23146 U A A U G C A AC AG A AG UGCCUGCCAAUU C A AC

2280 23159 UAAUGCACAUGUAGCUAGUUGUGAUGCAAU 2281 23163 GUUUUAAAUGAUAUCCUUUCACGUCUUGAC 2282 23164 UG AU U U ACAACCAU U AG AACAACCU ACU AG

2283 23170 UAAUGCACUUUUAUCUACUGAUGGUAACAA

2284 23174 UAAUGCAGCCAAUGUUUACCUUAAACAUGG

2285 23177 UGAUUUAGGUGACAUCUCUGGCAUUAAUGC

2286 23183 U U UCUGUGGUG UAGAUGCUGU AAAU UU ACU

2287 23187 UGAACUCGGUACAGAAGUAAAUGAGUUCGC

2288 23191 UUAAUGGUAUUGGAGUUACACAGAAUGUUC

2289 23193 UAGAGUGGUAACAACUUUUGAUUCUGAGUA

2290 23203 UGAUUUCAUACAAACCACGCCAGGUAGUGG

2291 23210 UGAACGUGU ACG CC A AG C U U U G U U A A A A AC

2292 23223 UAAUGCCUAUAUUAACCUUGACCAGGGCUU

2293 23225 UGUGUGUUUCAAUAGCACUUAUGCAUCUCA

2294 23228 GUUUAUAACACUUUGCUUCACACUCAAAAG

2295 23250 UUUACGCAUAUUUGCGUAAACAUUUCUCAA Sequence in priority

SEQ ID NO document Sequence

2296 23268 UGAACAUGUUACCUUCUUCAUCUACAAUAA

2297 23277 GUUUAUACAACAAAAGCUAGCUCUUGGAGG

2298 23279 UAAUGCUGCUAUCAGCGAUUAUGACUACUA

2299 23283 GUUAUGUAUGCAUCAGCUGUAGUGUUACUA

2300 23284 U G A AC AG AG A A A AC A AG A U GAU A AG A A A A U

2301 23285 UAGCAGAACUCGAAGGCAUUCAGUACGGUC

2302 23287 UGAACAGAAAUCAAUACUGAGUCCUCUUUA

2303 23294 UUGCAGACAUAUGUGACUCAACAAUUAAUU

2304 23295 UUUGUUACAGACACACCUAAAGGUCCUAAA

2305 23298 UAUUUCUACUACCUAGGAACUGGGCCAGAA

2306 23300 UAUUUCUAGUGAUGUUCUUGUUAACAACUA

2307 23306 UGAUUUUUGUGGAAAGGGCUAUCAUCUUAU

2308 23310 UAAUGCUUUAGAUCAAGCCAUUUCCAUGUG

2309 23312 U G A AC A AG AC A A A A AC ACCC A AG A AG U U U U

2310 23319 UGGUAUGCAAAAGUAUUCUACACUCCAGGG

2311 23324 UGAACAAAAGAUCGCUGAGAUUCCUAAAGA

2312 23327 UACUUAUAAAUUGGAUGGUGUUGUUUGUAC

2313 23346 UAUAGCUUGGAAUUCUAACAAUCUUGAUUC

2314 23361 UAUUUGACUCCUGGUGAUUCUUCUUCAGGU

2315 23381 GUGUUAAAUCCAGAGAAGAAACUGGCCUAC

2316 23385 UGAAAUCCUUCACUGUAGAAAAAGGAAUCU

2317 23390 UGAAAUCAAGGAUGCUACUCCUUCAGAUUU

2318 23391 UGGGGCUUGUGUUCUUUGCAAUUCACAGAC

2319 23406 UGAAAUAAUAAAAUCCCAAGAUUUAUCUGU

2320 23408 UUCAACACAUGGUUGUUAAAGCUGCAUUAU

2321 23417 GUUGGGAUUAUCCUAAAUGUGAUAGAGCCA

2322 23419 UUUCUUAGGAAUCAUCACAACUGUAGCUGC

2323 23421 UGCAAAUUAUCAAAAGGUUGGUAUGCAAAA

2324 23458 UCCGAAGGUCUUAAUGACAACCUUCUUGAA

2325 23469 UUGCAAUGCUCCAGGUUGUGAUGUCACAGA

2326 23480 UGAAACUUCAUGGCAGACGGGCGAUUUUGU

2327 23490 UGCAACUGAGGGAGCCUUGAAUACACCAAA

2328 23492 U G C A AC UGCAGAAGCUGAACUUG C A A AG A A

2329 23514 UCCUGAUCUUCUGGUCUAAACGAACUAAAU

2330 23517 UUUAUGUGUUGACAUACCUGGCAUACCUAA

2331 23520 U G A A AC A UUUGUCACGCACU C A A AG G G A U U

2332 23523 UGAAACAUCAAAUUCGUUUGAUGUACUGAA

2333 23532 UUGCAACUUGCUGUUGUUGUUUGUAACAGU

2334 23533 UAGAGUUGAUGGUCAAGUAGACUUAUUUAG

2335 23537 UUGCAACUGAGGGAGCCUUGAAUACACCAA

2336 23538 UAUUUUAAAAUAUAUUCUAAGCACACGCCU

2337 23547 UAUUUUAAAUAUUGGGAUCAGACAUACCAC

2338 23551 UAAAACUCUUUGACCGUUAUUUUAAAUAUU

2339 23565 UAAUGGUUUAACUUCUAUUAAAUGGGCAGA

2340 23569 UGCAAUAUGGCAGUUUUUGUACACAAUUAA Sequence in priority

SEQ ID NO document Sequence

2341 23582 UGAAAAUACUCAAUAAUUUGGGUGUGGACA

2342 23593 UAAUGUAGCAUUUGAGCUUUGGGCUAAGCG

2343 23594 UAUAGAAUUUCUUAAGAGAGGUGAUAAAAG

2344 23603 UGAAAAGAAAAAGCUUGAUGGCUUUAUGGG

2345 23617 UGAAAACAUGACACCCCGUGACCUUGGUGC

2346 23619 UUUUGUUACCUUCUCUUGCCACUGUAGCUU

2347 23631 UUCAACAUGCCAAUUUAGAUUCUUGCAAAA

2348 23636 UGCAAUUUACAAGUCUUGAAAUUCCACGUA

2349 23637 UGCAAUUUAGGUGGUGCUGUCUGUAGACAU

2350 23638 UGAAAAAGGCGUUUUGCCUCAACUUGAACA

2351 23639 UGCAAUUUCAAGUGUUUUAAAUGAUAUCCU

2352 23640 UACUUACCCCAAAAUGCUGUUGUUAAAAUU

2353 23641 GUUUAUGAUUACUUAGUUUCUACACAGGAG

2354 23648 UGUGUACACACACUGGUACUGGUCAGGCAA

2355 23654 UCUUUUUUUUGUAUGAAAAUGCCUUUUUAC

2356 23682 UUACAAACAAUUUGAUACUUAUAACCUCUG

2357 23698 U G U G U A A A AC UUGUGGACAACAGCAG AC A A

2358 23701 UGCACCAACAAAGGUUACUUUUGGUGAUGA

2359 23714 UGCACCAGGUACAGCUGUUUUAAGACAGUG

2360 23715 UAUACUGAAAAAUGGGAAUCUGGAGUAAAA

2361 23734 U A A A ACC A AC AG UGGUUGUUAAUGCAGCCA

2362 23740 UAAAACAUUUUAUGUUUUACCUAAUGAUGA

2363 23747 UUACAACCAUCUGUAGGUCCCAAACAAGCU

2364 23754 UAAUGUUCAACUCAGGGUUAUUGGACAUUC

2365 23756 UGCACUACGACAGAUGUCUUGUGCUGCCGG

2366 23760 UAUACUAAUGACAAAGCUUGCCCAUUGAUU

2367 23774 UCUUUGUUCUUUUUUUUGUAUGAAAAUGCC

2368 23780 UUACAAGAGUGUGAAUAUCACUUUUGAACU

2369 23782 U AAUG U UG U AACAACAAAG AU AGCACU U AA

2370 23786 UAUUUUUGGUGCUGACCCUAUACAUUCUUU

2371 23804 GUUUUAAUGUCUAAUUUAGGCAUGCCUUCU

2372 23806 G U U U AU U ACC AC A A A A AC A AC A A A AG UUGG

2373 23810 G U U U AU U ACCCUG ACAAAG U U UUCAGAUCC

2374 23812 UCUUUGGCUUGAUGACGUAGUUUACUGUCC

2375 23816 UGCAGAAAAUUCAGUUGCUUACUCUAAUAA

2376 23823 UAAUGUUUUAGCUUGGUUGUACGCUGCUGU

2377 23840 UAAUUAAAGUUACACUUGUGUUCCUUUUUG

2378 23859 UUUUAUGUCUGAAGCAAAAUGUUGGACUGA

2379 23871 UCUUUGCAAUUCACAGACUUCAUUAAGAUG

2380 23891 UAAUUACCAGUGUGGUCACUAUAAACAUAU

2381 23897 UUACACAAAAGUUGAUGGUGUUGAUGUAGA

2382 23922 UCUUUCUACCCUCCAGAUGAGGAUGAAGAA

2383 23925 GUUUAUUCUACAGGUUCUAAUGUUUUUCAA

2384 23939 UAAUUAUAAUUACCUGUAUAGAUUGUUUAG

2385 23947 UUGAUGUACUGAAGUCAGAGGACGCGCAGG Sequence in priority

SEQ ID NO document Sequence

2386 23951 UUACACCACUAAUUCAACCUAUUGGUGCUU

2387 23956 UGCAGCCGAUCAUCAGCACAUCUAGGUUUC

2388 23965 UUUUAUGUGUGUUGAGUAUUGCCCUAUUUU

2389 23981 UCUUUAUUAUCAAAACAAUGUUUUUAUGUC

2390 23992 UUCAACCUCAAUUAGAGAUGGAACUUACAC

2391 24000 UCUUUAUCAGGAUGUUAACUGCACAGAAGU

2392 24002 UACUUAACAAUGAUUAUUACAGAUCUUUAC

2393 24010 UGCAGGAGCCUUAAAUAAGGCUACUAACAA

2394 24015 UCUUUAGUAAUUACCUAAAGAGACGUGUAG

2395 24036 UUUUGUACACAAUUAAACCGUGCUUUAACU

2396 24045 UUGAUGCUUACGUUAAUACGUUUUCAUCAA

2397 24047 U AG AU AAAU AU U U U AAG AAUCAU ACAUCAC

2398 24051 UCUUUACCAACCACCACAAACCUCUAUCAC

2399 24053 UGCAGGUAUAUGCGCUAGUUAUCAGACUCA

2400 24055 UUACACUGUAGAGGAGGCAAAGACAGUGCU

2401 24059 UGCAGGUGCUGCAUUACAAAUACCAUUUGC

2402 24076 UUACAGAAUAAAUUGGAUCACCGGUGGAAU

2403 24081 UGUGGCAGAUGCUGUCAUAAAAACUUUGCA

2404 24103 UUACAGAGAAGGCUAUUUGAACUCUACUAA

2405 24106 UUAUGAGAAUCUUCACAAUUGGAACUGUAA

2406 24108 UGCAGUUAAAAUGUUUGAUGCUUACGUUAA

2407 24109 GUUUAUUUUGCUUCCACUGAGAAGUCUAAC

2408 24113 UGGUGACGGUAAAAUGAAAGAUCUCAGUCC

2409 24121 U C U U G U U A AC A AC U A A ACG A AC A A U G U U U G

2410 24127 UUCACCAUCUGGUGUUUACCAAUGUGCUAU

2411 24130 GUGUUGGUGGCAAACCUUGUAUCAAAGUAG

2412 24131 UCUUGUGGAUCCUGCUGCAAAUUUGAUGAA

2413 24143 GUUAUUGGACAUUCUAUGCAAAAUUGUGUA

2414 24150 UUCAACUAUACAGCGUAAAUAUAAGGGUAU

2415 24153 UCAAAUCAAUGAUAUGAUUUUAUCUCUUCU

2416 24175 UGUGGACAUUGCUGCUAAUACUGUGAUCUG

2417 24187 G U G U U A A U C U U AC A ACC AG A AC U C A A U U AC

2418 24216 UGCAUCGUGUUGUCUGUACUGCCGUUGCCA

2419 24239 UUGAUCACAGGCAGACUUCAAAGUUUGCAG

2420 24246 UCAACAAGACGGCAGUGAGGACAAUCAGAC

2421 24248 U AAU UG UG ACACAU U AAAAG AAAU ACU UG U

2422 24249 UUUGCUAACAAACAUGCUGAUUUUGACACA

2423 24255 UCAACAAUGGGGUUUUACAGGUAACCUACA

2424 24273 UCAACACAUGGUUGUUAAAGCUGCAUUAUU

2425 24276 UUACAGUCAUGUACUCAACAUCAACCAUAU

2426 24280 GUUUCAAUAGCACUUAUGCAUCUCAAGGUC

2427 24284 UCUUGCUCG C A A AC A U AC A ACG UGUUGUAG

2428 24292 U AAU U U AAAACAAU U ACCAU UUUUCUAUUA

2429 24294 UUUGCU AAAU UCCUAAAAACU AAU UGUUGU

2430 24302 UAUAAUCUACCAACAAUGUGUGAUAUCAGA Sequence in priority

SEQ ID NO document Sequence

2431 24326 UUCAACUGGAUACCACUUCAGAGAGCUAGG

2432 24330 UCAACCAAAAUGCACAAGCUUUAAACACGC

2433 24337 GUUCUGUUAUUGAUUUAUUACUUGAUGAUU

2434 24338 U U U AUG AU AAU AAGCU U AAAGCACAU AAAG

2435 24370 UUACAUCCUACACAGGCACCUACACACCUC

2436 24373 UGGUGACUUUAAACUUAAUGAAGAGAUCGC

2437 24374 UAAUUUCAAAAAUCUUAGGGAAUUUGUGUU

2438 24375 UUGAUACUAGUUUGUCUGGUUUUAAGCUAA

2439 24382 UUACAUCUACUGAUUGGACUAGCUAAACGU

2440 24390 UCAACCUCAAUUAGAGAUGGAACUUACACC

2441 24396 UUGAUACAGCCAAUCCUAAGACACCUAAGU

2442 24400 UUUGUGCUUGCUGCUGUUUACAGAAUAAAU

2443 24404 U A A A A AC UGUUUAUAGUGAUGU AG A A A ACC

2444 24412 UUUGAAAACCCUUGCUACUCAUGGUUUAGC

2445 24419 UUUUCUUGUUUUAUUGCCACUAGUCUCUAG

2446 24421 UUUAUGAGGCUAUGUACACACCGCAUACAG

2447 24422 U A A A A AC UAUUUCAUAACAGAUGCG C A A AC

2448 24442 UUGAUAACCCUGUCCUACCAUUUAAUGAUG

2449 24450 UCCCACCUACAAGUUUUGGACCACUAGUGA

2450 24455 UCAACUCAGGGUUAUUGGACAUUCUAUGCA

2451 24473 UGGUAGUUGUGUUUUAAGCGGACACAAUCU

2452 24487 U AAU U U U AAAG U U AC A AAAG G A A A AG C U A A

2453 24489 UAAAAACAGUACAAUUCUGUGAUGCCAUGC

2454 24493 UAAUUUUAACAAAGACUUCUAUGACUUUGC

2455 24497 UGCCAAGAAUUUAAAUGAAUCUCUCAUCGA

2456 24501 UCAACUUAGUGAAAUUAGUAUGGACAAUUC

2457 24527 U A A A A AC A A A U G U G U C A A UUUCAACUUCAA

2458 24535 UCAAGAAAUUCAACUCCAGGCAGCAGUAGG

2459 24536 U U ACCAACCAU ACAG AG U AG U AG U ACU U UC

2460 24541 UCAAGAACUUUACUCUCCAAUUUUUCUUAU

2461 24542 UAAUUUUCCUCUGGCUGUUAUGGCCAGUAA

2462 24561 UCUUCGGAAUGUCGCGCAUUGGCAUGGAAG

2463 24566 UGCCACUACUUGUGGUUACUUACCCCAAAA

2464 24574 UUACCAAUGUGCUAUGAGGCCCAAUUUCAC

2465 24583 UGGUAGUUAUACUAAUGACAAAGCUUGCCC

2466 24588 UGCCACUUCUGCUGCUCUUCAACCUGAAGA

2467 24594 UCAAGAGGGUGUUUUAACUGCUGUGGUUAU

2468 24604 U A U A AG A A ACC U G C U U C A AG AG AG C U U AAA

2469 24627 U AC A A A AG A A A A U G ACU C U A A AG AG G G U U U

2470 24635 U AC A A A AG G A A A AG C U A A A A A AG G U G CC U G

2471 24636 UGCCAUAACAAGUGUGCCUAUUGGGUUCCA

2472 24652 U G CC A U C A A A U U G G A U G AC A A AG A U CCA A A

2473 24653 UCUUCACGACAUUGGUAACCCUAAAGCUAU

2474 24665 UGUGAUGUCACAGAUGUGACUCAACUUUAC

2475 24669 UACAAACGUAAUAGAGCAACAAGAGUCGAA Sequence in priority

SEQ ID NO document Sequence

2476 24676 UGUGAUGGUGGCAGUUUGUAUGUAAAUAAA

2477 24684 UUACCCAAUAAUACUGCGUCUUGGUUCACC

2478 24696 UGUGAUGCAAUCAUGACUAGGUGUCUAGCU

2479 24700 UGUGAUGAUGAUUAUUUCAAUAAAAAGGAC

2480 24714 UUGAGCUGGUAGCAGAACUCGAAGGCAUUC

2481 24719 U All AACACCAGGAACAAAU ACU UCU AACCA

2482 24723 UCUUAUUACAGAAGGUAGUGUUAAAGGUUU

2483 24725 UGUGAUCAACUCCGCGAACCCAUGCUUCAG

2484 24737 UUGAGCCAUCAACUCAAUAUGAGUAUGGUA

2485 24769 UAUAAAUUAGAAGGCUAUGCCUUCGAACAU

2486 24773 UCUUAUCAGAGGCACGUCAACAUCUUAAAG

2487 24775 U U ACCG AGG UACAACAACU U AC AAAU U AAA

2488 24782 UACAACAACUCUGGAAGAAACUAAGUUCCU

2489 24783 UACAACAACU UACAAAUUAAAUGUUGGUGA

2490 24793 UAUAAAUGGAGACAGGUGGUUUCUCAAUCG

2491 24801 UCAAG U AG ACU U AU U U AG AAAUGCCCG U AA

2492 24815 UACAACAGUACUUUUAAAAGAACCUUGCUC

2493 24842 UACAACAUUUACUUAUGCAUCAGCAUUGUG

2494 24866 UCUUACUGAGUCUAACAAAAAGUUUCUGCC

2495 24891 UCUUACCUUUCUUUUCCAAUGUUACUUGGU

2496 24892 UACAACUACACUUAACGGUCUUUGGCUUGA

2497 24914 UUACCUUAAACAUGGAGGAGGUGUUGCAGG

2498 24926 UGCCUACGGGUACGCUGCUUGUCGAUUCAG

2499 24933 UUGUUUUUCUUGUUUUAUUGCCACUAGUCU

2500 24944 UAGCACACCUUGUAAUGGUGUUGAAGGUUU

2501 24947 UUGUUUUUGUUACCUUCUCUUGCCACUGUA

2502 24965 UACAAGAGUGUGAAUAUCACUUUUGAACUU

2503 24977 UCU UAAUGACAACCU UCU UG AAAU ACUCCA

2504 24981 UCCUUUUUGUUGCUGCUAUUUUCUAUUUAA

2505 24985 UUGACCUACACAGGUGCCAUCAAAUUGGAU

2506 25005 UGUCUUUGUUUCAAAUGGCACACACUGGUU

2507 25019 UGUCUUUGGAG C AC A A A ACC AG U U G A A AC A

2508 25021 UGUCUUUGAUGAAAUUUCAAUGGCCACAAA

2509 25039 UACAAGUAACUUGUGGUACAACUACACUUA

2510 25054 GUUUCCUUUAGUACUUUUGAAGAAGCUGCG

2511 25060 UGCCUGGAAUAUUGGUGAACAGAAAUCAAU

2512 25061 UUACGCCCUGACACACGUUAUGUGCUCAUG

2513 25074 UCUUAAAAAGUUGAAGAAGUCUUUGAAUGU

2514 25084 UGUCUUGAAAACUGGUGAUUUACAACCAUU

2515 25085 GUUGCUGAUUAUUCUGUCCUAUAUAAUUCC

2516 25094 GUUUUAACUGCUGUGGUUAUACCUACUAAA

2517 25099 UGUCUUCCUAUUCUUUAUUUGACAUGAGUA

2518 25117 UACAAUCACUUCUGGUUGGACCUUUGGUGC

2519 25134 UGGUGAUAGUGCGGAAGUUGCAGUUAAAAU

2520 25136 UCUGUUGCUUAUGAAAGUUUACGCCCUGAC Sequence in priority

SEQ ID NO document Sequence

2521 25142 UACAAUGCCACUUGGCUAUGUAACACAUGG

2522 25149 UGCCUUUAAUACUUUACUAUUCCUUAUGUC

2523 25154 UCAAUUAUUAUAAGAAAGUUGAUGGUGUUG

2524 25160 UGGCUAUUGAUUAUAAACACUACACACCCU

2525 25161 UCUGUUAUUGAUUUAUUACUUGAUGAUUUU

2526 25174 UCUGUUAGAGUGGUAACAACUUUUGAUUCU

2527 25186 UGUCUGUACUGCCGUUGCCACAUAGAUCAU

2528 25212 UAGUUUAGCUGCCACAGUACGUCUACAAGC

2529 25220 UGCGAGAGACUUGUCACUACAGUUUAAAAG

2530 25234 GUUGCUAUGCCUAAUCUUUACAAAAUGCAA

2531 25240 U ACACAACAACCAU AAAACCAG U U ACU U AU

2532 25254 UACACAAUGACAUUCUCUUAGCUAAAGAUA

2533 25257 UUUGUCGUGCCUGGUUUGCCUGGCACGAUA

2534 25266 UAGUUGUGUUUUAAGCGGACACAAUCUUGC

2535 25274 UACACACCACUGGUUGUUACUCACAAUUUU

2536 25275 UACACACCAUCAAAACUUAUAGAGUACACU

2537 25289 UACACAGAAUGUUCUCUAUG AG A ACC A A A A

2538 25320 UGUCUCAAGGGCUGUUGUUCUUGUGG AUCC

2539 25330 UCCUCGGAACUUGUCGGCGUUGUCCUGCUG

2540 25337 UCACACCUUUAGUACCUUUCUGGAUAACAA

2541 25338 UG UCU AUG UGAUAGACGUGCCACAUGCUUU

2542 25364 UUUAUAUAAAAAUACAUGUGUUGGUAGCGA

2543 25369 UGCGGCAAUAGUGUUUAUAACACUUUGCUU

2544 25374 UUACUACAGUCAGCUUAUGUGUCAACCUAU

2545 25377 UUUUCUGUUUGGAACUUUAAUUUUAGCCAU

2546 25378 UGUCUAGCUGUCCACGAGUGCUUUGUUAAG

2547 25384 UUGAAGCAGUUAAUUAAAGUUACACUUGUG

2548 25385 UUUAAAUGAUAUCCUUUCACGUCUUGACAA

2549 25405 UUUAAAUGGUUACACUGUAGAGGAGGCAAA

2550 25406 UACACCGGAAGCCAAUAUGGAUCAAGAAUC

2551 25407 UUCAAGCUUUUUGGAAAUGAAGAGUGAAAA

2552 25437 UGCGUAGUGAUGUGCUAUUACCUCUUACGC

2553 25451 U G CG U C ACC A A A U G A AU G C A ACC A A A U G U G

2554 25452 UCACAUCUGAUUUGGCUACUAACAAUCUAG

2555 25462 UUACUAUAGCAGAGAUAUUACUAAUUAUUA

2556 25463 UACACGGAACGUUCUGAAAAGAGCUAUGAA

2557 25470 UACACGGUGUUUAAACCGUGUUUGUACUAA

2558 25472 UUUAUAGCUGGCUUGAUUGCCAUAGUAAUG

2559 25482 UGUCGGCCCAAAUGUUAACAAAGGUGAAGA

2560 25490 GUGUUGCUAUGCCUAAUCUUUACAAAAUGC

2561 25496 UGUCGCUUCCAAGAAAAGGACGAAGAUGAC

2562 25498 GUUCACUUUGUUUGCAACUUGCUGUUGUUG

2563 25511 UUUAACAGGCACAGGUGUUCUUACUGAGUC

2564 25520 UUUAACAUAGAUUAUGACUGUGUCUCUUUU

2565 25526 UCCCAAACAAGCUAGUCUUAAUGGAGUCAC Sequence in priority

SEQ ID NO document Sequence

2566 25529 UAGUUAUACUAAUGACAAAGCUUGCCCAUU

2567 25543 UCACCAUCUGGUGUUUACCAAUGUGCUAUG

2568 25555 UGCUAAACAUGACUUCUUUAAGUUUAGAAU

2569 25559 UUACUCAACCGCUACUUUAGACUGACUCUU

2570 25567 UUACUCACACCUUUUGCUCGUUGCUGCUGG

2571 25569 UGUCCUUGUCCCUCAUGUGGGCGAAAUACC

2572 25573 UACACUGUAGAGGAGGCAAAGACAGUGCUU

2573 25585 UGCUAACAAAGACGGCAUCAUAUGGGUUGC

2574 25589 UCACCGCUCUCACUCAACAUGGCAAGGAAG

2575 25593 UACACUUAUGAUUGAACGGUUCGUGUCUUU

2576 25610 U U G A A A A U A A A AC A AC A UUACCUGUUAAUG

2577 25613 UACACUUGUGUUCCUUUUUGUUGCUGCUAU

2578 25617 GUUCAGAUACCUUGUACGUGUGGUAAACAA

2579 25623 UUGAAAAGAAAAAGCUUGAUGGCUUUAUGG

2580 25626 UUGAAAACCCUUGCUACUCAUGGUUUAGCU

2581 25653 UUCUUUUUUAGCACAUAUUCAGUGGAUGGU

2582 25659 UACAGAAGUAAAUGAGUUCGCCUGUGUUGU

2583 25665 UUUAUACAACAAAAGCUAGCUCUUGGAGGU

2584 25670 UGGUAGCGAUAAUGUUACUGACUUUAAUGC

2585 25674 UUUAACUGCUGUGGUUAUACCUACUAAAAA

2586 25685 UACAGACACACCUAAAGGUCCUAAAGUGAA

2587 25693 UAGUGUUGGUUUUAACAUAGAUUAUGACUG

2588 25697 UUUAACUUCUAUUAAAUGGGCAGAUAACAA

2589 25707 UUAUGAUAAUAAGCUUAAAGCACAUAAAGA

2590 25713 UACAGAGAAGGCUAUUUGAACUCUACUAAU

2591 25720 UGCUAAUGGUGAUUCUGAAGUUGUUCUUAA

2592 25721 UGUCCAACAAU U ACCUG AAACU U ACU U U AC

2593 25740 UUUAAGACAGUGGUUGCCUACGGGUACGCU

2594 25750 UGCUACAUCACGAACGCUUUCUUAUUACAA

2595 25759 UGUCAUGCUACUAGAGAAGCUGUUGGUACC

2596 25766 UAGUGUUAAAGGUUUACAACCAUCUGUAGG

2597 25771 UGUCAUCUCGCAAAGGCUCUCAAUGACUUC

2598 25788 G UG U U AG AGG U ACAACAG U ACU U U UAAAAG

2599 25792 U C AC U A U A A AC A UAUAACUUCU A A AG A A AC

2600 25797 UCACUAUAUGUUAAACCAGGUGGAACCUCA 2601 25810 UGUCAUACCAGACUAUAACACAUAU A A A A A 2602 25819 UCUGAUGUUCUU U ACCAACCACCAC AAACC

2603 25826 UUUAAGCGGACACAAUCUUGCUAAACACUG

2604 25830 UGUCAGUGUUAUAACACCAGGAACAAAUAC

2605 25831 UUCUUUAGUAAUUACCUAAAGAGACGUGUA

2606 25833 UUUAAGCUAAAAGACUGUGUUAUGUAUGCA

2607 25835 UGCUAGAUUUUACUUU U ACACCAG U AAAAC

2608 25845 UGCUAGGAGAGUGUGGACACUUAUGAAUGU

2609 25846 UUUAUAAGGGUGUUAUCACGCAUGAUGUUU

2610 25850 UACAGCGUAUAAUGGUUAUCUUACUUCUUC Sequence in priority

SEQ ID NO document Sequence

2611 25852 UUUAAGGAAUCACCUUUUGAAUUAGAAGAU

2612 25854 UUUAAGGAAUUACUUGUGUAUGCUGCUGAC

2613 25856 UUACUGUCCAAGACAUGUGAUCUGCACCUC

2614 25866 GUGUUCUCUUAUGUUGGUUGCCAUAACAAG

2615 25878 UACAGCUGUUUUAAGACAGUGGUUGCCUAC

2616 25894 UGUCACUCGUGACAUAGCAUCUACAGAUAC

2617 25931 UUACUUACCCCAAAAUGCUGUUGUUAAAAU

2618 25949 UACAGGCUGGUAAUGUUCAACUCAGGGUUA

2619 25963 UCCAUUUGUAGUUUCAACUGGAUACCACUU

2620 25965 UUCUUGGAAUUUGCGAGAAAUGCUUGCACA 2621 25969 UGCUAUGCCUAAUCUUUACAAAAUGCAAAG 2622 25991 UGUCAAUGCCAGAUUACGUGCUAAGCACUA

2623 25996 UGCUAUUACCAGAGCAAAAGUAGGCAUACU

2624 26005 UCACUUUGUUUGCAACUUGCUGUUGUUGUU

2625 26011 UGCUAUUCAUGCAGAUCAACUUACUCCUAC

2626 26012 GUUAAAGGUUUACAACCAUCUGUAGGUCCC

2627 26029 UGGCUGUAUUAAUGCUAACCAAGUCAUCGU

2628 26041 G U U U U AAGCGG ACACAAUCU UGCU AAACAC

2629 26050 UAGUGGAGUUCCUGUUGUAGAUUCUUAUUA

2630 26056 GUUAAUCU U ACAACCAG AACUCAAU UACCC

2631 26067 UCUCUUAUGUUGGUUGCCAUAACAAGUGUG

2632 26068 UGUCAAAGUGACUAUUGACUAUACAGAAAU

2633 26096 UUCAAUAGCACUUAUGCAUCUCAAGGUCUA

2634 26115 UUACUUUUGGUGAUGACACUGUGAUAGAAG

2635 26121 GUUCAUCAAACGUUCGGAUGCUCGAACUGC

2636 26122 GUUUUUUCACUUACAUUUGUGGGUUUAUAC

2637 26131 UAGUGCUAAACCACCGCCUGGAGAUCAAUU

2638 26152 UUAGAAAAUGUGGCUUUUAAUGUUGUAAAU

2639 26156 U G C U CG A A A U C A A AG AC AC AG A A A AG U AC U

2640 26170 UUCUUCACCUGAUGCUGUUACAGCGUAUAA

2641 26182 UACAUAAACCUAUUGUUUGGCAUGUUAACA

2642 26206 UCAGACUAUUGAAGUGAAUAGUUUUAGUGG

2643 26215 UCUCUAUGAGAACCAAAAAUUGAUUGCCAA

2644 26253 UUAGAAUAGACGGUGACAUGGUACCACAUA

2645 26256 UUCUUAGGCUAUUUUUGUACUUGUUACUUU

2646 26270 UUAGAAUGUACAUCUUCUUUGCAUCAUUUU

2647 26271 UGUAUUACACAGUUACUUCACUUCAGACUA

2648 26279 UCAGAGUUUAUUCUAGUGCGAAUAAUUGCA

2649 26291 UCAGAUACCUUGUACGUGUGGUAAACAAGC

2650 26295 UACAUCCUACACAGGCACCUACACACCUCA

2651 26304 UGCUGACCCUAUACAUUCUUUAAGAGUUUG

2652 26320 UUAUGAUCCUUUGCAACCUGAAUUAGACUC

2653 26334 UGUAUGGUACAAGUAACUUGUGGUACAACU

2654 26336 UCCUCACAGAAAACUUGUUACUUUAUAUUG

2655 26344 UAGUGACAUUGACAUCACUUUCUUAAAGAA Sequence in priority

SEQ ID NO document Sequence

2656 26359 UACAUGCACCAUAUGGAAUUACCAACUGGA

2657 26361 UUCUGUUUCUUCACCUGAUGCUGUUACAGC

2658 26366 UGCUGAUUAUUCUGUCCUAUAUAAUUCCGC

2659 26367 UGGUGCUGUCUGUAGACAUCAUGCUAAUGA

2660 26369 UGGGUGUUGGUGGCAAACCUUGUAUCAAAG 2661 26370 UGUAUGCCUAUUUUGGAAUUGCAAUGUCGA 2662 26373 UUCUGUUGCUUAUGAAAGUUUACGCCCUGA

2663 26378 UGGUGAUUAUUUUGUGCUGACAUCACAUAC

2664 26395 UGCUGCAGCUUAUUAUGUGGGUUAUCUUCA

2665 26398 UUCUGUUAGAGUGGUAACAACUUUUGAUUC

2666 26404 UGCUGCAUUACAAAUACCAUUUGCUAUGCA

2667 26407 UACAUGUCAGCAUUAAAUCACACUAAAAAG

2668 26418 UAGUCUUGUAGUGCGUUGUUCGUUCUAUGA

2669 26462 UGCUGCUAUUUUCUAUUUAAUAACACCUGU

2670 26478 UGCUGCUGGCCUUGAAGCCCCUUUUCUCUA

2671 26489 GUUAAAUCCAGAGAAGAAACUGGCCUACUC

2672 26499 UUUAGUGGUUAUUUAAAACUUACUGACAAU

2673 26513 UUAGAUAUAUGAAUUCACAGGGACUACUCC

2674 26514 UCUCACUUGAACUGCAAGAUCAUAAUGAAA

2675 26516 UGUAUACGUUGUCUUUGGAGCACAAAACCA

2676 26520 UUUGUACUUGCACUGUUAUCCGAUUUACAG

2677 26554 UACAUUUACUUGUGCUAGUGAGUACACUGG

2678 26557 UUAGAUGAUGAUAGUCAACAAACUGUUGGU

2679 26572 UGCUGGUUCUGAUAAAGGAGUUGCACCAGG

2680 26574 UACAUUUGGCUAGGUUUUAUAGCUGGCUUG 2681 26598 UGCUGUACCUACAGGUUAUGUUGAUACACC 2682 26602 UGCUGUAGACAUAAACAAGCUUUGUGAAGA

2683 26606 GUUGCAGGAGCCUUAAAUAAGGCUACUAAC

2684 26617 UGCUGUAGUUGUCUCAAGGGCUGUUGUUCU

2685 26618 UACUGAAGAUGAUUACCAAGGUAAACCUUU

2686 26624 GUUCUCUUAUGUUGGUUGCCAUAACAAGUG

2687 26627 UACAUUUUUCCCUGACUUAAAUGGUGAUGU

2688 26632 UUAGAUUCUUUAGACACCUAUCCUUCUUUA

2689 26642 GUUUUUCGGCUUUAGAACCAUUGGUAGAUU

2690 26648 UGCUGUCUGUAGACAUCAUGCUAAUGAGUA

2691 26660 UCAGGCAAUAACAGUUACACCGGAAGCCAA

2692 26661 UUCUGCCUUUCCAACAAUUUGGCAGAGACA

2693 26665 GUUCCACGUGCUAGCGCUAACAUAGGUUGU

2694 26675 UGUAGUCUUCUUGCAUGUGACUUAUGUCCC

2695 26679 GUUGCAGCCGAUCAUCAGCACAUCUAGGUU

2696 26693 U ACCAACCAU ACAG AG U AG U AG U ACU U UCU

2697 26713 UGCUGUUCUUUAUCAGGAUGUUAACUGCAC

2698 26721 UUCUGAUGUUCUU U ACCAACCACCAC AAAC

2699 26725 UUUGAUAACCCUGUCCUACCAUUUAAUGAU

2700 26739 UCAGGGUUUAAAUGGUUACACUGUAGAGGA Sequence in priority

SEQ ID NO document Sequence

2701 26744 UUCUGAUAAAGGAGUUGCACCAGGUACAGC

2702 26756 UACCAAUUUACCUUUACAGCUAGGUUUUUC 270B 26758 UUUAGUCCAGAGUACUCAAUGGUCUUUGUU

2704 26776 UACCACAGAAAUUCUACCAGUGUCUAUGAC

2705 26781 UACCACAUAUAUCACGUCAACGUCUUACUA

2706 26793 UG U AGG AG ACAU U AU ACU UAAACCAGCAAA

2707 26803 UCUAUGAUGCACAGCCUUGUAGUGACAAAG

2708 26806 UGUAGCUUGUCACACCGUUUCUAUAGAUUA

2709 26810 UGCUUACUCUAAUAACUCUAUUGCCAUACC

2710 26821 UCUAUGACUGACAUAGCCAAGAAACCAACU

2711 26827 GUUCCAUUUGUAGUUUCAACUGGAUACCAC

2712 26833 UCUAUGAAGACUUUUUAGAGUAUCAUGACG

2713 26837 UUUUGGCAUAUAUUCUUUUCACUAGGUUUU

2714 26855 GUUCCCACCUACAAGUUUUGGACCACUAGU

2715 26857 UCCUAUUCUGGACAAUCUACACAACUAGGU

2716 26858 U U U G U A AC AC A A AG G A A U U U U U AUG AACCA

2717 26864 UUAUGGAGAUUUUAGUCAUAGUCAGUUAGG

2718 26865 UGCUUAUGAAAGUUUACGCCCUGACACACG

2719 26872 GUGUGGACAUUGCUGCUAAUACUGUGAUCU

2720 26884 UAGAUGAUGAUAGUCAACAAACUGUUGGUC

2721 26901 UCUAUAUGCCUGCUAGUUGGGUGAUGCGUA

2722 26905 GUUGCAACUGAGGGAGCCUUGAAUACACCA

2723 26912 UGUAGAUUCUUAUUAUUCAUUGUUAAUGCC

2724 26921 UUUUCUAUGUACUUGGAUUGGCUGCAAUCA

2725 26928 UGUAGAUGCUGUAAAUUUACUUACUAAUAU

2726 26930 UGUAGAUGCAGAUAGUAAAAUUGUUCAACU

2727 26932 UUUUGUCGUGCCUGGUUUGCCUGGCACGAU

2728 26953 UUAGCUGCCACAGUACGUCUACAAGCUGGU

2729 26963 UUAGCUGCUGUUAAUAGUGUCCCUUGGGAU

2730 26967 GUUCCCUUGAACAUAAUACCUCUUACAACA

2731 26975 UCUAGUGGCUAGCAUAAAGAACUUUAAGUC

2732 26985 UGUAGACGGUUGUAAUUCAUCAACUUGUAU

2733 26990 UGCUUGCAUACGUAGACCAUUCUUAUGUUG

2734 27003 UACUGGUCAGGCAAUAACAGUUACACCGGA

2735 27004 UUUUCAAACACGUGCAGGCUGUUUAAUAGG

2736 27015 UGUAGAAGCUGUUAUGUACAUGGGCACACU

2737 27017 UUAGGAAGUCUAAUCUCAAACCUUUUGAGA

2738 27022 UUCUCACUUGAACUGCAAGAUCAUAAUGAA

2739 27030 UCAGUUGACUUCGCAGUGGCUAACUAACAU

2740 27035 UUCUCAAUCGAUUUACCACAACUCUUAAUG

2741 27036 UGCUUGUAUUGACUGUAGUGCGCGUCAUAU

2742 27045 UAGUACAUUUAUUAGUGAUGAAGUUGCGAG

2743 27068 UUUAAUGGUAUUGGAGUUACACAGAAUGUU

2744 27069 UAGUACAACUACUAACAUAGUUACACGGUG

2745 27086 UCCUAUUACGGAUGUUUUCUACAAAGAAAA Sequence in priority

SEQ ID NO document Sequence

2746 27092 UGCUUUACUU AC A A AG U CC U C AG A A U AC A A

2747 27100 UGUACUGACAUUAGAUAAUCAAGAUCUCAA

2748 27135 UCUACUUGCACCAUUAUUAUCAGCUGGUAU

2749 27144 UUUUUGGCAUAUAUUCUUUUCACUAGGUUU

2750 27158 GUUUUUAACAUUUGUCAAGCUGUCACGGCC

2751 27164 UGCUUUGGACAUAUCAGCAUCUAUAGUAGC

2752 27172 UGUACGCUGCUGUUAUAAAUGGAGACAGGU

2753 27186 UGUACGAUCAAUUUUCUCCCGCACUCUUGA

2754 27188 UUUAAUGUCUAAUUUAGGCAUGCCUUCUUA

2755 27214 UUCUAUCAUUAAUAACACUGUUUACACAAA

2756 27220 UACCCGUGAACUCAUGCGUGAGCUUAACGG

2757 27227 UUCUAUAGAUUAGCUAAUGAGUGUGCUCAA

2758 27234 UUAUGAUUACUUAGUUUCUACACAGGAGUU

2759 27243 UGGAAAAGAUGGCUGAUCAAGCUAUGACCC

2760 27246 UCCGUGGCUAUAAAGAUAACAGAACAUUCU

2761 27280 UACUGGUAAGAGUCAUUUUGCUAUUGGCCU

2762 27335 UAGGUUUGUACUUGCACUGUUAUCCGAUUU

2763 27341 UGGAACCUCAUCAGGAGAUGCCACAACUGC

2764 27343 UGGUACCAAUUUACCUUUACAGCUAGGUUU

2765 27355 UCAUCAAACGUUCGGAUGCUCGAACUGCAC

2766 27372 UGGUGCAUCGUGUUGUCUGUACUGCCGUUG

2767 27393 UCUAAUGUUUUUCAAACACGUGCAGGCUGU

2768 27395 UCAUCAGACAAGAGGAAGUUCAAGAACUUU

2769 27401 UUUUUCACUUACAUUUGUGGGUUUAUACAA

2770 27405 UGUAAUUCAUCAACUUGUAUGAUGUGUUAC

2771 27421 UUCUACACAGGAGUUUAGAUAUAUGAAUUC

2772 27422 UUUAAUUAUGCUUAUUAUCUUUUGGUUCUC

2773 27436 UUCUAAUGUUUUUCAAACACGUGCAGGCUG

2774 27437 UCAUCCGGAGUUGUUAAUCCAGUAAUGGAA

2775 27438 UGUAAUGGCCUACAUUACAGGUGGUGUUGU

2776 27443 GUUUUGUCGUGCCUGGUUUGCCUGGCACGA

2777 27459 UUAUGCUUGGAACAGGAAGAGAAUCAGCAA

2778 27470 UCAUCUAAGUGUGUGUGUUCUGUUAUUGAU

2779 27474 UUCUAAGGUUGUCAAAGUGACUAUUGACUA

2780 27479 UACUGACUUUAAUGCAAUUGCAACAUGUGA

2781 27485 UUUAGCUUGGUUGUACGCUGCUGUUAUAAA

2782 27487 UGGAAUUGCUAUCGCAAUGGCUUGUCUUGU

2783 27489 UCCAUGUGGUCAUUCAAU CC AG A A AC U A AC

2784 27501 UG U AAU AGG AAU UG UCAACAACACAG U U U A

2785 27505 UAGGUGGUUUACAUCUACUGAUUGGACUAG

2786 27530 UUCUAAAUCACCCAUUCAGUACAUCGAUAU

2787 27534 UGUAAUAACUAUAUGCUCACCUAUAACAAA

2788 27536 UGGACAAUUAUUAUAAGAAAGACAAUUCUU

2789 27543 UCUAAAUCACCCAUUCAGUACAUCGAUAUC

2790 27546 UUUAGCUGCUGUUAAUAGUGUCCCUUGGGA Sequence in priority

SEQ ID NO document Sequence

2791 27551 UUUAAUUGUUACUUUCCUUUACAAUCAUAU

2792 27561 UGGACAGCCUUUGUUACUAAUGUGAAUGCG

2793 27566 UGGACAGCUGGUGCUGCAGCUUAUUAUGUG

2794 27570 GUUGAUGUAGAAUUGUUUGAAAAUAAAACA

2795 27575 UAGGUGAUGUUAGAGAAACAAUGAGUUACU

2796 27580 UCUAAACGAACUAAAUAUUAUAUUAGUUUU

2797 27588 UUAUGAUUGAUGUUCAACAAUGGGGUUUUA

2798 27591 UAGAUUUGCCAAUAGGUAUUAACAUCACUA

2799 27609 UGGACCCUCAGAUUCAACUGGCAGUAACCA

2800 27623 UUCGUGUCUUUAGCUAUAGAUGCUUACCCA 2801 27626 UGGACCUUUGGUGCAGGUGCUGCAUUACAA 2802 27640 UGUAACCAUACAGGUGUUGUUGGAGAAGGU

2803 27656 GUUCCUUUUUGUUGCUGCUAUUUUCUAUUU

2804 27660 U G U A AC A AC A A AG A U AGCACUUAAGGGUGG

2805 27682 GUUUUGGCUGCUGAAUGUACAAUUUUUAAA

2806 27684 UCAUGCUGGCACAGACUUAGAAGGUAACUU

2807 27690 U U U AAU U U U UCACAAAU AU U ACCAG AUCCA

2808 27692 UGUAAAUGCUGUUACGACCAUGUCAUAUCA

2809 27693 UGGAGAAGGUUCCGAAGGUCUUAAUGACAA

2810 27696 UUCGUCCGUGUUGCAGCCGAUCAUCAGCAC 2811 27702 UCGUUCUAUGAAGACUUUUUAGAGUAUCAU 2812 27707 UUUUCUACAGGUGUUAACCUAGUUGCUGUA

2813 27718 UGUAAAUAAGGGACACUUUGAUGGACAACA

2814 27728 UAGGUACAUGUCAGCAUUAAAUCACACUAA

2815 27730 UGUAAAGAUGGCCAUGUAGAAACAUUUUAC

2816 27732 UCCUAUAAAGAUUGGUCCUAUUCUGGACAA

2817 27735 UUUACAAACAAUUUGAUACUUAUAACCUCU

2818 27741 UACCUUCUCUUGCCACUGUAGCUUAUUUUA

2819 27742 U G U A A AC A U U C A A A A AG A A A UUGACCGCCU

2820 27744 UACCUUCUUCAUCUACAAUAAAAUUGUUGA 2821 27752 UUAGUUCCCUUCCAUCAUAUGCAGCUUUUG 2822 27754 UACUGGCGAUAGUUGUAAUAACUAUAUGCU

2823 27756 UCGUGUUGUUUUAGAUUUCAUCUAAACGAA

2824 27779 UCAUGUCAUGUCUAAACAUACUGACUUUUC

2825 27780 UUUUUUCACUUACAUUUGUGGGUUUAUACA

2826 27781 UCGUGUCUUUAGCUAUAGAUGCUUACCCAC

2827 27790 UAGAUGGGUACUUAACAAUGAUUAUUACAG

2828 27803 UCAUGUGGUAGUGUUGGUUUUAACAUAGAU

2829 27806 GUGUUAUCACGCAUGAUGUUUCAUCUGCAA

2830 27809 UCAUGUGUGGCGGUUCACUAUAUGUUAAAC

2831 27818 UCAUGUUAUGGUUGAGCUGGUAGCAGAACU

2832 27820 U U U ACAACCAUCUG U AGG UCCCAAACAAGC

2833 27828 UAGAUUUCCUAAUAUUACAAACUUGUGCCC

2834 27837 UACGACCAUGUCAUAUCAACAUCACAUAAA

2835 27844 GUUUGUACUAAUUAUAUGCCUUAUUUCUUU Sequence in priority

SEQ ID NO document Sequence

2836 27848 UACGACUAUUGUAUACCUUACAAUAGUGUA

2837 27849 UUCGCGACGUGCUCGUACGUGGCUUUGGAG

2838 27856 UGGUUUUAAUUU U UCACAAAU AU UACCAGA

2839 27857 G U U U U ACAGG U AACCU ACAAAGCAACCAUG

2840 27862 UGGUUUUAACAUAGAUUAUGACUGUGUCUC

2841 27865 UGGAUAAUGAUGCACUCAACAACAUUAUCA

2842 27901 UGGAUAUGGUUGAUACUAGUUUGUCUGGUU

2843 27909 U U A U A AC AC UUUGCUUCACACU C A A A AG A A

2844 27916 UGGUUUCUCAAUCGAUUUACCACAACUCUU

2845 27933 UUUAGAUUUCAUCU A A ACG A AC A A AC U AAA

2846 27941 UUAUAAGAAACCUGCUUCAAGAGAGCUUAA

2847 27947 UCCAUGCUAUACAUGUCUCUGGGACCAAUG

2848 27948 UUUAGAUUCUUUAGACACCUAUCCUUCUUU

2849 27958 UUUGCAACAACUCAGAGUAGAAUCAUCAUC

2850 27970 UGGAUGGAAAGUGAGUUCAGAGUUUAUUCU

2851 27971 UGGUUUACAUCUACUGAUUGGACUAGCUAA

2852 27997 UCGUAGUGGUGAGACACUUGGUGUCCUUGU

2853 27999 UUCCUUUAGUACUUUUGAAGAAGCUGCGCU

2854 28008 UUCACUAUAUGUUAAACCAGGUGGAACCUC

2855 28013 UUUGCCUCAACUUGAACAGCCCUAUGUGUU

2856 28038 UACGCUGCUUGUCGAUUCAGAUCUUAAUGA

2857 28047 UGGUUGGCACAACAUGUUAAAAACUGUUUA

2858 28048 GUGUUGAGUAUUGCCCUAUUUUCUUCAUAA

2859 28051 GUUUGUUCUAUGACUGACAUAGCCAAGAAA

2860 28060 UCAUUUAUUGAAGAUCUACUUUUCAACAAA 2861 28062 UGGUUGCCAUAACAAGUGUGCCUAUUGGGU 2862 28063 U ACGG ACACAACU AU UACAG UUAAUGUUUU

2863 28074 UGGCAAACCUUGUAUCAAAGUAGCCACUGU

2864 28098 UACGGCGCCGAUCUAAAGUCAUUUGACUUA

2865 28103 U U UACACU UAAAAACACAGUCUGUACCGUC

2866 28127 UUUAGAUAUGUGUGCUUCAUUAAAAGAAUU

2867 28133 UUAUACAACAAAAGCUAGCUCUUGGAGGUU

2868 28137 UUUACAGAAGGCCGCUAUAACAAUACUAGA

2869 28141 UUCACUACUUUCUGUUUUGCUUUCCAUGCA

2870 28153 U G G C AC A AC A U G U U A A A A AC UGUUUAUAGU

2871 28156 G U U U U ACAG AAGGCCGCU AU AACAAU ACU A

2872 28161 UUCCUAUUCCUUACAUGGAUUUGUCUUCUA

2873 28175 UGGCACUACUGAAAUGCUAGCGAAAGCUUU

2874 28176 UUCCUAUAAAGAUUGGUCCUAUUCUGGACA

2875 28184 UCCUAAAGUGAAGUAUUUAUACUUUAUUAA

2876 28206 GUUUGUCUUAGUGGUUUAGAUUCUUUAGAC

2877 28214 UCGGAUGCUCGAACUGCACCUCAUGGUCAU

2878 28225 UGGUUAUACUGAAAAAUGGGAAUCUGGAGU

2879 28233 GUUUUACACUU A A A A AC AC AG UCUGUACCG

2880 28239 UUCCGUGGCUAUAAAGAUAACAGAACAUUC Sequence in priority

SEQ ID NO document Sequence

2881 28243 UCCAACUUAUUUGGAUGGAGCUGAUGUUAC

2882 28246 UUUACAGGUAACCUACAAAGCAACCAUGAU

2883 28257 UGGU U ACCAACCAU ACAG AG U AG U AG U ACU

2884 28258 UGGCAGUUUGUAUGUAAAUAAACAUGCAUU

2885 28261 UUUUCGGCUUUAGAACCAUUGGUAGAUUUG

2886 28263 UUAUACUGAAAAAUGGGAAUCUGGAGUAAA

2887 28272 UUUACAGGUUCGCGACGUGCUCGUACGUGG

2888 28280 UGGUAAUUAUAAUUACCUGUAUAGAUUGUU

2889 28283 UUCCGAAGGUCUUAAUGACAACCUUCUUGA

2890 28286 UGGCAUCAUUCUAUUGGAUUUGAUUACGUC

2891 28287 UACGUGCCAGAUCAGUUUCACCUAAACUGU

2892 28301 UAGCUUACUACAACACAACAAAGGGAGGUA

2893 28305 UCCAAUUAACACCAAUAGCAGUCCAGAUGA

2894 28321 UACUGCUGUU AUG UCU UUAAAAGAAGGUCA

2895 28335 UGGUAAAAUUGUUAAUAAUUGGUUGAAGCA

2896 28337 GUGUUCUGUUAUUGAUUUAUUACUUGAUGA

2897 28341 UGGUGUUGUUCAGUUGACUUCGCAGUGGCU

2898 28360 UUUACAUCUACUGAUUGGACUAGCUAAACG

2899 28372 UGGCCACACAGAUCUAAUGGCUGCUUAUGU

2900 28381 UCGCGCUACUGCAACGAUACCGAUACAAGC

2901 28384 UUUUCAGAGCGCUUCCAAAAUCAUAACCCU

2902 28389 UUUACAUUCAACUCAGGACUUGUUCUUACC

2903 28393 UCGCGACGUGCUCGUACGUGGCUUUGGAGA

2904 28400 UUCCAUUUGGAAUCUUGAUUACAUCAUAAA

2905 28401 UCGCCUGUGUUGUGGCAGAUGCUGUCAUAA

2906 28417 UCCACGUGCUAGCGCUAACAUAGGUUGUAA

2907 28418 GUUUGUGUAUCUACUAGUGGUAGAUGGGUA

2908 28426 UUCCAUGCUAUACAUGUCUCUGGGACCAAU

2909 28430 UUCCAUCCAUCUUUACUUUGAUAAAGCUGG

2910 28431 UGGUAAACCUAGACCACCACUUAACCGAAA

2911 28435 UUAUAGUGAUGUAGAAAACCCUCACCUUAU

2912 28442 U CGC AU U CAACCAG G AC AG AC U U U U U CAG U

2913 28452 GUUGAGUAUUGCCCUAUUUUCUUCAUAACU

2914 28466 UUAUAUAAAAAUACAUGUGUUGGUAGCGAU

2915 28472 UGGUGUCACUCGUGACAUAGCAUCUACAGA

2916 28474 GUUAACCUAGUUGCUGUACCUACAGGUUAU

2917 28477 UCCAGACAUGUUCCUCGGAACUUGUCGGCG

2918 28487 UCGCACUAUUGCCUUUGGAGGCUGUGUGUU

2919 28490 UGGUGUACUGACAUUAGAUAAUCAAGAUCU

2920 28492 UACUAAGAGGUUUGAUAACCCUGUCCUACC

2921 28505 UUCCACGUGCUAGCGCUAACAUAGGUUGUA

2922 28520 UUUUGUAUAUAAUUAAGUUAAUUUUCCUCU

2923 28531 UACUAAUCCUUAUGACAGCAAGAACUGUGU

2924 28556 UACUAAUGUGAAUGCGUCAUCAUCUGAAGC

2925 28568 UGGUGGUAAUUAUAAUUACCUGUAUAGAUU Sequence in priority

SEQ ID NO document Sequence

2926 28589 UUCCAACCCACUAAUGGUGUUGGUUACCAA

2927 28604 UACUACACAAACUGCUUGCACUGAUGACAA

2928 28610 UAGAAUGUACAUCUUCUUUGCAUCAUUUUA

2929 28616 GUUGAGGCUUUUGAGUACUACCACACAACU

2930 28620 UAGAAUUACUGGCUUAUACCCAACACUCAA

2931 28630 UUUGGAUUAUAAAGCAUUCAAACAAAUUGU

2932 28631 UAGAAUUCGAUCUGUCUAUCCAGUUGCGUC

2933 28638 UGGUGGCAAACCUUGUAUCAAAGUAGCCAC

2934 28640 G UUGACACU AAA U U C A A A AC U G A AG G U U U A

2935 28642 UUAUUCUACAGGUUCUAAUGUUUUUCAAAC

2936 28643 UUAUUCUAGUGCGAAUAAUUGCACUUUUGA

2937 28655 UUUUGGUUUAUAUAAAAAUACAUGUGUUGG

2938 28661 GUUGACAUACCUGGCAUACCUAAGGACAUG

2939 28662 GUUCUUUGCAAUUCACAGACUUCAUUAAGA

2940 28669 UUUGCUGCAUACAGUCGCUACAGGAUUGGC

2941 28673 GUUGAAAAGAAAAAGCUUGAUGGCUUUAUG

2942 28677 UAGACAAUGCUCAGGUGUUACUUUCCAAAG

2943 28702 UAGCGGGUACAAUCACUUCUGGUUGGACCU

2944 28708 UUAUUAUGGUAAUGCUUUAGAUCAAGCCAU

2945 28718 UUUGCCUGGCACGAUAUUACGCACAACUAA

2946 28723 UAGACAUGUAUUCUGUUAUGCUUACUAAUG

2947 28730 UUAUCACCCGCGAAGAAGCUAUAAGACAUG

2948 28752 UACUACUUUAGAUUCGAAGACCCAGUCCCU

2949 28759 UUAUUGGACAUUCUAUGCAAAAUUGUGUAC

2950 28763 UUCAUGUGGUAGUGUUGGUUUUAACAUAGA

2951 28782 UAGCGAUAAUGUUACUGACUUUAAUGCAAU

2952 28783 UACUAGAUCAGGCAUUAGUGUCUGAUGUUG

2953 28793 UUUACCUAAUGAUGACACUCUACGUGUUGA

2954 28797 UUUGCUUUCCAUGCAGGGUGCUGUAGACAU

2955 28816 UUAUUACCCUGACAAAGUUUUCAGAUCCUC

2956 28819 U U AU U ACCACAAAAACAACAAAAG U UGG AU

2957 28833 U AG ACU U AU AAU U AG AG AAAACAACAG AG U

2958 28834 UACUUUUGGUGAUGACACUGUGAUAGAAGU

2959 28835 UACUAGUGCUAUGCAGACAAUGCUUUUCAC

2960 28845 UUAUUGUUUCUUAGGCUAUUUUUGUACUUG

2961 28849 UUAUUUAAAACUUACUGACAAUGUAUACAU

2962 28855 UUCAUCUGCAAUUAACAGGCCACAAAUAGG

2963 28858 U AG AG AAACAAUG AG U U ACU UG U U UCAACA

2964 28865 UUCAUCUAAGUGUGUGUGUUCUGUUAUUGA

2965 28876 UACUAUAGCAGAGAUAUUACUAAUUAUUAU

2966 28879 UUUGGCUGCUGAAUGUACAAUUUUUAAAGA

2967 28880 UUCAUCCGGAGUUGUUAAUCCAGUAAUGGA

2968 28892 GUUGAACAUGUUACCUUCUUCAUCUACAAU

2969 28907 UUCAUCAAAAAUUAUUGAAAUCAAUAGCCG

2970 28910 UACUUUCCUUUACAAUCAUAUGGUUUCCAA Sequence in priority

SEQ ID NO document Sequence

2971 28912 U AC U U U CCA A AG U G C AG U G A A A AG A AC A A U

2972 28924 UACUUUAUAUUGACAUUAAUGGCAAUCUUC

2973 28927 U UAUCGUGUAACU A A A A AC AG U A A AG U ACA

2974 28948 UUAUGUUGAUACACCUAAUAAUACAGAUUU

2975 28972 UGUUUGUUCUAUGACUGACAUAGCCAAGAA

2976 28977 UUUUAAUUGUUACUUUCCUUUACAAUCAUA

2977 28979 UGUUUUAACUGCUGUGGUUAUACCUACUAA

2978 28988 UGUUUGUGUAUCUACUAGUGGUAGAUGGGU

2979 28990 UACUUGUUUCAACAUGCCAAUUUAGAUUCU

2980 28991 G U U AG AGG U ACAACAG U ACU U U UAAAAGAA

2981 28995 U U G U A AC AC A A AG G A A U U U U U AUG AACCAC

2982 28998 UUUUAAUUU U UCACAAAU AU UACCAGAUCC

2983 29001 UUGUAACAGUUUACUCACACCUUUUGCUCG

2984 29002 UGUUUUAAUGUCUAAUUUAGGCAUGCCUUC

2985 29004 UUGUAACCAUACAGGUGUUGUUGGAGAAGG

2986 29016 UGUUUGUACAGAAAUUGACCCUAAGUUGGA

2987 29017 UGUUUGUAACAGUUUACUCACACCUUUUGC

2988 29024 UGGUCGCACUAUUGCCUUUGGAGGCUGUGU

2989 29029 GUUGUGGCAGAUGCUGUCAUAAAAACUUUG

2990 29032 UG U U U U AG AU U UCAUCU AAACG AACAAACU

2991 29036 UUUCCUAUUCCUUACAUGGAUUUGUCUUCU

2992 29053 UUGUAAUUCAUCAACUUGUAUGAUGUGUUA

2993 29067 UAACCUAGUUGCUGUACCUACAGGUUAUGU

2994 29072 UAACCUACAAAGCAACCAUGAUCUGUAUUG

2995 29074 GUUGAAGAAGUU AC A AC A AC U C U G G A AG A A

2996 29077 UUGUACAGAAAUUGACCCUAAGUUGGACAA

2997 29089 U U U UACACU U AAAAACACAG UCUG U ACCG U

2998 29102 UAACCCUAAAGCUAUUAAGUGUGUACCUCA

2999 29106 UAUGCUUACUAAUGAUAACACUUCAAGGUA

3000 29115 UAACUGCACAGAAGUCCCUGUUGCUAUUCA

3001 29117 UUGUACGCUGCUGUUAUAAAUGGAGACAGG

3002 29122 UUGUACUAAUUAUAUGCCUUAUUUCUUUAC

3003 29130 U U U U ACAGG U A ACC U AC A A AG C A ACC A U G A

3004 29148 UAACUGGUAUGAUUUCGGUGAUUUCAUACA

3005 29151 U UG U ACU UGCACUGUUAUCCGAUUU ACAGG

3006 29155 UAACUGGUUAUAAGAAACCUGCUUCAAGAG

3007 29167 UAACUGUGAUGUUGUAAUAGGAAUUGUCAA

3008 29181 UAACUGUUUGGAUGACAGAUGCAUUCUGCA

3009 29188 UAACUUAGACAACCUGAGAGCUAAUAACAC

3010 29190 UUGUAGAUGCAGAUAGUAAAAUUGUUCAAC

3011 29202 UUGUAGAUUUGACACUAGAGUGCUAUCUAA

3012 29203 G U U ACU U U CCA A AG U G C AG U G A A A AG A AC A

3013 29218 UUAUGUUCACACCUUUAGUACCUUUCUGGA

3014 29222 UUGGUGGUAAUUAUAAUUACCUGUAUAGAU

3015 29235 UAACAUCUGUUACACACCAUCAAAACUUAU Sequence in priority

SEQ ID NO document Sequence

3016 29238 UGUUUCCUUUAGUACUUUUGAAGAAGCUGC

3017 29240 UUGGUGGACCCUCAGAUUCAACUGGCAGUA

3018 29244 U AUGGAGUGUCUCCU ACU AAAU UAAAUG AU

3019 29247 GUUAACUGUUUGGAUGACAGAUGCAUUCUG

3020 29258 UUUCCAUUGUGUGCUAAUGGACAAGUUUUU

3021 29271 UAUGCAAAAG UAU UCU ACACUCCAGGG ACC

3022 29278 UAUGAUUUUGUAGAAAACCCAGAUAUAUUA

3023 29280 UAACAGGACACAUGUUAGACAUGUAUUCUG

3024 29281 UAACUUUUAUGGACCUUUUGUUGACAGGCA

3025 29313 UGUUUAUUUUGCUUCCACUGAGAAGUCUAA

3026 29317 UCCAUCCAUCUUUACUUUGAUAAAGCUGGU

3027 29326 UAUGAUUUCGGUGAUUUCAUACAAACCACG

3028 29330 UUUUGCACAAGU C A A AC A A A U U U AC A A A AC

3029 29334 GUGUUUAU U ACCACAAAAACAACAAAAG U U

3030 29344 U AACACUCCAACAAAU AG AG U UG AAG U U U A

3031 29348 UGUUUAUUACCCUGACAAAGUUUUCAGAUC

3032 29350 UAUGGCCAGUAACUUUAGCUUGUUUUGUGC

3033 29351 UG U U U AU U ACCACAAAAACAACAAAAG U UG

3034 29364 UUGUAUGGUACAAGUAACUUGUGGUACAAC

3035 29367 UGGUAACAUCUGUUACACACCAUCAAAACU

3036 29370 UUGUAUGUAAAUAAACAUGCAUUCCACACA

3037 29374 UGUUUAUGAUUACUUAGUUUCUACACAGGA

3038 29376 UUGUAUGUGAUAAUAUCAAAUUUGCUGAUG

3039 29394 UAACAAUGCAACUAAUAAAGCCACGUAUAA

3040 29396 UUGGUCCAACUUAUUUGGAUGGAGCUGAUG

3041 29415 UACUAUUACCGUUGAAGAGCUUAAAAAGCU

3042 29417 UUAUUUUAAAAUAUAUUCUAAGCACACGCC

3043 29420 UAUGAUGUCAGCACCACCUGCUCAGUAUGA

3044 29423 UUGUCAAACAUAAGCAUGCAUUUCUCUGUU

3045 29429 UUGUCAAAGUGACUAUUGACUAUACAGAAA

3046 29434 UAACAACUUUUGAUUCUGAGUACUGUAGGC

3047 29441 U AACAACU AAACG AACAAUG U UUGUUUUUC

3048 29447 UUGGUAUGCAAAAGUAUUCUACACUCCAGG

3049 29462 U A AC A A AG GUGAAGACAUUCAACUUCUUAA

3050 29468 GUUUGCCUAGGUUCUUUAAUCUACUCAACC

3051 29472 U AG C A A A A AG UCACAACAUUGCUUUGAUAU

3052 29473 UUAACACCAGUUUACUCAUUCUUACCUGGU

3053 29482 UCGCACAAAUGUCUACUUAGCUGUCUUUGA

3054 29496 UUCUUUAAUCUACUCAACCGCUGCUUUAGG

3055 29499 U U AU ACCU UCCCAGG U AACAAACCAACCAA

3056 29509 UUACUCAUUCUUACCUGGUGUUUAUUCUGU

3057 29510 U U UAU ACCU UCCCAGG U AACAAACCAACCA

3058 29522 UUGCCUAGGUUCUUUAAUCUACUCAACCGC

3059 29544 UUGUGUAGAUACUGUUCGCACAAAUGUCUA

3060 29547 UAACAAACCAACCAACUUUCGAUCUCUUGU Sequence in priority

SEQ ID NO document Sequence

3061 29548 UCUUUAAUCUACUCAACCGCUGCUUUAGGU

3062 29566 GUGGCUGUCACUCGGCUGCAUGCUUAGUGC

3063 29579 GUAGAUACUGUUCGCACAAAUGUCUACUUA

3064 29594 CACUCGGCUGCAUGCUUAGUGCACUCACGC

3065 29602 ACUCUGUUUAACACCAGUUUACUCAUUCUU

3066 29608 ACACUGACUUUGCAACAUCAGCUUGUGUUU

3067 29612 AACAGGACUCUUUAAAGAUUGUAGUAAGGU

3068 29623 ACUCUUUAAAGAUUGUAGUAAGGUAAUCAC

3069 29635 CACAACAUUGCUUUGAUAUGGAACGUUAAA

3070 29670 AACAAACCAACCAACUUUCGAUCUCUUGUA

3071 29693 GGCUGUCACUCGGCUGCAUGCUUAGUGCAC

3072 29697 AGAUACUGUUCGCACAAAUGUCUACUUAGC

3073 29700 CUGCAUGCUUAGUGCACUCACGCAGUAUAA

3074 29701 GCACUCACGCAGUAUAAUUAAUAACUAAUU

3075 29724 AG C A A A A AG UCACAACAUUGCUUUGAUAUG

3076 29736 AUG UCCGCAAU U UACAACACAGACU U U AUG

3077 29762 CCGCAAUUUACAACACAGACUUUAUGAGUG

3078 29767 CUGUCACUCGGCUGCAUGCUUAGUGCACUC

3079 29799 AACACAAGCUUUCGGCAGACGUGGUCCAGA

3080 29815 U U ACCU U U UACAAU U AAU UGCCAGG AACCU

3081 29818 UUUAGCCAGCGUGGUGGUAGUUAUACUAAU

3082 29825 UUCCUGUUUACCUUUUACAAUUAAUUGCCA

3083 29834 UAAUUAUACAGUUUCCUGUUUACCUUUUAC

3084 29835 UUAGCCAGCGUGGUGGUAGUUAUACUAAUG

3085 29869 AAUUAUACAGUUUCCUGUUUACCUUUUACA

3086 29875 GUUUGCCUAGGUUCUUUAACCUACUCAACC

3087 29897 U AG C A A A A AG UCACAGCAUUGCUUUGAUAU

3088 29905 UUCUUU AACCU ACUCAACCGCUGCUUUAGG

3089 29909 UUGCCUAGGUUCUUU AACCU ACUCAACCGC

3090 29916 UUGUGUAGAUACUGUUCGCACGAAUGUCUA

3091 29921 UCUUU AACCU ACUCAACCGCUGCUUUAGGU

3092 29929 UCGCACGAAUGUCUACUUAGCUGUCUUUGA

3093 29957 CUGUCACUCGGCAGCAUGCCGAGUGCAGCC

3094 29975 GUAGAUACUGUUCGCACGAAUGUCUACUUA

3095 29977 AGCAAAAAGUCACAGCAUUGCUUUGAUAUG

3096 29982 AGAUACUGUUCGCACGAAUGUCUACUUAGC

3097 30005 GCAGCCACACAGUAUAAUUAAUAACUAAUU

3098 30015 GUGGCUGUCACUCGGCAGCAUGCCGAGUGC

3099 30027 ACACUGACAUUGCAACAUCAGCUUGUGUUU

3100 30037 GGCUGUCACUCGGCAGCAUGCCGAGUGCAG

3101 30041 CACUCGGCAGCAUGCCGAGUGCAGCCACAC

3102 30045 CACAGCAUUGCUUUGAUAUGGAACGUUAAA

3103 30048 CAGCAUGCCGAGUGCAGCCACACAGUAUAA

Claims

1. A protein-RNA complex where here the protein is CAS13 and where and the RNA is an RNA guide strand that comprises a sequence that is complimentary to one of the sequences: SEQ ID NO 3029, OR ONE OF SEQ ID NO 1- SEQ ID NO 3028 or ONE OF SEQ ID NO 3030 - SEQ ID NO 3103.

2. The protein-RNA complex of claim 1 where the sequence is SEQ ID NO 3029.

3. A protein-RNA complex according to claim 1 or 2 for use in therapy.

4. A protein-RNA complex according to any one of claims 1 to 3 for use in the treatment of a corona virus infection.

5. A plasmid encoding the protein is CAS13 and an RNA guide strand that comprises a se quence that is complimentary to one of the sequences SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, where the plasmid is adapted for expression of the protein and the transcription of the RNA guide strand in a mammalian cell.

6. A pharmaceutical composition comprising a. a protein -RNA complex according to any one of claims 1 to 4 or b. a plasmid according to claim 5; or c. two separate plasmids of which one encodes the protein is CAS13 and the other encodes an RNA guide strand that comprises a sequence that is complimentary to one of the sequences SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, where the plasmids are adapted for expression of the protein and transcription of the RNA guide strand in a mammalian cell, or d. an RNA guide strand for Casl3 comprising a sequence that is complimentary to one of SEQ ID NO 1 to SEQ ID NO 3103, preferably SEQ ID no 3029, and a plasmid that encodes the protein Casl3 where the plasmid is adapted for expression of the protein in a mammalian cell.

7. A method of treatment of a virus infection comprising administering a protein-RNA com plex according to claim 1 to 4 or a plasmid according to claim 5 or pharmaceutical accord ing to claim 6 to a patient in need thereof.

8. A method for RNA knock-down of virus RNA in a virus-infected cell comprising using a pro- tein-RNA complex comprising a Cas 13 protein and an RNA guide strand that comprises a sequence that is complimentary to one of sequences SEQ ID NO 1 to SEQ ID NO 3103, pref erably SEQ ID no 3029, and where the method comprises introducing the protein-RNA complex, or means for expression of these, in a cell.