CN101952272B - 6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 - Google Patents
6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 Download PDFInfo
- Publication number
- CN101952272B CN101952272B CN200880117819.9A CN200880117819A CN101952272B CN 101952272 B CN101952272 B CN 101952272B CN 200880117819 A CN200880117819 A CN 200880117819A CN 101952272 B CN101952272 B CN 101952272B
- Authority
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- China
- Prior art keywords
- methyl
- optionally substituted
- alkyl
- oxo
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(N(C(CCC(N1)=O)C1=O)C(c1c2)=*)=Nc1ccc2O Chemical compound CC(N(C(CCC(N1)=O)C1=O)C(c1c2)=*)=Nc1ccc2O 0.000 description 5
- OGVQZFJASIMJNI-UHFFFAOYSA-N CC(N(C(CCC(N1)=O)C1=O)C1O)=Nc(cc2)c1cc2F Chemical compound CC(N(C(CCC(N1)=O)C1=O)C1O)=Nc(cc2)c1cc2F OGVQZFJASIMJNI-UHFFFAOYSA-N 0.000 description 1
- CCWDLAQVWJGKNV-UHFFFAOYSA-N CC(N1C(CCC(N2)=O)C2=O)=Nc(c(O)ccc2)c2C1=O Chemical compound CC(N1C(CCC(N2)=O)C2=O)=Nc(c(O)ccc2)c2C1=O CCWDLAQVWJGKNV-UHFFFAOYSA-N 0.000 description 1
- RUBYGQWIIMAGQN-UHFFFAOYSA-N CC(N1C(CCC(N2)=O)C2=O)=Nc(cc(cc2)F)c2C1=O Chemical compound CC(N1C(CCC(N2)=O)C2=O)=Nc(cc(cc2)F)c2C1=O RUBYGQWIIMAGQN-UHFFFAOYSA-N 0.000 description 1
- YHZRBSMOCBSJLY-UHFFFAOYSA-N CC(N1C(CCC(N2)=O)C2=O)=Nc(ccc(CNC(C2CC2)=O)c2)c2C1=O Chemical compound CC(N1C(CCC(N2)=O)C2=O)=Nc(ccc(CNC(C2CC2)=O)c2)c2C1=O YHZRBSMOCBSJLY-UHFFFAOYSA-N 0.000 description 1
- PHBJGZGVULTCJK-UHFFFAOYSA-N Cc(cc1)cc2c1C=CN(C(CCC(N1)=O)C1=O)C2=O Chemical compound Cc(cc1)cc2c1C=CN(C(CCC(N1)=O)C1=O)C2=O PHBJGZGVULTCJK-UHFFFAOYSA-N 0.000 description 1
- FITDZHDEBVRWGI-UHFFFAOYSA-N Cc(cc12)ccc1N=C(C)N(C(CCC(N1)=O)C1=O)C2=O Chemical compound Cc(cc12)ccc1N=C(C)N(C(CCC(N1)=O)C1=O)C2=O FITDZHDEBVRWGI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99567607P | 2007-09-26 | 2007-09-26 | |
| US60/995,676 | 2007-09-26 | ||
| PCT/US2008/011124 WO2009042177A1 (en) | 2007-09-26 | 2008-09-25 | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410362879.4A Division CN104211684A (zh) | 2007-09-26 | 2008-09-25 | 6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101952272A CN101952272A (zh) | 2011-01-19 |
| CN101952272B true CN101952272B (zh) | 2014-08-27 |
Family
ID=40225265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880117819.9A Expired - Fee Related CN101952272B (zh) | 2007-09-26 | 2008-09-25 | 6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 |
| CN201410362879.4A Pending CN104211684A (zh) | 2007-09-26 | 2008-09-25 | 6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410362879.4A Pending CN104211684A (zh) | 2007-09-26 | 2008-09-25 | 6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US8492395B2 (OSRAM) |
| EP (1) | EP2200999B1 (OSRAM) |
| JP (1) | JP5637852B2 (OSRAM) |
| KR (1) | KR101593242B1 (OSRAM) |
| CN (2) | CN101952272B (OSRAM) |
| AU (1) | AU2008305581C1 (OSRAM) |
| BR (1) | BRPI0817525A2 (OSRAM) |
| CA (1) | CA2704710C (OSRAM) |
| CO (1) | CO6270228A2 (OSRAM) |
| CR (1) | CR11355A (OSRAM) |
| ES (1) | ES2523925T3 (OSRAM) |
| IL (2) | IL204763A (OSRAM) |
| MX (1) | MX347987B (OSRAM) |
| MY (1) | MY157495A (OSRAM) |
| NI (1) | NI201000041A (OSRAM) |
| NZ (1) | NZ584425A (OSRAM) |
| RU (1) | RU2476432C2 (OSRAM) |
| SG (2) | SG176442A1 (OSRAM) |
| UA (1) | UA102078C2 (OSRAM) |
| WO (1) | WO2009042177A1 (OSRAM) |
| ZA (1) | ZA201002303B (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RS52349B (sr) | 2006-09-26 | 2012-12-31 | Celgene Corporation | 5-supstituisani derivati hinazolinona kao antitumorski agensi |
| US8354417B2 (en) * | 2007-09-26 | 2013-01-15 | Celgene Corporation | Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same |
| HUE026296T2 (en) | 2009-08-31 | 2016-06-28 | Merck Sharp & Dohme | Positive allosteric pyranyl arylmethyl benzoquinazolinone M1 receptor modulators |
| WO2011049731A1 (en) | 2009-10-21 | 2011-04-28 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| CA2829570C (en) | 2011-03-11 | 2019-05-07 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| RU2017120977A (ru) * | 2011-03-11 | 2018-11-15 | Селджин Корпорейшн | Способ лечения рака с использованием 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона |
| WO2012135299A1 (en) | 2011-03-28 | 2012-10-04 | Deuteria Pharmaceuticals Inc | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| EP2943201B2 (en) | 2013-01-14 | 2020-07-29 | Deuterx, LLC | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| WO2014152833A1 (en) * | 2013-03-14 | 2014-09-25 | Deuterx, Llc | 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| TWI654979B (zh) | 2013-04-17 | 2019-04-01 | 美商標誌製藥公司 | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| WO2014179661A1 (en) | 2013-05-03 | 2014-11-06 | Celgene Corporation | Methods for treating cancer using combination therapy |
| PT3182996T (pt) | 2014-08-22 | 2023-03-21 | Celgene Corp | Métodos de tratamento de mieloma múltiplo com compostos imunomoduladores em combinação com anticorpos |
| US10973822B2 (en) | 2015-07-02 | 2021-04-13 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
| US11001566B2 (en) * | 2016-01-14 | 2021-05-11 | Kangpu Biopharmaceuticals, Ltd. | Quinazolinone derivative, preparation method therefor, pharmaceutical composition, and applications |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| WO2018208123A1 (ko) * | 2017-05-12 | 2018-11-15 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| KR102014478B1 (ko) * | 2017-05-12 | 2019-08-26 | 한국화학연구원 | 신규한 피페리딘-2,6-디온 유도체 및 이의 용도 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| EP3679028A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Dihydroquinolinones |
| EP3679026A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Glutarimide |
| CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
| US11459293B2 (en) * | 2017-10-27 | 2022-10-04 | Immunebridge Inc. | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADATION AND DEGRADATION AGENTS FOR TARGETED PROTEIN DEGRADATION |
| WO2019191112A1 (en) | 2018-03-26 | 2019-10-03 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
| WO2019204354A1 (en) | 2018-04-16 | 2019-10-24 | C4 Therapeutics, Inc. | Spirocyclic compounds |
| EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
| CN120698985A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| EA202192738A1 (ru) | 2019-04-12 | 2022-03-17 | С4 Терапьютикс, Инк. | Трициклические соединения, обеспечивающие разрушение белка ikaros и белка aiolos |
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| EP4198030A4 (en) * | 2020-08-14 | 2024-01-10 | Shanghaitech University | Immunoregulatory compound and antitumor application thereof |
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