CN101939009B - 药学固体形式 - Google Patents

药学固体形式 Download PDF

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Publication number
CN101939009B
CN101939009B CN200980104255XA CN200980104255A CN101939009B CN 101939009 B CN101939009 B CN 101939009B CN 200980104255X A CN200980104255X A CN 200980104255XA CN 200980104255 A CN200980104255 A CN 200980104255A CN 101939009 B CN101939009 B CN 101939009B
Authority
CN
China
Prior art keywords
type
diol
ethynyl
androstane
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980104255XA
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English (en)
Chinese (zh)
Other versions
CN101939009A (zh
Inventor
斯蒂芬·K·怀特
德怀特·斯蒂克尼
埃林·奥尔松
基斯·R·罗里梅尔
布伦登·S·沃尔夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Biosciences Inc
Original Assignee
Harbor Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Biosciences Inc filed Critical Harbor Biosciences Inc
Publication of CN101939009A publication Critical patent/CN101939009A/zh
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Publication of CN101939009B publication Critical patent/CN101939009B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN200980104255XA 2008-02-05 2009-02-05 药学固体形式 Expired - Fee Related CN101939009B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2647208P 2008-02-05 2008-02-05
US61/026,472 2008-02-05
US9369408P 2008-09-02 2008-09-02
US61/093,694 2008-09-02
PCT/US2009/033280 WO2009100258A1 (en) 2008-02-05 2009-02-05 Pharmaceutical solid state forms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013102558234A Division CN103467554A (zh) 2008-02-05 2009-02-05 药学固体形式

Publications (2)

Publication Number Publication Date
CN101939009A CN101939009A (zh) 2011-01-05
CN101939009B true CN101939009B (zh) 2013-07-17

Family

ID=40952461

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200980104255XA Expired - Fee Related CN101939009B (zh) 2008-02-05 2009-02-05 药学固体形式
CN2013102558234A Pending CN103467554A (zh) 2008-02-05 2009-02-05 药学固体形式

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2013102558234A Pending CN103467554A (zh) 2008-02-05 2009-02-05 药学固体形式

Country Status (10)

Country Link
US (4) US8518922B2 (enExample)
EP (1) EP2249838A4 (enExample)
JP (1) JP2011511011A (enExample)
KR (1) KR20100113602A (enExample)
CN (2) CN101939009B (enExample)
AU (1) AU2009212314C1 (enExample)
CA (1) CA2712005C (enExample)
EA (1) EA018974B9 (enExample)
IL (1) IL207378A0 (enExample)
WO (1) WO2009100258A1 (enExample)

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UA102534C2 (xx) 2007-12-07 2013-07-25 Вертекс Фармасьютикалз Инкорпорейтед ТВЕРДА ФОРМА 3-(6-(1-(2,2-ДИФТОРБЕНЗО$d]$1,3]-ДІОКСОЛ-5-ІЛ)-ЦИКЛОПРОПАНКАРБОКСАМІДО)-3-МЕТИЛПІРИДИН-2-ІЛ)БЕНЗОЙНОЇ КИСЛОТИ (ВАРІАНТИ)$ТВЕРДАЯ ФОРМА 3-(6-(1-(2,2-ДИФТОРБЕНЗО$d]$1,3]-ДИОКСОЛ-5-ИЛ)-ЦИКЛОПРОПАНКАРБОКСАМИДО)-3-МЕТИЛПИРИДИН-2-ИЛ)БЕНЗОЙНОЙ КИСЛОТЫ (ВАРИАНТЫ)
CA2728889C (en) * 2008-04-03 2016-06-14 Harbor Biosciences, Inc. Solid state forms of a pharmaceutical
EP2506855A4 (en) * 2009-11-30 2014-07-30 Harbor Biosciences Inc ANTICARCINOMA COMPOUNDS AND SCREENING METHODS
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2012083161A1 (en) * 2010-12-17 2012-06-21 Harbor Biosciences, Inc. Steroid tetrol solid state forms
CN104173353B (zh) * 2013-05-22 2018-08-21 中国医药工业研究总院 不含表面活性剂的固体制剂及其制备方法
BR112016010403A2 (pt) * 2013-11-12 2017-08-08 Vertex Pharma Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por cftr
CN105434444B (zh) * 2014-09-29 2021-02-05 上海奥奇医药科技有限公司 一种A-失碳-5α雄甾烷化合物的口服制剂
RU2017112748A (ru) 2014-11-17 2018-12-19 Арно Терапьютикс, Инк. Композиции онапристона пролонгированного действия и способы
US10308676B2 (en) 2015-09-25 2019-06-04 Context Biopharma Inc. Methods of making onapristone intermediates
CN108883067B (zh) 2015-12-15 2021-03-09 康特斯生物制药公司 非晶奥那司酮组合物及其制备方法
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
IL269667B2 (en) * 2017-03-30 2024-09-01 Merck Patent GmbH Solid forms of (s)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl) methanol, its preparation and pharmaceutical compositions containing them
RU2668526C1 (ru) * 2017-08-18 2018-10-01 Федеральное государственное бюджетное учреждение "Информационно-методический центр по экспертизе, учету и анализу обращения средств медицинского применения" Федеральной службы по надзору в сфере здравоохранения Способ идентификации и последующего количественного определения основных компонентов в инъекционных лекарственных средствах
AU2019389175B2 (en) 2018-11-30 2025-03-06 Caris Mpi, Inc. Next-generation molecular profiling
CN111773388B (zh) * 2019-04-04 2023-07-18 上海奥奇医药科技有限公司 A-失碳-5α雄甾烷化合物类药物与抗癌药物的联合应用
EP4069865A4 (en) 2019-12-02 2023-12-20 Caris MPI, Inc. PLATINUM RESPONSE PREDICTOR IN A PAN-CANCER APPROACH

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567830A (en) * 1994-02-14 1996-10-22 Cocensys, Inc. Process for synthesis of acetylenic carbinols
US20070129548A1 (en) * 2005-12-07 2007-06-07 Lushi Tan Polymorphs of an androgen receptor modulator
US20080021006A1 (en) * 1999-09-30 2008-01-24 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical Compositions

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DE681869C (de) * 1935-11-22 1939-10-03 Schering Ag Verfahren zur Darstellung von tertiaeren Alkoholen der Cyclopentanopolyhydrophenanthrenreihe
CH202847A (de) * 1937-06-26 1939-02-15 Chem Ind Basel Verfahren zur Darstellung von Acetylen-Derivaten der Cyclopentanopolyhydrophenanthren-Reihe.
DE69325253T2 (de) * 1992-08-28 1999-12-02 Bone Care International Inc., Madison 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
AU708053B2 (en) 1996-03-29 1999-07-29 Duphar International Research B.V. Piperazine and piperidine compounds
ZA986614B (en) * 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
US7045513B1 (en) * 1999-03-18 2006-05-16 Genelabs Technologies, Inc. DHEA composition and method
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
SK288222B6 (sk) * 2000-12-14 2014-09-04 Ortho-Mcneil Pharmaceutical, Inc. Steroidné hormonálne prípravky a spôsoby ich prípravy
AR034206A1 (es) 2001-02-16 2004-02-04 Solvay Pharm Bv Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos
DE10314610A1 (de) * 2003-04-01 2004-11-04 Aventis Pharma Deutschland Gmbh Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
US7540016B2 (en) * 2004-07-21 2009-05-26 Beachhead Solutions, Inc. System and method for lost data destruction of electronic data stored on a portable electronic device which communicates with servers that are inside of and outside of a firewall
US7964604B2 (en) * 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
TWI305979B (en) * 2006-03-24 2009-02-01 Hon Hai Prec Ind Co Ltd Wireless transceiving system
PL2012773T3 (pl) * 2006-04-22 2012-12-31 Harbor Biosciences Inc Leki i zastosowania
DE102007063671A1 (de) * 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567830A (en) * 1994-02-14 1996-10-22 Cocensys, Inc. Process for synthesis of acetylenic carbinols
US20080021006A1 (en) * 1999-09-30 2008-01-24 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical Compositions
US20070129548A1 (en) * 2005-12-07 2007-06-07 Lushi Tan Polymorphs of an androgen receptor modulator

Also Published As

Publication number Publication date
EA018974B9 (ru) 2014-04-30
AU2009212314C1 (en) 2014-05-08
CN103467554A (zh) 2013-12-25
CA2712005A1 (en) 2009-08-13
US20130345455A1 (en) 2013-12-26
KR20100113602A (ko) 2010-10-21
AU2009212314B2 (en) 2013-11-21
US20090291932A1 (en) 2009-11-26
EP2249838A1 (en) 2010-11-17
EA018974B1 (ru) 2013-12-30
US20130338125A1 (en) 2013-12-19
CN101939009A (zh) 2011-01-05
CA2712005C (en) 2014-04-15
AU2009212314A1 (en) 2009-08-13
IL207378A0 (en) 2010-12-30
JP2011511011A (ja) 2011-04-07
HK1147695A1 (en) 2011-08-19
WO2009100258A1 (en) 2009-08-13
EA201070713A1 (ru) 2011-08-30
EP2249838A4 (en) 2012-05-02
US8518922B2 (en) 2013-08-27
US20130345184A1 (en) 2013-12-26
US9314471B2 (en) 2016-04-19

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