CN101934009A - Preparation method for processed arisaema tubers - Google Patents
Preparation method for processed arisaema tubers Download PDFInfo
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- CN101934009A CN101934009A CN 201010249233 CN201010249233A CN101934009A CN 101934009 A CN101934009 A CN 101934009A CN 201010249233 CN201010249233 CN 201010249233 CN 201010249233 A CN201010249233 A CN 201010249233A CN 101934009 A CN101934009 A CN 101934009A
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- arisaema
- tubers
- rhizoma arisaematis
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- 241000489492 Arisaema Species 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 14
- 238000004140 cleaning Methods 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 8
- 238000005406 washing Methods 0.000 claims abstract description 7
- 241000234314 Zingiber Species 0.000 claims abstract description 6
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 6
- 235000008397 ginger Nutrition 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 210000000941 bile Anatomy 0.000 claims description 4
- 230000002000 scavenging effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 14
- 239000004615 ingredient Substances 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000005520 cutting process Methods 0.000 abstract description 3
- 230000008595 infiltration Effects 0.000 abstract description 2
- 238000001764 infiltration Methods 0.000 abstract description 2
- 229940037003 alum Drugs 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 description 5
- 230000007096 poisonous effect Effects 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 238000002791 soaking Methods 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 241000317412 Arisaema amurense Species 0.000 description 2
- 241000317400 Arisaema heterophyllum Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 229930194567 Pedatisectine Natural products 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000013386 optimize process Methods 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method for processed arisaema tubers, which comprises the following steps of: screening raw arisaema tubers, and separating the arisaema tubers according to the size; putting the separated arisaema tubers into a medicament washing machine, and quickly cleaning the arisaema tubers by using running water; putting the cleaned arisaema tubers into a medicament infiltrating machine to perform thermal infiltration, infiltrating the large arisaema tubers for 2 hours and infiltrating the small arisaema tubers for 1 hour at the temperature of 50 DEG C by applying pressure of 0.4MPa and adding water in an amount which is 4 times that of the arisaema tubers, and taking out and drying the infiltrated arisaema tubers; transferring the dried arisaema tubers into boiling water solution of dried ginger slices and alum, wherein 12.5 kilograms of dried ginger and 6 kilograms of alum are used in every 100 kilograms of raw product, the arisaema tubers are boiled for 2 hours and the water level is higher than the medicament; and after boiling, taking out and cleaning the arisaema tubers, drying the arisaema tubers to be 40 to 60 percent of dryness, cutting the arisaema tubers into slices, and drying the slices in the vacuum of 0.04MPa at the temperature of 60 DEG C. The method has the advantages of shortening the production time, reducing the loss rate of the finished product, improving the production efficiency, reducing the consumption of auxiliary materials, saving the production cost, simplifying the production flow and fully retaining the effective ingredients of the arisaema tubers.
Description
[technical field]
The present invention relates to the concocting method of Chinese crude drug, more particularly, relate to the concocting method of Rhizoma Arisaematis (processed).
[background technology]
This product is the dry tuber of aroid Rhizoma Arisaematis Arisaema erubecens (Wall.) Schott, Arisaema heterophyllum B1. Arisaema heterophyllum Bl. or arisaema amurense Maxim Arisaema amurense Maxim..Rhizoma Arisaematis bitter in the mouth, suffering, warm in nature; Poisonous.Return lung, liver, spleen channel.The hot warm-dryness syndrome of Arisaema Cum Bile is strong, poisonous, many externals.Person for oral administration is also arranged, to expelling wind and relieving convulsion, be used for tetanus, more as Yuzhen San; Also be used for epilepsy, loose as Rhizoma Arisaematis.Carbuncle skin ulcer scabies, snake bite and insect sting are controlled in external.Rhizoma Arisaematis (processed) toxicity reduces, and the effect of drying dampness to eliminate phlegm strengthens.Be used for the pertinacious phlegm cough more, as control the Jiang Gui ball of cough due to damp-phlegm.
Traditional concocting method of Rhizoma Arisaematis (processed) is: get clean Rhizoma Arisaematis, soak with clear water respectively by size, change water 2-3 every day, when playing foam, add Alumen (every 100kg Rhizoma Arisaematis adds Alumen 2kg) after changing water as the water surface, steep after one day, change water again and float to taste and littlely take out when numb feeling in the tongue is arranged to cutting opening.Other get Alumen, ginger slice put add suitable quantity of water in the pot and boil after, pour into when Rhizoma Arisaematis boils to the no dried heart altogether and take out, remove Rhizoma Zingiberis, dry in the air to 4-6 to become to do, shave, drying, sieve removes chip.Every 100kg Rhizoma Arisaematis is with Rhizoma Zingiberis Recens, each 12.5kg of Alumen.(" one one of one one of Chinese pharmacopoeia version in 2005 and version in 2010)
Processing action: the one, for reducing toxicity, relax dry strong property, the 2nd, the synergism of performance adjuvant reaches the purpose to efficacy enhancing and toxicity reducing.
In traditional concocting method, through the soaking, float of long period, long period of soaking then water soluble ingredient runs off Rhizoma Arisaematis in a large number mostly, and its drug effect obviously reduces, and therefore shortens water-soaking time, in order to avoid loss of effective components is a Chinese medicine industry technical barrier anxious to be solved.
[summary of the invention]
Technical problem to be solved by this invention is to provide a kind of new technology of concocting the method Rhizoma Arisaematis, has shortened the production time, has improved production efficiency, has reduced loss of active ingredients, to guarantee clinical efficacy.
Technical scheme of the present invention is:
The concocting method of Rhizoma Arisaematis (processed) may further comprise the steps:
A, get Arisaema Cum Bile and sieve, sieve dedust bits separate by size; With the described Rhizoma Arisaematis that cleaned, it is clean with the circulating water Rapid Cleaning to put into medicine-washing machine, and described medicine-washing machine drum speed is 10 rev/mins, and scavenging period is 20 minutes;
B, the Rhizoma Arisaematis of described cleaning placed carry out the heat profit in the medicine processing device, pressurization 0.4MPa, 50 ℃ of temperature, amount of water is 4 times of Rhizoma Arisaematis, big person's infiltrating time 2 hours, little person was soaked into 1 hour, was dipped to the heart and was degree, and the Rhizoma Arisaematis that soaked into is taken out, and filtered dried;
C, will filter the Rhizoma Arisaematis of doing and change over to the water liquid of the ginger slice of an amount of water boil and Alumen, every 100kg gives birth to product Rhizoma Zingiberis Recens 12.5kg, and Alumen 6kg boiled 2 hours;
After D, the boiling, take out, cleaning, drying to four are done to sixty percent, thinly slice, and be 0.04MPa oven dry down in 60 ℃ of vacuums.
Principle of the present invention is: the contained needle-like calcium oxalate crystal of Rhizoma Arisaematis can make multiple mucosa produce strong impulse, is the main zest toxicity composition of Rhizoma Arisaematis.The effective ingredient of Rhizoma Arisaematis is still indeterminate so far, therefore requires on the one hand to concoct the requirement that reaches " detoxifcation " when processing is concocted, and will prevent a large amount of losses of effective ingredient (water-soluble active ingredient) on the other hand, to guarantee its clinical efficacy.Experiment shows that Alumen is the crucial adjuvant that reduces or eliminate the Rhizoma Arisaematis toxic and side effects, and it can make that having the toxic composition albumen needle-like calcium oxalate crystal of stimulation in the Rhizoma Arisaematis destroys, and reduces or eliminate the zest toxicity of Rhizoma Arisaematis.In addition, its detoxifcation mechanism also with the absorption poisonous substance, the physicochemical property, physiologically active and the enhancing body detoxification ability that change poisonous substance are relevant, have function of detoxification as Rhizoma Zingiberis Recens in the adjuvant, play synergism with Rhizoma Arisaematis; Alumen becomes Al (OH) 3 gels in water, absorption poisonous substance or detoxify with toxicopexis.Studies show that the content of pedatisectine second, aminoacid, the cupreol product of giving birth to all have reduction in various degree in the processed product.Therefore in processing procedure, should reduce treatment time of water as far as possible.Because Alumen and Rhizoma Zingiberis Recens play significant feature in concocting detoxifcation, so, in the concocting process, the water logging time, add the Alumen amount, must use properly with Rhizoma Zingiberis Recens amount and heat treated four processes, heat and can shorten the time of the process of preparing Chinese medicine, pressurization equally also can be shortened the time of immersion.Consider above four factors, adopt orthogonal design, optimize process conditions of the present invention.
The invention has the advantages that: this technology is compared with traditional processing procedure, has following advantage:
(1) shortens the production time, reduced the proportion of goods damageds of finished product, improved production efficiency.Traditional handicraft was produced a collection of common needs 10 days, and new technology only needs 2 days, in addition, because traditional handicraft is soaked for a long time, caused the part Rhizoma Arisaematis to be difficult to cutting and was shaped, and caused the proportion of goods damageds too high.
(2) reduce supplementary product consumption, saved production cost.The every 100kg Rhizoma Arisaematis of new technology only needs Rhizoma Zingiberis Recens 12.5kg, Alumen 6kg; The every 100kg Rhizoma Arisaematis of traditional handicraft then need be used Rhizoma Zingiberis Recens 12.5kg, Alumen 12.5kg.
(3) simplified production procedure, production process is easy to control, has realized automatization, scale and the standardization of concocting; New technology adopts mechanized operation in a large number, as: adopt medicine processing device to be used for the fast softening and the infiltration of Rhizoma Arisaematis, use tilting-type steaming and decocting jacketed pan boiling Rhizoma Arisaematis; Traditional handicraft then adopts fermentation vat, and it is big to take up room, and is not easy to control and operation.
(4) fully kept the effective ingredient of Rhizoma Arisaematis, toxic component reduces greatly, has guaranteed product quality, improves the product curative effect, has guaranteed the safety of medication.The traditional handicraft long period of soaking cause the effective ingredient of Rhizoma Arisaematis to run off in a large number, and new technology has shortened soak time greatly, has fully kept effective ingredient.
[specific embodiment]
1, get Arisaema Cum Bile and sieve, sieve dedust bits separate by size; With the described Rhizoma Arisaematis that cleaned, it is clean with the circulating water Rapid Cleaning to put into medicine-washing machine, and described medicine-washing machine drum speed is 10 rev/mins, and scavenging period is 20 minutes;
2, the Rhizoma Arisaematis of described cleaning is placed carry out the heat profit in the medicine processing device, pressurization 0.4MPa, 50 ℃ of temperature, amount of water is 4 times of Rhizoma Arisaematis, big person's infiltrating time 2 hours, little person was soaked into 1 hour, was dipped to the heart and was degree (the interior no white heart), the Rhizoma Arisaematis that soaked into is taken out, and (only removing outside moisture) done in filter;
3, will filter the Rhizoma Arisaematis of doing and change over to the water liquid of the ginger slice of an amount of water boil and Alumen, every 100kg gives birth to product Rhizoma Zingiberis Recens 12.5kg, and Alumen 6kg boiled 2 hours, and the water liquid level will be higher than medicine;
4, after the boiling, take out, cleaning, drying to four are done to sixty percent, and available cool method of shining is thinly sliced, and is 0.04MPa oven dry down in 60 ℃ of vacuums.
The technology of the present invention advanced person, technological design is scientific and reasonable, and production efficiency improves greatly, and can guarantee product quality, satisfies the effective demand of people to health care.The present invention is fit to scale, automated production, is convenient to operation control, and exemplary role is played in the industrial structure optimization and the technology upgrading of prepared slices of Chinese crude drugs production.
Though more than described the specific embodiment of the present invention; but being familiar with those skilled in the art is to be understood that; our described specific embodiment is illustrative; rather than be used for qualification to scope of the present invention; those of ordinary skill in the art are in the modification and the variation of the equivalence of doing according to spirit of the present invention, all should be encompassed in the scope that claim of the present invention protects.
Claims (1)
1. the concocting method of a Rhizoma Arisaematis (processed) is characterized in that: comprise the steps:
Step 1, get Arisaema Cum Bile and sieve, sieve dedust bits separate by size; With the described Rhizoma Arisaematis that cleaned, it is clean with the circulating water Rapid Cleaning to put into medicine-washing machine, and described medicine-washing machine drum speed is 10 rev/mins, and scavenging period is 20 minutes;
Step 2, the Rhizoma Arisaematis of described cleaning placed carry out the heat profit in the medicine processing device, pressurization 0.4MPa, 50 ℃ of temperature, amount of water is 4 times of Rhizoma Arisaematis, big person's infiltrating time 2 hours, and little person was soaked into 1 hour, be dipped to the heart and be degree, the Rhizoma Arisaematis that soaked into is taken out, filter is done;
Step 3, will filter the Rhizoma Arisaematis of doing and change over to the water liquid with the ginger slice of water boil and Alumen, every 100kg gives birth to product Rhizoma Zingiberis Recens 12.5kg, and Alumen 6kg boiled 2 hours, and the water liquid level will be higher than medicine;
After step 4, the boiling, take out, cleaning, drying to four are done to sixty percent, thinly slice, and be 0.04MPa oven dry down in 60 ℃ of vacuums.
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| CN 201010249233 CN101934009A (en) | 2010-08-03 | 2010-08-03 | Preparation method for processed arisaema tubers |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010249233 CN101934009A (en) | 2010-08-03 | 2010-08-03 | Preparation method for processed arisaema tubers |
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| CN101934009A true CN101934009A (en) | 2011-01-05 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205014A (en) * | 2011-05-26 | 2011-10-05 | 南京中医药大学 | Method for processing rhizoma arisaematis |
| CN102670887A (en) * | 2012-05-23 | 2012-09-19 | 河北医科大学 | Method for processing rhizoma arisaematis |
| CN104645133A (en) * | 2014-12-02 | 2015-05-27 | 江西江中中药饮片有限公司 | Preparation method of fried coix seeds |
| CN105777921A (en) * | 2014-12-26 | 2016-07-20 | 王贵孝 | Astragalus polysaccharide extraction process and application thereof |
| CN106511668A (en) * | 2016-12-06 | 2017-03-22 | 康美（北京）药物研究院有限公司 | Ginger processed rhizoma pinelliae and processing method thereof |
| CN107158181A (en) * | 2017-06-29 | 2017-09-15 | 黑龙江中医药大学 | A kind of rhizoma arisaematis concocting method and its product |
| CN107213296A (en) * | 2017-06-24 | 2017-09-29 | 河南省青山药业有限公司 | A kind of concocting method of rhizoma arisaematis |
| CN107595950A (en) * | 2017-10-13 | 2018-01-19 | 河南省三禾药业有限公司 | A kind of monkshood detoxification processing procedure and processing monkshood |
| CN108112985A (en) * | 2017-11-08 | 2018-06-05 | 湖南省中医药研究院 | A kind of method for medical and edible dual purpose plant calcium oxalate crystal growth in healthy needle of degrading |
| CN111388581A (en) * | 2019-11-29 | 2020-07-10 | 浙江桐君堂中药饮片有限公司 | Preparation method of processed rhizoma arisaematis |
| CN114617926A (en) * | 2022-02-28 | 2022-06-14 | 四川香雪制药有限公司 | Processing method of rhizoma arisaematis |
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| CN1785328A (en) * | 2005-11-18 | 2006-06-14 | 石家庄乐仁堂制药有限责任公司 | Preparation method of Chinese medicinal material |
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2010
- 2010-08-03 CN CN 201010249233 patent/CN101934009A/en active Pending
Patent Citations (1)
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| CN1785328A (en) * | 2005-11-18 | 2006-06-14 | 石家庄乐仁堂制药有限责任公司 | Preparation method of Chinese medicinal material |
Non-Patent Citations (2)
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| 《中国药典一部》 20001231 中国药典委员会 天南星 43 1 , 1 * |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205014A (en) * | 2011-05-26 | 2011-10-05 | 南京中医药大学 | Method for processing rhizoma arisaematis |
| CN102205014B (en) * | 2011-05-26 | 2012-06-06 | 南京中医药大学 | Method for processing rhizoma arisaematis |
| CN102670887A (en) * | 2012-05-23 | 2012-09-19 | 河北医科大学 | Method for processing rhizoma arisaematis |
| CN102670887B (en) * | 2012-05-23 | 2015-02-04 | 河北中医学院 | Method for processing rhizoma arisaematis |
| CN104645133A (en) * | 2014-12-02 | 2015-05-27 | 江西江中中药饮片有限公司 | Preparation method of fried coix seeds |
| CN105777921A (en) * | 2014-12-26 | 2016-07-20 | 王贵孝 | Astragalus polysaccharide extraction process and application thereof |
| CN106511668A (en) * | 2016-12-06 | 2017-03-22 | 康美（北京）药物研究院有限公司 | Ginger processed rhizoma pinelliae and processing method thereof |
| CN107213296A (en) * | 2017-06-24 | 2017-09-29 | 河南省青山药业有限公司 | A kind of concocting method of rhizoma arisaematis |
| CN107158181A (en) * | 2017-06-29 | 2017-09-15 | 黑龙江中医药大学 | A kind of rhizoma arisaematis concocting method and its product |
| CN107595950A (en) * | 2017-10-13 | 2018-01-19 | 河南省三禾药业有限公司 | A kind of monkshood detoxification processing procedure and processing monkshood |
| CN107595950B (en) * | 2017-10-13 | 2021-01-19 | 河南省三禾药业有限公司 | Toxin-removing processing technology for radix aconiti and processed radix aconiti |
| CN108112985A (en) * | 2017-11-08 | 2018-06-05 | 湖南省中医药研究院 | A kind of method for medical and edible dual purpose plant calcium oxalate crystal growth in healthy needle of degrading |
| CN111388581A (en) * | 2019-11-29 | 2020-07-10 | 浙江桐君堂中药饮片有限公司 | Preparation method of processed rhizoma arisaematis |
| CN114617926A (en) * | 2022-02-28 | 2022-06-14 | 四川香雪制药有限公司 | Processing method of rhizoma arisaematis |
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Application publication date: 20110105 |