CN102670887B - Method for processing rhizoma arisaematis - Google Patents
Method for processing rhizoma arisaematis Download PDFInfo
- Publication number
- CN102670887B CN102670887B CN201210162570.1A CN201210162570A CN102670887B CN 102670887 B CN102670887 B CN 102670887B CN 201210162570 A CN201210162570 A CN 201210162570A CN 102670887 B CN102670887 B CN 102670887B
- Authority
- CN
- China
- Prior art keywords
- rhizoma arisaematis
- lime
- quicklime
- water
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a method for processing rhizoma arisaematis, which comprises the following steps of: taking 80-120 parts by weight of rhizoma arisaematis, adding clear water till immersing the rhizoma arisaematis, soaking for a day till soakage and fishing out; taking 5-15 parts by weight of quicklime blocks, adding water till immersing the quicklime blocks, mixing into suspension, and sieving to obtain lime liquid; and adding the lime liquid in the soaked rhizoma arisaematis till immersing the rhizoma arisaematis, uniformly stirring, infusing, drying to obtain finished products. The method disclosed by the invention has the advantages that active constituents of the processed rhizoma arisaematis are not decreased; alumen is replaced by the quicklime in processing the rhizoma arisaematis to ensure that the residues of aluminum ions in the alumen are eliminated; the sulfur dioxide residual in sulphur-fumigated original medicinal materials is decreased by utilizing the lime liquid; and the quicklime is wide in source, economic and easy to obtain, capable of serving as crude building materials after being used so as to avoid pollution.
Description
Technical field
The present invention relates to a kind of concocting method of Rhizoma Arisaematis, belong to Chinese medicine processing field.
Background technology
Rhizoma Arisaematis is conventional toxic herb material, the processing aids of " Pharmacopoeia of People's Republic of China (one) " (version in 2010) Rhizoma Arisaematis (processed) is Alumen and Rhizoma Zingiberis Recens, concrete steps are as follows: get clean Rhizoma Arisaematis, be soaked in water respectively by size, every day changes water 2-3 time, during as played foam, add Alumen (every 100kg Rhizoma Arisaematis, adds Alumen 2kg) after changing water, steep after one day, carry out again changing water, to cutting opening taste micro-have during numb feeling in the tongue take out.Ginger slice, Alumen are put in pot and adds after suitable quantity of water boils, pour Rhizoma Arisaematis into and boil altogether and take out to without during the dry heart, removing Rhizoma Zingiberis, dry in the air to four to sixty percent dry, shave, dry.Every 100kg Rhizoma Arisaematis, with Rhizoma Zingiberis Recens, each 12.5kg of Alumen.Object reduces to stimulate the while of eliminating toxicity to prevent Rhizoma Arisaematis to ferment in immersion process corruption.But the main component of Alumen is 12 hydrazine aluminum sulfate potassium, vitriol water soaking technique produces aluminium ion, correlational study shows, Long Term Contact or absorption aluminium ion can cause early alzheimer disease, cause hypochrosis, too much owing to adding Alumen in Rhizoma Arisaematis concocting process, increase on the contrary although spicy property eliminates animal acute toxicity.
At present, fresh Rhizoma Arisaematis rots to go mouldy for preventing after gathering, and increases surperficial whiteness, generally adopts stove drying, every 100kg fresh tuber 0.5kg sulfur.Easily cause sulfur dioxide to exceed standard (sulfur dioxide residual quantity is more than 150mg/kg), affect medical material outlet.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of concocting method of Rhizoma Arisaematis, the present invention is the improvement to existing processing procedure, while minimizing zest, elimination toxicity, reduce the toxic and side effects such as the aluminium ion caused owing to adopting existing concocting method exceeds standard, better ensure drug safety.
The present invention adopts quicklime to concoct Rhizoma Arisaematis, the mechanism of action is: in Rhizoma Arisaematis, main pungent component is needle-like calcium oxalate crystal, the superfine length of its crystal, needle point is sharp, and surface has agnail, and strong but pliable in texture resistance to mechanical power is strong, be difficult to fracture, intense stimulus can be produced to oral mucosa, oral cavity swelling can be caused once eat, time serious, also can cause dyspnea.This technique adopts quicklime to concoct Rhizoma Arisaematis, be needle-like calcium oxalate crystal in Rhizoma Arisaematis from outside to inside, little by little corroded to needle body by needle tip, come off, rust, rupture, thus lose zest and toxicity, to reach the effect of attenuation.Lime liquor decreases the residual of sulfur dioxide to a certain extent simultaneously.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of concocting method of Rhizoma Arisaematis, and its step is as follows:
1) get the Rhizoma Arisaematis that parts by weight are 80 ~ 120 parts, add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out;
2) get the caustic lime block that parts by weight are 5 ~ 15 parts, add water to submergence caustic lime block, furnishing suspension, sieves, and obtains lime liquor;
3) by 2) obtained lime liquor is added to 1) in the Rhizoma Arisaematis that soaked into, to submergence Rhizoma Arisaematis, stir evenly, infuse, dry, get product.
Concocting method advantage compared with traditional handicraft of Rhizoma Arisaematis of the present invention is: after concocting by the inventive method, the effective ingredient of Rhizoma Arisaematis does not reduce; Quicklime instead of Alumen and concocts Rhizoma Arisaematis, avoids in Alumen aluminum ions residual; After lime liquor is concocted, the sulfur dioxide minimizing that stove drying crude drug is residual; Quicklime convenient sources, economy is easy to get, and still can not be able to pollute as building materials coarse fodder after using.
On the basis of technique scheme, the present invention can also do following improvement.
Further, step 2) described in the temperature of water be 60 ~ 100 DEG C, be preferably 80 DEG C.
The beneficial effect of above-mentioned further scheme is adopted to be: fully to melt, caustic lime block;
Further, step 2) described in the aperture of sieving be 1 ~ 3mm, be preferably 1.5 ~ 2mm.
The beneficial effect of above-mentioned further scheme is adopted to be: sieve the lime particle that can remove and not melt and rock ballast etc., reduces the residual quantity of impurity in Rhizoma Arisaematis medical material, ensure drug safety;
Further, the time of infuse described in step 3) is 40 ~ 60 hours, is preferably 48 hours.
Accompanying drawing explanation
Fig. 1 is canonical plotting prepared by the present invention;
Fig. 2 is sulfur dioxide residual quantity test instrunment device;
In accompanying drawing, the list of parts representated by each label is as follows:
A, 1000ml two neck round-bottomed flask; B, vertical reflux condensing tube; C, (with a scale) separatory funnel; D, connection nitrogen influx; E, sulfur dioxide gas export mouth.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
Get 100g Rhizoma Arisaematis and add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out; Get 10g caustic lime block, add the water of 80 DEG C to submergence caustic lime block, furnishing suspension, crossing aperture is the sieve of 1.5mm, obtains lime liquor; Lime liquor is added in the Rhizoma Arisaematis soaked into, to submergence Rhizoma Arisaematis, stirs evenly, infuse 48 hours, dry, get product;
Embodiment 2
Get 80g Rhizoma Arisaematis and add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out; Get 5g caustic lime block, add the water of 60 DEG C to submergence caustic lime block, furnishing suspension, crossing aperture is the sieve of 2mm, obtains lime liquor; Lime liquor is added in the Rhizoma Arisaematis soaked into, to submergence Rhizoma Arisaematis, stirs evenly, infuse 48 hours, dry, get product;
Embodiment 3
Get 120g Rhizoma Arisaematis and add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out; Get 15g caustic lime block, add the water of 100 DEG C to submergence caustic lime block, furnishing suspension, crossing aperture is the sieve of 3mm, obtains lime liquor; Lime liquor is added in the Rhizoma Arisaematis soaked into, to submergence Rhizoma Arisaematis, stirs evenly, infuse 40 hours, dry, get product;
Embodiment 4
Get 100g Rhizoma Arisaematis and add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out; Get 10g caustic lime block, add the water of 60 DEG C to submergence caustic lime block, furnishing suspension, crossing aperture is the sieve of 1mm, obtains lime liquor; Lime liquor is added in the Rhizoma Arisaematis soaked into, to submergence Rhizoma Arisaematis, stirs evenly, infuse 60 hours, dry, get product;
Embodiment 5
Get 120g Rhizoma Arisaematis and add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out; Get 8g caustic lime block, add the water of 70 DEG C to submergence caustic lime block, furnishing suspension, crossing aperture is the sieve of 2.5mm, obtains lime liquor; Lime liquor is added in the Rhizoma Arisaematis soaked into, to submergence Rhizoma Arisaematis, stirs evenly, infuse 54 hours, dry, get product;
Experimental example 1
1, material
For examination material: Rhizoma Arisaematis, Rhizoma Arisaematis (processed)
Experimental facilities: UV-754 type ultraviolet/visible spectrophotometer (Shanghai Hong Ji instrument and equipment company limited), ultrasonic cleaning instrument
Main agents: quicklime, apigenin standard substance (Shanghai along vigorous biological engineering company limited, 201202), ethanol, triethylamine lot number:
2, method
2.1 quicklime concoct the screening study of Rhizoma Arisaematis process conditions
Adopt orthogonal experiment, according to the correlative factor affecting Calx concocted method, selecting the consumption (g) of the every 100g medical material of process of preparing Chinese medicine adjuvant quicklime used, soak time (h), melting the water temperature (DEG C) of adjuvant quicklime is three factors investigated, respectively get three levels, in table 1, adopt L
9(3
4) measure the mass fraction of Rhizoma Arisaematis calcium oxalate crystal growth in healthy needle under various condition.
Table 1 Calx concocted method orthogonal test factor level table
Oxalic acid calcium catalyst: the method is XH with reference to the author of Science Press's publication in 1981, " the photobiochemistry analytical method " of Bo Qinnuoke, P285 ~ 286,1ml HCL solution (1: 1) is added in the amalyzing substances precipitation in centrifuge tube, 15ml distilled water, stirs, puts into hot water (about 70 DEG C), periodic agitation 10min is then centrifugal.It is in the beaker of 50ml that solution pours volume into, and residue 0.1mol/L HCL reprocessing twice, use 10ml HCL at every turn, water-bath is heated 5min, will constantly stir simultaneously.At every turn with centrifugal after HCL process, and acid lixiviating solution is collected together.
In order to precipitate oxalic acid, in the acid solution of gained, add 2ml 25%CaCl
2solution, is heated to 70 ~ 80 DEG C, adds a methyl orange, then adds several NH
4oH concentrated solution is until occur muddy.Solution is under constantly stirring, and heating 1 ~ 2min, to make precipitation merge become crystallization, then continues heating, add several ammonia solutions until indicator becomes yellow.After this solution heats 5 ~ 10min again, and places 2h or a night.
Centrifugal after placing, pour out solution, and precipitation uses 10ml distilled water wash once.After pouring out the solution in precipitation, give in precipitation and add 10ml 1mol/L H
2sO
4solution stirs evenly, and while stirring, heat 3 ~ 5min in boiling water, centrifugal, solution is poured in titration bottle.Residue uses 10ml 1mol/L H again
2sO
4washing once, centrifugally to be poured solution in titration bottle into afterwards.Solution is heated to 60 ~ 70 DEG C, adds 1ml10%MnSO
4, then use 0.005mol/L MnSO
4it is rose-colored that solution is titrated to appearance, and no longer changed in several seconds.1ml 0.005mol/L MnSO
4be equivalent to 0.45mg H
2c
2o
4. with Ca
2+its content of the oxalic acid combined calculates according to the formula of water solublity salt-form oxalic acid amount in plant.In order to calculating oxalate calcium, acquired results is multiplied by 1.442.
Result: the optimum condition of Integrated Selection Calx concocted method, result as Table 2,3.
Table 2 orthogonal experiments
Table 3 analysis of variance table
2.2 measure the content that lime methods and CP method concoct effective ingredient after Rhizoma Arisaematis
Sample: the Rhizoma Arisaematis after the process of preparing Chinese medicine of lime method sample Example 1; CP method sample is the Rhizoma Arisaematis after concocting according to pharmacopeia " Pharmacopoeia of People's Republic of China (one) " (version in 2010) technique.
The preparation of reference substance solution: get apigenin (C
15h
10o
5) reference substance is appropriate, accurately weighed, add 60% ethanol and make the solution of every 1ml containing 12 μ g, to obtain final product.
The preparation of standard curve: precision measures reference substance solution 1ml, 2ml, 3ml, 4ml, 5ml, put in 10ml measuring bottle respectively, respectively add 60% ethanol to 5ml, add 1% triethylamine solution to scale, shake up, with corresponding reagent for blank, adopt the silica cuvette of 1cm, measure absorbance at the wavelength place of 400nm, corresponding absorbance A drawing standard curve, regression equation is y=0.159x+0.0092, R
2=0.9973, as shown in Figure 1.
Algoscopy: get two kinds of sample powder each (crossing No. four sieves) about 0.6g respectively, accurately weighed, put in tool plug conical flask, precision adds 60% ethanol 50ml, close plug, supersound process (power 250W, frequency 40kHz) 45 minutes, lets cool, weighed weight again, supply the weight of less loss with 60% ethanol, shake up, filter.Precision measures subsequent filtrate 5ml, puts in 10ml measuring bottle, the method under the preparation of sighting target directrix curve, from " 1% triethylamine solution ", measures absorbance in accordance with the law, reads the weight containing apigenin in need testing solution from standard curve, calculates, to obtain final product.This product is pressed dry product and is calculated, containing total flavones in apigenin (C
15h
10o
5).
Result: Rhizoma Arisaematis (processed) (CP method) general flavone content 0.095%, Rhizoma Arisaematis (processed) (lime method) general flavone content 0.103%.
2.3 measure the residual quantity that lime methods and CP method concoct sulfur dioxide after Rhizoma Arisaematis
Sample: the Rhizoma Arisaematis after the process of preparing Chinese medicine of lime method sample Example 1; CP method sample is the Rhizoma Arisaematis after concocting according to pharmacopeia " Pharmacopoeia of People's Republic of China (one) " (version in 2010) technique.
Algoscopy: the content measuring sulfur dioxide according to 2010 editions " Chinese Pharmacopoeia " annex IX U sulfur dioxide residual quantity algoscopys, device as shown in Figure 2, the each about 10g of sample thief powder, accurately weighed respectively, puts in two neck round-bottomed flasks, add water 300 ~ 400ml and 6mo1/L hydrochloric acid solution 10ml, connect scale separatory funnel, and import at the bottom of nitrogen to bottle, connect reflux condensing tube, connect airway at the E mouth place, upper end of condensing tube, airway is inserted bottom 250ml conical flask.125ml and starch indicator solution 1ml add water in conical flask as absorbing liquid, is placed on magnetic stirring apparatus and constantly stirs.Heat solution in two neck round-bottomed flasks to boiling, and start with iodine titration solution (0.01mol/L) titration after keeping micro-boiling about 3 minutes, continued for 20 seconds to blue or bluish violet and do not take off, and the result blank assay of titration is corrected.Calculate according to following formula:
In formula, A is the volume (ml) that test sample consumes iodine titration solution; B is the blank volume (ml) consuming iodine titration solution; C is iodine titration solution concentration 0.01mol/L; W is the weight (g) of test sample; 0.032 is the weight (g) of the suitable sulfur dioxide of every 1ml iodine titration solution (1mol/L).
Result: Rhizoma Arisaematis (processed) (CP method) sulfur content 165mg/kg, Rhizoma Arisaematis (processed) (lime method) sulfur content 76mg/kg.
3 sum up
3.1 pairs of lime methods concoct the summary of Rhizoma Arisaematis technique
According to the technique of " Pharmacopoeia of People's Republic of China (one) " (2010 editions) Rhizoma Arisaematis (processed), the mass fraction recording the needle-like calcium oxalate crystal of Rhizoma Arisaematis (processed) in CP method is 0.245%.When the Rhizoma Arisaematis calcium oxalate crystal growth in healthy needle mass fraction that Calx concocted method obtains is equal to or less than this value, namely think that Rhizoma Arisaematis (processed) now reaches drug safety.
The each factor of comprehensive analysis affects result to inspection target, and the optimised process being obtained lime method by direct analysis is A
2b
3c
1.Can find out that from variance analysis A, B, C factor has appreciable impact to inspection target, therefore select A
2(10g), B
3(48h), C
1(80 DEG C), therefore A
2b
3c
1for the optimised process of Calx concocted method, namely every 100g clean Rhizoma Arisaematis adjuvant Calx 10g, soaks 48 hours, opens quicklime by 80 DEG C of aquations.
The summary of active constituent content after 3.2 pairs of two kinds of methods process of preparing Chinese medicine Rhizoma Arisaematiss
Shown by above experimental result, the Rhizoma Arisaematis that lime method is concocted is compared with CP method Rhizoma Arisaematis (processed), and active constituent content does not reduce.
The summary of sulfur dioxide residual quantity after 3.3 pairs of two kinds of methods process of preparing Chinese medicine Rhizoma Arisaematiss
Fresh Rhizoma Arisaematis rots to go mouldy for preventing after gathering, and increases surperficial whiteness, dries, cause sulfur dioxide residue in medical material after generally adopting sulfur smoked.In Calx concocting process, sulfur dioxide is met water generation sulphoxylic acid and is reacted with the lime liquor generation acid-base neutralization of alkalescence, considerably reduces the residual of sulfur dioxide, ensure that drug safety.And do not use Alumen in quicklime concocting process, namely not containing Al
3+etc. harmful material.Therefore select lime method to concoct Rhizoma Arisaematis, Rhizoma Arisaematis quality can be improved, ensure drug safety.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. a concocting method for Rhizoma Arisaematis, is characterized in that, step is as follows:
1) get the Rhizoma Arisaematis that parts by weight are 80 ~ 120 parts, add clear water to submergence Rhizoma Arisaematis, soak one day to thoroughly, pull out;
2) get the caustic lime block that parts by weight are 5 ~ 15 parts, add water to submergence caustic lime block, the temperature of water is 60 ~ 100 DEG C, and furnishing suspension, sieves, and the aperture of sieving is 1 ~ 3mm, obtains lime liquor;
3) by 2) obtained lime liquor is added to 1) in the Rhizoma Arisaematis that soaked into, to submergence Rhizoma Arisaematis, stir evenly, infuse, the time of described infuse is 40 ~ 60 hours, dry, gets product.
2. the concocting method of Rhizoma Arisaematis according to claim 1, is characterized in that, step 2) described in the temperature of water be 80 DEG C.
3. the concocting method of Rhizoma Arisaematis according to claim 1, is characterized in that, step 2) described in the aperture of sieving be 1.5 ~ 2mm.
4. the concocting method of Rhizoma Arisaematis according to claim 1, is characterized in that, step 3) described in time of infuse be 48 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210162570.1A CN102670887B (en) | 2012-05-23 | 2012-05-23 | Method for processing rhizoma arisaematis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210162570.1A CN102670887B (en) | 2012-05-23 | 2012-05-23 | Method for processing rhizoma arisaematis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102670887A CN102670887A (en) | 2012-09-19 |
| CN102670887B true CN102670887B (en) | 2015-02-04 |
Family
ID=46803872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210162570.1A Expired - Fee Related CN102670887B (en) | 2012-05-23 | 2012-05-23 | Method for processing rhizoma arisaematis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102670887B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388581B (en) * | 2019-11-29 | 2021-12-28 | 浙江桐君堂中药饮片有限公司 | Preparation method of processed rhizoma arisaematis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1785328A (en) * | 2005-11-18 | 2006-06-14 | 石家庄乐仁堂制药有限责任公司 | Preparation method of Chinese medicinal material |
| CN101934009A (en) * | 2010-08-03 | 2011-01-05 | 北京同仁堂（亳州）饮片有限责任公司 | Preparation method for processed arisaema tubers |
-
2012
- 2012-05-23 CN CN201210162570.1A patent/CN102670887B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1785328A (en) * | 2005-11-18 | 2006-06-14 | 石家庄乐仁堂制药有限责任公司 | Preparation method of Chinese medicinal material |
| CN101934009A (en) * | 2010-08-03 | 2011-01-05 | 北京同仁堂（亳州）饮片有限责任公司 | Preparation method for processed arisaema tubers |
Non-Patent Citations (2)
| Title |
|---|
| 中药炮制简牍和临床用药安全浅析;赵慧洁;《中国医药指南》;20060630(第6期);第26-29页 * |
| 天南星炮制;佚名;《就医网-药品频道-中药天地-基础知识-中药炮制-根茎类-正文》;20060314;"（8）生姜石灰制"项下 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102670887A (en) | 2012-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106728878A (en) | The concocting method of sealwort | |
| CN101712470A (en) | Edible activated carbon prepared from pine nut shells | |
| CN112370514A (en) | Granular composition for harmonizing stomach and strengthening spleen and preparation method thereof | |
| CN102552768A (en) | Medicine for clearing heat, resolving phlegm, calming panting and suppressing cough and preparation method thereof | |
| CN106138541A (en) | The fresh Rhizoma Pinelliae processing technique processed in a kind of place of production | |
| CN109331103A (en) | A kind of concocting method of pinellia | |
| CN109646303A (en) | A kind of method of quality control and equipment of prepared slices of Chinese crude drugs processing | |
| CN102670887B (en) | Method for processing rhizoma arisaematis | |
| CN102038786A (en) | Preparation method of morinda officinalis traditional Chinese medicine | |
| JP6523457B2 (en) | Method for extracting stilbene compounds | |
| CN103652103A (en) | Liquorice tea and preparation method thereof | |
| CN105476946B (en) | A kind of preparation method of deodorization pearl powder | |
| CN102188463A (en) | Preparation method of hazel leaf extract | |
| CN107441169A (en) | A kind of concocting method of Chinese medicine vomiting nut | |
| CN104212639A (en) | Eaglewood essential oil distillation extractor | |
| CN206265348U (en) | The prepared slices of Chinese crude drugs are formulated unit | |
| CN101856472B (en) | Production method of spur pain-relieving capsule | |
| CN104001006B (en) | A kind of method extracting free amino acid from Radix Asparagi | |
| CN106511439A (en) | Eucommia bark processing method | |
| CN204111718U (en) | A kind of agilawood essential oil distillation extraction device | |
| CN112957414A (en) | Rhizoma pinellinae praeparata and production place processing and concocting integrated preparation process thereof | |
| CN106880651A (en) | The concocting method of radix cyathulae | |
| CN107582898B (en) | Pharmaceutical composition for relieving cough and stopping phlegm as well as preparation method and application thereof | |
| CN106146528A (en) | A kind of new diterpene alkaloid compounds and preparation method thereof and medical usage | |
| CN101926933A (en) | Chinese medicinal composition for treating gastritis, gastric ulcer and duodenal ulcer and identification method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: HEBEI UNIVERSITY OF CHINESE MEDICINE Free format text: FORMER OWNER: HEBEI MEDICAL UNIVERSITY Effective date: 20141229 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 050091 SHIJIAZHUANG, HEBEI PROVINCE TO: 050000 SHIJIAZHUANG, HEBEI PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20141229 Address after: 050000 No. 3 Apricot Garden Road, Luquan Economic Development Zone, Hebei, Shijiazhuang Applicant after: HEBEI MEDICAL UNIVERSITY Address before: 050091 Hebei Medical University, 326, Xinshi South Road, Hebei, Shijiazhuang (West Campus) Applicant before: Hebei Medical University |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150204 Termination date: 20150523 |
|
| EXPY | Termination of patent right or utility model |