CN112370514A - Granular composition for harmonizing stomach and strengthening spleen and preparation method thereof - Google Patents
Granular composition for harmonizing stomach and strengthening spleen and preparation method thereof Download PDFInfo
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- CN112370514A CN112370514A CN202011330805.4A CN202011330805A CN112370514A CN 112370514 A CN112370514 A CN 112370514A CN 202011330805 A CN202011330805 A CN 202011330805A CN 112370514 A CN112370514 A CN 112370514A
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- spleen
- stomach
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- powder
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Abstract
The invention provides a granular composition for harmonizing stomach and strengthening spleen and a preparation method thereof, and relates to the technical field of Mongolian medicines. The stomach harmonizing and spleen strengthening granular composition is mainly prepared from the following raw materials in parts by weight: 180 portions of alkali tooth, 220 portions of milk-made red gypsum, 100 portions of rhubarb, 80 to 150 portions of myrobalan, 50 to 120 portions of rhizoma kaempferiae and 20 to 80 portions of costus root. The stomach-harmonizing and spleen-tonifying granular composition has the advantages that the stomach-harmonizing and spleen-fortifying granular composition increases the specific surface area of the medicine, improves the in-vivo disintegration speed and absorption speed, enhances the curative effect and improves the medicine taking compliance of patients on the basis of keeping various beneficial components of the original powder by using the reasonable compatibility of the medicinal materials in a specific proportion and combining a specific preparation process.
Description
Technical Field
The invention relates to the technical field of Mongolian medicines, and particularly relates to a granular composition for harmonizing stomach and tonifying spleen and a preparation method thereof.
Background
Mongolian medicine is one of four minority national medicines in China, occupies an important position in national medicine culture, and has a long history and a complete theoretical system. The Mongolian medicine theory considers that the habitual constipation is the disease of difficult defecation accumulation caused by insufficient body fluid in intestines and the like. The pathogenesis of the anal fistula is caused by the hypofunction of the lower clear lung-heat, excessive blood Hila and the loss of liquid in the intestines, and the inability to moisten the sabina vulgaris and the intestines so as to make the intestines comfortable and the anus dry. For example, blood heat due to tobacco and alcohol consumption or physical injury due to strong fatigue or residual heat after fever burn, essence-strengthening, puerperal, obesity, aging, sedentary and restlessness are all the inducing factors. The Anxiao six-ingredient granules are prepared according to the empirical prescription with remarkable curative effect in Mongolian families, the traditional Mongolian medicine decoction powder is poor in production equipment and production environment due to rough production process, lack of purification facilities and non-standard packaging materials, so that the phenomena of dampness and mildew often occur in the storage process of the medicine, the powder is caked after being heated, pills become hard, and the quality of the medicine is affected. The finished product has the defect that bacteria and heavy metal are easy to exceed the standard, and the powder has a large dosage because the preparation process is rough and the effective content is low, and the large dosage causes poor compliance of patients in taking the medicine.
The Mongolian medicinal decoction is always an important traditional formulation of Mongolian medicaments, and has the main advantages of cheap and easily-obtained raw materials, simple preparation, large specific surface area, quick absorption, strong curative effect and easy exertion of medicinal effect. However, the decoction powder has simple process, the raw materials are crushed and mixed to cause bitter, spicy, pungent and sour taste of the finished product, and the defects of large amount, strong irritation to the pharynx and the esophagus, difficulty in swallowing and the like exist, so that patients feel afraid of taking the medicine, the medicine is particularly unfavorable for children, the compliance of the medicine is greatly reduced, and the 'difficult drinking' seems to become a pronoun of the Mongolian medicine, and the development and the application of the Mongolian medicine are restricted to a certain extent.
Disclosure of Invention
The invention aims to provide a stomach and spleen harmonizing granular composition, which changes the dosage form, improves the disintegration speed and the absorption speed in vivo and improves the medicine taking compliance of patients on the basis of keeping various beneficial components of the original powder.
The invention also aims to provide a preparation method of the stomach-harmonizing and spleen-tonifying granule composition, which applies a modern pharmaceutical technical method, adopts a raw powder granulation process, does not have heating, concentration and extraction processes, and ensures the multi-drug effect of a Mongolian medicine formula.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a stomach-harmonizing and spleen-fortifying granular composition which is mainly prepared from the following raw materials in parts by weight: 180 portions of alkali tooth, 220 portions of milk-made red gypsum, 100 portions of rhubarb, 80 to 150 portions of myrobalan, 50 to 120 portions of rhizoma kaempferiae and 20 to 80 portions of costus root.
In another aspect, the present application provides a method for preparing the aforementioned stomach and spleen strengthening granule composition, comprising the following steps: and (2) crushing and sieving the alkali teeth, the milk-made red gypsum, the rheum officinale, the myrobalan, the kaempferia galanga and the elecampane to obtain mixed powder, adding auxiliary materials into the mixed powder, uniformly mixing, and granulating to obtain the stomach-harmonizing and spleen-tonifying granular composition.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the stomach-harmonizing and spleen-tonifying granule composition provided by the invention is guided by the traditional Chinese medicine formula granule concept and the Mongolian medicine theory, ensures the traditional Mongolian medicine raw principle, keeps the original taste and flavor of Mongolian medicine, overcomes the defect of inconvenient taking of Mongolian medicine decoction powder on the basis of the traditional decoction powder, can be taken directly with warm water, is rapidly disintegrated or dissolved in stomach, has pharmacokinetic parameters which are extremely close to those of powdery decoction powder, overcomes the irritation of throat and esophagus of the decoction powder, and can be used as a substitute preparation form of the decoction powder in clinical use. And because the specific surface area of the medicine is larger, the disintegration speed and the absorption speed in vivo are greatly improved compared with the traditional water-bindered pill, the curative effect is enhanced, and the compliance of the oral medicine for children is improved. In addition, the stomach-harmonizing and spleen-tonifying granular composition is more convenient to take and carry, and has small irritation, quick absorption and obviously improved drug effect.
The preparation method provided by the invention applies a modern pharmaceutical technical method, adopts a raw powder granulation process, has no heating, no concentration and no extraction process, ensures the multi-drug effect of the Mongolian medicine formula, prepares the stomach and spleen tonifying granular composition into a dosage form suitable for modern clinical application, not only maintains the characteristics of the Mongolian medicine, retains the beneficial components of the original medicinal powder or powder, but also has the characteristic of quick response of the powder, and is more favorable for improving the medicine taking compliance of patients. In addition, can also combine together with automatic branch medicine machine, promote the productivity.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a thin layer chromatogram for identifying rhubarb in a stomach and spleen harmonizing granule composition provided in examples 1 to 3 of the present invention;
FIG. 2 is a thin layer chromatogram for identifying rhizoma Kaempferiae in the stomach and spleen harmonizing granule composition provided in examples 1-3 of the present invention;
FIG. 3 is a thin-layer chromatogram for identifying myrobalan in the stomach and spleen harmonizing granule composition provided in examples 1-3 of the present invention;
FIG. 4 is a thin-layer chromatogram for identification of Aucklandia lappa Decne in the stomach and spleen harmonizing granule composition provided in examples 1-3 of the present invention;
FIG. 5 is a chromatogram of a reference sample of chrysophanol and emodin in the stomach and spleen harmonizing and strengthening granule composition provided in examples 1-3 of the present invention;
FIG. 6 is a sample chromatogram of the contents of total chrysophanol and total emodin in the stomach-harmonizing and spleen-fortifying granule composition provided in examples 1 to 3 of the present invention;
FIG. 7 is a sample chromatogram of the content of free chrysophanol and free total emodin in the stomach and spleen harmonizing and strengthening granule composition provided in examples 1-3 of the present invention;
FIG. 8 is a process flow diagram of a stomach and spleen strengthening granule composition provided in examples 1-5 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
On one hand, the embodiment of the application provides a stomach-harmonizing and spleen-fortifying granular composition which is mainly prepared from the following raw materials in parts by weight: 180 portions of alkali tooth, 220 portions of milk-made red gypsum, 100 portions of rhubarb, 80 to 150 portions of myrobalan, 50 to 120 portions of rhizoma kaempferiae and 20 to 80 portions of costus root.
In some embodiments of the present invention, the stomach and spleen strengthening granule composition is mainly prepared from the following raw materials in parts by weight: 214.28 parts of alkaline teeth, 178.57 parts of milk-made red gypsum, 142.86 parts of rhubarb, 107.15 parts of myrobalan, 71.43 parts of rhizoma kaempferiae and 35.71 parts of costus root.
In some embodiments of the present invention, the stomach and spleen strengthening granule composition further comprises an auxiliary material, wherein the auxiliary material comprises 245 parts by weight of a filler 235-245, a binder and a lubricant, the mass percentage of the binder is 10%, and the mass percentage of the lubricant is 5%.
In some embodiments of the present invention, the filler in the above-mentioned stomach and spleen strengthening particulate composition comprises one or more of sucrose powder, dextrin and lactose powder.
In another aspect, the present application provides a method for preparing the aforementioned stomach and spleen strengthening granule composition, comprising the following steps: and (2) crushing and sieving the alkali teeth, the milk-made red gypsum, the rheum officinale, the myrobalan, the kaempferia galanga and the elecampane to obtain mixed powder, adding auxiliary materials into the mixed powder, uniformly mixing, and granulating to obtain the stomach-harmonizing and spleen-tonifying granular composition.
In some embodiments of the present invention, the milk-made red gypsum in the above preparation method is prepared by calcining red gypsum on open fire until the red gypsum is completely red, taking out the red gypsum, cooling to 200 ℃, putting the red gypsum in the defatted yogurt for crusting, taking out the red gypsum, and drying in the air to obtain the milk-made red gypsum.
In some embodiments of the present invention, before adding the auxiliary materials into the mixed powder, the preparation method further comprises the following step of sterilizing the mixed powder at 50-60 ℃ for 1-3 hours.
In some embodiments of the present invention, the sieve in the above preparation method has a pore size of 80 to 100 mesh.
In some embodiments of the present invention, the preparing method of the present invention includes the following steps, mixing the mixed powder and the auxiliary materials by a wet method for 30min to obtain mixed powder, adding a binder to the mixed powder to prepare a soft material, sieving the soft material to obtain wet granules, drying the wet granules, sieving, adding a lubricant, and mixing to obtain the stomach and spleen harmonizing granule composition.
In some embodiments of the present invention, in the above preparation method, the soft material is sieved by 12 to 14 meshes, the temperature for drying the wet granules is 50 to 60 ℃, the time for drying the wet granules is 1 to 3 hours, the moisture content of the wet granules is less than 8%, and the sieved mesh after the wet granules are dried is 14 to 16 meshes.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide a stomach-harmonizing and spleen-fortifying granule composition, which is mainly prepared by the following steps:
(1) calcining red gypsum on open fire until the red gypsum is completely red, taking out, cooling to 200 ℃, putting into a container filled with the defatted yogurt, covering, quenching, and air drying to obtain the milk-made red gypsum;
(2) crushing coarse powder: weighing five-ingredient Mongolian medicine decoction pieces, specifically comprising 178.57g of milk-made red gypsum, 142.86g of rhubarb, 107.15g of myrobalan, 71.43g of rhizoma kaempferiae and 35.71g of costus root, and crushing into medicinal coarse powder;
(3) and (3) sterilization: spreading the crude powder of the medicinal materials in the step (2) in a tray with holes on the whole body, keeping the temperature of the materials at 50-60 ℃, preserving the heat for 1-3 hours and sterilizing;
(4) crushing and sieving: pulverizing the sterilized crude powder of the medicinal materials in the step (3) into fine powder, and sieving the fine powder with a 80-100-mesh sieve to obtain fine powder of the medicinal materials;
(5) mixing: weighing 245g of a filler, preferably sucrose powder, adding 214.28g of the filler, 214.28g of the alkaline teeth and the fine powder of the medicinal materials obtained in the step (4) into a whole-grain wet mixing granulator, and mixing for 30 minutes to obtain mixed medicinal powder;
(6) preparing a soft material: adding an adhesive into the mixed medicinal powder obtained in the step (5) to prepare a soft material, taking out the soft material for later use when the soft material can be held by hands to be agglomerated and loosened, wherein the final mass percent of the adhesive is 10%, and starch slurry is preferred;
(7) and (3) granulating: sieving the soft material in the step (6) with a 12-14 mesh sieve for granulation, wherein the prepared wet granules are complete and uniform in size;
(8) and (3) drying: uniformly paving the wet granules prepared in the step (7) in a tray, wherein the thickness of the wet granules is 3-5cm, putting the wet granules on a skip car, pushing the skip car into a hot air circulation oven, adjusting the temperature to be 50-60 ℃, drying for 1-3h, and controlling the moisture of the granules to be within 8% to obtain dried granules;
(9) straightening: putting the dried granules in the step (8) into a YK160 swing granulator, granulating with a 14-16-mesh sieve, putting the granules into a clean container lined with a plastic bag, observing whether black spots and foreign matters exist in the granules, timely replacing the sieve if the sieve is damaged, and weighing after granulation;
(10) sieving: placing the particles prepared in the step (9) into a rotary vibration sieve for particle selection, removing large blocks on the upper layer by using a 10-mesh sieve, removing fine powder on the lower layer by using a 60-mesh sieve, collecting middle particles, placing the middle particles into a clean container for standby, and taking the part which passes through the 10-mesh sieve and does not pass through the 60-mesh sieve as qualified particles (the qualification rate is more than 95%);
(11) mixing: putting the qualified granules prepared in the step (10) into a mixer, adding a lubricant (magnesium stearate, the final mass percentage is 0.5%) and mixing for 15 minutes to obtain a stomach and spleen harmonizing granule composition;
(12) subpackaging: adjusting the filling amount according to the weight of each bag, operating according to the 'granule filling SOP' and the operating rules of the granule subpackaging post, pumping the filling amount every 10min in the subpackaging process, recording the sampling result, and ensuring that the filling amount of each bag is within the control range; the bagged particles are put into a special container, and each bag contains 2g or 4g of the granules, which is equivalent to about 1.5g or 3g of the raw medicinal materials;
(13) and (3) outer packaging: according to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; and placing a product qualification certificate in the outer box, sealing by using a sealing adhesive tape, and bundling firmly.
Example 2
The present embodiment aims to provide a stomach-harmonizing and spleen-fortifying granule composition, which is mainly prepared by the following steps:
(1) calcining red gypsum on open fire until the red gypsum is completely red, taking out, cooling to 200 ℃, putting into a container filled with the defatted yogurt, covering, quenching, and air drying to obtain the milk-made red gypsum;
(2) crushing coarse powder: weighing five-ingredient Mongolian medicine decoction pieces, specifically comprising 178.57g of milk-made red gypsum, 142.86g of rhubarb, 107.15g of myrobalan, 71.43g of rhizoma kaempferiae and 35.71g of costus root, and crushing into medicinal coarse powder;
(3) and (3) sterilization: spreading the crude powder of the medicinal materials in the step (2) in a tray with holes on the whole body, keeping the temperature of the materials at 50-60 ℃, preserving the heat for 1-3 hours and sterilizing;
(4) crushing and sieving: pulverizing the sterilized crude powder of the medicinal materials in the step (3) into fine powder, and sieving the fine powder with a 80-100-mesh sieve to obtain fine powder of the medicinal materials;
(5) mixing: weighing 245g of a filler, preferably dextrin, adding 214.28g of the filler, 214.28g of the alkali teeth and the medicinal material fine powder obtained in the step (4) into a whole-grain wet mixing granulator, and mixing for 30 minutes to obtain mixed medicinal powder;
(6) preparing a soft material: adding an adhesive into the mixed medicinal powder obtained in the step (5) to prepare a soft material, taking out the soft material for later use when the soft material can be held by hands to be agglomerated and loosened, wherein the final mass percent of the adhesive is 10%, and starch slurry is preferred;
(7) and (3) granulating: sieving the soft material in the step (6) with a 12-14 mesh sieve for granulation, wherein the prepared wet granules are complete and uniform in size;
(8) and (3) drying: uniformly paving the wet granules prepared in the step (7) in a tray, wherein the thickness of the wet granules is 3-5cm, putting the wet granules on a skip car, pushing the skip car into a hot air circulation oven, adjusting the temperature to be 50-60 ℃, drying for 1-3h, and controlling the moisture of the granules to be within 8% to obtain dried granules;
(9) straightening: putting the dried granules in the step (8) into a YK160 swing granulator, granulating with a 14-16-mesh sieve, putting the granules into a clean container lined with a plastic bag, observing whether black spots and foreign matters exist in the granules, timely replacing the sieve if the sieve is damaged, and weighing after granulation;
(10) sieving: placing the particles prepared in the step (9) into a rotary vibration sieve for particle selection, removing large blocks on the upper layer by using a 10-mesh sieve, removing fine powder on the lower layer by using a 60-mesh sieve, collecting middle particles, placing the middle particles into a clean container for standby, and taking the part which passes through the 10-mesh sieve and does not pass through the 60-mesh sieve as qualified particles (the qualification rate is more than 95%);
(11) mixing: putting the qualified granules prepared in the step (10) into a mixer, adding a lubricant (magnesium stearate, the final mass percentage is 0.5%) and mixing for 15 minutes to obtain a stomach and spleen harmonizing granule composition;
(12) subpackaging: adjusting the filling amount according to the weight of each bag, operating according to the 'granule filling SOP' and the operating rules of the granule subpackaging post, pumping the filling amount every 10min in the subpackaging process, recording the sampling result, and ensuring that the filling amount of each bag is within the control range; the bagged particles are put into a special container, and each bag contains 2g or 4g of the granules, which is equivalent to about 1.5g or 3g of the raw medicinal materials;
(13) and (3) outer packaging: according to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; and placing a product qualification certificate in the outer box, sealing by using a sealing adhesive tape, and bundling firmly.
Example 3
The present embodiment aims to provide a stomach-harmonizing and spleen-fortifying granule composition, which is mainly prepared by the following steps:
(1) calcining red gypsum on open fire until the red gypsum is completely red, taking out, cooling to 200 ℃, putting into a container filled with the defatted yogurt, covering, quenching, and air drying to obtain the milk-made red gypsum;
(2) crushing coarse powder: weighing five-ingredient Mongolian medicine decoction pieces, specifically comprising 178.57g of milk-made red gypsum, 142.86g of rhubarb, 107.15g of myrobalan, 71.43g of rhizoma kaempferiae and 35.71g of costus root, and crushing into medicinal coarse powder;
(3) and (3) sterilization: spreading the crude powder of the medicinal materials in the step (2) in a tray with holes on the whole body, keeping the temperature of the materials at 50-60 ℃, preserving the heat for 1-3 hours and sterilizing;
(4) crushing and sieving: pulverizing the sterilized crude powder of the medicinal materials in the step (3) into fine powder, and sieving the fine powder with a 80-100-mesh sieve to obtain fine powder of the medicinal materials;
(5) mixing: weighing 245g of a filler, preferably lactose, and adding 214.28g of the filler, 214.28g of the alkali teeth and the fine powder of the medicinal materials in the step (4) into a whole-grain wet mixing granulator for mixing for 30 minutes to obtain mixed medicinal powder;
(6) preparing a soft material: adding an adhesive into the mixed medicinal powder obtained in the step (5) to prepare a soft material, taking out the soft material for later use when the soft material can be held by hands to be agglomerated and loosened, wherein the final mass percent of the adhesive is 10%, and starch slurry is preferred;
(7) and (3) granulating: sieving the soft material in the step (6) with a 12-14 mesh sieve for granulation, wherein the prepared wet granules are complete and uniform in size;
(8) and (3) drying: uniformly paving the wet granules prepared in the step (7) in a tray, wherein the thickness of the wet granules is 3-5cm, putting the wet granules on a skip car, pushing the skip car into a hot air circulation oven, adjusting the temperature to be 50-60 ℃, drying for 1-3h, and controlling the moisture of the granules to be within 8% to obtain dried granules;
(9) straightening: putting the dried granules in the step (8) into a YK160 swing granulator, granulating with a 14-16-mesh sieve, putting the granules into a clean container lined with a plastic bag, observing whether black spots and foreign matters exist in the granules, timely replacing the sieve if the sieve is damaged, and weighing after granulation;
(10) sieving: placing the particles prepared in the step (9) into a rotary vibration sieve for particle selection, removing large blocks on the upper layer by using a 10-mesh sieve, removing fine powder on the lower layer by using a 60-mesh sieve, collecting middle particles, placing the middle particles into a clean container for standby, and taking the part which passes through the 10-mesh sieve and does not pass through the 60-mesh sieve as qualified particles (the qualification rate is more than 95%);
(11) mixing: putting the qualified granules prepared in the step (10) into a mixer, adding a lubricant (magnesium stearate, the final mass percentage is 0.5%) and mixing for 15 minutes to obtain a stomach and spleen harmonizing granule composition;
(12) subpackaging: adjusting the filling amount according to the weight of each bag, operating according to the 'granule filling SOP' and the operating rules of the granule subpackaging post, pumping the filling amount every 10min in the subpackaging process, recording the sampling result, and ensuring that the filling amount of each bag is within the control range; the bagged particles are put into a special container, and each bag contains 2g or 4g of the granules, which is equivalent to about 1.5g or 3g of the raw medicinal materials;
(13) and (3) outer packaging: according to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; and placing a product qualification certificate in the outer box, sealing by using a sealing adhesive tape, and bundling firmly.
Example 4
The present embodiment aims to provide a stomach-harmonizing and spleen-fortifying granule composition, which is mainly prepared by the following steps:
(1) calcining red gypsum on open fire until the red gypsum is completely red, taking out, cooling to 200 ℃, putting into a container filled with the defatted yogurt, covering, quenching, and air drying to obtain the milk-made red gypsum;
(2) crushing coarse powder: weighing five-ingredient Mongolian medicine decoction pieces, specifically comprising 150g of milk-made red gypsum, 100g of rhubarb, 80g of myrobalan, 50g of rhizoma kaempferiae and 20g of costus root, and crushing into crude powder;
(3) and (3) sterilization: spreading the crude powder of the medicinal materials in the step (2) in a tray with holes on the whole body, keeping the temperature of the materials at 50-60 ℃, preserving the heat for 1-3 hours and sterilizing;
(4) crushing and sieving: pulverizing the sterilized crude powder of the medicinal materials in the step (3) into fine powder, and sieving the fine powder with a 80-100-mesh sieve to obtain fine powder of the medicinal materials;
(5) mixing: weighing 245g of a filler, preferably dextrin, adding 180g of the filler, 180g of the alkali teeth and the medicinal material fine powder obtained in the step (4) into a whole-grain wet mixing granulator, and mixing for 30 minutes to obtain mixed medicinal powder;
(6) preparing a soft material: adding an adhesive into the mixed medicinal powder obtained in the step (5) to prepare a soft material, taking out the soft material for later use when the soft material can be held by hands to be agglomerated and loosened, wherein the final mass percent of the adhesive is 10%, and starch slurry is preferred;
(7) and (3) granulating: sieving the soft material in the step (6) with a 12-14 mesh sieve for granulation, wherein the prepared wet granules are complete and uniform in size;
(8) and (3) drying: uniformly paving the wet granules prepared in the step (7) in a tray, wherein the thickness of the wet granules is 3-5cm, putting the wet granules on a skip car, pushing the skip car into a hot air circulation oven, adjusting the temperature to be 50-60 ℃, drying for 1-3h, and controlling the moisture of the granules to be within 8% to obtain dried granules;
(9) straightening: putting the dried granules in the step (8) into a YK160 swing granulator, granulating with a 14-16-mesh sieve, putting the granules into a clean container lined with a plastic bag, observing whether black spots and foreign matters exist in the granules, timely replacing the sieve if the sieve is damaged, and weighing after granulation;
(10) sieving: placing the particles prepared in the step (9) into a rotary vibration sieve for particle selection, removing large blocks on the upper layer by using a 10-mesh sieve, removing fine powder on the lower layer by using a 60-mesh sieve, collecting middle particles, placing the middle particles into a clean container for standby, and taking the part which passes through the 10-mesh sieve and does not pass through the 60-mesh sieve as qualified particles (the qualification rate is more than 95%);
(11) mixing: putting the qualified granules prepared in the step (10) into a mixer, adding a lubricant (magnesium stearate, the final mass percentage is 0.5%) and mixing for 15 minutes to obtain a stomach and spleen harmonizing granule composition;
(12) subpackaging: adjusting the filling amount according to the weight of each bag, operating according to the 'granule filling SOP' and the operating rules of the granule subpackaging post, pumping the filling amount every 10min in the subpackaging process, recording the sampling result, and ensuring that the filling amount of each bag is within the control range; the bagged particles are put into a special container, and each bag contains 2g or 4g of the granules, which is equivalent to about 1.5g or 3g of the raw medicinal materials;
(13) and (3) outer packaging: according to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; and placing a product qualification certificate in the outer box, sealing by using a sealing adhesive tape, and bundling firmly.
Example 5
The present embodiment aims to provide a stomach-harmonizing and spleen-fortifying granule composition, which is mainly prepared by the following steps:
(1) calcining red gypsum on open fire until the red gypsum is completely red, taking out, cooling to 200 ℃, putting into a container filled with the defatted yogurt, covering, quenching, and air drying to obtain the milk-made red gypsum;
(2) crushing coarse powder: weighing five-ingredient Mongolian medicine decoction pieces, specifically 220g of milk-made red gypsum, 200g of rheum officinale, 150g of myrobalan, 120g of rhizoma kaempferiae and 80g of costus root, and crushing into medicinal coarse powder;
(3) and (3) sterilization: spreading the crude powder of the medicinal materials in the step (2) in a tray with holes on the whole body, keeping the temperature of the materials at 50-60 ℃, preserving the heat for 1-3 hours and sterilizing;
(4) crushing and sieving: pulverizing the sterilized crude powder of the medicinal materials in the step (3) into fine powder, and sieving the fine powder with a 80-100-mesh sieve to obtain fine powder of the medicinal materials;
(5) mixing: weighing 245g of a filling agent 235-245, preferably dextrin, adding the filling agent, 240g of the alkaline teeth and the medicinal material fine powder in the step (4) into a whole-grain wet mixing granulator, and mixing for 30 minutes to obtain mixed medicinal powder;
(6) preparing a soft material: adding an adhesive into the mixed medicinal powder obtained in the step (5) to prepare a soft material, taking out the soft material for later use when the soft material can be held by hands to be agglomerated and loosened, wherein the final mass percent of the adhesive is 10%, and starch slurry is preferred;
(7) and (3) granulating: sieving the soft material in the step (6) with a 12-14 mesh sieve for granulation, wherein the prepared wet granules are complete and uniform in size;
(8) and (3) drying: uniformly paving the wet granules prepared in the step (7) in a tray, wherein the thickness of the wet granules is 3-5cm, putting the wet granules on a skip car, pushing the skip car into a hot air circulation oven, adjusting the temperature to be 50-60 ℃, drying for 1-3h, and controlling the moisture of the granules to be within 8% to obtain dried granules;
(9) straightening: putting the dried granules in the step (8) into a YK160 swing granulator, granulating with a 14-16-mesh sieve, putting the granules into a clean container lined with a plastic bag, observing whether black spots and foreign matters exist in the granules, timely replacing the sieve if the sieve is damaged, and weighing after granulation;
(10) sieving: placing the particles prepared in the step (9) into a rotary vibration sieve for particle selection, removing large blocks on the upper layer by using a 10-mesh sieve, removing fine powder on the lower layer by using a 60-mesh sieve, collecting middle particles, placing the middle particles into a clean container for standby, and taking the part which passes through the 10-mesh sieve and does not pass through the 60-mesh sieve as qualified particles (the qualification rate is more than 95%);
(11) mixing: putting the qualified granules prepared in the step (10) into a mixer, adding a lubricant (magnesium stearate, the final mass percentage is 0.5%) and mixing for 15 minutes to obtain a stomach and spleen harmonizing granule composition;
(12) subpackaging: adjusting the filling amount according to the weight of each bag, operating according to the 'granule filling SOP' and the operating rules of the granule subpackaging post, pumping the filling amount every 10min in the subpackaging process, recording the sampling result, and ensuring that the filling amount of each bag is within the control range; the bagged particles are put into a special container, and each bag contains 2g or 4g of the granules, which is equivalent to about 1.5g or 3g of the raw medicinal materials;
(13) and (3) outer packaging: according to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; and placing a product qualification certificate in the outer box, sealing by using a sealing adhesive tape, and bundling firmly.
Example 6
The purpose of this example is to provide a method for quality control of a granular composition that harmonizes the stomach and strengthens the spleen.
1. Trait detection
The properties of the stomach and spleen harmonizing particle composition obtained in the embodiments 1 to 5 of the present invention are detected by using visual inspection, nasal smell and oral taste methods, and the detection results show that the stomach and spleen harmonizing particle composition provided by the embodiments of the present invention is a yellow brown to dark brown particle; light smell, salty and slightly bitter taste.
2. Microscopic identification
The stomach and spleen harmonizing granule composition obtained in examples 1 to 5 of the present invention was observed under a microscope, and the same was observed under a microscope: the starch grains are round, oval or triangular, the diameter is 10-30 mu m, and the umbilical points and the striations are not obvious (kaempferia galanga). The calcium oxalate cluster crystal is large and has the diameter of 60-140 pm (rhubarb). Inulin is colorless and is in the form of fan-shaped or irregular pieces (radix aucklandiae). The results show that the stomach and spleen harmonizing granule compositions obtained in examples 1 to 5 all have the significant characteristics of kaempferia galanga, rheum officinale and costustoot.
3. Identification by thin layer chromatography
The apparatus used in the test comprises a mortar, a measuring cylinder, a round-bottom flask, a straight condenser tube, an electric heating jacket, a filter, a tray balance, an evaporation dish, a sample applicator, a GF254 thin layer plate, a silica gel G thin layer plate, an ultraviolet sample application analyzer, a chromatographic cylinder and an oven; the reference medicinal materials include radix et rhizoma Rhei reference medicinal material, rhizoma Kaempferiae reference medicinal material, fructus Chebulae reference medicinal material and radix aucklandiae reference medicinal material; the required reagents comprise methanol, cyclohexane, ethyl acetate, formic acid, petroleum ether (30-60 ℃), trichloromethane, sulfuric acid and ethanol.
The identification is carried out by thin layer chromatography in the following specific way:
the test method 1: 1.5g of the stomach and spleen harmonizing granule composition provided in examples 1 to 3 was taken, 4ml of methanol was added, sonication was performed for 10 minutes, and the filtrate was filtered to obtain a sample solution. Taking 0.3g of rhubarb reference medicinal material and 0.2g of kaempferia galanga reference medicinal material, respectively adding 3ml of methanol into the rhubarb reference medicinal material and the kaempferia galanga reference medicinal material, carrying out ultrasonic treatment for 10 minutes, and taking supernatant to obtain a rhubarb reference medicinal material solution and a kaempferia galanga reference medicinal material solution. According to the thin layer chromatography (general rule 0502), 3-6 μ l of each solution is absorbed, and respectively spotted on the same silica gel GF254 thin layer plate, cyclohexane ethyl acetate-formic acid (12: 3: 0.1) is used as developing agent, and the developing solution is taken out, dried and inspected under an ultraviolet lamp (365 m). The result is shown in fig. 1, in the chromatogram of the test sample, at the position corresponding to the chromatogram of the rhubarb reference drug, the fluorescence spots with the same color are shown, 1 is the solution of the rhubarb reference drug, and 2-4 sequentially correspond to the test sample solution prepared by the particle composition for harmonizing the stomach and strengthening the spleen provided in the examples 1-3: and then placing the sample solution under an ultraviolet lamp (254nm) for inspection, wherein the result is shown in fig. 2, main spots with the same color appear on the sample chromatogram at the positions corresponding to the kaempferia galanga reference drug chromatogram, 1 is a kaempferia galanga reference drug solution, and 2-4 sequentially correspond to the sample solution prepared from the particle composition for harmonizing the stomach and tonifying the spleen provided in the embodiments 1-3.
And (3) a detection method 2: 1.5g of the stomach and spleen harmonizing granule composition provided in examples 1 to 3 was taken, 4ml of methanol was added, sonication was performed for 10 minutes, and the filtrate was filtered to obtain a sample solution. Taking 0.2g of the myrobalan control medicinal material, adding 3ml of methanol, carrying out ultrasonic treatment for 10 minutes, and taking supernatant fluid to obtain myrobalan control medicinal material solution. Performing thin-layer chromatography (general rule 0502) test, collecting 3-6 μ l of each of the test solution and the control solution, respectively dropping on a same-silica gel GF254 thin-layer plate, developing with cyclohexane-ethyl acetate-formic acid (6: 4: 0.5) as developing agent, taking out, air drying, and inspecting under ultraviolet lamp (254 nm). The result is shown in fig. 3, in the chromatogram of the test sample, spots with the same color appear at the corresponding positions of the chromatogram of the reference drug, 1 is the myrobalan reference drug solution, and 2-4 are sequentially corresponding to the test sample solution prepared from the stomach-harmonizing and spleen-invigorating granular composition provided in examples 1-3.
The inspection method 3: 2g of the stomach-harmonizing and spleen-fortifying granular composition provided in example 1-3 was respectively ground, 20ml of ethyl acetate was added, reflux extraction was performed for 30 minutes, filtration was performed, the filtrate was evaporated to dryness in a water bath, and 2ml of ethyl acetate was added to the residue to dissolve the residue, thereby obtaining a sample solution. Taking another radix aucklandiae reference medicinal material 2g, and making into radix aucklandiae reference medicinal material solution by the same method. According to a thin-layer chromatography test (0502 of the general Law of the national pharmacopoeia 2015), sucking 10 mu l of each of the two solutions, respectively dropping the two solutions on the same silica gel G thin-layer plate, developing by using petroleum ether (30-60 ℃) and trichloromethane-ethyl acetate (4: 6: 5) as developing agents, taking out, airing, spraying 10% sulfuric acid ethanol solution, drying for 10 minutes at 105 ℃, and inspecting under sunlight. In the chromatogram of the test sample, spots with the same color appear at the corresponding positions of the chromatogram of the reference medicinal material, 1 is a radix aucklandiae reference medicinal material solution, and 2-4 sequentially correspond to the test sample solution prepared from the stomach and spleen harmonizing granule composition provided in examples 1-3.
4. Content determination of various effective components
The test method 1: performing high performance liquid chromatography on total chrysophanol (C) in the stomach and spleen harmonizing and strengthening granule composition obtained in example 1-315H0O4) And total emodin (C)15H10O5) Content of and binding to Total chrysophanol (C) in the anthraquinone15H0O4) And total emodin (C)15H10O5) The content of the free chrysophanol and the emodin in the anthraquinone is detected, and the content is combined with the difference value between the total content of the total chrysophanol and the total emodin and the total content of the free chrysophanol and the emodin.
The instrument in the test comprises a high performance liquid chromatograph, an analytical balance, a pipette, an ultrasonic cleaner, a conical bottle with a plug, a brown measuring flask and a microporous filter membrane (0.45 um); reagents include methanol (chromatographically pure), phosphoric acid solution, water (twice redistilled water); the reference comprises chrysophanol reference and emodin reference
Chromatographic conditions and system applicability test: octadecylsilane chemically bonded silica is used as a filler, acetonitrile-methanol-0.1% phosphoric acid solution (42:23:35) is used as a mobile phase, and the detection wavelength is 254 nm. The number of theoretical plates is not less than 3000 calculated according to chrysophanol peak.
Preparation of control solutions: weighing appropriate amount of chrysophanol reference substance and emodin reference substance, precisely weighing, and adding methanol to obtain mixed solution containing chrysophanol 18 μ g and emodin 8 μ g per 1 ml.
Test solution for content determination of total chrysophanol and total emodin: taking a sample (the stomach harmonizing and spleen tonifying particle composition provided by the embodiments 1-3, the labels are 1, 2 and 3 in sequence) of 1.0g, precisely weighing, placing the sample in a conical flask with a plug, precisely adding 25ml of a methanol-hydrochloric acid (10:1) mixed solution, weighing, placing the mixture in a C water bath for heating and refluxing for 30 minutes, removing the adhered substances on the wall of the flask by ultrasonic treatment, weighing again, complementing the lost weight with methanol, shaking up, filtering, precisely weighing 2ml of a subsequent filtrate, placing the subsequent filtrate in a 5ml measuring flask, adding 1ml of a 2% sodium hydroxide solution, adding methanol to the scale, shaking up, filtering, and taking the subsequent filtrate for measuring the content of the total chrysophanol and the total emodin.
Test solution for content determination of free chrysophanol and free emodin: a sample (the stomach harmonizing and spleen strengthening particle composition provided in examples 1-3, which are sequentially labeled as 1, 2 and 3) is taken 0.7g, precisely weighed, placed in a conical flask with a stopper, precisely added with 25ml of methanol, weighed, ultrasonically treated for 30 minutes (power of 160W, pause rate of 50kH2), cooled, weighed again, made up to the reduced weight with methanol, homogenized, filtered, and a subsequent filtrate is taken for measuring the contents of free chrysophanol and free emodin.
The specific operation is as follows: precisely sucking 10-20ul of the reference solution and the two test solutions, respectively, injecting into a liquid chromatograph, and measuring. Calculating the total amount of total chrysophanol and total emodin and the total amount of free chrysophanol and free emodin; the difference between the total amount of total chrysophanol and total emodin and the total amount of free chrysophanol and free emodin is used as the total amount of chrysophanol and emodin in the conjugated anthraquinone. The stomach-harmonizing and spleen-fortifying granule composition provided in examples 1 to 3 contains rhubarb as total chrysophanol (C) per 1g15H10O4) The total emodin (C) is counted and neutralized15H10O5) Not less than 1.05mg, based on the total amount of (A); to bind chrysophanol (C) in anthraquinone15H10O4) And emodin (C)15H10O5) Should not be less than 0.6mg in total. The results of the chrysophanol and emodin, the total chrysophanol and emodin, and the free chrysophanol and emodin are shown in the figures 5-7 in sequence, wherein 1 represents chrysophanol and 2 represents emodin in the three figures.
Three batches of product containing rhubarb and total chrysophanol (C) per 1g were produced as described in examples 1 to 315H10O4) And total rhubarbHormone (C)15H10O5) Respectively, 1.36mg, 1.38mg and 1.40 mg. Are all larger than 1.05 mg; to bind chrysophanol (C) in anthraquinone15H10O4) And emodin (C)15H10O5) Respectively, 0.80mg, 0.82mg, 0.84mg, all greater than 0.6 mg.
And (3) a detection method 2: the content of total alkali in the product is determined by titration method.
The instrument in the test comprises an acid burette, an analytical balance, a pipette, an ultrasonic cleaner and a conical bottle with a plug; the reagents used include methyl red, bromocresol green and hydrochloric acid.
The specific operation is as follows: taking about 1.5g of the stomach and spleen harmonizing particle composition provided in examples 1-3 heated to a constant weight at 250-270 ℃, precisely weighing, adding 50ml of water to dissolve, adding 10 drops of methyl red-bromocresol green mixed indicator solution, titrating with hydrochloric acid titration solution (0.5mol/L) until the solution is changed from green to dark red, boiling for 2 minutes, cooling to room temperature, and continuously titrating until the solution is changed from green to purple red. Each 1ml of hydrochloric acid titration solution (0.5mol/L) corresponds to 26.50mg of sodium carbonate (Na)2CO3). Three batches of product were produced as described in examples 1 to 3, with sodium carbonate (Na) per 1g total alkali2CO3) 125mg, 127mg and 130mg respectively. Are all larger than 107 mg.
The detection method 3: determination of calcium sulfate (CaSO) in product by complexometric titration method4) The content of (a).
The instrument in the test comprises an acid burette, an analytical balance, a pipette, an ultrasonic cleaner and a conical bottle with a plug; the reagent comprises methyl red, potassium hydroxide, calcein and disodium ethylene diamine tetraacetate.
The specific operation is as follows: taking about 0.2g of the product, precisely weighing, placing in an erlenmeyer flask, adding 10ml of dilute hydrochloric acid, heating to dissolve, adding 100ml of water and 2 drops of methyl red indicator solution, dropwise adding potassium hydroxide test solution until the solution becomes yellow, adding 5ml more, adding a small amount of calcein, and titrating with ethylene diamine tetraacetic acid disodium titrating solution (0.05mol/L) until the yellow green fluorescence of the solution disappears and becomes orange. Every 1ml of disodium ethylene diamine tetraacetate titration solution (0.05mol/L) is equivalent to 6.807g of sulfuric acidCalcium (CaSO)4)。
Three batches of product containing calcium sulphate (CaSO) per 1g were produced as described in examples 1 to 34) 185mg, 187mg and 190mg respectively. Are all larger than 151 mg.
In conclusion, the granular composition for harmonizing the stomach and strengthening the spleen provided by the embodiment of the invention is mild in alkaline and salty taste, can promote digestion, relieve constipation, remove blood stasis and treat dyspepsia and constipation, and is a monarch drug. The rhubarb, which is bitter and sour and cool, is good at promoting digestion and relieving diarrhea, treats indigestion and constipation and is a ministerial drug. The milk-made red gypsum is pungent and warm in property, can dispel stomach heat, promote digestion and treat epigastric pain; kaempferia galanga is bitter in taste and hot in nature, warms middle energizer and removes blood stasis, and is used for treating dyspepsia, female blood stasis and dysmenorrhea. The second medicine is an adjuvant medicine. Radix aucklandiae dispels the heat of Badagan and promotes digestion; myrobalan opsonizes voxels, and is used as a guiding drug together. The medicines are combined to play the functions of invigorating stomach, assisting digestion, relieving hyperacidity and relaxing bowels, so that the traditional Chinese medicine composition is good for treating indigestion, stomach fire weakness, dyspepsia, stomach heat, gastral cavity distending pain, pantothenic acid, eructation, dry Heryi asthma, diarrhea, abdominal distension, constipation and unsmooth menstruation. Has effects of invigorating stomach, resolving food stagnation, relieving hyperacidity, and relaxing bowels, and can be used for treating dyspepsia, eruptive disease, stomach ache, acid regurgitation, belch, asthma, abdominal distention, constipation, and menstrual disorder. The stomach-harmonizing and spleen-tonifying granular composition is guided by the traditional Chinese medicine formula granule concept and the Mongolian medicine theory, ensures the traditional Mongolian medicine raw principle, keeps the original taste and flavor of Mongolian medicine, overcomes the defect of inconvenient taking of Mongolian medicine decoction powder on the basis of the traditional decoction powder, can be taken directly with warm water, is rapidly disintegrated or dissolved in the stomach, has pharmacokinetic parameters which are extremely close to those of powdery decoction powder, overcomes the irritation of throat and esophagus of the decoction powder, and can be used as a substitute dosage form of the decoction powder in clinical use. And because the specific surface area of the medicine is larger, the disintegration speed and the absorption speed in vivo are greatly improved compared with the traditional water-bindered pill, the curative effect is enhanced, and the oral compliance of children is improved. In addition, the stomach-harmonizing and spleen-tonifying granular composition is more convenient to take and carry, and has small irritation, quick absorption and obviously improved drug effect.
The preparation method provided by the embodiment of the invention applies a modern pharmaceutical technical method, adopts a raw powder granulation process, has no heating, no concentration and no extraction process, ensures the multi-drug effect of the Mongolian medicine formula, prepares the stomach and spleen tonifying granular composition into a dosage form suitable for modern clinical application, not only maintains the characteristics of the Mongolian medicine, retains the beneficial components of the original medicine powder or powder, but also has the characteristic of quick effect taking of the powder, and is more beneficial to improving the medicine taking compliance of patients. In addition, can also combine together with automatic branch medicine machine, promote the productivity.
The quality control method of the stomach-harmonizing and spleen-tonifying granule composition provided by the embodiment of the invention has the following effects: through a plurality of tests, the quality control method provided by the invention sets out microscopic identification, thin-layer identification and content measurement items in the quality standard of the stomach and spleen harmonizing particle composition, and sets out the specific indexes and parameters of the quality inspection method and the standard of the stomach and spleen harmonizing particle composition.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A granular composition for harmonizing stomach and strengthening spleen is characterized by being mainly prepared from the following raw materials in parts by weight: 180 portions of alkali tooth, 220 portions of milk-made red gypsum, 100 portions of rhubarb, 80 to 150 portions of myrobalan, 50 to 120 portions of rhizoma kaempferiae and 20 to 80 portions of costus root.
2. The stomach and spleen harmonizing granular composition according to claim 1, which is characterized by being mainly prepared from the following raw materials in parts by weight: 214.28 parts of alkaline teeth, 178.57 parts of milk-made red gypsum, 142.86 parts of rhubarb, 107.15 parts of myrobalan, 71.43 parts of rhizoma kaempferiae and 35.71 parts of costus root.
3. The stomach and spleen harmonizing particulate composition as claimed in claim 1 or 2, further comprising an auxiliary material, wherein the auxiliary material comprises 235-245 parts by weight of a filler, a binder and a lubricant, the mass percent of the binder is 10%, and the mass percent of the lubricant is 5%.
4. The gastric and spleen strengthening particulate composition of claim 3 wherein the bulking agent comprises one or more of sucrose powder, dextrin and lactose powder.
5. A process for the preparation of a gastric and spleen strengthening granular composition according to claim 3 or 4, characterized by comprising the following steps: and (2) crushing and sieving the alkali teeth, the milk-made red gypsum, the rheum officinale, the myrobalan, the kaempferia galanga and the elecampane to obtain mixed powder, adding auxiliary materials into the mixed powder, uniformly mixing, and granulating to obtain the stomach-harmonizing and spleen-tonifying granular composition.
6. The preparation method of claim 5, wherein the milk-based red gypsum is prepared by calcining red gypsum on open fire until the red gypsum is completely red, taking out the red gypsum, cooling to 200 ℃, putting the red gypsum in the defatted yogurt for crusting, taking out the red gypsum and drying in the air to obtain the milk-based red gypsum.
7. The preparation method according to claim 5, wherein before adding the auxiliary materials into the mixed powder, the method further comprises the step of sterilizing the mixed powder at 50-60 ℃ for 1-3 h.
8. The method of claim 5, wherein the mesh has a pore size of 80-100 mesh.
9. The preparation method according to claim 5, wherein the uniformly mixing and granulating comprises the steps of mixing the mixed powder and the auxiliary materials by a wet method for 30min to obtain mixed powder, adding a binder to the mixed powder to prepare a soft material, sieving the soft material to obtain wet granules, drying the wet granules, sieving, adding a lubricant, and mixing to obtain the stomach and spleen harmonizing granule composition.
10. The preparation method according to claim 9, wherein the soft material is sieved with 12 to 14 meshes, the wet granulation is dried at 50 to 60 ℃ for 1 to 3 hours, the moisture content of the wet granulation is less than 8%, and the wet granulation is sieved with 14 to 16 meshes after being dried.
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| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
| CN112999172A (en) * | 2021-03-26 | 2021-06-22 | 那生桑 | Mineral Mongolian medicine powder formula granule and preparation method thereof |
| CN112999171A (en) * | 2021-03-26 | 2021-06-22 | 王伟 | Fiber-containing Mongolian medicine powder formula granule and preparation method thereof |
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| CN112999172A (en) * | 2021-03-26 | 2021-06-22 | 那生桑 | Mineral Mongolian medicine powder formula granule and preparation method thereof |
| CN112999171A (en) * | 2021-03-26 | 2021-06-22 | 王伟 | Fiber-containing Mongolian medicine powder formula granule and preparation method thereof |
| CN113041225A (en) * | 2021-03-26 | 2021-06-29 | 齐晓慧 | Sugar-containing Mongolian medicine powder formula granule and preparation method thereof |
| CN112891377B (en) * | 2021-03-26 | 2023-09-19 | 那生桑 | Precious fine Mongolian medicinal powder formula granule and preparation method thereof |
| CN113332248A (en) * | 2021-06-02 | 2021-09-03 | 祈蒙股份有限公司 | Kaempferia galanga composition particles and preparation process thereof |
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Application publication date: 20210219 |