CN112891377B

CN112891377B - Precious fine Mongolian medicinal powder formula granule and preparation method thereof

Info

Publication number: CN112891377B
Application number: CN202110324359.4A
Authority: CN
Inventors: 宋亚红
Original assignee: Individual
Current assignee: Na Shengsang; Song Hongchun; Wang Wei
Priority date: 2021-03-26
Filing date: 2021-03-26
Publication date: 2023-09-19
Anticipated expiration: 2041-03-26
Also published as: CN112891377A

Abstract

The invention relates to the technical field of Mongolian medicine preparations, and provides precious fine Mongolian medicine powder formula granules and a preparation method thereof. The precious fine Mongolian medicine powder formula granule comprises precious fine Mongolian medicine and lactose; the preparation method provided by the invention comprises the steps of crushing the precious fine Mongolian medicine, adding lactose, and carrying out wet granulation by taking ethanol solution as a wetting agent to obtain precious fine Mongolian medicine powder formula granules. The invention prepares the precious fine Mongolian medicine into the formula granules, thereby realizing the improvement of the dosage form of the precious fine Mongolian medicine and solving the problems of difficult administration, easy pollution and deterioration of the Mongolian medicine; the invention can fully retain the traditional attribute and the medication habit of the precious fine Mongolian medicine, comprehensively improve the quality controllability and the stability of the precious fine Mongolian medicine, and the precious fine Mongolian medicine powder formula particles are convenient for accurate weighing, and can solve the problems of large dosage deviation and easy influence on the curative effect of the traditional precious fine Mongolian medicine.

Description

Precious fine Mongolian medicinal powder formula granule and preparation method thereof

Technical Field

The invention relates to the technical field of pharmaceutical preparations, in particular to precious fine Mongolian medicinal powder formula granules and a preparation method thereof.

Background

Mongolian medicine is an important component part of the world and Chinese traditional medicine, has clear Mongolian national culture characteristics, is a traditional medicine system with long history, complete theory, reliable curative effect and unique color, occupies important positions in national medical culture, not only provides medical guarantee for the reproduction of Mongolian nations and human health, but also makes great contribution to social progress. Western medicine is not suitable for many modern diseases, and in the process of seeking a solution, the natural concept of the teachers and the laws is returned to the public, and the very natural attribute is the congenital gene of Mongolian medicine. Therefore, ethnic medicines including Mongolian medicines are attracting attention to the public.

The traditional dosage form of the Mongolian medicine decoction pieces is fine powder, namely, the raw medicines are directly ground and taken, so that the administration is extremely inconvenient, the patient compliance is extremely poor, the defects of easy pollution, deterioration and the like are overcome, the requirements of modern people on life quality cannot be met, the market acceptance is low, and the development and the application of the Mongolian medicine are seriously restricted. The root cause of the defects is that the Mongolian medicine preparation and the decoction pieces are in a relatively original state, the production process is simple, the technological content is low, and meanwhile, the theory and the medicine method are unique, and the preparation technology of the traditional Chinese medicine decoction pieces cannot be imitated simply. When the traditional Chinese medicine is prepared into formula granules, the traditional Chinese medicine needs to be decocted and purified firstly, and then the obtained extract is utilized for granulating, and the method is applied to the Mongolian medicine, so that the medicine effect of the Mongolian medicine can be influenced, the Mongolian medicine can not be formulated accurately clinically, and the treatment effect is influenced.

The precious fine Mongolian medicine is a Mongolian medicine which has scarce sources, high price and needs fine storage, the dosage of the precious fine Mongolian medicine is extremely small, generally between 0.1 and 0.5g, the precious fine Mongolian medicine is difficult to accurately weigh, the deviation in dosage is large, the curative effect is easy to influence, and the potential safety hazard exists.

Disclosure of Invention

Accordingly, the present invention is directed to a precious fine Mongolian medicinal powder formulation granule and a preparation method thereof. The invention prepares the precious fine Mongolian medicine into the formula granules, thereby realizing the improvement of the dosage form of the precious fine Mongolian medicine and solving the problems of difficult administration, easy pollution and deterioration of the Mongolian medicine; and the precious fine Mongolian medicinal powder formula particles prepared by the invention are easy to weigh accurately, so that potential safety hazards are avoided.

In order to achieve the above object, the present invention provides the following technical solutions:

a powder granule comprises precious fine Mongolian medicine and lactose; the mass fraction of the precious fine Mongolian medicine is 8-13%, and the mass fraction of lactose is 87-92%.

Preferably, the mass fraction of the precious fine Mongolian medicine is 10%, and the mass fraction of lactose is 90%.

Preferably, the precious fine Mongolian medicine is used in the form of precious fine Mongolian medicine raw powder, and the mesh number of the precious fine Mongolian medicine raw powder is less than or equal to 100 meshes.

Preferably, the precious fine Mongolian medicine is artificial bezoar, buffalo horn concentrated powder, rhizoma Gymnadeniae, bezoar, blumea balsamifera, cordyceps sinensis, rhizoma Gymnadeniae, stigma croci Sativi, flos Trollii, flos Rhododendri mollis, parched wide angle, parched cornu Bubali, parched cornu Saigae Tataricae, radix Gentianae Marcrophyllae, fel Ursi powder, burnt cornu Cervi Pantotrichum, lignum Santali albi, bufonis venenum powder or Moschus.

Preferably, the water content of the precious fine Mongolian medicinal powder formula particles is less than or equal to 8%; the repose angle of the precious fine Mongolian medicinal powder formula particles is less than or equal to 41 degrees; the sum of the particles which do not pass through the first sieve and the particles which can pass through the fifth sieve in the precious fine Mongolian medicine powder formula particles is less than or equal to 15 percent.

The invention provides a preparation method of the precious fine Mongolian medicine powder formula granule, which comprises the following steps:

pulverizing the precious fine Mongolian medicine, and sieving to obtain precious fine Mongolian medicine raw powder;

mixing the fine Mongolian medicine raw powder, lactose and ethanol solution for wet granulation, and drying the obtained wet granules to obtain fine Mongolian medicine powder formula granules.

Preferably, the sieving is a 100-mesh sieving, and the undersize is noble fine Mongolian medicine raw powder.

Preferably, the mixing is: mixing the precious fine Mongolian medicine raw powder and lactose for 20-40 min, and then adding ethanol solution for stirring.

Preferably, the volume fraction of the ethanol solution is 49-51%, and the dosage ratio of the precious fine Mongolian medicine to the lactose to the ethanol solution is 8-13 g:87-92 g:20-30 mL.

Preferably, the mesh number of the screen mesh used for the wet granulation is 14-16 mesh.

Preferably, the drying temperature is 30-40 ℃.

Preferably, after the drying, the method further comprises the step of granulating the obtained dry granules; the mesh number of the screen for finishing is 18-20 meshes.

The invention provides precious fine Mongolian medicine powder formula granules, which comprise precious fine Mongolian medicine and lactose; the mass fraction of the precious fine Mongolian medicine is 8-13%, and the mass fraction of lactose is 87-92%. The invention adopts lactose with stable property as auxiliary material, prepares the precious fine Mongolian medicine into formula particles, and controls the lactose dosage to be about 9 times of the quality of the precious fine Mongolian medicine, the obtained formula particles are equivalent to 10 times of powder of the precious fine Mongolian medicine, and when the invention is specifically used, the quality of the precious fine Mongolian medicine is easier to measure, the accurate dosage of the precious fine Mongolian medicine can be ensured, and the medication safety is increased; the invention improves the fluidity, lubricity and stability of the formula particles by controlling the dosage of lactose, and the obtained formula particles have high CRH value, are not easy to absorb moisture and have good stability; in addition, lactose does not influence the property of the precious fine Mongolian medicine, can promote the dissolution of the medicine and improve the bioavailability of the precious fine Mongolian medicine, and the precious fine Mongolian medicine powder formula granule has large lactose consumption, almost negligible influence of the property of the Mongolian medicine on the granulating yield and high granulating yield. The invention realizes the improvement of the dosage form of the Mongolian medicine, solves the problems of difficult administration, low bioavailability, easy pollution and deterioration of the Mongolian medicine, and the prescription granule is easy to accurately weigh, thus solving the problems of large dosage deviation and easy influence on the curative effect of the traditional precious and fine Mongolian medicine.

In addition, the precious fine Mongolian medicinal powder formula granule provided by the invention has unified specification and dosage form standard, can be used for clinical Mongolian medicinal formulas, breaks through the inequality situation that Mongolian medicines can only be granulated by medical institutions, and comprehensively realizes clinical administration of Mongolian medicines, disease-causing formulas and one person; when the traditional Chinese medicine composition is required to be taken in a decoction form, the prescription granule provided by the invention can be prepared and decocted before decoction, so that the defect that the clinical curative effect is affected due to the lack of the traditional Chinese medicine prescription granule and the common decoction is avoided.

The invention also provides a preparation method of the precious fine Mongolian medicinal powder formula granule. The invention directly pulverizes the precious fine Mongolian medicine, then adds lactose, uses ethanol solution as wetting agent, and prepares the prescription granule by adopting a wet granulation method. The invention adopts ethanol solution as wetting agent, which is beneficial to the forming of particles, and the prepared formula particles accord with the production process requirement; the invention adopts the fine precious Mongolian medicine raw powder to prepare the formula particles, does not need decoction or purification, can completely retain the traditional attribute and the medication habit of the fine precious Mongolian medicine, protects volatile components to a great extent, comprehensively improves the quality controllability of the fine precious Mongolian medicine, and ensures the safety and the effectiveness of the fine precious Mongolian medicine; in addition, the invention adopts the crushed and sieved precious fine Mongolian medicine raw powder for granulation, the crushed and sieved precious fine Mongolian medicine raw powder has fine particles and high dissolution in gastrointestinal tract, and the bioavailability of the precious fine Mongolian medicine can be further improved. In addition, the preparation method adopted by the invention has simple process flow and low cost, can realize large-scale production, provides possibility for comprehensively realizing industrialization of the Mongolian medicine, and has low preparation cost.

Drawings

FIG. 1 is a general process flow diagram for preparing the precious fine Mongolian medicinal powder formula granule (taking bear gall powder as an example) of the invention.

Detailed Description

The invention provides precious fine Mongolian medicine powder formula granules which comprise precious fine Mongolian medicine and lactose.

In the present invention, the mass fraction of the precious fine Mongolian medicine is preferably 8-13%, more preferably 9-11%, most preferably 10%, and the mass fraction of lactose is preferably 87-92%, more preferably 89-91%, most preferably 90%.

In the present invention, the precious fine Mongolian medicine is preferably used in the form of precious fine Mongolian medicine raw powder, and the mesh number of the precious fine Mongolian medicine raw powder is preferably not more than 100 meshes, more preferably not more than 120 meshes.

In the invention, the precious fine Mongolian medicine is preferably artificial bezoar, buffalo horn concentrated powder, gymnadenia conopsea, bezoar, blumea balsamifera, cordyceps sinensis, milk ginseng, stigma croci, trollius chinensis, rhododendron molle, fried wide angle, fried buffalo horn, fried antelope horn, large-leaf gentian, bear gall powder, burnt hairy antler, sandalwood, toad venom powder or musk, and the precious fine Mongolian medicine powder formula particles are artificial bezoar powder formula particles, buffalo horn concentrated powder formula particles, hand ginseng powder formula particles, bezoar powder formula particles, blumea balsamifera powder formula particles, cordyceps sinensis powder formula particles, milk ginseng powder formula particles, saffron powder formula particles, chinese azalea powder formula particles, sheep pollen formula particles, fried wide angle powder formula particles, fried buffalo horn powder formula particles, fried antelope horn powder formula particles, large-leaf gentian powder formula particles, bear gall powder formula particles, burnt hairy antler powder formula particles, sandalwood powder formula particles, toad venom powder formula particles or musk powder formula particles.

In the invention, the dosage of the precious fine Mongolian medicine in the formula particle is small, the property of the precious fine Mongolian medicine has no influence on the preparation of the formula particle basically, the precious fine Mongolian medicine can be classified into 3 types according to the density of the precious fine Mongolian medicine raw powder, and concretely comprises a low-density type, a medium-density type and a high-density type, wherein the low-density type comprises bear gall powder, musk, bezoar, artificial bezoar, cordyceps sinensis, venenum bufonis and Chinese mugwort slices, the medium-density type comprises sandalwood, gymnadenia, trollius chinensis, rhododendron molle, radix ginseng with milk, large-leaf gentian and saffron, and the high-density type comprises buffalo horn concentrated powder, fried wide angle, fried buffalo horn, fried antelope horn and burnt hairy antler.

In the invention, the water content of the precious fine Mongolian medicinal powder formula granule is preferably less than or equal to 8%, more preferably less than or equal to 6%; the repose angle of the precious fine Mongolian medicinal powder formula particles is preferably less than or equal to 41 degrees, more preferably less than or equal to 40 degrees; the sum of the particles which do not pass through a first sieve and the particles which pass through a fifth sieve in the precious fine Mongolian medicinal powder formula particles is less than or equal to 15 percent, preferably less than or equal to 10 percent, more preferably less than or equal to 6.5 percent; the particle size of the precious fine Mongolian medicinal powder formula particle is measured according to the Chinese pharmacopoeia (2020 edition) particle size and particle size distribution method (general rule 0982 second method), and the total weight of the particles passing through the first sieve and the fifth sieve is not more than 15% of the total weight of the test sample.

The invention also provides a preparation method of the precious fine Mongolian medicinal powder formula granule, which comprises the following steps of:

mixing the fine Mongolian medicine raw powder, lactose and ethanol for wet granulation, and drying the obtained wet granules to obtain fine Mongolian medicine powder formula granules.

The invention is to crush and screen the precious fine Mongolian medicine to obtain the precious fine Mongolian medicine raw powder. The method of the invention has no special requirements on the crushing method, and the method is well known to the person skilled in the art; in the invention, the sieving is preferably a 100-mesh sieving, and the undersize is noble fine Mongolian medicine raw powder; the sieving is preferably performed using an electromagnetic vibrating screen.

After the precious fine Mongolian medicine raw powder is obtained, the precious fine Mongolian medicine raw powder, lactose and ethanol solution are mixed for wet granulation, and the obtained wet granules are dried to obtain precious fine Mongolian medicine powder formula granules. In the present invention, the volume fraction of the ethanol solution is preferably 49 to 51%, more preferably 50%; the ethanol solution plays a role of a wetting agent, can improve the viscosity of materials, and enables the materials to meet the requirements of wet granulation. In the invention, the dosage ratio of the precious fine Mongolian medicine to the lactose to the ethanol solution is preferably 8-13 g, 87-92 g, 20-30 mL, more preferably 9-11 g, 89-91 g, 20-30 mL, and even more preferably 10g, 90g and 25mL.

In the invention, the mixing is preferably that the precious fine Mongolian medicine raw powder and lactose are mixed for 20-40 min, preferably 30min, and then ethanol solution is added for stirring; the method has no special requirement on the mixing method, and can uniformly mix materials to obtain a soft material with proper viscosity.

In the present invention, the mesh number of the screen used for the wet granulation is preferably 14 to 16 mesh, more preferably 15 mesh; the wet granulation is particularly preferably: and extruding and sieving the soft materials obtained by mixing to obtain wet granules with consistent particle sizes.

After the wet granules are obtained, the wet granules obtained are dried, wherein the drying temperature is 30-40 ℃, more preferably 35-40 ℃, and the drying is preferably performed until the water content of the granules is less than or equal to 8%.

After drying, the invention preferably carries out granule finishing on the obtained dry granules to obtain precious fine Mongolian medicinal powder formula granules; the mesh number of the screen for finishing is preferably 18-20 meshes; the invention improves the smoothness of wet grains through the grain sizing, thereby improving the fluidity and the lubricity of the wet grains.

In the specific embodiment of the invention, the obtained precious fine Mongolian medicine powder formula particles are preferably packaged by using an inner packaging material, then are subjected to external packaging, and are inspected after packaging is finished, and are stored in a warehouse after being inspected to be qualified. In the present invention, the inspection of the precious fine Mongolian medicine powder formula granule preferably comprises dosage form inspection and quality standard identification; the preparation form inspection preferably comprises inspection of granularity, moisture, filling quantity difference, filling quantity and microorganism limit, and all the inspection is performed according to the method in the Chinese pharmacopoeia four-part rule 0104; the quality standard identification is preferably carried out according to the same name decoction piece item in the inner Mongolian medicine decoction piece processing Specification (2020 edition).

In the present invention, the above-mentioned processes of low-temperature pulverization, sieving, mixing, wet granulation, drying, granulation and sub-packaging are preferably performed in a D-stage clean zone.

The technical solutions of the present invention will be clearly and completely described in the following in connection with the embodiments of the present invention.

Example 1

The preparation of the low-density precious fine Mongolian medicine powder formula granule takes bear gall powder formula granule as a representative variety.

Preparation of bear gall powder formula particles: the raw materials are bear gall powder, lactose and 50% ethanol solution (hereinafter referred to as 50% ethanol solution) with the volume fraction, and the dosage ratio of the raw materials is shown in table 1.

The preparation method comprises the following steps: weighing fel Ursi powder, pulverizing, and sieving with electromagnetic vibrating screen to obtain 100 mesh fel Ursi powder; mixing the bear gall powder raw powder with lactose for 30min, and then adding 50% ethanol solution for mixing to obtain a soft material; extruding the soft material, sieving with 16 mesh sieve, drying the obtained wet granules at 40 ℃ until the water content is lower than 8%, and then finishing the granules with 20 mesh sieve to obtain bear gall powder formula granules; and (3) subpackaging the bear gall powder formula granules by using an inner packaging material, then packaging the granules with an outer package, and warehousing and preserving the granules after passing the inspection. The preparation flow of the bear gall powder formula particle is shown in figure 1.

Detecting the repose angle, CRH value (critical relative humidity) and particle yield of the obtained bear gall powder formula particles, wherein the repose angle is used for representing the fluidity and lubricity of the particles, the smaller the repose angle is, the better the fluidity of the particles is, the more the requirements of fluidity in the particle production process can be met, and in a specific embodiment, the repose angle is less than or equal to 41 degrees, and the production requirements can be considered to be met; the CRH value is used for representing the stability of the medicine, and the greater the CRH value is, the lower the hygroscopicity is, and the stability is increased; the particle yield is used for representing the formability and the compressibility of the soft material obtained by mixing, and the particle yield is high, so that the better the formability and the compressibility of the soft material obtained by mixing are proved. The test results are shown in Table 1.

The angle of repose and CRH values were measured in the same manner using the unsized bear gall powder as a comparison, and the test results are shown in Table 1.

TABLE 1 raw material ratio and Performance test results of bear gall powder formulation particles

According to Table 1, it can be seen that the addition ratio of lactose as an auxiliary material influences the fluidity, stability and formability of the obtained bear gall powder formula particles, wherein when the dosage ratio of the bear gall powder to lactose to ethanol solution is 10g:90g:25mL, the obtained bear gall powder formula particles have the best fluidity and stability and the highest particle yield, and compared with the bear gall powder, the preparation method of the formula particles has the advantages that the repose angle is reduced by 27.9 degrees, the flowability of materials is increased, the dosage is accurate, the critical relative humidity CRH value is increased by 9.5%, the hygroscopicity is reduced, the stability is increased, and the palatability is increased, so that the clinical compliance is improved. When the dosage ratio of bear gall powder, lactose and 50% ethanol solution is 20g:80g:25mL and 30g:70g:25mL, the repose angle of the particles is increased, and the yield of the particles is reduced.

In addition, when the dosage ratio of bear gall powder to lactose to starch slurry is 10g to 90g to 25mL, the hardness and brittleness of the prepared formula particles are ideal, and the prepared formula particles are convenient to split, transport, store and use.

Comparative example 1

The bear gall powder formula particles are prepared by respectively using starch, dextrin, sugar powder and calcium phosphate as auxiliary materials, 50% ethanol solution is used as wetting agents, and the dosage proportion of the raw materials, the auxiliary materials and the 50% ethanol solution is shown in table 2.

The preparation method is the same as in example 1. The angle of repose, CRH value and granule yield of the obtained bear gall powder formula granule were tested, and the obtained results are shown in Table 2.

TABLE 2 raw material ratio and Performance test results of bear gall powder formulation particles

As can be seen from the results in Table 2, when starch, dextrin, powdered sugar and calcium phosphate are used as auxiliary materials, the repose angle of the obtained formulated granules cannot meet the requirements, and the granule yield is low.

Example 2

The preparation of the medium-density precious fine Mongolian medicinal powder formula granule takes the sandalwood powder formula granule as a representative variety.

The sandalwood is used as a raw material to prepare sandalwood powder formula particles, lactose is used as an auxiliary material, 50% ethanol solution is used as a wetting agent, and the dosage ratio of the sandalwood, the lactose and the 50% ethanol solution is 10g to 90g to 25mL; the preparation method is the same as in example 1.

The resultant formulated granules were tested for angle of repose, CRH value, particle size, granule yield, drug content and moisture content, and the drug quality was examined, and the results are shown in table 3. Wherein the particle size is determined according to the method of particle size and particle size distribution (second method of general rule 0982) of Chinese pharmacopoeia (2020 edition), and the sum of the passing of the first sieve and the passing of the fifth sieve is not more than 15%; the quality inspection of the medicine is carried out according to the standards under the corresponding variety item of the inner Mongolian medicine decoction piece processing Specification (2020 edition).

Example 3

The preparation of the high-density noble fine Mongolian medicinal powder formula granule takes buffalo horn concentrated powder formula granule as a representative variety.

Preparing cornu bubali concentrated powder formula particles by taking cornu bubali concentrated powder as a raw material, wherein auxiliary materials are lactose, and the dosage ratio of the cornu bubali concentrated powder to lactose to 50% ethanol solution is 10g:90g:25mL; the preparation method is the same as in example 1.

The resultant formulated granules were tested for angle of repose, CRH value, particle size, granule yield, drug content and moisture content, and the quality of the drug was examined, and the detection method was the same as in example 2, and the results obtained are shown in table 3.

The particle size, drug content and moisture content of bear gall powder formulation particles prepared in example 1 with the ratio of bear gall powder, lactose and 50% ethanol solution of 10g:90g:25mL were tested, and the drug quality was checked, and the results are shown in Table 3.

TABLE 3 Performance test results of precious fine Mongolian powder formulation particles

According to the data in Table 3, the invention uses lactose as auxiliary material and 50% ethanol solution as wetting agent, can prepare high, medium and low density precious fine Mongolian medicine into prescription granule with satisfactory performance, and has high granule yield and stable medicine performance.

Example 4

Musk kernels, bezoar, artificial bezoar, cordyceps sinensis, venenum bufonis, blumea, gymnadenia conopsea, trollius chinensis, azalea, milk-handed ginseng, large-leaf gentian root, saffron, fried wide-angle, fried cornu bubali, fried antelope horn and burnt cornu Cervi Pantotrichum are respectively used as raw materials, and musk powder formula particles, bezoar powder formula particles, artificial bezoar powder formula particles, cordyceps sinensis powder formula particles, venenum bufonis powder formula particles, blumea powder formula particles, gymnadenia conopsea powder formula particles, trollius chinensis powder formula particles, rhododendron molle powder formula particles, milk-handed ginseng powder formula particles, large-leaf gentian root powder formula particles, saffron powder formula particles, fried wide-angle powder formula particles, fried cornu bubali powder formula particles and burnt cornu bubali powder formula particles are prepared according to a general process.

The general process is as follows: the dosage ratio of the precious fine Mongolian medicine raw powder, lactose and 50% ethanol solution is 10g:90g:25mL, and other conditions are the same as in example 1.

The obtained formula particles are tested for repose angle, CRH value, granularity, particle yield, medicine content and moisture content, and the result shows that the repose angle of the obtained formula particles is below 40 degrees, the CRH value is above 65%, the particle yield is above 96%, the granularity, the medicine content and the moisture content meet the requirements, and the quality of the formula particles meets the requirements in the inner Mongolian medicine decoction piece processing Specification (2020 edition).

The above embodiment shows that the invention uses the aim of 'not changing the drug substance basis' in the national drug research and development, applies the technical method of modern pharmacy, pulverizes the single decoction piece of the precious and fine Mongolian medicine, directly adds auxiliary materials for wet granulation, prepares novel formula granules, can be used for clinical use of Mongolian medicine, overcomes the defect of inconvenient administration of Mongolian medicine powder, and is beneficial to realizing temporary preparation and dialectical administration; the preparation method provided by the invention is simple, is easy to carry out industrial production, and is beneficial to realizing automation and intellectualization of complex and accurate formula work with technical requirements.

The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.

Claims

1. The precious fine Mongolian medicine powder formula granule is characterized by comprising the following components of precious fine Mongolian medicine and lactose; the mass fraction of the precious fine Mongolian medicine is 8-13%, and the mass fraction of lactose is 87-92%; the precious fine Mongolian medicine is artificial bezoar, buffalo horn concentrated powder, hand ginseng, bezoar, blumea balsamifera, aweto, milk hand ginseng, stigma croci Sativi, trollius chinensis, rhododendron molle, fried wide angle, fried buffalo horn, fried antelope horn, large leaf gentian, bear gall powder, burnt pilose antler, sandalwood, toad venom powder or musk kernel.

2. The precious fine Mongolian medicine powder formula granule according to claim 1, wherein the precious fine Mongolian medicine has a mass fraction of 10% and lactose has a mass fraction of 90%.

3. The precious fine Mongolian medicine powder formula granule according to claim 1 or 2, wherein the precious fine Mongolian medicine is used in the form of precious fine Mongolian medicine raw powder, and the mesh number of the precious fine Mongolian medicine raw powder is less than or equal to 100 meshes.

4. The precious fine Mongolian medicinal powder formulation granule according to claim 1, wherein the water content of the precious fine Mongolian medicinal powder formulation granule is less than or equal to 8%; the repose angle of the precious fine Mongolian medicinal powder formula particles is less than or equal to 41 degrees; the sum of the particles which do not pass through the first sieve and the particles which can pass through the fifth sieve in the precious fine Mongolian medicine powder formula particles is less than or equal to 15 percent.

5. The method for preparing the precious fine Mongolian medicine powder formula granule as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps:

mixing the fine Mongolian medicine raw powder, lactose and ethanol solution for wet granulation, and drying the obtained wet granules to obtain fine Mongolian medicine powder formula granules; the mixing is as follows: mixing the precious fine Mongolian medicine raw powder and lactose for 20-40 min, and then adding an ethanol solution for stirring; the volume fraction of the ethanol solution is 49-51%, and the dosage ratio of the precious fine Mongolian medicine to the lactose to the ethanol solution is 8-13 g:87-92 g:20-30 mL.

6. The method of claim 5, wherein the sieving is a 100 mesh sieve and the undersize is a fine Mongolian powder.

7. The method according to claim 5, wherein the mesh number of the screen used for wet granulation is 14 to 16 mesh;

the drying temperature is 30-40 ℃.

8. The method according to claim 5 or 7, wherein the drying further comprises granulating the obtained dry particles; the mesh number of the screen for finishing is 18-20 meshes.