CN110302297A - A kind of anaesthetic and its granule and preparation method - Google Patents
A kind of anaesthetic and its granule and preparation method Download PDFInfo
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- CN110302297A CN110302297A CN201910549528.7A CN201910549528A CN110302297A CN 110302297 A CN110302297 A CN 110302297A CN 201910549528 A CN201910549528 A CN 201910549528A CN 110302297 A CN110302297 A CN 110302297A
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- 230000003444 anaesthetic effect Effects 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000008187 granular material Substances 0.000 title claims abstract description 23
- 239000000341 volatile oil Substances 0.000 claims abstract description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 29
- 239000006071 cream Substances 0.000 claims abstract description 24
- 235000019441 ethanol Nutrition 0.000 claims abstract description 17
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 14
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 13
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 13
- 235000009754 Vitis X bourquina Nutrition 0.000 claims abstract description 13
- 235000012333 Vitis X labruscana Nutrition 0.000 claims abstract description 13
- 239000010440 gypsum Substances 0.000 claims abstract description 13
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 11
- 244000294611 Punica granatum Species 0.000 claims abstract description 6
- 238000007605 air drying Methods 0.000 claims abstract description 5
- 239000008213 purified water Substances 0.000 claims description 24
- 239000000706 filtrate Substances 0.000 claims description 23
- 239000002245 particle Substances 0.000 claims description 20
- 239000003643 water by type Substances 0.000 claims description 19
- 239000007864 aqueous solution Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 241000219991 Lythraceae Species 0.000 claims description 7
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- 238000005054 agglomeration Methods 0.000 claims description 6
- 230000002776 aggregation Effects 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
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- 238000009423 ventilation Methods 0.000 claims description 3
- 241000219095 Vitis Species 0.000 claims 5
- 239000002893 slag Substances 0.000 claims 2
- 229940124326 anaesthetic agent Drugs 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 abstract description 9
- 238000000605 extraction Methods 0.000 abstract description 6
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- 238000002845 discoloration Methods 0.000 abstract description 3
- 230000004936 stimulating effect Effects 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 238000001256 steam distillation Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 19
- 239000013558 reference substance Substances 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- 229960004756 ethanol Drugs 0.000 description 12
- 239000012085 test solution Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 5
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- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 3
- 229960004949 glycyrrhizic acid Drugs 0.000 description 3
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 3
- 239000001685 glycyrrhizic acid Substances 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
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- 239000012362 glacial acetic acid Substances 0.000 description 2
- 235000011477 liquorice Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- WVVOBOZHTQJXPB-UHFFFAOYSA-N N-anilino-N-nitronitramide Chemical compound [N+](=O)([O-])N(NC1=CC=CC=C1)[N+](=O)[O-] WVVOBOZHTQJXPB-UHFFFAOYSA-N 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000010437 gem Substances 0.000 description 1
- 229910001751 gemstone Inorganic materials 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
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- 238000000691 measurement method Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of anaesthetic and its granule and preparation methods；A kind of anaesthetic of the present invention includes: that white grape does 160-200 parts, 60-80 parts of cortex cinnamomi, 120-140 parts of rhizoma cyperi, 90-110 parts of Radix Glycyrrhizae, 50-80 parts of safflower, 120-170 parts of gypsum, 120-150 parts of Quan Shiliu；A kind of anaesthetic granule of the present invention and preparation method thereof mainly passes through the volatile oil of extraction by steam distillation cortex cinnamomi of the present invention and rhizoma cyperi simple, clear cream is obtained after other compositions water decoction processing, clear cream air drying obtains dry cream, and with suitable concentration ethyl alcohol adjusting humidity, granule is made in method by hand after dry cream crushing；The process for producing granula is simple, rationally, environmental protection, acquired granule meets the quality standard, stable effective ingredients, high yield rate, solves that hygroscopicity present in powder and pill is big, smell is big, has strong and stimulating；There is the problems such as discoloration, piebald.
Description
Technical field
The present invention relates to anaesthetic fields, specifically, being related to a kind of anaesthetic and its preparation and preparation method.
Background technique
Mongolian medicine's pharmacy is a bright jewel in motherland's medical treasure-house, it is with a long history, and especially Mongolian medicine's prescription has solely
Special and complete theoretical system and exact curative effect, with the development of society, the improvement of people's living standards to we have proposed
The requirement of novel, significant in efficacy, convenient to take, the kind that has characteristic the research and development of dosage form.It is difficult that Mongolia Medicine is good at treatment
Miscellaneous disease, but since the limitation of traditional Mongolian medicinal preparation and Mongolia patent drug hinders the development prospect of the special medicine of Mongolian medicine.Therefore anaesthetic
Form improvement, be a problem to be solved.
Anaesthetic " Wu Zhumu -7 " has cough and asthma relieving efficacy.Be clinically used for it is uncomfortable in chest cough, asthma, phlegm uncomfortable in chest it is thick.Institute at present
The conventional dosage forms used, such as: during thering is powder and pill, two kinds of dosage forms to produce extensively there is the viscosity of raw material raisins
The problem of crushing difficulty influences production process greatly；When preparing conventional dosage forms powder dispersion degree it is big and caused by hygroscopicity, smell
Greatly, there is strong and stimulating；Occurs the problems such as discoloration, piebald when pill.Therefore, the present invention mainly passes through sufficiently analysis Wu Zhumu -7
On the basis of ingredient, it is improved, and is made into granule, in the presence of solving the problems, such as powder and pill；Moreover,
Anaesthetic " Wu Zhumu -7 form improvement " also in compliance under the guidance of Mongolia Medicine theory and Mongolian medicine's clinical experience, in conjunction with modern study side
Method is come what is studied, and Technical Design is reasonable, technical thought is clear, Research Thinking, using advanced method, obtains and accurately may be used
The data leaned on have the characteristic of oneself in terms of anaesthetic preventing phlegm from forming and stopping coughing.
Summary of the invention
An object of the present invention is to provide a kind of anaesthetic；
The second object of the present invention is to provide a kind of preparation method of anaesthetic；
The third object of the present invention is to provide a kind of anaesthetic granule and preparation method thereof；
To achieve the goals above, the present invention is achieved through the following technical solutions:
A kind of anaesthetic, which is characterized in that the anaesthetic simple matched by following parts by weight forms: white grape does 160-
200 parts of full pomegranate 120- of 60-80 parts of cortex cinnamomi 120-140 parts of rhizoma cyperi 90-110 parts of Radix Glycyrrhizae 120-170 parts of gypsum of 50-80 parts of safflower
150 parts；
A kind of anaesthetic above-mentioned, which is characterized in that preferably, the anaesthetic simple matched by following parts by weight forms:
White grape does 170-190 parts of 60-70 parts of cortex cinnamomi 130-140 parts of rhizoma cyperi 60-70 parts of safflower of 100-110 parts of Radix Glycyrrhizae gypsum 140-160
Full 130-140 parts of the pomegranate of part；
A kind of anaesthetic above-mentioned, which is characterized in that preferably, the anaesthetic simple matched by following parts by weight forms:
White grape does 180 parts of 66 parts of cortex cinnamomi, 138 parts of rhizoma cyperi, 108 parts of Radix Glycyrrhizae complete 132 parts of pomegranate of 150 parts of gypsum of 66 parts of safflower.
A kind of preparation method of anaesthetic above-mentioned, which comprises the following steps:
(1) precision weighs cortex cinnamomi simple of the present invention, smashes it through double sieves and obtains coarse powder, 4-7 times of purified water is added,
It is 0.5-1 hours ultrasonic；It extracts volatile oil 1-3 hours, lets cool, stands, release volatile oil after oily layering completely, volatile oil is cold
Freeze and save, aqueous solution and the another device of bits save；
(2) precision weighs rhizoma cyperi simple of the present invention, and coarse powder is obtained after pulverizing and sieving, and 2-5 times of purified water is added, and surpasses
Sound 0.5-1 hours；2-4 times of purified water is added, is extracted volatile oil 1.5 hours, is let cool, stands, is released after oily layering completely
Volatile oil, volatile oil freezen protective, aqueous solution and the another device of bits are saved；
(3) gypsum simple of the present invention is weighed, 5-7 times of purified water is added, is added and is ground into after decocting 0.5-1 hours
The Radix Glycyrrhizae of the present invention of coarse powder, Quan Shiliu simple, at the same be added the dry simple of white grape and extract volatile oil rhizoma cyperi and
2-4 times of purified water is added in cortex cinnamomi bits, and common to decoct 1.5 hours, filtering is three times；3 times of purified waters are added on the dregs of a decoction for the first time
It is common to decoct 1.5 hours, with five layers of filtered through gauze；Second of 3 times of purified water of addition on dregs of a decoction, is added after decocting 1 hour
Safflower simple and immersion liquid in 1 hour are impregnated with 7 times of purified waters, it is common to decoct 0.5 hour, with five layers of filtered through gauze, filtrate storage
It deposits in container；3 times of purified waters are added in third time on the dregs of a decoction, decoct 0.5 hour, with five layers of filtered through gauze, filtrate storage container
In, the dregs of a decoction are discarded, filtrate is saved；
(4) resulting filtrate merges after filtering three times, and the rhizoma cyperi for extracting volatile oil and cortex cinnamomi aqueous solution is added, is concentrated to give
To clear cream, clear cream is dried, anaesthetic of the present invention had both been obtained.
Preferably, aforementioned anaesthetic preparation method, which is characterized in that preparation method the following steps are included:
(1) precision weighs cortex cinnamomi simple of the present invention, smashes it through double sieves and obtains coarse powder, 5 times of purified waters are added, surpass
Sound 0.5 hour；It extracts volatile oil 1.5 hours, lets cool, stands, release volatile oil after oily layering completely, volatile oil is freezed and is protected
It deposits, aqueous solution and the another device of bits save；
(2) precision weighs rhizoma cyperi simple of the present invention, obtains coarse powder after pulverizing and sieving, and 3 times of purified waters are added, ultrasound
0.5 hour；3 times of purified waters are added, is extracted volatile oil 1.5 hours, is let cool, stands, release volatile oil after oily layering completely,
Volatile oil freezen protective, aqueous solution and the another device of bits are saved；
(3) gypsum simple of the present invention is weighed, be added after 6 times of purified waters decoct 0.5-1 hours plus is ground into coarse powder
Radix Glycyrrhizae of the present invention, Quan Shiliu simple, while be added the dry simple of white grape and extract volatile oil rhizoma cyperi and cortex cinnamomi
Bits, 3 times of purified waters are added and decoct jointly 1.5 hours, filtering three times；It is common that 3 times of purified waters are added on the dregs of a decoction for the first time
It decocts 1.5 hours, with five layers of filtered through gauze；Second of 3 times of purified water of addition on dregs of a decoction, is added after decocting 1 hour with 7 times
Purified water impregnates safflower simple and immersion liquid in 1 hour, common to decoct 0.5 hour, with five layers of filtered through gauze, filtrate storage container
In；3 times of purified waters are added in third time on the dregs of a decoction, decoct 0.5 hour, with five layers of filtered through gauze, in filtrate storage container, discard
The dregs of a decoction save filtrate；
(4) resulting filtrate merges after filtering three times, and the aqueous solution of the rhizoma cyperi and cortex cinnamomi of extracting volatile oil, concentration is added
Clear cream is obtained, clear cream is dried, had both obtained anaesthetic of the present invention.Anaesthetic preparation method above-mentioned, which is characterized in that described
Double sieves are respectively 24 mesh and 60 meshes.Anaesthetic preparation method above-mentioned, which is characterized in that the temperature of the drying is 45~50
Degree.A kind of preparation method of anaesthetic granule above-mentioned, which is characterized in that preparation method the following steps are included:
(1) dry cream will be obtained after obtained anaesthetic clear cream air drying of the present invention, fine powder, fine powder stirring is obtained after crushing
Humidity is adjusted with edible ethanol after mixing, softwood is made, is sieved, uniform particle is made, ventilation obtains dry after drying in the shade
Particle；
(2) dry particle agent is sieved and removes the big particle of agglomeration, adhesion, then sieving removes fine powder, obtains uniformly
Particle；
(3) by the volatilization of penetrating edible ethanol diluted rhizoma cyperi and cortex cinnamomi in above-mentioned obtained anaesthetic granule
Oil, closed placement, to bored suction uniformly to get anaesthetic granule of the present invention.
Aforementioned anaesthetic granule, which is characterized in that the edible ethanol is 95% ethyl alcohol.
Aforementioned anaesthetic granule, which is characterized in that the sieve was followed successively by 14 meshes and particle is made, and crosses 10 meshes and removes
Agglomeration crosses 80 meshes and removes subdivision；The closed standing time is 12 hours.
The invention has the beneficial effects that: the present invention provides a kind of anaesthetic and its granule and preparation methods；The present invention
The main volatile oil for passing through extraction by steam distillation cortex cinnamomi of the present invention and rhizoma cyperi simple, other compositions water decoction processing
After obtain clear cream, clear cream air drying obtains dry cream, and dry cream with suitable concentration ethyl alcohol adjusts humidity after crushing, and method is made by hand
Granule；The process for producing granula is simple, reasonable, environmentally friendly, and acquired granule is met the quality standard, effective component is steady
Fixed, high yield rate, solves that hygroscopicity present in powder and pill is big, smell is big, has strong and stimulating；There is discoloration, piebald
The problems such as.
Specific embodiment
Embodiments of the present invention are described below by embodiment, for those skilled in the art it should be appreciated that
These specific embodiments only indicate to reach the purpose of the present invention and the implementation technical solution that selects, are not to technical side
The limitation of case.Introduction according to the present invention, be to the improvement of technical solution of the present invention in conjunction with the prior art it is obvious, belong to this
Invent the range of protection.
Embodiment 1
White grape does the full pomegranate of 180g cortex cinnamomi 66g rhizoma cyperi 138g Radix Glycyrrhizae 108g safflower 66g gypsum 150g
132g
Preparation method:
1. volatile oil extracting:
(1) extraction of Cortex Cinnamomi volatile oil: precision, which weighs cortex cinnamomi 66g and crushed the coarse powder obtained after the double sieves of 24 mesh, 60 mesh, sets
Enter in large beaker, adds and handled 0.5 hour in ultrasonic cleaner after purified water 330mL；It is opened after getting out volatile oil extractor
Begin to extract, determination of volatile oil condenser pipe starts to start timing when lower drop, extracts 1.5 hours, lets cool, stands after oily layering completely
Volatile oil is released, volatile oil sets refrigerator freezing.The another device of aqueous solution saves, and bits are placed in large beaker.
(2) extraction of Rhizoma Cyperi volatile oil: precision, which weighs rhizoma cyperi 138g, crushed the big burning of coarse powder merging obtained after 10 meshes
In cup, adds in purified water 400mL ultrasonic cleaner and handle 0.5 hour, start after adding at 300mL purified water to the 2/3 of flask
Volatile oil is extracted, determination of volatile oil condenser pipe starts to start timing when lower drop, extracts 1.5 hours, lets cool, stands and divide completely to oil
Volatile oil is released after layer, volatile oil sets refrigerator freezing.The another device of aqueous solution saves, and bits are placed in large beaker.
2. decocting:
Weigh Radix Glycyrrhizae 108g, Quan Shiliu that gypsum 150g adds purified water 900mL to decoct after forty minutes plus be ground into coarse powder
132g, while also plus after the bits of the rhizoma cyperi and cortex cinnamomi of the dry 180g of white grape and extraction volatile oil purified water 1600mL being added to decoct jointly
It boils 1.5 hours, with five layers of filtered through gauze；Filtrate is set in large beaker；Second on dregs of a decoction plus purified water 1500mL decoction 1 is small
When after joined 66g safflower and the immersion liquid impregnated with 500mL purified water 1 hour, it is common to decoct 0.5 hour, with five layers of gauze mistake
Filter, filtrate are set in large beaker；Third time decocts 0.5 hour on the dregs of a decoction plus after 2000mL purified water, with five layers of filtered through gauze, filter
Liquid is set in large beaker；Discard the dregs of a decoction；Add the aqueous solution of the rhizoma cyperi and cortex cinnamomi of extracting volatile oil after the filtrate obtained three times is merged,
Slow fire is concentrated to get clear cream, and clear cream moves to drying box, and the temperature of drying is 45~50 degree.
3. pelleting:
Clear cream air drying obtained dry cream after 15 days, obtained fine powder after being crushed with small pulverizer, fine powder is used after stirring and evenly mixing
95% edible ethanol adjusts humidity, and the softwood of " hand pinch agglomerating, flicking both dissipated " is made, then 14 meshes are crossed in a manner of manual expression
Net, is made uniform particle, and manufactured particle ventilation obtains dry particle after drying in the shade；
4. whole grain:
The big particle that 10 meshes remove agglomeration, adhesion is crossed into dry particle agent, 80 meshes is then crossed and removes fine powder, obtain
Uniform particle；Volatile oil of the penetrating with 95% edible ethanol diluted rhizoma cyperi and cortex cinnamomi later, closed placement certain time, to
It is bored to inhale uniformly.
5. packaging:
It is stored at shady and cool drying after the timely sealed package of dry particle after arrangement.
The Quality Identification of 1 anaesthetic granule of experimental example
1) appearance is dry, particle is uniform, and color is consistent, no softening, the moisture absorption, agglomeration, deliquescence.
2) granularity cannot pass through No. 1 according to granularity and determination of particle size distribution (the double sieve methods of 0,982 second method of general rule) measurement
Sieve and the summation that can be sieved by No. 5 are 6.2%.
3) moisture Chinese herbal granules are measured according to moisture (general rule 0832), and unless otherwise specified free surface moisture must not exceed 8%.Measurement
Method: taking test sample 5g, is laid in the dry flat weighing bottle to constant weight, and thickness is no more than 5mm, accurately weighed, opens bottle cap
It is 5 hours dry at 100~105 DEG C, bottle cap is covered, is moved in drier, is let cool 0.5 hour, it is accurately weighed, then in above-mentioned temperature
Degree is 1 hour dry, lets cool, and weighs, until the difference weighed twice in succession is no more than 5mg.It is calculated and is supplied according to the weight of less loss
Water content in test product.
Measurement result:
Flat bottle weight 23.4408g before drying
Drug weight 2.3958g
The important weight 25.6473g of bottle after drying
(23.4408+2.3958) -25.6473/2.3958X100%=7.9%
Moisture meets regulation.
4) melting takes test sample 10g, heats water 200mL, stirs 5 minutes, observes immediately, sol particle is all molten
Change, without foreign matter, without breeze.
2 anaesthetic finished product identification experiment of experimental example
1) identification of Radix Glycyrrhizae:
This product 5g is taken, adds hydrochloric acid 1mL plus chloroform 15mL heat to flow back 1 hour, lets cool, filter, filtrate is evaporated, residue
Ethyl alcohol 2mL is added to make to dissolve, as test solution.
Another extracting liquorice hypo acid reference substance, adds dehydrated alcohol that solution of every 1mL containing 2mg is made, as reference substance solution.According to thin
Layer chromatography (general rule 0502) test, absorption 1~2uL of test solution, reference substance solution 2uL put thin in same silica G respectively
On laminate, with petroleum ether (30~60 DEG C)-toluene-ethyl acetate-glacial acetic acid (10:20:7:0.5) for solvent, expansion,
It takes out, dries, spray with 10% phosphomolybdic acid ethanol solution, it is clear to be heated to spot development.
In sample chromatogram, it is on the corresponding position of reference substance, shows the spot of same color.
2) identification of cortex cinnamomi:
This product 5g is taken, add diethyl ether 20mL, shakes extraction 15 minutes, filtration, and filtrate is evaporated, and it is molten that residue adds dehydrated alcohol 1mL to make
Solution, as test solution.Cinnaldehydrum reference substance separately is taken, adds dehydrated alcohol that solution of every 1mL containing 1uL is made, as reference substance
Solution.It is tested according to thin-layered chromatography (general rule 0502), draws test solution 10uL, reference substance solution 5uL, respectively point Yu Tongyi
On silica gel g thin-layer plate, with petroleum ether (60~90 DEG C)-ethyl acetate (17:3) for solvent, takes out, dry, spray with dinitro
Phenylhydrazine ethyl alcohol test solution.
In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown.
3) identification of rhizoma cyperi:
This product 10g is taken, add diethyl ether 50mL, impregnates 0.5 hour, constantly shakes, and filters, and filtrate volatilizes, and residue adds ethyl alcohol
0.5mL makes dissolution as test solution.Rhizoma cyperi control medicinal material 1g separately is taken, is made in the same way of control drug solution.A-rhizoma cyperi is taken again
Ketone reference substance adds ethyl alcohol that solution of every 1mL containing 1mg is made, and as reference substance solution, tries according to thin-layered chromatography (general rule 0502)
It tests, draws above-mentioned each 10u L of three kinds of solution, put respectively on same silica gel g thin-layer plate, with petroleum ether (60~90 DEG C)-acetic acid
Ethyl ester (3:2) is solvent, is unfolded, and takes out, dries, and spray is dried 10 minutes at 105 DEG C, set ultraviolet with 1% vanillin-sulfuric acid solution
It is inspected under lamp (365nm).
In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the fluorescence spot with color is shown.
3 anaesthetic assay of experimental example
It is measured according to high performance liquid chromatography (general rule 0512).
Chromatographic condition and system suitability are using octadecylsilane chemically bonded silica as filler；With methanol-
0.2moL/L ammonium acetate solution-glacial acetic acid (67:33:1) is mobile phase；Detection wavelength is 250nm.Number of theoretical plate presses glycyrrhizic acid
Peak, which calculates, should be not less than 2500.
The preparation of reference substance solution: extracting liquorice acid ammonium reference substance is appropriate, micrometric measurement, adds mobile phase that every 1mL is made and contains
The solution of 0.2mg is to get (be equivalent to every 1mg and contain glycyrrhizic acid 0.1959mg)
The preparation of test solution: taking this product 1g, accurately weighed, sets in stuffed conical flask, and mobile phase 25mL is added in precision,
Weighed weight is ultrasonically treated 0.5 hour, lets cool, then weighed weight, the weight of less loss is supplied with mobile phase, is shaken up, and filters, essence
Close measurement subsequent filtrate 10mL, is evaporated, and residue water 20mL dissolves, and the n-butanol being saturated with water extracts 4 times, each 20ml, merges
N-butanol liquid, to doing, residue flowing phased soln is transferred in 10mL measuring bottle, and be diluted to scale, shakes up, i.e., recycling design
?.
Measuring method: accurate absorption reference substance solution and each 10uL of test solution respectively, injection liquid chromatograph, measurement,
To obtain the final product.
The every 1g of this product in terms of glycyrrhizic acid (C42H62O16), obtains 1.7mg containing Radix Glycyrrhizae.
Claims (10)
1. a kind of anaesthetic, which is characterized in that the anaesthetic simple matched by following parts by weight forms:
White grape does 160-200 portions of 90-110 parts of Radix Glycyrrhizae of 120-140 portions of rhizoma cyperis of 60-80 portions of cortex cinnamomi
Full 120-150 parts of pomegranate of 120-170 parts of gypsum of 50-80 parts of safflower.
2. anaesthetic according to claim 1, which is characterized in that the anaesthetic simple matched by following parts by weight forms:
White grape does 170-190 portions of 100-110 parts of Radix Glycyrrhizae of 130-140 portions of rhizoma cyperis of 60-70 portions of cortex cinnamomi
Full 130-140 parts of pomegranate of 140-160 parts of gypsum of 60-70 parts of safflower.
3. anaesthetic according to claim 1, which is characterized in that the anaesthetic simple matched by following parts by weight forms:
White grape does 180 portions of 66 portions of cortex cinnamomi, 108 parts of Radix Glycyrrhizae of 138 portions of rhizoma cyperis
Complete 132 parts of pomegranate of 66 parts of safflower, 150 parts of gypsum.
4. the preparation method of anaesthetic described in -3 any one according to claim 1, which is characterized in that preparation method includes following
Step:
(1) precision weighs cortex cinnamomi simple of the present invention, smashes it through double sieves and obtains coarse powder, 4-7 times of purified water, ultrasound is added
0.5-1 hours；It extracts volatile oil 1-3 hours, lets cool, stands, release volatile oil after oily layering completely, volatile oil is freezed and is protected
It deposits, aqueous solution and the another device of bits save；
(2) precision weighs rhizoma cyperi simple of the present invention, and coarse powder is obtained after pulverizing and sieving, and 2-5 times of purified water, ultrasound is added
0.5-1 hours；2-4 times of purified water is added, is extracted volatile oil 1.5 hours, is let cool, stands, releases and waves after oily layering completely
Hair oil, volatile oil freezen protective, aqueous solution and the another device of bits are saved；
(3) gypsum simple of the present invention is weighed, 5-7 times of purified water is added, is added after decocting 0.5-1 hours and is ground into coarse powder
Radix Glycyrrhizae of the present invention, Quan Shiliu simple, while be added the dry simple of white grape and extract volatile oil rhizoma cyperi and cortex cinnamomi
2-4 times of purified water is added in bits, and common to decoct 1.5 hours, filtering is three times；It is common that 3 times of purified waters are added on the dregs of a decoction for the first time
It decocts 1.5 hours, with five layers of filtered through gauze；Second of 3 times of purified water of addition on dregs of a decoction, is added after decocting 1 hour with 7 times
Purified water impregnates safflower simple and immersion liquid in 1 hour, common to decoct 0.5 hour, with five layers of filtered through gauze, filtrate storage container
In；3 times of purified waters are added in third time on the dregs of a decoction, decoct 0.5 hour, with five layers of filtered through gauze, in filtrate storage container, discard
The dregs of a decoction save filtrate；
(4) resulting filtrate merges after filtering three times, and the rhizoma cyperi for extracting volatile oil and cortex cinnamomi aqueous solution is added, and is concentrated to get clear
Cream dries clear cream, had both obtained anaesthetic of the present invention.
5. anaesthetic preparation method according to claim 4, which is characterized in that preparation method the following steps are included:
(1) precision weighs cortex cinnamomi simple of the present invention, smashes it through double sieves and obtains coarse powder, 5 times of purified waters is added, ultrasound
0.5 hour；It extracts volatile oil 1.5 hours, lets cool, stands, release volatile oil after oily layering completely, volatile oil is freezed and is protected
It deposits, aqueous solution and the another device of bits save；
(2) precision weighs rhizoma cyperi simple of the present invention, obtains coarse powder after pulverizing and sieving, and 3 times of purified waters, ultrasound 0.5 is added
Hour；3 times of purified waters are added, is extracted volatile oil 1.5 hours, is let cool, stands, release volatile oil after oily layering completely,
Volatile oil freezen protective, aqueous solution and the another device of bits save；
(3) gypsum simple of the present invention is weighed, the sheet of coarse powder is added after 6 times of purified waters decoct 0.5-1 hours plus is ground into
The Radix Glycyrrhizae, Quan Shiliu simple are invented, while the dry simple of white grape is added and extracts the rhizoma cyperi of volatile oil and the slag of cortex cinnamomi
Son is added 3 times of purified waters and decocts jointly 1.5 hours, and filtering is three times；3 times of purified waters are added on the dregs of a decoction for the first time to decoct jointly
1.5 hours, with five layers of filtered through gauze；Second of 3 times of purified water of addition on dregs of a decoction, is added after decocting 1 hour and is purified with 7 times
Water impregnates safflower simple and immersion liquid in 1 hour, common to decoct 0.5 hour, with five layers of filtered through gauze, in filtrate storage container；
3 times of purified waters are added in third time on the dregs of a decoction, decoct 0.5 hour, with five layers of filtered through gauze, in filtrate storage container, discard medicine
Slag saves filtrate；
(4) resulting filtrate merges after filtering three times, and the aqueous solution of the rhizoma cyperi and cortex cinnamomi of extracting volatile oil is added, is concentrated to get
Clear cream dries clear cream, had both obtained anaesthetic of the present invention.
6. according to the described in any item anaesthetic preparation methods of claim 4-5, which is characterized in that double sieves are respectively 24 mesh
With 60 meshes.
7. according to the described in any item anaesthetic preparation methods of claim 4-5, which is characterized in that the temperature of the drying is 45
~50 degree.
8. the granule of -3 anaesthetics according to claim 1, which is characterized in that the process for producing granula includes:
(1) dry cream will be obtained after obtained anaesthetic clear cream air drying of the present invention, fine powder is obtained after crushing, fine powder stirs and evenly mixs
Humidity is adjusted with edible ethanol afterwards, softwood is made, is sieved, uniform particle is made, ventilation obtains dry particle after drying in the shade；
(2) dry particle agent is sieved and removes the big particle of agglomeration, adhesion, then sieving removes fine powder, obtains uniform
Grain；
(3) close by the volatile oil of penetrating edible ethanol diluted rhizoma cyperi and cortex cinnamomi in above-mentioned obtained anaesthetic granule
Placement is closed, to bored suction uniformly to get anaesthetic granule of the present invention.
9. anaesthetic granule according to claim 8, which is characterized in that the edible ethanol is 95% ethyl alcohol.
10. anaesthetic granule according to claim 9, which is characterized in that the sieve was followed successively by 14 meshes and is made
Grain crosses 10 meshes and removes agglomeration, crosses 80 meshes and removes subdivision；The closed standing time is 12 hours.
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