CN113925920A - Traditional Chinese medicine atomized liquid for treating chronic pharyngitis and preparation method and application thereof - Google Patents
Traditional Chinese medicine atomized liquid for treating chronic pharyngitis and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine atomized liquid for treating chronic pharyngitis and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines, and the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following raw materials in parts by weight: 35-40 parts of grapes, 15-20 parts of pomegranate, 25-30 parts of saffron crocus, 15-20 parts of liquorice, 25-30 parts of rhizoma cyperi, 15-20 parts of cinnamon and 15-20 parts of rhodiola rosea. The traditional Chinese medicine atomized liquid can effectively treat chronic pharyngitis, can be used in a traditional Chinese medicine atomization inhalation mode, not only retains the efficacy of raw medicinal materials, improves the administration route based on traditional Chinese medicine decoction, enables the medicine to directly act on the affected part by inhaling the atomized liquid, achieves the treatment effect of quick healing and quick effect, and has the characteristics of good curative effect, quick effect, difficult relapse and convenient carrying.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine atomized liquid for treating chronic pharyngitis and a preparation method and application thereof.
Background
Chronic pharyngitis is caused by obstruction of nasal orifices due to various nasal diseases, long-term mouth breathing, and stimulation of pharynx due to physical and chemical factors, neck radiotherapy and the like. Various chronic diseases of the whole body, such as anemia, constipation, lower respiratory tract inflammation, cardiovascular diseases and the like can also be secondary to the disease. Chronic pharyngitis in the four medical classics is a general term for several pharyngeal diseases, such as pharyngeal inflammation, hoarseness, and obstructed breathing. According to traditional Chinese medicine, the pathogenic factors of chronic pharyngitis can be summarized into three types, namely pathogen, deficiency and stasis. Wherein the pathogenic factors are wind and fire. Fire pathogen is classified into excess fire and deficient fire. Deficiency is mainly caused by yin deficiency and qi deficiency. Blood stasis is mainly caused by qi stagnation, phlegm accumulation and blood stasis. The pathogenesis is characterized by the mixed pathogen, deficiency and stasis, which causes the disease of the dysfunction of qi activity, qi stagnation and blood stasis, phlegm congealing and fire depression. When a patient with chronic pharyngitis sees a doctor, the patient often complains about discomfort, itching and cough of the pharynx, and the pharynx has physical obstruction, cannot spit out and swallow, and also utters 'pronunciation and click' sound at times. This is the disease called "chronic pharyngitis" in TCM.
In Western medicine, antibiotics and anti-inflammatory drugs are adopted to control microbial infection and inflammation, or iodine agents and vitamins are used to improve symptoms, or interferon treatment is adopted, and external treatment methods such as laser and radio frequency are used if necessary. But often has the problems that the chronic pharyngitis can not be completely cured and the disease is easy to relapse; meanwhile, the side effects of high price, easy initiation of glandular secretion, scar contracture and the like exist. Therefore, the provided traditional Chinese medicine atomized liquid which is safe, has no side effect, is low in price and has high cure rate has important significance in treating chronic pharyngitis.
Disclosure of Invention
In view of the above disadvantages, the present invention aims to provide a Chinese medicinal atomized liquid for treating chronic pharyngitis, and a preparation method and an application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 35-40 parts of grapes, 15-20 parts of pomegranate, 25-30 parts of saffron crocus, 15-20 parts of liquorice, 25-30 parts of rhizoma cyperi, 15-20 parts of cinnamon and 15-20 parts of rhodiola rosea.
Further, the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following raw materials in parts by weight: 40 parts of grapes, 20 parts of pomegranate, 30 parts of saffron, 20 parts of liquorice, 30 parts of rhizoma cyperi, 20 parts of cinnamon and 20 parts of rhodiola rosea.
Further, the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following raw materials in parts by weight: 35 parts of grapes, 15 parts of pomegranate, 28 parts of saffron crocus, 17 parts of liquorice, 25 parts of rhizoma cyperi, 16 parts of cinnamon and 15 parts of rhodiola rosea.
Further, the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following raw materials in parts by weight: 38 parts of grape, 18 parts of pomegranate, 25 parts of saffron, 15 parts of liquorice, 20 parts of rhizoma cyperi, 15 parts of cinnamon and 18 parts of rhodiola rosea.
The invention also provides a preparation method of the traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following steps:
(1) adding the crushed medicinal materials and the extraction solvent into a container, heating to 25-100 ℃, stirring until the medicinal materials and the extraction solvent are uniformly mixed, preserving the temperature, stirring and extracting for 30-120 min, centrifuging, taking supernatant, and filtering to obtain crude drugs;
(2) and (2) adding a solvent into the crude drug obtained in the step (1) to adjust the concentration of the crude drug in the feed liquid to 0.4-0.5 g/g crude drug, sterilizing and filling to obtain the traditional Chinese medicine.
Further, the extraction solvent comprises water, ethanol or propylene glycol; propylene glycol is preferred.
Further, when the concentration of the crude drug in the solution is adjusted by the solvent, the mass ratio of the crude drug to the solvent is 1: 1-10, preferably 1: 2-5, and most preferably 1: 3-5.
Further, when the concentration of the crude drug in the feed solution is adjusted by a solvent, the solvent is preferably propylene glycol.
Further, the extraction temperature is preferably 70 to 90 ℃, and most preferably 80 ℃.
Further, the extraction time is preferably 30-60 min.
The invention also provides application of the traditional Chinese medicine atomized liquid for treating chronic pharyngitis in preparation of electronic cigarettes.
Furthermore, when the traditional Chinese medicine atomizing liquid is applied, the traditional Chinese medicine atomizing liquid is atomized by using commercially available electronic cigarette equipment, and the use is convenient.
An electronic cigarette adopts the traditional Chinese medicine atomized liquid for treating chronic pharyngitis as electronic cigarette liquid.
The brief introduction of the effects of the raw material medicines in the traditional Chinese medicine atomized liquid for treating chronic pharyngitis provided by the invention is as follows:
grape: neutral in nature and sweet and sour in taste, and has the effects of tonifying qi and blood, tonifying liver and kidney, promoting the production of body fluid, strengthening tendons and bones, relieving cough and relieving restlessness, tonifying qi and blood and promoting urination when entering lung, spleen and kidney channels.
Pomegranate: sweet, sour and astringent, warm in nature and taste, and has the effects of killing parasites, astringing intestines, stopping dysentery and the like.
Saffron: sweet taste and mild nature, and can promote blood circulation to disperse blood clots, disperse stagnation and relieve pain. The main components of crude drug include crocetin, crocin, crocetin dimethyl ester, crocin, volatile oil, etc. In addition, the medicine also contains compounds such as eucalyptol, pinene, various vitamins such as riboflavin, thiamine and the like, has the effects of activating blood and dredging channels, and removing blood stasis and relieving pain, and particularly takes saffron as a main drug in many traditional formulas of Mongolian Tibetan medicines.
Licorice root: sweet in flavor and neutral in nature, and entering heart, lung, spleen and stomach meridians. Has the functions of clearing away heat and toxic material, eliminating phlegm and stopping cough and is a blend medicine.
Rhizoma cyperi: it enters liver, spleen and triple energizer meridians, soothes liver and regulates qi, regulates menstruation and relieves pain, and is used for treating diseases caused by liver depression and qi stagnation.
Cinnamon: has great heat property and pungent and sweet taste, and has the effects of tonifying fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, promoting blood circulation and stimulating the menstrual flow.
Rhodiola root: alias: rhodiola rosea, scandent macburl (Tibetan name); is a perennial herbaceous plant. Cold in nature, sweet and astringent in flavor. It enters lung meridian. Has effects in invigorating qi, clearing away lung-heat, improving intelligence, nourishing heart, astringing, stopping bleeding, dispelling blood stasis, and relieving swelling. Can be used for treating qi deficiency, asthenia, aversion to cold, short breath, asthenia, cough due to lung heat, hemoptysis, leucorrhea with diarrhea, and traumatic injury.
In summary, the invention has the following advantages:
1. the invention provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which is prepared by reasonably matching through the synergistic effect of the components, fully exerts the double-layer effect of treating and conditioning organisms of a traditional Chinese medicine compound preparation, and has the characteristics of good curative effect, quick response and difficult relapse. The method specifically comprises the following steps: the grapes are used as monarch drugs in the formula, enter lung and kidney, tonify kidney water, nourish lung and kidney, and dispel lung-kidney yin deficiency; pomegranate and saffron are used as ministerial drugs in the prescription, nourish qi and blood, promote the production of body fluid and moisten throat, promote blood circulation to remove blood stasis, dispel stagnation and resolve stagnation, and help monarch drugs to dispel lung-kidney yin deficiency; the rhizoma cyperi, the cinnamon and the rhodiola root are used as adjuvant drugs in the prescription to tonify fire and strengthen yang, so that the deficiency of lung and kidney qi can be supplemented; the liquorice is used as a guiding drug in the prescription, has the effects of nourishing yin, moistening dryness, moistening lung, tonifying deficiency and harmonizing the drugs in the recipe.
2. The traditional Chinese medicine atomized liquid can effectively treat chronic pharyngitis, can be used in a traditional Chinese medicine atomization inhalation mode, not only retains the efficacy of raw medicinal materials, improves the administration route based on traditional Chinese medicine decoction, enables the medicine to directly act on the affected part by inhaling the atomized agent, achieves the treatment effect of quick healing and quick effect, and has the advantages of convenient use, high bioavailability, stable quality and simple production process.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 40 parts of grapes, 20 parts of pomegranate, 30 parts of saffron, 20 parts of liquorice, 30 parts of rhizoma cyperi, 20 parts of cinnamon and 20 parts of rhodiola rosea.
The preparation method of the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following steps:
(1) adding pulverized medicinal materials and propylene glycol into a container, heating to 80 deg.C, stirring to mix well, maintaining the temperature, extracting under stirring for 60min, centrifuging, collecting supernatant, and filtering to obtain crude drug;
(2) adding propylene glycol into the crude drug obtained in the step (1) to adjust the concentration of the crude drug in the feed liquid to 0.45g/g crude drug amount, sterilizing and filling to obtain the traditional Chinese medicine composition; wherein the mass ratio of the crude drug to the solvent is 1: 5.
Example 2
The embodiment provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 35 parts of grapes, 15 parts of pomegranate, 28 parts of saffron crocus, 17 parts of liquorice, 25 parts of rhizoma cyperi, 16 parts of cinnamon and 15 parts of rhodiola rosea.
The preparation method is the same as that of example 1.
Example 3
The embodiment provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 38 parts of grape, 18 parts of pomegranate, 25 parts of saffron, 15 parts of liquorice, 20 parts of rhizoma cyperi, 15 parts of cinnamon and 18 parts of rhodiola rosea.
The preparation method is the same as that of example 1.
Comparative example 1
The embodiment provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 20 parts of grape, 18 parts of pomegranate, 25 parts of saffron, 15 parts of liquorice, 20 parts of rhizoma cyperi, 15 parts of cinnamon and 18 parts of rhodiola rosea.
The preparation method is the same as that of example 1.
Comparative example 2
The embodiment provides a traditional Chinese medicine atomized liquid for treating chronic pharyngitis, which comprises the following raw materials in parts by weight: 40 parts of grapes, 18 parts of pomegranate, 25 parts of honeysuckle, 15 parts of liquorice, 20 parts of rhizoma cyperi, 15 parts of cinnamon and 18 parts of rhodiola rosea.
The preparation method is the same as that of example 1.
Examples of the experiments
The traditional Chinese medicine atomized liquid for treating chronic pharyngitis obtained in examples 1-3 in the invention is used for observing the curative effect of 180 patients with chronic pharyngitis in 2010-2018 (wherein the products obtained in examples 1-3 are respectively used for 60 patients). The use method of the traditional Chinese medicine atomized liquid for treating chronic pharyngitis comprises the following steps: 20mL of the finished product is taken and put into an atomizer each time, 2 times a day, 20min each time, and 25 days is a course of treatment.
The curative effect standard is as follows: (1) healing is achieved; the symptoms of pharyngalgia, dryness and foreign body sensation disappear completely, and the pharyngeal mucosa returns to normal; (2) the effect is shown: the symptoms of pharyngalgia, dryness and foreign body sensation basically disappear, and the acute congestion of pharyngeal mucosa subsides; (3) the method has the following advantages: symptoms of pharyngeal surge, decassimus and foreign body sensation are relieved, and congestion of pharyngeal mucosa is relieved compared with that before administration; (4) and (4) invalidation: the above symptoms were unchanged and the pharynx was still engorged with blood.
Treatment results statistics were performed after one treatment course: 108 cases (60.0%) were cured, with 39 cases in example 1, 33 cases in example 2, and 36 cases in example 3; 32 cases (17.8%) of significant effect, wherein example 1 is 13 cases of significant effect, example 2 is 10 cases of significant effect, and example 3 is 9 cases of significant effect; 36 cases (20%) are effective, wherein example 1 is effective for 7 cases, example 2 is effective for 15 cases, and example 3 is effective for 14 cases; 4 cases (2.2%) were void, of which examples 1-3 were 1, 2 and 1, respectively; the total effective rate is 97.8%.
In addition, the traditional Chinese medicine atomized liquid obtained in the comparative examples 1-2 is used for observing the curative effect of 30 patients with chronic pharyngitis in 2010-2018, (wherein the products obtained in the comparative examples 1-2 are respectively used for 15 patients), and the treatment method, the treatment course, the treatment standard and the like are the same as those of the products obtained in the above examples 1-3. The results show that: comparative example 1:3 cases (20.0%) are cured, and 6 cases (40.0%) are obviously effective; effective 2 cases (13.3%); null 4 cases (26.7%); the total effective rate is 73.3%. Comparative example 2: 0 case (0%) is cured, and 3 cases (20.0%) are obviously effective; effective 2 cases (13.3%); no 10 cases (66.7%); the total effective rate is 33.3%.
The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to supplement or replace the specific embodiments described by those skilled in the art without inventive faculty.
Claims (10)
1. The traditional Chinese medicine atomized liquid for treating chronic pharyngitis is characterized by comprising the following raw materials in parts by weight: 35-40 parts of grapes, 15-20 parts of pomegranate, 25-30 parts of saffron crocus, 15-20 parts of liquorice, 25-30 parts of rhizoma cyperi, 15-20 parts of cinnamon and 15-20 parts of rhodiola rosea.
2. The traditional Chinese medicine atomized liquid for treating chronic pharyngitis according to claim 1, which is prepared from the following raw materials in parts by weight: 40 parts of grapes, 20 parts of pomegranate, 30 parts of saffron, 20 parts of liquorice, 30 parts of rhizoma cyperi, 20 parts of cinnamon and 20 parts of rhodiola rosea.
3. The traditional Chinese medicine atomized liquid for treating chronic pharyngitis according to claim 1, which is prepared from the following raw materials in parts by weight: 35 parts of grapes, 15 parts of pomegranate, 28 parts of saffron crocus, 17 parts of liquorice, 25 parts of rhizoma cyperi, 16 parts of cinnamon and 15 parts of rhodiola rosea.
4. The traditional Chinese medicine atomized liquid for treating chronic pharyngitis according to claim 1, which is prepared from the following raw materials in parts by weight: 38 parts of grape, 18 parts of pomegranate, 25 parts of saffron, 15 parts of liquorice, 20 parts of rhizoma cyperi, 15 parts of cinnamon and 18 parts of rhodiola rosea.
5. The method for preparing the atomized traditional Chinese medicine liquid for treating chronic pharyngitis according to any one of claims 1 to 4, which is characterized by comprising the following steps:
(1) adding the crushed medicinal materials and the extraction solvent into a container, heating to 25-100 ℃, stirring until the medicinal materials and the extraction solvent are uniformly mixed, preserving the temperature, stirring and extracting for 30-120 min, centrifuging, taking supernatant, and filtering to obtain crude drugs;
(2) and (2) adding a solvent into the crude drug obtained in the step (1) to adjust the concentration of the crude drug in the feed liquid to 0.4-0.5 g/g crude drug, sterilizing and filling to obtain the traditional Chinese medicine.
6. The method for preparing the atomized traditional Chinese medicine liquid for treating chronic pharyngitis according to claim 5, wherein the extraction solvent comprises water, ethanol or propylene glycol.
7. The method for preparing the atomized traditional Chinese medicine liquid for treating chronic pharyngitis according to claim 5, wherein when the solvent is added to adjust the concentration of the crude drug in the liquid, the mass ratio of the crude drug to the solvent is 1: 1-10.
8. The method for preparing the atomized traditional Chinese medicine liquid for treating chronic pharyngitis according to claim 5, wherein the temperature in the step (1) is 70-90 ℃ and the time is 30-60 min.
9. The use of the Chinese medicinal atomized liquid for treating chronic pharyngitis according to any one of claims 1 to 4 in the preparation of electronic cigarettes.
10. An electronic cigarette, characterized in that the Chinese medicinal atomized liquid for treating chronic pharyngitis according to any one of claims 1 to 4 is used as an electronic cigarette liquid.
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| CN116920043A (en) * | 2023-08-22 | 2023-10-24 | 东莞市吉纯生物技术有限公司 | Traditional Chinese medicine atomized liquid for treating chronic pharyngitis and preparation method and application thereof |
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