CN113041225A - Sugar-containing Mongolian medicine powder formula granule and preparation method thereof - Google Patents
Sugar-containing Mongolian medicine powder formula granule and preparation method thereof Download PDFInfo
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- CN113041225A CN113041225A CN202110324381.9A CN202110324381A CN113041225A CN 113041225 A CN113041225 A CN 113041225A CN 202110324381 A CN202110324381 A CN 202110324381A CN 113041225 A CN113041225 A CN 113041225A
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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Abstract
The invention provides a sugar-containing Mongolian medicine powder formula particle and a preparation method thereof, belonging to the technical field of Mongolian medicine preparations, wherein the sugar-containing Mongolian medicine powder formula particle comprises a sugar-containing Mongolian medicine, dextrin and starch; the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is (73-77) - (14-16) - (9-11), and the mass percentage of the sugar-containing Mongolian medicine in the sugar-containing Mongolian medicine powder formula particles is 74.9% -75.1%. The sugar-containing Mongolian medicine powder formula granule provided by the invention is prepared by taking traditional single sugar-containing Mongolian medicine decoction pieces as raw materials through the steps of low-temperature crushing, auxiliary material addition, granulation and the like. The invention aims to 'the basis of the drug substance is not changed' in the research and development of the national drugs, and applies the method of modern pharmacy to process Mongolian drugs into single decoction pieces into novel formula granules, thereby comprehensively improving the quality controllability and stability of the Mongolian drugs, and ensuring the safety and effectiveness of the Mongolian drugs.
Description
Technical Field
The invention belongs to the technical field of Mongolian medicine preparations, and particularly relates to sugar-containing Mongolian medicine powder formula granules and a preparation method thereof.
Background
Mongolian medicine is an important component of world and Chinese traditional medicine, and has bright Mongolian cultural characteristics. Mongolian medicines have long history, complete theory and reliable curative effect, occupy an important position in national medical culture for a traditional medicine system with unique colors, provide medical guarantee for the reproduction of Mongolian nationalities and the health of human beings, and make great contribution to social progress. Western medicine is unforgetted by many modern disease restraints, and in the process of seeking solutions, the concepts of the law and law nature are returned to the public vision, and the natural attribute is the innate gene of Mongolian medicine, so that Mongolian medicine is developed in a accumulating manner.
The traditional basic dosage form of sugar-containing Mongolian medicine decoction pieces is fine powder, is extremely inconvenient to take, has extremely poor patient compliance, cannot meet the requirement of modern people on paying attention to the quality of life, has low market acceptance, and seriously restricts the development and application of Mongolian medicines. The root cause of the defects is that the Mongolian medicine preparation and the decoction pieces are in original states, the production process is simple, the original medicine is mostly adopted to be smashed into powder, but the sugar-containing Mongolian medicine has the problems of large viscosity ratio, difficulty in smashing, easiness in moisture absorption of the smashed powder and the like.
Therefore, on the basis of completely retaining the traditional property and clinical medication habit of the Mongolian medicine, the technical problems that the administration of the sugar-containing Mongolian medicine is difficult, and the further development of the sugar-containing Mongolian medicine is in urgent need of solving the problem of improving the medication compliance of the sugar-containing Mongolian medicine are solved.
Disclosure of Invention
In view of the above, the present invention aims to provide a sugar-containing Mongolian medicine powder formula granule and a preparation method thereof, wherein the sugar-containing Mongolian medicine powder formula granule solves the problem that sugar-containing Mongolian medicines are extremely difficult to take, and improves the compliance of the sugar-containing Mongolian medicines; the preparation method of the sugar-containing Mongolian medicine comprehensively improves the quality controllability and stability of sugar-containing Mongolian medicine decoction pieces, and ensures the safety and effectiveness of the sugar-containing Mongolian medicine.
In order to achieve the above purpose, the invention provides the following technical scheme:
the invention provides sugar-containing Mongolian medicine powder formula granules, which comprise sugar-containing Mongolian medicines and auxiliary materials, wherein the auxiliary materials comprise dextrin and starch; the mass ratio of the sugar-containing Mongolian medicine to the dextrin to the starch is (73-77) to (14-16) to (9-11); the mass percentage of the sugar-containing Mongolian medicine in the sugar-containing Mongolian medicine powder formula particles is 74.9-75.1%.
Preferably, the sugar content of the sugar-containing Mongolian medicine is more than 10%, and the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is (74.5-75.5): (13.5-14.5): (10.5-11.5).
Preferably, the sugar content of the sugar-containing Mongolian medicine is between 5 and 10 percent, and the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is (74.5-75.5) to (14.5-15.5) to (9.5-10.5).
Preferably, the sugar content of the sugar-containing Mongolian medicine is less than 5%, and the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is (74.5-75.5): (15.5-16.5): (8.5-9.5).
Preferably, the angle of repose of the sugar-containing Mongolian medicine powder formula particles is 37.5-40.1 degrees, the water content is less than or equal to 9 percent, and the CRH value is 61-65.
Preferably, the sugar-containing Mongolian medicine is selected from one of medlar, white grape, persimmon, sea buckthorn paste, Thladiantha dubia, syzygium jambos, hawthorn, pomegranate, radix ophiopogonis, asparagus cochinchinensis, milk asparagus fern, rhizoma polygonati, milk sealwort, polygonatum odoratum, milk polygonatum odoratum, Mirabilis jalapa, lily, fructus choerospondiatis, cistanche deserticola, emblic leafflower fruit, schisandra chinensis, dried sour pear, ginseng, papaya, fried water caltrop, dried garlic, Chinese olive, Chinese torreya seed, fritillaria ussuriensis, fritillaria thunbergii, echeveria glauca, lotus seed, mango seed, sword bean, shinyleaf yellowhorn paste, fried round-grained rice, lalang grass rhizome.
The invention provides a preparation method of sugar-containing Mongolian medicine powder formula granules, which comprises the following steps:
1) crushing the sugar-containing Mongolian medicine at low temperature to obtain sugar-containing Mongolian medicine powder, wherein the temperature of the low-temperature crushing is-21 ℃ to-19 ℃;
2) mixing the sugar-containing Mongolian powder, dextrin and starch, wetting by using 83-87% of ethanol by volume percentage, and performing wet granulation to obtain the sugar-containing Mongolian powder formula granule.
Preferably, the low-temperature pulverization of step 1) further comprises: and (3) sieving the obtained crushed material by a sieve of 100-140 meshes, and collecting the sieved components as sugar-containing Mongolian medicine powder.
Preferably, the wet granulation in the step 2) comprises granulation, drying and size stabilization, wherein the mesh number of the granulation is 14-16 meshes, the drying temperature is 55-65 ℃, and the mesh number of the size stabilization is 18-20 meshes.
Preferably, the mixing time in the step 2) is 25-35 min.
The sugar-containing Mongolian medicine powder formula granule provided by the invention is prepared by taking traditional single sugar-containing Mongolian medicine decoction pieces as raw materials through the steps of low-temperature crushing, auxiliary material adding and granulation. The mass percentage content of the plant sugar-containing Mongolian medicine in the sugar-containing Mongolian medicine powder formula particle is 74.9-75.1 percent, and the sugar-containing Mongolian medicine powder formula particle is novel particles with unified specification, unified dose and unified dosage form standard (the execution particle standard, namely granularity, fluidity (repose angle), water content, CRH value, original medicine content, microorganism limit and the like are unified standards; is convenient for Mongolian medicine clinical prescription.
The sugar-containing Mongolian medicine powder formula particle provided by the invention improves the dosage form of decoction pieces on the premise of completely keeping the traditional attribute and clinical medication habit of Mongolian medicine, and overcomes the defect that Mongolian medicine powder is inconvenient to take; solves the problem that the Mongolian medicine is extremely difficult to take, and improves the compliance of the Mongolian medicine.
Furthermore, the angle of repose theta of the sugar-containing type Mongolian medicine particles provided by the invention is less than 40.1 degrees, and the requirement of the flowability of the granules in the production process is met; the critical relative humidity value CRH is increased by about 5 percent compared with the powder, thereby increasing the stability of the medicine.
The sugar-containing Mongolian medicine powder has high viscosity and poor lubricating property, formability and fluidity, and the traditional sugar-containing Mongolian medicine is mostly used in the form of decoction pieces, so that the traditional sugar-containing Mongolian medicine is more convenient to measure by volume and difficult to accurately control the medicine dosage.
The raw powder of the sugar-containing Mongolian medicine is granulated, so that the use amount of auxiliary materials is greatly reduced, and the defect of excessive auxiliary materials of the traditional Chinese medicine formula granules is overcome; meanwhile, the fine powder grade raw powder is used for preparing a granular preparation, so that volatile components are protected to a greater extent; the preparation method of the invention has low scale production cost, and the cost is about 1/3 of the traditional Chinese medicine formula particles; the preparation method of the invention provides possibility for the traditional Mongolian medicine to realize industrialization comprehensively.
Furthermore, the sugar-containing Mongolian medicine powder formula particle breaks through the situation that Mongolian medicines only depend on preparations of medical institutions, and clinically-administered Mongolian medicines, disease-causing formulas or one part of Mongolian medicines are comprehensively realized; the Mongolian medicine granular preparation prepared by the preparation method of the sugar-containing classified Mongolian medicine powder formula granule can reach the standard of granular preparation formulations in Chinese pharmacopoeia, and can synchronously realize intelligent automatic formula blending. The preparation method of the traditional Chinese medicine formula granule comprises the following steps: the single medicine is decocted, concentrated, dried and granulated, and then is matched with other traditional Chinese medicines to obtain a traditional Chinese medicine formula for patients. The preparation method of the Mongolian medicine powder formula particle comprises the following steps: the single medicine is crushed and granulated to obtain a granular preparation, and the granular preparation is used for patients after being decocted with other medicines. Therefore, the decoction prepared by the sugar-containing Mongolian medicine powder formula particle formula disclosed by the invention is decocted after being prepared, so that the defect that the clinical curative effect is influenced because the traditional Chinese medicine formula particles are not decocted together is overcome.
Drawings
FIG. 1 is a thin layer diagram of fructus Lycii granule, wherein 1-5 are fructus Lycii granule 1, fructus Lycii granule 2, fructus Lycii granule 3, fructus Lycii control 5 μ l and fructus Lycii control 10 μ l, respectively.
Detailed Description
The invention provides sugar-containing Mongolian medicine powder formula granules, which comprise sugar-containing Mongolian medicines and auxiliary materials, wherein the auxiliary materials comprise dextrin and starch; the mass ratio of the sugar-containing Mongolian medicine to the dextrin to the starch is (73-77) to (14-16) to (9-11); the mass percentage of the sugar-containing Mongolian medicine in the sugar-containing Mongolian medicine powder formula particles is 74.9-75.1%.
In the invention, the powder of the sugar-containing Mongolian medicine after being crushed has relatively high viscosity and relatively poor lubricating property, moldability and fluidity, and the moldability and compressibility of the material are improved by adding dextrin and starch as auxiliary materials. Compared with powder, the sugar-containing Mongolian powder formula granule prepared by mixing the sugar-containing Mongolian medicine, dextrin and starch according to the mass ratio has the advantages of reduced repose angle, increased fluidity and accurate dosage; the critical relative humidity CRH value is increased, the hygroscopicity is reduced, and the stability is increased; the palatability is improved, and the drug compliance is improved. In addition, the sugar-containing Mongolian medicine powder formula particles provided by the invention have ideal hardness and brittleness, and are convenient to subpackage, transport, store and use.
In the present invention, when the sugar content of the sugar-containing type Mongolian drug is more than 10%, the mass ratio of the sugar-containing type Mongolian drug to dextrin to starch is preferably (74.5-75.5): (13.5-14.5): (10.5-11.5). More preferably (74.8-75.2): (13.8-14.2): (10.8-11.2), and most preferably 75:14: 11. In the present invention, the sugar-containing smectite having a sugar content of more than 10% preferably includes lycium barbarum, vitis vinifera, kaki, hippophae rhamnoides paste, fructus xanthii, syzygium jambos, hawthorn and punica granatum, and the examples of the present invention are described with respect to lycium barbarum.
In the invention, when the sugar content of the sugar-containing Mongolian medicine is between 5% and 10%, the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is preferably (74.5-75.5): (14.5-15.5): 9.5-10.5), more preferably (74.8-75.2): 14.8-15.2): 9.8-10.2, and most preferably 75:15: 10. In the invention, the sugar-containing Mongolian medicines with the sugar content of 5-10% comprise radix ophiopogonis, asparagus fern, milk asparagus fern, rhizoma polygonati, milk rhizoma polygonati, polygonatum odoratum, milk polygonatum odoratum, mirabilis jalapa, lily, fructus choerospondiatis and cistanche, and the embodiment of the invention takes the radix ophiopogonis as an example for description.
In the invention, when the sugar content of the sugar-containing Mongolian medicine is less than 5%, the mass ratio of the sugar-containing Mongolian medicine to dextrin to starch is preferably (74.5-75.5): (15.5-16.5): (8.5-9.5), more preferably (74.8-75.2): (15.8-16.2): (8.8-9.2), and most preferably 75:16: 9. In the invention, the sugar-containing Mongolian medicine with the sugar content less than 5 percent is subdivided into two types, namely, the sugar content is between 1 percent and 5 percent and the sugar content is less than 1 percent; the sugar-containing Mongolian medicine with the sugar content of 1-5% comprises phyllanthus emblica, schisandra chinensis, dried sour pears, ginseng, pawpaw, fried water caltrop, dried garlic, Chinese olive and Chinese torreya seeds, and the example of the invention is illustrated by using the phyllanthus emblica. In the invention, the sugar-containing Mongolian medicines with the sugar content less than 1 percent comprise fritillaria ussuriensis, unibract fritillary bulb, thunberg fritillary bulb, bitter herb of rockwork, lotus seed, mango seed, sword bean, shinyleaf yellowhorn paste, fried polished round-grained rice, lalang grass rhizome and rhizoma arisaematis; in the examples of the present invention, fritillary bulb is taken as an example for explanation.
The invention has no special requirements on the source of the sugar-containing Mongolian medicine, and the Mongolian medicine is purchased from a Mongolian medicine decoction piece processing factory with GMP qualification, for example: inner Mongolia group company or inner Mongolia praying Mongolia industry company.
The invention also provides a preparation method of the sugar-containing Mongolian medicine powder formula granule, which comprises the following steps: 1) crushing the sugar-containing Mongolian medicine at low temperature to obtain sugar-containing Mongolian medicine powder, wherein the temperature of the low-temperature crushing is-21 ℃ to-19 ℃; 2) mixing the sugar-containing Mongolian powder, dextrin and starch, wetting by using 83-87% of ethanol by volume percentage, and performing wet granulation to obtain the sugar-containing Mongolian powder formula granule.
In the invention, the sugar-containing Mongolian medicine is pulverized at low temperature to obtain the sugar-containing Mongolian medicine powder. In the invention, the low-temperature crushing temperature is preferably-20 ℃, and the problems of high viscosity, low brittleness and low crushing efficiency of the plant sugar-containing Mongolian medicine can be solved by adopting low-temperature crushing. The crushing apparatus is not particularly limited, and the crushing apparatus conventional in the art can be used. In the invention, the crushed material is preferably screened by an electromagnetic vibrating screen; the crushed materials are preferably sieved by a sieve of 100-140 meshes, and the sieved components are collected to be the sugar-containing Mongolian medicine powder.
After the sugar-containing Mongolian medicine powder is obtained, the sugar-containing Mongolian medicine powder, dextrin and starch are mixed, ethanol with the volume percentage of 83-87% is used for wetting, and wet granulation is carried out to obtain the sugar-containing Mongolian medicine powder formula granules. In the invention, the mixing time is 25-35 min, more preferably 28-32 min, and most preferably 30 min; the mixing is preferably carried out in a medicinal mixing machine, and in the invention, because the selected auxiliary materials are suitable and scientific, the medicinal powder is uniformly crushed, and the like, the mixing time is more accurate and reliable.
In the invention, the ethanol is preferably ethanol with the volume percentage of 84-86%, and more preferably ethanol with the volume percentage of 85%. In the present invention, the mass ratio of the total mass of the sugar-containing Mongolian medicine powder, dextrin and starch mixed with ethanol is preferably 100 g: 20-25 mL; the mixed soft material is granulated, and the granulating method selects wet granulation. In the invention, the wet granulation comprises granulation, drying and size stabilization, the mesh number of the granulation is preferably 14-16 meshes, and the drying temperature is preferably 55-65 ℃, more preferably 58-62 ℃, and most preferably 60 ℃; the mesh number of the whole granules is preferably 18 to 20 meshes. In the present invention, the granulation and straightening are preferably carried out in a wet granulator; the specification and parameters of the wet granulator are not particularly limited, and the granulator which is conventional in the field can be adopted.
After the wet granulation, the method preferably further comprises the steps of packaging and quality inspection. In the invention, the prepared sugar-containing Mongolian medicine powder formula particles are preferably subpackaged in packaging materials; the quality inspection comprises outer package quality inspection and pharmaceutical preparation quality inspection; the quality inspection of the outer package is carried out by manually checking whether the outer package is intact or damaged; in the present invention, the quality inspection of the pharmaceutical preparation is preferably performed according to pharmaceutical quality standards, and in the present invention, specific reference is made to "chinese pharmacopoeia" (0104, the fourth general rule of 2020 edition).
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Preparation of medlar powder formula granule
Weighing 35kg of fructus Lycii decoction pieces, pulverizing at-20 deg.C, sieving with electromagnetic vibrating sieve to obtain powder of Mongolian medicinal decoction pieces containing saccharide with strong viscosity, sieving with 100 mesh sieve, and collecting sieved components to obtain 33kg of fructus Lycii powder.
Mixing 7.5kg of medlar powder, 1.4kg of dextrin and 1.1kg of starch in a swing mixer for 30min to obtain a mixed material. And (3) mixing the mixed material with about 2.5L of ethanol with the volume percentage content of 85%, reducing the viscosity of the material, putting the mixture into a granulator for wet granulation, carrying out 14-16-mesh granulation, drying at 60 ℃ for 1h, and carrying out 18-20-mesh granulation.
Packaging and quality testing the prepared medlar powder formula particles; the packaging material is a nationally specified medicinal transparent polyethylene bottle or medicinal PVC special bag, and the specification is 250-300 g/bottle or 250-300 g/bag.
The test was carried out according to the Chinese pharmacopoeia (2020 edition four ministry of general rules 0104).
[ particle size ] unless otherwise specified, the sum of the particles which cannot pass through the first sieve and the particles which can pass through the fifth sieve, as determined by particle size and particle size distribution determination (second method double sieve method 0982 general rule), must not exceed 15%.
[ water ] was measured by the water content measuring method (general rule 0832), but not more than 8.0% unless otherwise specified.
[ difference in loading ] the granules packed in a single dose were checked as follows and should meet the specifications. The inspection method comprises the following steps: 10 bags (bottles) of the test article were taken, the package was removed, the weight of the content in each bag (bottle) was weighed, and the bag content and the average content of the content in each bag (bottle) were determined. The amount of each bag (bottle) is compared with the average amount of each bag (no content measured granule or marked granule, the amount of each bag (bottle) should be compared with the marked amount of each bag), and the amount of each bag (bottle) is not more than 2 bags, and not more than 1 bag is 1 time of the amount of each bag.
TABLE 1 Standard for load variation
[ LOADING ] the granules packed in multiple doses were checked by the minimum filling inspection method (general rule 0942) and were in compliance with the regulations.
[ microbial Limit ] according to the non-sterile product microbial Limit test method: the microorganism count method (general rule 1105), the controlled bacteria inspection method (general rule 1106) and the non-sterile drug microorganism limit standard (general rule 1107) are required to meet the regulations.
2. The quality standard inspection basis of each variety is as follows: the prescription of decoction pieces of Mongolian medicine in inner Mongolia (2020 edition) is specified under the same name decoction piece. The inspection bases of the Mongolian medicine powder formula particles are as follows:
(2) wolfberry fruit granules (character) this product is a yellow-brown to reddish-brown granule. Light smell and sweet taste. [ IDENTIFICATION ] 0.5g of the product is taken, 35ml of water is added, the mixture is heated and boiled for 15 minutes, the mixture is cooled and filtered, the filtrate is extracted by 15ml of ethyl acetate through shaking, and ethyl acetate solution is respectively taken and concentrated to 1ml to be used as test solution. Taking 0.5g of fructus Lycii as reference material, and making into reference material solution by the same method. Performing thin layer chromatography (general rule 0502) test, sucking 5 μ l of the above two solutions, respectively dropping on the same silica gel G thin layer plate, and using ethyl acetate-chloroform-formic acid (3:2:1) as developing agent. Developing, taking out, air drying, and inspecting under ultraviolet lamp (365 nm). The test chromatogram shows the same color of fluorescent spot at the corresponding position of the control chromatogram (as shown in FIG. 1). [ EXTRACT ] is not less than 40.0% as measured by hot dipping method under item of water soluble EXTRACT assay (general rule 2201).
The results of the tests on the wolfberry granules are shown in table 2.
TABLE 2 examination of the medlar powder formula granules
The properties of the medlar powder formula particle and medlar powder are compared in a table 3, and the results show that: after the powder formula particles are prepared, the angle of repose is reduced by 26.1 degrees, which indicates that the fluidity is increased and the divided dose is accurate; an increase in the critical relative humidity CRH value of 6% indicates a decrease in hygroscopicity and an increase in stability; the palatability is improved, and the clinical administration compliance is improved. In addition, the hardness and brittleness of the particles are ideal, and the particles are convenient to subpackage, transport, store and use.
TABLE 3 comparison of the properties of the powder and granules of Lycium barbarum
Example 2
Preparation of dwarf lilyturf tuber powder formula granules
Weighing 35kg radix Ophiopogonis decoction pieces, pulverizing at-20 deg.C, sieving with electromagnetic vibration sieve to obtain powder containing saccharide Mongolian medicinal materials, sieving with 100 mesh sieve, and collecting sieved fraction to obtain 34.0kg radix Ophiopogonis powder.
Mixing 7.5kg of radix Ophiopogonis powder, 1.5kg of dextrin and 1.0kg of starch in a swing mixer for 30min to obtain a mixed material. And (3) mixing the mixed material with about 2.5L of ethanol with the volume percentage content of 85%, reducing the viscosity of the material, putting the mixture into a granulator for wet granulation, carrying out 14-16-mesh granulation, drying at 60 ℃ for 1h, and carrying out 18-20-mesh granulation.
Packaging and quality testing the prepared dwarf lilyturf tuber powder formula particles; the packaging material is a nationally specified medicinal transparent polyethylene bottle or medicinal PVC special bag, and the specification is 250-300 g/bottle or 250-300 g/bag.
The results of the testing of the ophiopogon japonicus granules are shown in table 4.
TABLE 4 radix Ophiopogonis granule test results
TABLE 5 comparison of the characteristics of Mai Dong powder and Mai Dong granules
Example 3
Preparation of emblic leafflower fruit powder formula granules
Weighing 35kg of emblic leafflower fruit decoction pieces, crushing at minus 20 ℃, sieving sugar-containing mongolian medicine decoction piece powder with strong viscosity by using an electromagnetic vibrating screen, sieving by using a 100-mesh sieve, and collecting undersize components to obtain 33.5kg of emblic leafflower fruit powder.
Mixing 7.5kg of emblic leafflower fruit powder, 1.6kg of dextrin and 0.9kg of starch in a swing mixer for 30min to obtain a mixed material. And (3) mixing the mixed material with about 2.5L of ethanol with the volume percentage content of 85%, reducing the viscosity of the material, putting the mixture into a granulator for wet granulation, carrying out 14-16-mesh granulation, drying at 60 ℃ for 1.5h, and finishing granules of 18-20 meshes.
Packaging and quality testing the prepared emblic leafflower fruit powder formula particles; the packaging material is a nationally specified medicinal transparent polyethylene bottle or medicinal PVC special bag, and the specification is 250-300 g/bottle or 250-300 g/bag.
The results of the examination of the particles of emblic leafflower fruit are shown in table 6.
TABLE 6 Phyllanthus emblica fruit granule test results
TABLE 7 comparison of the properties of Phyllanthus emblica powder and Phyllanthus emblica granules
Example 4
Preparation of Pingbei mother powder formula granules
Weighing Bulbus Fritillariae Ussuriensis decoction pieces 35kg, pulverizing at-20 deg.C, sieving with electromagnetic vibration sieve to obtain Mongolian medicinal beverage powder containing saccharide with strong viscosity, sieving with 100 mesh sieve, and collecting sieved components to obtain Bulbus Fritillariae Ussuriensis powder 33.5 kg.
7.5kg of fritillary powder, 1.6kg of dextrin and 0.9kg of starch are mixed in a swing mixer for 30min to obtain a mixed material. And (3) mixing the mixed material with about 2.5L of ethanol with the volume percentage content of 85%, reducing the viscosity of the material, putting the mixture into a granulator for wet granulation, carrying out 14-16-mesh granulation, drying at 60 ℃ for 1.2h, and finishing granules of 18-20 meshes.
Packaging and quality inspection are carried out on the prepared Pingbei mother powder formula particles; the packaging material is a nationally specified medicinal transparent polyethylene bottle or medicinal PVC special bag, and the specification is 250-300 g/bottle or 250-300 g/bag.
The test results of fritillary bulb granules are shown in table 8.
TABLE 8 fritillary bulb granule test results
TABLE 9 comparison of properties of Pingbu Bei mu san and Pingbu Bei mu Li Ke Li
Comparative example 1
Influence of auxiliary material dosage on material formability
The auxiliary material dextrin is easy to dissolve in boiling water, and has good compressibility and moldability. The 15% dextrin is used as the auxiliary material of Mongolian medicine wolfberry powder formula granules, so that the viscosity of the Mongolian medicine containing much carbohydrate can be reduced, and the compressibility and formability of the material can be improved. The 10% starch is used as a bonding agent to facilitate the wet granulation process; a proper amount of 85% ethanol solution is used as a wetting agent, so that the viscosity of materials can be reduced and improved, and the preparation of soft materials and the formability of granules are facilitated. The amount of dextrin and starch has a great influence on the granulation result of the Mongolian medicine medlar powder formula granules. The results of the experiment are shown in Table 10.
TABLE 10 influence of different proportions of auxiliary materials on the moldability of the materials
The experimental results show that: when the Chinese wolfberry powder is used: dextrin: the medlar powder formula particle prepared when the starch is 75:14:11 has small angle of repose, good fluidity and lubricity and high particle yield.
Comparative example 2
Influence of auxiliary material type on material formability
Wolfberry powder granules were prepared according to the method of example 1, except that dextrin in the adjuvant was replaced with starch, calcium phosphate, calcium sulfate, talc and lactose, respectively, and the angle of repose, CRH value and granule yield of the prepared wolfberry powder granules were measured, and the results are shown in table 11.
TABLE 11 influence of different auxiliary materials on the moldability of the materials
The results show that: after the auxiliary materials are replaced, the prepared medlar powder formula particle has large angle of repose, small CRH value, low particle yield and poor material formability.
Comparative example 3
Comparison of influence of wolfberry fruit crushing temperature on material crushing effect
The wolfberry fruits were pulverized at different temperatures, and the pulverization effect is shown in table 12.
TABLE 12 influence of different Low temperature conditions on the crushing efficiency
From the above results, it is understood that the pulverization effects at-20 ℃ and-40 ℃ are equivalent, and it is most reasonable to employ low-temperature pulverization at-20 ℃ from the viewpoint of energy saving.
According to the embodiment, the sugar-containing Mongolian medicine powder formula particles provided by the invention are novel particles with uniform specification, uniform dosage and uniform dosage form standard, the quality controllability and stability of Mongolian medicine decoction pieces are comprehensively improved, and the safety and effectiveness of Mongolian medicine are ensured.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The sugar-containing Mongolian medicine powder formula particle is characterized by comprising sugar-containing Mongolian medicines and auxiliary materials, wherein the auxiliary materials comprise dextrin and starch; the mass ratio of the sugar-containing Mongolian medicine to the dextrin to the starch is (73-77) to (14-16) to (9-11); the mass percentage of the sugar-containing Mongolian medicine in the sugar-containing Mongolian medicine powder formula particles is 74.9-75.1%.
2. The sugar-containing Mongolian medicine powder formula particle as claimed in claim 1, wherein the sugar content of the sugar-containing Mongolian medicine is more than 10%, and the mass ratio of the sugar-containing Mongolian medicine, dextrin and starch is (74.5-75.5): (13.5-14.5): (10.5-11.5).
3. The sugar-containing Mongolian medicine powder formula particle as claimed in claim 1, wherein the sugar content of the sugar-containing Mongolian medicine is 5-10%, and the mass ratio of the sugar-containing Mongolian medicine, dextrin and starch is (74.5-75.5): (14.5-15.5): (9.5-10.5).
4. The sugar-containing Mongolian medicine powder formula granule as claimed in claim 1, wherein the sugar content of the sugar-containing Mongolian medicine is less than 5%, and the mass ratio of the sugar-containing Mongolian medicine, dextrin and starch is (74.5-75.5): (15.5-16.5): (8.5-9.5).
5. The sugar-containing Mongolian powder formulation granule according to any one of claims 1 to 4, wherein the angle of repose of the sugar-containing Mongolian powder formulation granule is 37.5 to 40.1 °, the water content is 9% or less, and the CRH value is 61 to 65.
6. The sugar-containing Mongolian medicine powder formula granule according to any one of claims 1 to 4, wherein the sugar-containing Mongolian medicine is selected from one of wolfberry, white grape, persimmon, sea buckthorn paste, fructus Thladianthae Dubiae, syzygium jambos, hawthorn, pomegranate, radix Ophiopogonis, radix asparagi, rhizoma Polygonati, milk rhizoma Polygonati, rhizoma Polygonati Odorati, milk rhizoma Polygonati Odorati, Mirabilis jalapa, lily, fructus Choerospondiatis, herba cistanches, fructus Phyllanthi, fructus Schisandrae chinensis, dried sour pear, ginseng, papaya, fried water caltrop, dried garlic, fructus Chebulae, Torreya grandiflora, fritillary bulb, Fritillaria thunbergii, Lychnis, lotus seed, mango seed, sword bean, shinyleaf yellowhorn paste, fried rice, lalang grass rhizome and rhizoma arisaemati.
7. The method for preparing the sugar-containing Mongolian medicine powder formula granule of any one of claims 1 to 6, comprising the following steps:
1) crushing the sugar-containing Mongolian medicine at low temperature to obtain sugar-containing Mongolian medicine powder, wherein the temperature of the low-temperature crushing is-21 ℃ to-19 ℃;
2) mixing the sugar-containing Mongolian powder, dextrin and starch, wetting by using 83-87% of ethanol by volume percentage, and performing wet granulation to obtain the sugar-containing Mongolian powder formula granule.
8. The method of claim 6, wherein the cryogenically pulverizing of step 1) further comprises: and sieving the obtained crushed material by a sieve of 100-140 meshes, wherein the sieved component is sugar-containing Mongolian powder.
9. The method according to claim 6, wherein the wet granulation in the step 2) comprises granulation, drying and size stabilization, the granulation has a mesh size of 14 to 16 mesh, the drying temperature is 55 to 65 ℃, and the size of the size stabilization is 18 to 20 mesh.
10. The method according to claim 6, wherein the mixing time in the step 2) is 25 to 35 min.
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711913A (en) * | 2005-06-20 | 2005-12-28 | 甘肃祁连山生物科技开发有限责任公司 | Anti-fatigue health-care food and production thereof |
| CN1724033A (en) * | 2005-06-20 | 2006-01-25 | 甘肃祁连山生物科技开发有限责任公司 | Health-care food having functions of retarding-senility and regulating-immunity, and its prepn. method |
| CN101116722A (en) * | 2006-08-01 | 2008-02-06 | 天津市轩宏医药技术有限公司 | Pharmaceutical formulations with the raw material containing panax, ophiopogon root and schisandra fruit, processes for their preparation, the raw material and the quality control method for the prepa |
| US20130123212A1 (en) * | 2010-07-27 | 2013-05-16 | Changjiang Xu | Anti-fatigue composition, formulation and use thereof |
| CN104352745A (en) * | 2014-10-29 | 2015-02-18 | 磐安县道地磐药中药研究所 | Fritillaria superfine powder as well as preparation method and application thereof |
| CN104435657A (en) * | 2013-11-13 | 2015-03-25 | 程惠华 | Medicine for preventing and treating side effects of hormone deprivation therapy and preparation method of medicine |
| CN106473038A (en) * | 2016-09-18 | 2017-03-08 | 天津北洋百川生物技术有限公司 | A kind of Herba Cistanches health-care tablet and preparation method thereof |
| CN108272998A (en) * | 2018-04-26 | 2018-07-13 | 内蒙古医科大学 | A kind of Mongolian compound preparation and preparation method thereof for treating insomnia |
| CN108837044A (en) * | 2018-09-06 | 2018-11-20 | 广东新南方青蒿药业股份有限公司 | A kind of lower blood-fat and reduce weight capsule and preparation method thereof |
| CN112370514A (en) * | 2020-11-24 | 2021-02-19 | 祈蒙股份有限公司 | Granular composition for harmonizing stomach and strengthening spleen and preparation method thereof |
| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
| CN113057999A (en) * | 2021-03-26 | 2021-07-02 | 王玉华 | Resin Mongolian medicine powder formula granule and preparation method thereof |
-
2021
- 2021-03-26 CN CN202110324381.9A patent/CN113041225B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711913A (en) * | 2005-06-20 | 2005-12-28 | 甘肃祁连山生物科技开发有限责任公司 | Anti-fatigue health-care food and production thereof |
| CN1724033A (en) * | 2005-06-20 | 2006-01-25 | 甘肃祁连山生物科技开发有限责任公司 | Health-care food having functions of retarding-senility and regulating-immunity, and its prepn. method |
| CN101116722A (en) * | 2006-08-01 | 2008-02-06 | 天津市轩宏医药技术有限公司 | Pharmaceutical formulations with the raw material containing panax, ophiopogon root and schisandra fruit, processes for their preparation, the raw material and the quality control method for the prepa |
| US20130123212A1 (en) * | 2010-07-27 | 2013-05-16 | Changjiang Xu | Anti-fatigue composition, formulation and use thereof |
| CN104435657A (en) * | 2013-11-13 | 2015-03-25 | 程惠华 | Medicine for preventing and treating side effects of hormone deprivation therapy and preparation method of medicine |
| CN104352745A (en) * | 2014-10-29 | 2015-02-18 | 磐安县道地磐药中药研究所 | Fritillaria superfine powder as well as preparation method and application thereof |
| CN106473038A (en) * | 2016-09-18 | 2017-03-08 | 天津北洋百川生物技术有限公司 | A kind of Herba Cistanches health-care tablet and preparation method thereof |
| CN108272998A (en) * | 2018-04-26 | 2018-07-13 | 内蒙古医科大学 | A kind of Mongolian compound preparation and preparation method thereof for treating insomnia |
| CN108837044A (en) * | 2018-09-06 | 2018-11-20 | 广东新南方青蒿药业股份有限公司 | A kind of lower blood-fat and reduce weight capsule and preparation method thereof |
| CN112370514A (en) * | 2020-11-24 | 2021-02-19 | 祈蒙股份有限公司 | Granular composition for harmonizing stomach and strengthening spleen and preparation method thereof |
| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
| CN113057999A (en) * | 2021-03-26 | 2021-07-02 | 王玉华 | Resin Mongolian medicine powder formula granule and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 乌日娜，等: "复方沙棘颗粒剂的喷雾干燥工艺优选", 《中国实验方剂学杂志》 * |
| 张影，等: "复方人参颗粒剂的制备工艺及活性研究", 《黑龙江农业科学》 * |
| 张淑丹，等: "不同药用辅料对枸杞颗粒吸湿性及成型性的影响", 《中成药》 * |
| 高琦瑛，等: "蒙药宝日扫日劳-8颗粒成型工艺的研究", 《中国民族医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
| CN112891377B (en) * | 2021-03-26 | 2023-09-19 | 那生桑 | Precious fine Mongolian medicinal powder formula granule and preparation method thereof |
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