CN106692687A - Quality improvement process for Mongolian medicine gymnadenia conopsea tuber - Google Patents
Quality improvement process for Mongolian medicine gymnadenia conopsea tuber Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention relates to a processing method of pharmaceuticals, namely a quality improvement process for Mongolian medicine gymnadenia conopsea tuber. The quality improvement process is characterized by comprising the following step: mixing gymnadenia conopsea tuber with milk to obtain milk gymnadenia conopsea tuber or milk gymnadenia conopsea tuber powder. The quality improvement process has the beneficial effects of obviously improving the medical effect of gymnadenia conopsea tuber, and being simple and convenient in process and low in cost, thereby being expected to become a first choice of process for processing gymnadenia conopsea tuber; raw materials are easy to obtain.
Description
Technical field
The present invention relates to a kind of processing method of medicine, i.e., a kind of anaesthetic hand ginseng process for upgrading.
Background technology
Hand ginseng is the ripe dry tuber of orchid hand ginseng Gymnadenia conopsea (L.) R. Br., is to cover
Doctor's conventional crude drugs, anaesthetic name " E and rise how-loud, high-pitched sound day ", with relieving cough and asthma, Yishen Jianpi, qi-regulating and blood, analgesic, nourishing is strong
The effects such as body.But, the usage of current hand ginseng is relatively simple, mostly plays powder life and uses or fried be used as medicine.Anaesthetic ancient books once has sheep
Milk cooks hand ginseng and says, but has no and spread.In addition ewe's milk amount is few, not easily collecting, does not form industry, and application prospect is failed to understand
It is bright, further investigation that so far there are no.Find that existing application method can't give full play to the medicine of hand ginseng through the analysis of opponent's ginseng composition
Effect, the therapeutic effect of hand ginseng is remained in larger space.
The content of the invention
It is an object of the invention to provide a kind of drug effect that can give full play to hand ginseng, and simple and easy to do anaesthetic hand ginseng upgrading
Technique.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic hand ginseng process for upgrading is provided, is characterized in：Hand is joined
Milk hand ginseng or milk hand ginseng powder are mixed and made into milk.
The milk hand ginseng is that handle participates in milk with 100：95-105 weight is than mixing, and immersion 7.8-8.2 is small
When, it is cooked by slow fire 1.8-2.2 hours, taking-up is dried and is formed.
In the immersion process, handle ginseng and milk load autoclave, are filled with gas at normal temperature and are pressurized to 0.2-0.3MPa,
Pressurize more than 2 hours again, while with the ultrasonic vibration more than 30 minutes of more than 22KHZ, then with being cooked by slow fire.
In the immersion process, handle ginseng and milk load autoclave, are filled with gas at normal temperature and are pressurized to 0.2-0.3MPa,
Pressurize 30 minutes, take out hand ginseng, be put into cryogenic vacuum bulking machine, be pressurized to 0.5-0.6MPa, temperature control below 120 DEG C,
Decompression is produced, then sends autoclave back to, is pressurized to 0.2-0.3MPa in milk, then pressurize more than 2 hours.Again simultaneously with 22KHZ
More than ultrasonic vibration more than 30 minutes, then with being cooked by slow fire.
The milk hand ginseng is that handle participates in milk with 100：65-75 weight squeezes into normal temperature than loading autoclave by air pump
To 0.5-0.8MPa, pressurize 2.2-2.5 hours is depressurized to 0.2MPa and is heated to 90-110 DEG C, insulation 0.8-1.2 gas
Hour, taking-up is dried and is formed.
Milk hand ginseng is that handle ginseng is flooded and soaked in milk 20-30 minutes, cryogenic vacuum is put into after taking-up expanded
Machine, squeezes into gas at normal temperature to 0.2-0.22MPa, pressurize 1.2-1.5 hours, 80-120 DEG C of temperature control, it is pressurized to 0.5-
0.6MPa, decompression is produced, then is flooded and be heated to 80-100 DEG C in milk, and slow fire is incubated 20-30 minutes, bleeds off unnecessary ox
Milk, slow fire dryouies.
The milk hand ginseng is that handle ginseng is flooded in milk, and ultrasonic vibration 20-30 minutes is put into cryogenic vacuum after taking-up
Bulking machine, squeezes into gas at normal temperature to 0.2-0.22MPa, and pressurize 1.2-1.5 hours, temperature control is pressurized to 80-120 DEG C
0.5-0.6MPa, decompression is produced, then is flooded and be heated to 80-100 DEG C in milk, ultrasonic vibration and slow fire is incubated 20-30 points
Clock, bleed off unnecessary milk, and slow fire dryouies.
The milk hand ginseng is that handle ginseng is flooded in milk, and heat boils ultrasonic vibration simultaneously 20-30 minutes, is put into after taking-up
Cold extraction tank, cold extraction 10-15 minutes below-180 DEG C, taking-up is put into cryogenic vacuum bulking machine, squeeze into gas at normal temperature to 0.2-
0.22MPa, pressurize 1.2-1.5 hours, temperature control is pressurized to 0.5-0.6MPa to 80-120 DEG C, and decompression is produced, then flood into
80-100 DEG C are heated in milk, simultaneously slow fire is incubated 20-30 minutes for ultrasonic vibration, bleeds off unnecessary milk, and slow fire takes after dryouting
Go out to be put into cold extraction tank, cold extraction 10-15 minutes below-180 DEG C,.
The milk hand ginseng powder is milk hand ginseng to be crushed the fine powder obtained by No. 6 sieves.
The milk hand ginseng powder is that handle ginseng is ground into fine powder, crosses No. 6 sieves and adds skimmed milk power, and powder is joined with hand：Skimmed milk power=
100：25-35 weight portion is mixed.
After the hand ginseng powder mixes with skimmed milk power, microcrystalline cellulose is added to mix to fluffy.
The milk hand ginseng powder is that handle ginseng is ground into powder, then joins powder with hand：Milk is with 100：75-85 weight is than mixing
Stirring, soaks 3.8-4.2 hours, is cooked by slow fire 0.9-1.2 hours, dry.
The milk hand ginseng powder is that handle ginseng is crushed and milk, with 100：55-65 weight ratio is mixed, in ultrasonic wave
The lower immersion of vibration 0.8-1.2 hours, is cooked by slow fire 0.5-0.6 hour, drying and dehydrating.
The beneficial effects of the invention are as follows：The drug effect of hand ginseng is significantly increased, and raw material is easy to get, technique is easy, with low cost, can
Hope the first-selected technique processed as hand ginseng.
Specific embodiment
The first embodiment：Produce milk hand ginseng.Choose hand ginseng finished product：Hand ginseng finished product is in bulk, slightly flat, shape such as palm, long 1
~4.5cm, 1~3cm of diameter.Surface is light yellow or burgundy, there is fine wrinkle, and there is stem residue on top, there is point-like root trace around it；
2~12 finger-like branches, 0.3~2.5cm of long branch, 2~8mm of diameter are arranged at bottom.Matter is hard, is not easily broken.Section yellow-white,
Cutin sample.Gas is micro-, lightly seasoned, the stickness chewed.
Handle joins finished product with milk with 100：95-105 weight ratio, preferably 100：100, mixing and stirring, immersion
7.8-8.2 hours, preferably 8 hours, also can constantly be stirred in immersion process or interval stirring, make what milk tried one's best to melt
In the middle of ginseng of starting with, then with being cooked by slow fire 1.8-2.2 hours, take out and dry.The slow fire is to instigate heating liquid to be in most
The thermal source of low fluidized state.Milk used should meet national standard.Milk hand ginseng surface yellow or the crineous produced, somewhat milk
Fragrance, it is lightly seasoned.Determined according to regulation method：Moisture is no more than 6.0%, and total ash is no more than 7.0%, and extract is no less than
20.0%.Milk hand ginseng dry product is containing total reducing sugar with glucose（C6H12O6) meter, no less than 10%.Containing polysaccharide with glucose（C6H12O6) meter,
No less than 6%.
Total reducing sugar and Methods in Determination of Polysaccaride Content：According to UV-VIS spectrophotometry（Chinese Pharmacopoeia version the 4th in 2015 is led to
Then 0401) determine.
1) total reducing sugar：It is appropriate to the DEXTROSE ANHYDROUS reference substance of constant weight that the preparation of reference substance solution takes drying, accurately weighed,
Plus distilled water is made solution of every lml containing 1.0 m g, obtains final product.
The preparation precision of standard curve measures the 5ml of reference substance solution 0., 1. 1.0ml, 5ml, 2. 0ml, 2. 5ml, point
Do not put in 50ml measuring bottles, respectively add water to scale, shake up.Precision measures above-mentioned solution 2ml respectively, in putting tool plug test tube, each precision
5% phenol solution 1ml is added, is shaken up, it is rapid accurate to add sulfuric acid 5ml, shake up, to put and be incubated 30 minutes in 40 °C of water-baths, take out,
Room temperature is rapidly cooled to, with corresponding reagent as blank, according to UV-VIS spectrophotometry（General rule 0401), in the ripple of 490nm
Strong point mensuration absorbance, with absorbance as ordinate, concentration is abscissa, draws standard curve.
Determination method：Take this product powder（Cross No. six sieves）About 0.5 g, it is accurately weighed, put in round-bottomed flask, add water 50 ml, plus
Heat backflow 1 hour, is let cool, then weighed weight, and the weight of less loss is supplied with water, is shaken up, and is filtered, and precision measures subsequent filtrate 1ml, puts
In 100ml measuring bottles, scale is added water to, shaken up, precision measures 25ml, put in 50ml measuring bottles, add water to scale, shaken up, precision amount
2ml is taken, is put in tool plug test tube, the method under sighting target directrix curve preparation from " 5% phenol solution 1ml ", determines extinction in accordance with the law
Degree, the weight of glucose from need testing solution is read on standard curve（mg）, calculate, obtain final product.
2) polysaccharide：This product polyoses content is by content of reducing sugar in determination sample, then subtracts reduced sugar by total sugar content
Cubage is obtained.
The preparation of reference substance solution：The DEXTROSE ANHYDROUS reference substance that drying is taken to constant weight is appropriate, accurately weighed, plus distilled water
Solution of every lml containing 1.0 m g is made, is obtained final product.
The preparation of standard curve：Precision measures reference substance solution 0.1ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.6 ml, point
Do not put in 10ml tool plug test tubes, respectively adding water makes into 3ml, it is each it is accurate add DNS test solution 2ml, to put and heat 8min in boiling water bath, take
Go out, be rapidly cooled to room temperature, scale is settled to water, with corresponding reagent as blank, according to UV-VIS spectrophotometry（It is logical
Then 0401), the mensuration absorbance at the wavelength of 494nm, with absorbance as ordinate, concentration is abscissa, draws standard curve.
The determination method of reduced sugar：Take this product powder（Cross No. six sieves）About 0.5 g, it is accurately weighed, put in round-bottomed flask, add water
50 ml, are heated to reflux 1 hour, let cool, then weighed weight, and the weight of less loss is supplied with water, are shaken up, and filtration, precision measures continuous filter
Liquid 2.5ml, puts in 10ml tool plug test tubes, and from " respectively adding water makes into 3ml ", mensuration absorbance, reads from standard curve in accordance with the law
The weight of glucose in need testing solution（mg）, calculate, obtain final product content of reducing sugar.
Polyoses content=total sugar content-content of reducing sugar.
Experiment Introduction
1. the drug effect difference of green hand's ginseng is participated in for clear and definite milk hand, substantial amounts of experiment has been carried out.Including to Silicotic rats model,
The contrast experiment that chronic pneumonia rat model and aging model are carried out.Silicotic rats model experiment is seen by pulmonary morphology
Examine, SOD water in expression, the blood of inflammatory factor TNF-a, IL-6 in LPO and iNOS levels, blood in lung organ index, urine
Flat, lung tissue LN levels, the detection of pathologic form, it was demonstrated that milk hand ginseng reduces Silicotic rats lung organ index, suppresses body
Internal oxidition material produce, lower blood in various inflammatory factor expression high, improve blood in activities of antioxidant enzymes, suppress lung tissue
The effect that middle level sticks connection albumen is significantly stronger than green hand's ginseng, and can more effectively reduce inflammation reaction, suppress lung caused by collagen deposition
Fibrosis, mitigates the pulmonary lesion that silicious dust is caused.Chronic pneumonia rat model is referred to by General observation and lungs device
Number, TNF-a, IL-1, IL-8, lung tissue LN levels, pathologic Morphology observation in inflammatory cell, blood in BALF, it was demonstrated that
Various inflammatory factors in number of inflammatory cells, downward BALF in milk hand ginseng reduction chronic pneumonia induced lung organ index, reduction BALF
The effect that height expression and suppression lung tissue middle level stick connection protein content is more more notable than hand ginseng health product, can more effectively reduce inflammation
Reaction.Aging model experiment by water maze and the detection of diving tower ability of learning and memory, organ index detection, brain tissue SOD,
The detection of MDA expressions, brain tissue pathology change's detection, hippocampus APP, Tau immunohistochemical staining interpretation of result, it was demonstrated that milk hand
The effect that ginseng improves mouse aging cerebral index, Immune Organs Index and ability of learning and memory is significantly better than green hand's ginseng.
2. technological parameter experiment：To milk amount, soak time, duration is decocted as three factors, if two levels, with small
Mouse swimming time is evaluation index, from L4(23) orthogonal, Optimizing Technical.As a result：Hand ginseng medicinal material such as adds at the fresh ox of weight
Milk, is stirred, and soaks 8 hours, is cooked by slow fire 2 hours, and taking-up is dried for optimal, and display soak time has notable shadow
Ring.Particularly：With the reduction of milk consumption, drug effect is also decreased, and when milk consumption is reduced to 60%, significantly falling occurs in drug effect
Difference.I.e. hand is joined：Milk=100:100 join with hand：Milk >=100:60 have significant difference.
3. clinical trial 36, patient is weakness due to chronic disease person, including waist and leg ache, " Ba Mu " disease, swim pain, " pottery relies "
Disease etc..With hand ginseng be control, hand ginseng and milk hand ginseng for etc. weight dry product, consumption be 0.5~1g/ times, decoct soup is taken.Examined with suiting the medicine to the illness
Survey and patient's private prosecution is foundation, it was demonstrated that the effective time of the milk hand reference hand ginseng of equivalent averagely shortens 30.6%, Synthetic curative effect
Fruit significantly increases.
Second embodiment：It is improved on the basis of the first embodiment.Handle joins finished product with milk with 100：
95-105 weight ratio, preferably 100：100, mixing and stirring is soaked 7.8-8.2 hours, preferably 8 hours, is being soaked
Cheng Zhong, handle ginseng and milk load autoclave, are filled with gas at normal temperature and are pressurized to 0.2-0.3MPa, then pressurize more than 2 hours, together
When with the ultrasonic vibration more than 30 minutes of more than 22KHZ, then with being cooked by slow fire 1.8-2.2 hours, taking-up is dried.
Contrast experiment proves that the indices of this example product are significantly better than that the product of the first embodiment.According to another 30
Clinical comparison experiment finds that the product of the present embodiment is higher than the product amount of cure of the first embodiment, by clinical observation with
And patient's readme is proved, this product paresthesia alleviateding time advances to 10 days in average 14 days than control, and symptom is clearly better by right
According to be reduced to 26 days within average 32 days.
The third embodiment：It is improved on the basis of second embodiment, increased puffing process.Handle joins finished product
With milk with 100：95-105 weight ratio, preferably 100：100, mixing and stirring is soaked 7.8-8.2 hours, and preferably 8 is small
When.In immersion process, handle ginseng and milk load autoclave, are filled with gas at normal temperature and are pressurized to 0.2-0.3MPa, 30 points of pressurize
Clock, takes out hand ginseng, appropriate to dry, and is put into cryogenic vacuum bulking machine, is pressurized to 0.5-0.6MPa, temperature control 120 DEG C with
Under, decompression is produced, then sends autoclave back to, is pressurized to 0.2-0.3MPa in milk, then pressurize more than 2 hours.While with
The ultrasonic vibration of more than 22KHZ more than 30 minutes, then with being cooked by slow fire 1.8-2.2 hours, taking-up is dried.
It is control with second product of embodiment, is tested by 22 clinical comparisons, finds the product ratio of the present embodiment
The product amount of cure of second embodiment is higher, and by clinical observation and patient's readme is proved, this product Average symptom is alleviated
What Time transfer receiver shone advances to 8 days for 10 days, and symptom is clearly better and be reduced to 21 days by 26 days compareed.Enter especially for minority
Mend relatively difficult, it is necessary to take medicine for a long time, the patient with severe symptoms and patient worn with age for resting that be discontinued are needed during medication, this
The product of embodiment is gentleer, easily absorbs, and without sense of discomfort, is rested without being discontinued, and therapeutic effect is especially prominent.
4th kind of embodiment：On the basis of previous embodiment, the reparation technology of milk hand ginseng is further explored, mainly in drop
It is low to use milk amount, shorten the aspects such as Production Time and carry out experiment and grope, finally select following scheme：Handle participates in milk with 100：
65-75 weight squeezes into gas at normal temperature to 0.5-0.8MPa than loading autoclave by air pump, and pressurize 2.2-2.5 hours subtracts
It is pressed onto 0.2MPa and adjusts temperature to 90-110 DEG C again, be incubated 0.8-1.2 hours, taking-up is dried and formed.
Quality through checking product meets the standard of the first embodiment, the experiment proved that drug effect and the first embodiment without
Significant difference, but process time significantly shorten, production cost is greatly reduced, be conducive to milk hand join industrialized production.
5th kind of embodiment：On the basis of previous embodiment, the reparation technology of milk hand ginseng is further explored, mainly in drop
It is low to use milk amount, shorten the aspects such as Production Time and carry out experiment and grope.Finally select following scheme：Handle ginseng is flooded in milk and is soaked
Wet 20-30 minutes, cryogenic vacuum bulking machine is put into after taking-up, squeezes into gas at normal temperature to 0.2-0.22MPa, pressurize 1.2-1.5
Hour, 80-120 DEG C of temperature control is pressurized to 0.5-0.6MPa, and decompression is produced, and hand ginseng volumetric expansion is in cellular, then is flooded into ox
It is heated to 80-100 DEG C in milk, slow fire is incubated 20-30 minutes, bleeds off unnecessary milk, slow fire dryouies.
The slow fire is the thermal source for instigating heating liquid to be in minimum fluidized state.Milk used should meet national mark
Standard, finally calculates milk hand ginseng：Milk=100：70—80.Milk hand ginseng surface yellow or the crineous produced, somewhat milk fragrance, taste
It is light.Determined according to regulation method：Moisture is no more than 6.0%, and total ash is no more than 7.0%, and extract is no less than 20.0%.Milk hand
Ginseng dry product is containing total reducing sugar with glucose（C6H12O6) meter, no less than 10%.Containing polysaccharide with glucose（C6H12O6) meter, no less than 6%.
Quality inspection method and pharmacological experimental method are identical with the first embodiment.
Experiment shows, drug effect and the first embodiment no significant difference, but significantly lowered with milk amount, and the time of processing is significantly
Shorten, production cost is substantially reduced, the industrialized production for being conducive to milk hand to join.
6th kind of embodiment：On the basis of previous embodiment, the reparation technology of milk hand ginseng is further explored, mainly in drop
It is low to use milk amount, shorten the aspects such as Production Time and carry out experiment and grope.Filter out following scheme：Handle ginseng is flooded in milk,
The ultrasonic vibration of more than 22KHZ 20-30 minutes, is put into cryogenic vacuum bulking machine after taking-up, squeeze into gas at normal temperature to 0.2-
0.22MPa, pressurize 1.2-1.5 hours, is heated to 80-120 DEG C, is pressurized to 0.5-0.6MPa, and decompression is produced, hand ginseng volume
Expansion is in cellular, then floods and be heated to 80-100 DEG C in milk, and the ultrasonic vibration of more than 22KHZ and slow fire insulation 20-
30 minutes, bleed off unnecessary milk, slow fire dryouies.
The slow fire is the thermal source for instigating heating liquid to be in minimum fluidized state.Milk used should meet national mark
It is accurate.Finally calculate milk hand ginseng：Milk=100：70—85.Milk hand ginseng surface yellow or the crineous produced, somewhat milk fragrance, taste
It is light.Determined according to regulation method：Moisture is no more than 6.0%, and total ash is no more than 7.0%, and extract is no less than 20.0%.Milk hand
Ginseng dry product is containing total reducing sugar with glucose（C6H12O6) meter, no less than 10%.Containing polysaccharide with glucose（C6H12O6) meter, no less than 6%.
Quality inspection method and pharmacological experimental method are identical with the first embodiment.
Experiment shows that drug effect significantly shortens with the indices of the first embodiment without significant difference, but the time of processing,
Production cost is substantially reduced, the industrialized production for being conducive to milk hand to join.
7th kind of embodiment：The milk hand ginseng is that handle ginseng is flooded in milk, and the ultrasound that heat boils more than 22KHZ simultaneously is shaken
It is dynamic 20-30 minutes, the cold extraction tank of liquid nitrogen is put into after taking-up, below-180 DEG C, cold extraction 10-15 minutes, taking-up is put into controllable temperature
Cryogenic vacuum bulking machine, squeeze into gas at normal temperature to 0.2-0.22MPa, pressurize 1.2-1.5 hours, temperature control to 80-120 DEG C,
0.5-0.6MPa is pressurized to, decompression is produced, then floods 80-100 DEG C, the ultrasonic vibration of more than 22KHZ are heated in milk
And slow fire is incubated 20-30 minutes, unnecessary milk is bled off, slow fire takes out after dryouting and is put into cold extraction tank, the cold extraction below-180 DEG C
10-15 minutes, take out.
It is observed that the hand for crossing low temperature cold extraction participate in milk combine it is even closer, and more resistant to storage, extended shelf-life 20%
More than.Through zoopery and clinical trial certificate, it is remarkably reinforced than the various embodiments described above through the milk hand ginseng drug effect of supercooling extraction, and
With significant difference.
8th kind of embodiment：Milk hand ginseng powder is produced, the milk hand that previous embodiment is produced joins powder processed, crosses No. 6 sieves, that is, be made
Milk hand joins powder.Milk hand joins powder for yellow-white powder, somewhat milk fragrance, lightly seasoned.Moisture is no more than 6.0%.Total ash is no more than
7.0%.Extract is no less than 20.0%.Microscopical characters：Hand ginseng powder is in light yellow, and amylum body is common, irregular mucilaginous substance agglomerate
It is numerous, plus iodine test solution is in hyacinthine.Parenchyma cell calcium oxalate crystal growth in healthy needle bunchy is dispersed in, long 8~65 μm.Scalariform, reticulate vessel
It is common, 13~55 μm of diameter.Dry product is containing total reducing sugar with glucose（C6H12O6) meter, no less than 8%, containing polysaccharide with glucose
（C6H12O6) meter, no less than 5%.
Content assaying method is identical with the first embodiment.
Experiment Introduction.
1. confirmed through antifatigue, resist oxygen lack pharmacological evaluation：Milk hand ginseng powder is significantly increased than the drug effect that hand is joined, and higher than milk
The drug effect of hand ginseng.
2. clinical trial 30, patient is weakness due to chronic disease person, including waist and leg ache, " Ba Mu " disease, swim pain, " pottery relies "
Disease etc..Decoct soup as control is joined with hand respectively, hand ginseng and milk hand are joined powder with 0.5~1g/ times, taken day 2 times.With clinic observation and trouble
Person's private prosecution is foundation, it was demonstrated that the milk hand ginseng powder of equivalent averagely shortens 35.2% than the effective time that hand is joined, while proving effective speed
Degree is substantially better than milk hand ginseng, and its combined therapy effect is significantly increased.Particularly the 7th kind milk through supercooling extraction treatment of embodiment
Hand is joined, and the drug effect after powder processed is more prominent.
Additionally, milk hand ginseng powder is more suitable for the figuration techniques such as compressing tablet, pill, filling capsule, it is more suitable for producing accumulating, patient's clothes
With more facilitate.
9th kind of embodiment：Produce milk hand ginseng powder.Handle ginseng is ground into fine powder, crosses No. 6 sieves, adds skimmed milk power, its weight
Part proportioning joins powder with hand：Skimmed milk power=100：25-35, mix.
After hand ginseng powder mixes with skimmed milk power, material viscosity is larger, and packaging and storage are inconvenient.Asked to solve this
Topic, adds multiple auxiliary materials to be tested.Wherein, addition microcrystalline cellulose reduction viscosity effect it is further preferred that.
Microcrystalline cellulose (cellulose microciystalline) English name:Microcrystalline
Cellulose, Chinese nickname：Microcrystalline, microcrystal, cellulose powder, sulfurous acid (salt) paper pulp, cellulose/microcrystalline cellulose is fine
Dimension element, cellulase, wood powder.It is a kind of purifying, the cellulose of part depolymerization, it is white, odorless, tasteless, by small porous particle
The crystalline powder of composition.Main component is the straight chain formula polysaccharose substance combined with β -1,4- glucoside bonds.The degree of polymerization is about
3000-10000 glucose molecules.In general string, microcrystalline cellulose accounts for 73%, and another 30% is amorphous fiber
Element.Consumption is easy to packed and transported to be defined to reduce the viscosity that milk hand joins powder, thus relatively more wide in range, typically adds 2-10%, mixes
To fluffy.
Milk hand joins moisture≤6.0% of powder, total ash≤7.0%, extract >=20.0%, containing total reducing sugar（With glucose
（C6H12O6) meter）>=8%, containing polysaccharide（With glucose（C6H12O6) meter）≥5%.
Detection method and experimental technique are with reference to the foregoing embodiments.
The experiment proved that drug effect reaches the 8th kind of level of embodiment.
Tenth kind of embodiment：Milk hand ginseng powder makes.Handle ginseng is ground into powder, crosses No. 6 sieves, then with milk with 100：75—85
Weight than mix, soak 3.8-4.2 hours, be cooked by slow fire 0.9-1.2 hours, be dried to powder.Milk hand joins the water of powder
Divide≤6.0%, total ash≤7.0%, extract >=20.0%, containing total reducing sugar with glucose（C6H12O6) meter, >=8%, containing polysaccharide with Portugal
Grape sugar（C6H12O6) meter, >=5%.
Detection method and experimental technique are with reference to the foregoing embodiments.Drug effect reaches the 8th kind of level of embodiment, during preparation
Between shorten dramatically, be suitable to industrialized production.
A kind of tenth embodiment：Milk hand ginseng powder makes.Handle ginseng crushed No. 6 sieves, with milk with 100：55-65 weight
Amount is soaked 0.8-1.2 hours than mixing under the ultrasonic activation of more than 22KHZ, dense as that can decoct with pure water adjustment
Degree, is cooked by slow fire 0.5-0.6 hour, drying and dehydrating.Milk hand joins moisture≤6.0% of powder, total ash≤7.0%, extract
>=20.0%, containing total reducing sugar（With glucose（C6H12O6) meter）>=8%, containing polysaccharide（With glucose（C6H12O6) meter）≥5%.
Detection method and experimental technique are with reference to the foregoing embodiments.
The experiment proved that drug effect reaches the 8th kind of level of embodiment, but its cost is greatly reduced, and is suitable to industrialized production.
Claims (13)
1. a kind of anaesthetic hand ginseng process for upgrading, is characterized in：Hand participates in milk and is mixed and made into milk hand ginseng or milk hand ginseng powder.
2. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：The milk hand ginseng is that handle participates in milk
With 100：95-105 weight is soaked 7.8-8.2 hours than mixing, and is cooked by slow fire 1.8-2.2 hours, and taking-up is dried
Form.
3. anaesthetic hand according to claim 2 joins process for upgrading, it is characterised in that：In the immersion process, handle ginseng and
Milk loads autoclave, is filled with gas at normal temperature and is pressurized to 0.2-0.3MPa, then pressurize more than 2 hours, while with more than 22KHZ
Ultrasonic vibration more than 30 minutes, then with being cooked by slow fire.
4. anaesthetic hand according to claim 2 joins process for upgrading, it is characterised in that：In the immersion process, handle ginseng and
Milk loads autoclave, is filled with gas at normal temperature and is pressurized to 0.2-0.3MPa, and pressurize 30 minutes is taken out hand ginseng, is put into cryogenic vacuum
Bulking machine, is pressurized to 0.5-0.6MPa, and temperature control below 120 DEG C, produce by decompression, then sends autoclave back to, adds in milk
It is pressed onto 0.2-0.3MPa, then pressurize more than 2 hours, then simultaneously with the ultrasonic vibration more than 30 minutes of more than 22KHZ, then with text
Fire is decocted.
5. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：The milk hand ginseng is that handle participates in milk
With 100：65-75 weight squeezes into gas at normal temperature to 0.5-0.8MPa than loading autoclave by air pump, and pressurize 2.2-2.5 is small
When, it is depressurized to 0.2MPa and is heated to 90-110 DEG C, 0.8-1.2 hours are incubated, taking-up is dried and is formed.
6. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：Milk hand ginseng be handle ginseng flood into
Soaked in milk 20-30 minutes, cryogenic vacuum bulking machine is put into after taking-up, squeeze into gas at normal temperature to 0.2-0.22MPa, pressurize
1.2-1.5 hours, 80-120 DEG C of temperature control was pressurized to 0.5-0.6MPa, and decompression is produced, then flooded in milk and be heated to
80-100 DEG C, slow fire is incubated 20-30 minutes, bleeds off unnecessary milk, and slow fire dryouies.
7. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：Milk hand ginseng be handle ginseng flood into
In milk, ultrasonic vibration 20-30 minutes is put into cryogenic vacuum bulking machine after taking-up, squeeze into gas at normal temperature to 0.2-
0.22MPa, pressurize 1.2-1.5 hours, temperature control is pressurized to 0.5-0.6MPa to 80-120 DEG C, and decompression is produced, then flood into
It is heated to 80-100 DEG C in milk, ultrasonic vibration and slow fire is incubated 20-30 minutes bleeds off unnecessary milk, slow fire dryouies.
8. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：Milk hand ginseng be handle ginseng flood into
In milk, heat boils ultrasonic vibration simultaneously 20-30 minutes, and cold extraction tank is put into after taking-up, cold 10-15 points of the extraction below-180 DEG C
Clock, taking-up is put into cryogenic vacuum bulking machine, squeezes into gas at normal temperature to 0.2-0.22MPa, pressurize 1.2-1.5 hours, and temperature control is arrived
80-120 DEG C, 0.5-0.6MPa is pressurized to, decompression is produced, then floods 80-100 DEG C are heated in milk, ultrasonic vibration is simultaneously
Slow fire is incubated 20-30 minutes, bleeds off unnecessary milk, and slow fire takes out after dryouting and is put into cold extraction tank, it is cold less than-180 DEG C extract 10-
15 minutes,.
9. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：The milk hand ginseng powder is that milk hand is joined powder
Fine powder obtained by No. 6 sieves of broken mistake.
10. anaesthetic hand according to claim 1 joins process for upgrading, it is characterised in that：The milk hand ginseng powder is that handle ginseng is ground
Into fine powder, cross No. 6 sieves and add skimmed milk power, powder is joined with hand：Skimmed milk power=100：25-35 weight portion is mixed.
11. anaesthetic hand ginseng process for upgrading according to claim 10, it is characterised in that：The hand ginseng powder is mixed with skimmed milk power
After conjunction, microcrystalline cellulose is added to mix to fluffy.
12. anaesthetic hand ginseng process for upgrading according to claim 1, it is characterised in that：The milk hand ginseng powder is handle ginseng powder
Powder is broken into, then powder is joined with hand：Milk is with 100：75-85 weight is soaked 3.8-4.2 hours than mixing, and is cooked by slow fire
0.9-1.2 hours, dry.
13. anaesthetic hand ginseng process for upgrading according to claim 1, it is characterised in that：The milk hand ginseng powder is handle ginseng powder
Broken and milk, with 100：55-65 weight is soaked 0.8-1.2 hours than mixing under ultrasonic activation, is cooked by slow fire
0.5-0.6 hour, drying and dehydrating.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030863A (en) * | 2017-12-18 | 2018-05-15 | 北京裕华佰奥生物技术有限公司 | A kind of concocting method of hand ginseng and its hand ginseng powder, the granule pieces of gained |
| CN109276651A (en) * | 2018-10-23 | 2019-01-29 | 江西景德中药股份有限公司 | Gymnadenia conopsea medicine materical crude slice and its concocting method |
| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
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| CN104147373A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation method of high-activity gymnadenia conopsea |
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| CN104147373A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation method of high-activity gymnadenia conopsea |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030863A (en) * | 2017-12-18 | 2018-05-15 | 北京裕华佰奥生物技术有限公司 | A kind of concocting method of hand ginseng and its hand ginseng powder, the granule pieces of gained |
| CN109276651A (en) * | 2018-10-23 | 2019-01-29 | 江西景德中药股份有限公司 | Gymnadenia conopsea medicine materical crude slice and its concocting method |
| CN112891377A (en) * | 2021-03-26 | 2021-06-04 | 宋亚红 | Gui-thin Mongolian medicine powder formula granule and preparation method thereof |
| CN112891377B (en) * | 2021-03-26 | 2023-09-19 | 那生桑 | Precious fine Mongolian medicinal powder formula granule and preparation method thereof |
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