CN113117008B - Preparation method of Zhibai Dihuang pills - Google Patents
Preparation method of Zhibai Dihuang pills Download PDFInfo
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Abstract
The invention discloses a preparation method of Zhibai Dihuang pills. The method comprises the following steps: a preparation method of Zhibai Dihuang Wan comprises the following steps: (1) powder: weighing 40 parts of rhizoma anemarrhenae, 40 parts of cortex phellodendri, 160 parts of prepared rehmannia root, 80 parts of dogwood (prepared), 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis according to weight components, crushing, sieving and uniformly mixing to obtain medicinal powder; (2) preparation of the adhesive: putting glycerol into a container, adding medicinal carboxymethyl cellulose salt, stirring, sealing, and heating until carboxymethyl cellulose salt is completely swelled to obtain adhesive; (3) preparation of pills: adding 20-60% adhesive into the medicinal powder, mixing, and making into pill. The invention has the advantages that the prepared Zhibai Dihuang pill does not use refined honey as a bonding agent, the Zhibai Dihuang pill is convenient to chew and take because the product has less water content and small water absorption and can be sealed by adopting a plastic bottle, plastic balls and wax-sealed packages are omitted, the Zhibai Dihuang pill has better flexibility, does not become hard after long-term storage, does not add honey as an auxiliary material, can be taken by diabetes patients with requirements due to a novel pill preparation method, and has relatively wider drug use crowd.
Description
Technical Field
The invention relates to a Zhibai Dihuang pill, in particular to a preparation method of the Zhibai Dihuang pill.
Background
The Zhibai Dihuang Wan takes the Liuwei Dihuang Wan as a basic prescription, is matched with rhizoma anemarrhenae for nourishing yin, clearing heat and purging fire, and the phellodendron for clearing heat in the lower jiao, has the effects of nourishing yin and clearing heat by combining the eight medicines, has sufficient yin fluid and clear deficient fire, has the efficacy of nourishing yin and reducing fire, and can be used for treating the symptoms of fire excess from yin deficiency, hectic fever, night sweat, dry mouth, sore throat, tinnitus, spermatorrhea and scanty and dark urine, thereby achieving the purpose of treating both principal and secondary aspects of diseases. The legal prescription and preparation method of Zhibai Dihuang Wan are recorded in the Chinese pharmacopoeia (2020 edition one P1146), and the prescription: 40g of rhizoma anemarrhenae, 40g of phellodendron, 160g of prepared rehmannia root, 80g of dogwood (prepared), 60g of tree peony bark, 80g of Chinese yam, 60g of tuckahoe and 60g of rhizoma alismatis, and the preparation method comprises the following steps: the eight medicines are crushed into fine powder, sieved and mixed evenly. Adding refined honey 80-110g into powder of each 100g of the powder, and making into honeyed pill. "
In the prior art, refined honey is mainly used as an adhesive for preparing pills, and the prepared pills are easy to absorb moisture, difficult to store for a long time and relatively poor in stability due to high viscosity and high dosage of the refined honey. In order to strictly control the water content, a wax sealing process is usually adopted, pills are placed in a plastic shell, a thick layer of wax is sealed, the wax sealing requirement is certain in thickness, the whole process is time-consuming, the wax sealing effect can be achieved by repeating the process for many times during wax hanging, the wax shell layer is easy to crack in the storage process, and the pills stored in the plastic ball are easy to stick to the plastic ball and are not easy to take out due to large amount of honey. When the honeyed pills are not sealed well or wax seal cracks, the honeyed pills easily lose moisture, become hard and lose softness.
Disclosure of Invention
The invention aims to provide a preparation method of Zhibai Dihuang pills. The prepared Zhibai Dihuang pill does not use refined honey as a binder, has the characteristics of less water content and small water absorption of the prepared Zhibai Dihuang pill, can be packaged and sealed by adopting a plastic bottle, omits a plastic ball and a wax seal package, has good flexibility, does not become hard after long-term storage, is convenient to chew and take, does not add honey as an auxiliary material, can be taken by diabetes patients with requirements by a novel pill preparation method, and has relatively wide medicine application range.
The technical scheme of the invention is as follows: a preparation method of Zhibai Dihuang Wan is characterized in that: the method comprises the following steps:
(1) Powder: weighing 40 parts of rhizoma anemarrhenae, 40 parts of cortex phellodendri, 160 parts of prepared rehmannia root, 80 parts of dogwood (prepared), 60 parts of cortex moutan radicis, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis according to the weight parts, crushing, sieving and mixing uniformly to obtain medicinal powder;
(2) Preparation of the adhesive: putting glycerol into a container, adding medicinal carboxymethyl cellulose salt, stirring, sealing, and heating until the carboxymethyl cellulose salt is completely swelled to obtain adhesive;
(3) Preparation of pills: adding 20-60% adhesive into the medicinal powder, mixing, and making into pill.
The pharmaceutically acceptable carboxymethyl cellulose salt includes: sodium carboxymethylcellulose or calcium carboxymethylcellulose.
In the step (2) of the preparation method of the Zhibai Dihuang pill, the weight ratio of glycerol to the pharmaceutically acceptable carboxymethyl cellulose salt = 100.
Specifically, in the step (2), glycerin/pharmaceutically acceptable carboxymethyl cellulose salt = 100.
More specifically, in the step (2), glycerin is added in a ratio of pharmaceutically acceptable carboxymethyl cellulose salt = 100.
In the step (2) of the preparation method of the Zhibai Dihuang pill, the heating condition is to heat at 70-105 ℃ for 4-10 hours.
In the step (2) of the preparation method of the Zhibai Dihuang pill, the heating is performed by stirring once every 0.5 to 2 hours.
In the step (3) of the preparation method of the Zhibai Dihuang pill, 25 to 50 percent of the amount of the prepared medicine is added into the adhesive.
In the step (3) of the preparation method of the Zhibai Dihuang pill, 30-45% of the amount of the prepared medicine is added into the adhesive.
Compared with the prior art, the invention has the following beneficial effects:
the components of the adhesive used in the invention meet the pharmacopeia standard, and the pill has no toxic and side effects, high safety, and stable and controllable quality.
The Zhibai Dihuang pill prepared by the invention does not use refined honey as a binder, and has the characteristics that the prepared Zhibai Dihuang pill has less water content and small water absorption, can be sealed by adopting a plastic bottle, omits plastic balls and wax-sealed packages, has better flexibility, does not become hard after long-term storage, is convenient to chew and take, does not add honey as an auxiliary material, can be taken by diabetes patients with requirements by a novel pill preparation method, and has relatively wider drug use population.
The applicant applies the preparation technology of the soft pills to the gynecological reconstruction pills, the children rejuvenation pills, the six-ingredient rehmannia pills, the medlar-chrysanthemum rehmannia pills, the storax pills and the Zhibai-rehmannia pills, and obtains remarkable effects. The following is the relevant experimental proof of the gynecological reconstruction pill-soft pill: :
in order to research/verify the technical scheme and the beneficial effects of the invention, the inventor conducts a large number of tests, and partial tests are recorded as follows:
inspection record of finished Zhibai Dihuang pill
The purpose is as follows: the existing honeyed pills of Zhibai Dihuang have the following problems:
(1) The honeyed pill has large honey addition amount (44.44-52.38% of the total amount) and large adjuvant consumption.
(2) The honey refining amount is large (the solid content of the refined honey is 82.89%), patients with diabetes cannot take the honey refining pill, and patients with mild diabetes are relatively dangerous to take the honey refining pill, so the honey refining pill of Zhibai Dihuang pill is prohibited to take the honey refining pill.
(3) The honeyed pills are sealed by wax pills, the wall of each wax pill is thick (the thickness reaches 3 mm), the wax sealing effect can be achieved by repeating the wax hanging process for multiple times, the wax is easy to crack in the storage process, the wax sealing thickness of the honeyed pills is shown in figures 1 and 2, and the actual substances of the honeyed pills are shown in figure 3.
(4) The honey is not easy to take out due to large amount, and is easy to stick on the plastic ball, as shown in figure 4.
(5) The honeyed pills easily lose moisture, become hard and lose softness without sealing or cracking of the wax seal, as shown in fig. 5.
The hardness test of 5 hours after the honeyed pills of Zhibai Dihuang are prepared is 2.27kg, as shown in figure 6; the hardness test of the honeyed pill of Zhibai Dihuang is 10.95kg after one month storage, which is shown in figure 7.
(Zhibai Dihuang Wan of the invention) has the advantages that:
(1) The plain ball and wax-sealed package is omitted, and the product has low water content and low water absorption, and can be packaged in a plastic bottle (see figure 8).
(2) Has good flexibility, can not become hard after long-term storage, and is convenient for chewing.
(Zhibai Dihuang Wan of the invention) hardness test was 0.91kg at 5 hours immediately after completion of the pill, see FIG. 9; the hardness test after one month of storage was 1.12kg, see FIG. 10.
(3) The honey is not added, and the honey can be taken by diabetics with needs or patients with adverse reactions to sugar, so that the audience is wide.
(4) The dosage of the auxiliary materials is reduced (the minimum dosage of the honeyed pill auxiliary materials is 44.44%, and the minimum dosage of the auxiliary materials is 20%).
Prescription: 40g of rhizoma anemarrhenae, 160g of prepared rehmannia root, 60g of moutan bark, 60g of poria cocos, 60g of phellodendron, 40g of dogwood (prepared), 80g of Chinese yam, 80g of rhizoma alismatis, 60g of
The preparation method comprises the following steps: pulverizing the above eight materials into fine powder, sieving, and mixing.
The existing Zhibai Dihuang pill honeyed pill (honeyed pill for short) is prepared by the following steps: 50.02g of powder is taken, and 40.66g of refined honey is added to prepare honeyed pills. Adding vegetable ball, suspending wax, and cooling.
The invention discloses a preparation method of Zhibai Dihuang pills (hereinafter referred to as follows):
powder: taking rhizoma anemarrhenae, radix rehmanniae Preparata, cortex moutan, poria, cortex Phellodendri, corni fructus, rhizoma Dioscoreae and Alismatis rhizoma according to the prescription of ZHIBAIDIHUANG pill, pulverizing, sieving, and mixing to obtain medicinal powder;
preparing an adhesive: putting 96.00g of glycerol into a beaker, adding 4.00g of sodium carboxymethylcellulose, uniformly stirring, and heating at 105 ℃ for 4 hours to completely swell for later use.
Taking 50.07g of powder, adding 24.42g of adhesive, mixing the powder and the adhesive uniformly, making pills, and putting the pills into a bottle to obtain the Chinese medicinal composition.
[ PROPERTIES ]
1. The product is black brown honeyed pill; sweet and sour-bitter.
2. The product is black brown; sweet and sour.
And (4) conclusion: the two pills have basically identical properties and similar appearance.
[ EXAMINATION ]
1. Moisture content: must not exceed 15% (honeyed pill)
Toluene process
Scale model:
balance number:
□HF-YF033
sampling quantity: 14.8600g
Amount of toluene: 200ml of
Moisture scale reading: 1.7ml
And (3) calculating: 1.7/14.8600 × 100% =11.44%
2. Moisture content: must not exceed 9% ()
Toluene process
Scale model:
□MS205DU
balance number:
□HF-YF033
sampling quantity: 14.5102g
Amount of toluene: 200ml of
Moisture scale reading: 1.1ml
And (3) calculating: 1.1/14.5102 × 100% =7.58%
And (4) conclusion: compared with honeyed pills, the water content is lower, and the product is more favorably stored.
3. Dissolution time limit:
complete dissolution should take place within 1 hour. ()
The appearance that disintegrates intelligently:
instrument numbering:
water temperature: disintegration solvent at 37.0 ℃: water (W)
Complete disintegration time: 27min, see FIG. 11.
And (4) conclusion: the Zhibai Dihuang pill can be completely disintegrated for less than 1 hour, and does not influence the absorption of the medicine.
[ Paeonol content determination ]
Measuring by high performance liquid chromatography (0512 in general rules of Chinese pharmacopoeia).
Room temperature: 26 ℃ and humidity: 65 percent;
scale model:
balance number: 9633HF-YF 032
The instrument model is as follows: 9633HF-YF 038
□HF-YF029
Instrument numbering: 9633LC-Ultimate 3000
□Agilent1260
A chromatographic column: specification: 4.6mm 250mm
Flow rate: 1ml/min; column temperature: 30 ℃;
name of reference substance: paeonol control, source: the Chinese food and drug testing institute;
batch number of paeonol reference substance: 110708 to 201908, control solution preparation batch number: 20201224;
chromatographic conditions and system applicability test: octadecylsilane chemically bonded silica is used as a filling agent; methanol-water (70; the detection wavelength was 274nm. The number of theoretical plates is not less than 3500 calculated according to the peak of paeonol.
Preparation of control solutions: taking appropriate amount of paeonol reference substance, precisely weighing, and adding methanol to obtain solution containing 15ug per 1 ml.
Preparing a test solution: taking the honeyed pill, grinding, taking 0.4g, and precisely weighing; placing in a conical flask with a plug, precisely adding 50ml of 50% methanol, sealing the plug, weighing, performing ultrasonic treatment (power 250W and frequency 33 kHz) for 45 minutes, cooling, weighing again, supplementing the lost weight with 50% methanol, shaking up, filtering, and taking the subsequent filtrate.
The determination method comprises the following steps: precisely sucking 10ul of the reference solution and 20ul of the sample solution, respectively, injecting into a liquid chromatograph, and measuring.
The product contains cortex moutan and paeonol (C) 9 H 10 O 3 ) The honeyed pill per lg should not be less than 0.80mg; the weight of the honeyed pill per lg should not be less than 0.55mg; the dosage of big honeyed pill should not be less than 5.0mg.
Weighing paeonol: 10.04mg, concentration: 0.02004mg/ml;
peak area of control (1) (dan): 1077888; peak area of control (2) (dan): 1087848;
peak area of control (3) (dan): 1090910; peak area of control (4) (dan): 1093525;
peak area of control (5) (dan): 1095629; peak area of control (6) (dan): 1096379;
average peak area a (red) of control: 1090363.2
Dilution times are as follows: 50
Weighing the honeyed pill sample (1): 0.5378g;
weighing the honeyed pill sample (2): 0.5358g;
peak area (pellet) of honeyed pill test product (1): 419393.5;
peak area (pellet) of honeyed pill sample (2): 410684.5;
weighing a sample (1) to be tested: 0.5282g;
weighing the sample (2): 0.4962g;
peak area (pellet) of the test sample (1): 428284.5;
peak area (pellet) of test sample (2): 418741;
and (3) calculating:
content of honeyed pill sample (1):
content of honeyed pill sample (2):
sample (1) content:
sample (2) content:
and (4) conclusion: the content of paeonol which is a volatile index component in the honeyed pills prepared from the rhizoma anemarrhenae, the phellodendron and the rehmannia glutinosa after being placed for a period of time is detected to find that: the content of the honeyed pill is slightly lower than that of the paeonol. But the difference between the two is small.
Chromatogram of paeonol reference substance is shown in fig. 12-17: FIG. 12 is a chromatogram of a paeonol reference substance (1) in the determination of paeonol content, which is proved by experiments of the present invention; FIG. 13 is a chromatogram of a paeonol control (2) in the assay of paeonol content, which is proved by the experiment of the present invention; FIG. 14 is a chromatogram of a paeonol control (3) in the assay of paeonol content, which is proved by the experiment of the present invention; FIG. 15 is a chromatogram of a paeonol control (4) in the assay of paeonol content, which is proved by the experiment of the present invention; FIG. 16 is a chromatogram of a paeonol reference substance (5) in the assay of paeonol content, which is proved by the experiment of the present invention; FIG. 17 is a chromatogram of the paeonol control (6) in the assay of paeonol content, which is proved by the experiment of the present invention.
The chromatogram of the honeyed pill is shown in fig. 18-21: FIG. 18 is a chromatogram of a honeyed pill sample (1) in the determination of paeonol content, which is proved by the experiment of the present invention; FIG. 19 is a chromatogram of a honeyed pill sample (1) in the determination of paeonol content, which is proved by the experiment of the present invention; FIG. 20 is a chromatogram of a honeyed pill sample (2) in the determination of paeonol content, which is proved by the experiment of the present invention; fig. 21 is a chromatogram of the honeyed pill sample (2) in the determination of paeonol content, which is proved by the experiment of the invention.
The chromatogram of the test sample is shown in FIGS. 22-25: FIG. 22 is a chromatogram of a test sample (1) in the assay of paeonol content, which is an experimental demonstration of the present invention; FIG. 23 is a chromatogram of a test sample (1) in the assay of paeonol content, which is an experimental demonstration of the present invention; FIG. 24 is a chromatogram of the test article (2) in the assay of paeonol content according to the present invention; FIG. 25 is a chromatogram of the test article (2) in the assay of paeonol content according to the present invention.
In conclusion, the prepared Zhibai Dihuang pill does not use refined honey as a binder, and has the beneficial effects that the prepared Zhibai Dihuang pill has less water content and small water absorption, can be packaged and sealed by plastic bottles, omits plastic balls and wax seal packages, has good flexibility, can not be hardened after long-term storage, is convenient to chew and take, does not add honey as an auxiliary material, can be taken by diabetes patients with requirements by a novel pill preparation method, and has relatively wide medicine application range.
Drawings
FIG. 1 is a diagram of wax-sealed material object of the existing Zhibai Dihuang pill honeyed pill proved by the experiment of the present invention;
FIG. 2 is a practical diagram of the wax seal thickness of the existing Zhibai Dihuang pill honeyed pill proved by the experiment of the present invention;
FIG. 3 is a diagram of the existing Zhibai Dihuang honeyed pill in the experiment of the present invention;
FIG. 4 is a diagram of a plastic ball of a honeyed pill of Zhibai Dihuang in the prior art;
FIG. 5 is a diagram showing that the existing honeyed pill of Zhibai Dihuang is not sealed or the wax seal is cracked;
FIG. 6 is a hardness test chart of 5 hours just after the pill preparation of the existing Zhibai Dihuang pill-honeyed pill in the invention is proved by tests;
FIG. 7 is a test chart of hardness of the existing Zhibai Dihuang pill honeyed pill stored for one month in the test of the present invention;
FIG. 8 is a diagram showing the sample of the present invention (Zhibai Dihuang Wan of the present invention);
FIG. 9 is a graph showing the hardness test of the present invention (Zhibai Dihuang pill of the present invention) immediately after completion of the pill preparation for 5 hours;
FIG. 10 is a graph showing hardness test after one month storage in the experimental demonstration of the present invention (Zhibai Dihuang pill of the present invention);
FIG. 11 is a graph showing the disintegration test in the experimental demonstration of the present invention (Zhibai Dihuang Wan of the present invention);
FIG. 12 is a chromatogram of a paeonol reference substance (1) in the determination of paeonol content, which is proved by experiments of the present invention;
FIG. 13 is a chromatogram of a paeonol control (2) in the assay of paeonol content, as demonstrated by the experiment of the present invention;
FIG. 14 is a chromatogram of a paeonol control (3) in the assay of paeonol content, which is proved by the experiment of the present invention;
FIG. 15 is a chromatogram of a paeonol control (4) in the assay of paeonol content, which is proved by the experiment of the present invention;
FIG. 16 is a chromatogram of a paeonol control (5) in the determination of paeonol content, which is proved by experiments of the present invention;
FIG. 17 is a chromatogram of a paeonol reference substance (6) in the assay of paeonol content, which is proved by the experiment of the present invention;
FIG. 18 is a chromatogram of a honeyed pill sample (1) in the determination of paeonol content, which is proved by the experiment of the present invention;
FIG. 19 is a chromatogram of a honeyed pill sample (1) in the determination of paeonol content, which is proved by the experiment of the present invention;
FIG. 20 is a chromatogram of a honeyed pill sample (2) in the determination of paeonol content, which is proved by the experiment of the present invention;
FIG. 21 is a chromatogram of a honeyed pill sample (2) in the determination of paeonol content, which is proved by the experiment of the present invention;
FIG. 22 is a chromatogram of a test sample (1) in the assay of paeonol content according to the present invention;
FIG. 23 is a chromatogram of a test sample (1) in the assay of paeonol content, which is an experimental demonstration of the present invention;
FIG. 24 is a chromatogram of the test sample (2) in the assay of paeonol content, which is an experimental demonstration of the present invention;
FIG. 25 is a chromatogram of the test article (2) in the assay of paeonol content according to the present invention.
Detailed Description
The invention is further illustrated by the following figures and examples, which are not to be construed as limiting the invention.
Example 1: a preparation method of Zhibai Dihuang Wan is prepared according to the following steps:
(1) Powder: weighing 40g of rhizoma anemarrhenae, 40g of cortex phellodendri, 160g of prepared rehmannia root, 80g of dogwood (prepared), 60g of moutan bark, 80g of Chinese yam, 60g of poria cocos and 60g of rhizoma alismatis according to weight components, crushing, sieving and uniformly mixing to obtain medicinal powder;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 4.16g of sodium carboxymethylcellulose, stirring uniformly, sealing, heating at 105 ℃ for 4 hours until the sodium carboxymethylcellulose is completely swelled, and stirring once every 0.5 hour to obtain an adhesive for later use;
(3) Preparation of the pill: adding adhesive in the amount of 32% of the total amount of the prepared medicinal materials, mixing, and making into pill.
Example 2: a preparation method of Zhibai Dihuang Wan is prepared according to the following steps:
(1) Powder: the preparation was carried out as described in example one;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 2g of carboxymethylcellulose calcium, stirring uniformly, sealing, heating at 85 ℃ for 8 hours until the carboxymethylcellulose calcium is completely swelled, and stirring once every 1 hour to obtain an adhesive for later use;
(3) Preparation of the pill: adding adhesive in the amount of 32% of the total amount of the prepared medicinal materials, mixing, and making into pill.
Example 3: a preparation method of Zhibai Dihuang Wan is prepared according to the following steps:
(1) Powder: the preparation was carried out as described in example one;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 4g of sodium carboxymethylcellulose, stirring uniformly, sealing, heating at 95 ℃ for 6 hours until the sodium carboxymethylcellulose is completely swelled, and stirring once every 0.5 hour to obtain an adhesive for later use;
(3) Preparation of the pill: adding binder 50% of the total amount of the prepared medicinal materials into the medicinal powder, mixing, and making into pill.
Example 4: a preparation method of Zhibai Dihuang Wan is prepared according to the following steps:
(1) Powder: the preparation was carried out as described in example one;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 5g of carboxymethylcellulose calcium, stirring uniformly, sealing, heating at 90 ℃ for 7 hours until the carboxymethylcellulose calcium is completely swelled, and stirring once every 2 hours to obtain an adhesive for later use;
(3) Preparation of pills: adding adhesive in an amount of 30% of the total amount of the prepared medicinal materials into the medicinal powder, mixing, and making into pill.
Example 5: a preparation method of Zhibai Dihuang pills comprises the following steps:
(1) Powder: the preparation was carried out as described in example one;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 10g of sodium carboxymethylcellulose, stirring uniformly, sealing, heating at 80 ℃ for 9 hours until the sodium carboxymethylcellulose is completely swelled, and stirring once every 1.5 hours to obtain an adhesive for later use;
(3) Preparation of pills: adding binder 45% of the total amount of the prepared medicinal materials into the medicinal powder, mixing, and making into pill.
Example 6: a preparation method of Zhibai Dihuang Wan is prepared according to the following steps:
(1) Powder: the preparation was carried out as described in example one;
(2) Preparation of the adhesive: adding 100g of glycerol into a container, adding 8g of sodium carboxymethylcellulose, stirring uniformly, sealing, heating at 70 ℃ for 10 hours until the sodium carboxymethylcellulose is completely swelled, and stirring once every 1 hour to prepare an adhesive for later use;
(3) Preparation of the pill: adding binder accounting for 25% of the total amount of the prepared medicine into the medicinal powder, mixing uniformly, and making into pills.
Claims (1)
1. A preparation method of Zhibai Dihuang Wan is characterized in that: the method comprises the following steps:
(1) Powder: weighing 40 parts of rhizoma anemarrhenae, 40 parts of cortex phellodendri, 160 parts of prepared rehmannia root, 80 parts of prepared dogwood fruit, 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis according to weight components, crushing, sieving and uniformly mixing to obtain medicinal powder;
(2) Preparation of the adhesive: putting 96.00g of glycerol into a beaker, adding 4.00g of sodium carboxymethylcellulose, uniformly stirring, and heating for 4 hours at 105 ℃ to completely swell for later use;
(3) Preparation of pills: taking 50.07g of the medicinal powder, adding 24.42g of the adhesive, mixing the medicinal powder and the adhesive uniformly, preparing pills, and putting the pills into a bottle to obtain the traditional Chinese medicine.
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