CN101856472B - Production method of spur pain-relieving capsule - Google Patents
Production method of spur pain-relieving capsule Download PDFInfo
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Abstract
The invention relates to a production method of a spur pain-relieving capsule. The method comprises a plurality of steps of processing angelica dahurica, angelica and coix seeds, processing radix aconiti preparata, radix aconiti kusnezoffii preparata and gentiana macrophylla, processing paniculate swallowwort roots and the like. The method can greatly improve the yield of the paeonol in the paniculate swallowwort root, greatly reduce the water consumption during extraction, greatly shorten the distillation time, obviously reduce the energy consumed by extraction and obviously improve the utilization rate of equipment. Therefore, the method has unexpected technical effect and very obvious economic benefit, and has very wide application prospect.
Description
[technical field]
The invention belongs to the Chinese drug preparation technique field, more specifically, the present invention relates to a kind of production method of bone spur pain-eliminating capsule.
[background technology]
Hyperosteogeny, rheumatic arthritis, rheumatalgia are a kind of commonly encountered diseases, and frequently-occurring disease belongs to the painful and arthromyodynia category of traditional Chinese medical science convulsion.From theory of Chinese medical science; Described hyperosteogeny diseases mainly be the limbs meridians by the damp and hot heresy of wind and cold obturation; It is obstructed to cause patient QI and blood to occur; Meridians are obstructed, and cause symptoms such as muscle, joint, muscles and bones pain takes place, are ached, numb, scorching hot, joint stuffiness, even also the joint swelling deformation symptom can occur.
According to world's arthrosis foundation statistics, the patient of osteoarthritis accounts for world population 1/10th.Owing to lack specific Therapeutic Method, patient is more and more, though be unlikely to endanger people's life, causes to family, to society to seriously influence, and brings inconvenience for patient's work, life.Weight person is with dysfunction, and the personal lifestyle trival matters all need be called upon others for help.
China medical worker goes out a kind of bone spur pain-eliminating capsule at the foundation development of summing up motherland's medical science precious legacy.Bone spur pain-eliminating capsule is the new drug of State Food and Drug Administration's approval, is the special effect Chinese preparation of treatment hyperosteogeny, rheumatic arthritis, rheumatalgia.Bone spur pain-eliminating capsule is regulated bone metabolism to the morbidity root of osteopathia rheumatism, dispels bony spur; Antiinflammatory is invigorated blood circulation; Liver and kidney tonifying, pain-alleviating and network vessel-freeing reaches from the effect of the said disease of basic healing; It has the effect of treatment prevention of osteoporosis hypertrophy, rheumatic arthritis, rheumatalgia, sciatica, cervical spondylosis, lumbar spondylosis, spur in heels, the effect with human body immunity improving power.
In bone spur pain-eliminating capsule, aconitine has the effect of dispelling cold by warming the meridian, wind-expelling pain-stopping; Radix Gentianae Macrophyllae, Semen Coicis have the effect of damp eliminating eliminating impediment; The Radix Angelicae Dahuricae, Rhizoma Arisaematis have the effect of warming for resolving cold-phlegm, detumescence relieving convulsion; Radix Angelicae Sinensis, Flos Carthami, Rhizoma Dioscoreae Nipponicae have activating blood circulation to dissipate blood stasis, analgesic effect; Radix Cynanchi Paniculati, Rhizoma Dioscoreae Hypoglaucae have the effect of detoxifcation pain relieving, the removing dampness of dispeling the wind.
At present; The existing method for preparing bone spur pain-eliminating capsule (is formulated ministry standard referring to State Food and Drug Administration, standard numbering WS3-B-3944-98, book page number: Z20-255) effectively implement; But the inventor finds through a large amount of experimental studies; Still there are some defectives in existing method for preparing, therefore existing method for preparing is improved, and is obtained good effect.
[summary of the invention]
[technical problem that will solve]
The production method that the purpose of this invention is to provide a kind of bone spur pain-eliminating capsule.
[technical scheme]
The present invention realizes through following technical proposals.
The present invention relates to a kind of production method of bone spur pain-eliminating capsule.The step of this method is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
The equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 80-150 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 200 weight portions; In addition Semen Coicis is pulverized, sieved, take by weighing 80-150 order Semen Coicis fine powder 200 weight portions;
Then, the above-mentioned Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder are mixed with the Semen Coicis fine powder, obtain a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 100 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3-4 that 10-12 doubly measures in the said decoction pieces mixture decocts 2-3 time, and 2.0-3.0 hour at every turn, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 300 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add the water-wet of doubly measuring again in Radix Cynanchi Paniculati fine powder gross weight 1-2; Distilled 2-4 hour toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 200 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 300 weight portions of mixed in equal amounts again, mix with medicinal residues with described filtrating again after they are mixed; Adding the water of doubly measuring in said five kinds of Chinese medicine weight 8-12 then decocts 2-3 time; Each 2.0-3.0 hour, collecting decoction filtered; The filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, and concentrating under reduced pressure obtains thick paste again;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry and pulverizing, obtains a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains, and adds lubricant then, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
A preferred embodiment of the invention, the water of said pH value 3-4 are that distilled water obtains with the aqueous hydrochloric acid solution adjusting.
According to another kind of preferred implementation of the present invention, the concentration of said aqueous hydrochloric acid solution is 3-6N.
According to another kind of preferred implementation of the present invention, the water that in step (2), adds the pH value 3-4 of 10 times of amounts in said Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae fine powder decocts each 2.0 hours 2 times.
According to another kind of preferred implementation of the present invention, toward the water-wet of 1 times of amount of Radix Cynanchi Paniculati fine powder adding, straight-through again water vapour distilled 2 hours in step (3).
According to another kind of preferred implementation of the present invention, be under the temperature 60-80 ℃ of condition with pressure 0.01-0.10MPa, to carry out at the concentrating under reduced pressure described in the step (3).
According to another kind of preferred implementation of the present invention, in temperature 60-80 ℃ vacuum drying oven, carry out in the drying described in the step (4).
According to another kind of preferred implementation of the present invention, described lubricant is one or more lubricants that are selected from magnesium stearate, magnesium palmitate or silicon dioxide.
Below the present invention will be described in more detail.
The present invention relates to a kind of production method of bone spur pain-eliminating capsule.The step of this method is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
The equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 80-150 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 200 weight portions; In addition Semen Coicis is pulverized, is sieved, take by weighing 80-150 order Semen Coicis fine powder 200 weight portions.
Then, the above-mentioned Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder are mixed with the Semen Coicis fine powder, obtain a kind of mixture.
In the present invention; Employed pulverizer can be the various disintegrating apparatus of on market, selling at present when pulverizing the Radix Angelicae Dahuricae, Radix Angelicae Sinensis or Semen Coicis, for example the high speed Universalpulverizer of your instrument and equipment company limited production of Hangzhou remittance, the auspicious auspicious machine-building company limited professional production Chinese medicine grinder in Chinese medicine grinder, Jiangyin that Qingdao Mai Kelong powder technology equipment company limited is produced.
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 100 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3-4 that 10-12 doubly measures in the said decoction pieces mixture decocts 2-3 time, and 2.0-3.0 hour at every turn, collecting decoction; Filter the filtrate for later use that obtains.
The water of said pH value 3-4 is that distilled water obtains with the aqueous hydrochloric acid solution adjusting.The concentration of said aqueous hydrochloric acid solution is 3-6N.
Preferably, the water that in step (2), adds the pH value 3-4 of 10 times of amounts in said Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae fine powder decocts each 2.0 hours 2 times.
Employed pulverizer can be identical with the equipment that the front is described when in the present invention, pulverizing Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata with Radix Gentianae Macrophyllae.
In the present invention, the filter plant of use is the filter plant that the technical staff in processing technique of Chinese herbs field knows, for example the Chinese medicine filter of Hangzhou Ri Kang cleaning equipment company limited production.
Formulate ministry standard according to State Food and Drug Administration, standard numbering WS3-B-3944-98, book page number: Z20-255, Radix Aconiti, Radix Aconiti Kusnezoffii Preparata, Radix Gentianae Macrophyllae extraction process only relate to decoct number of times and decocting time, do not relate to the water yield of use.Because Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Gentianae Macrophyllae all contain alkaloid, thus with its extractum and total alkaloids as investigating index, comprehensive grading carries out data analysis, further improves its method for distilling.
The research of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Gentianae Macrophyllae three flavor medicine amount of water.
Experimental technique: take by weighing three parts of equivalent Radix Aconiti Preparatas, Radix Aconiti Kusnezoffii Preparata, Radix Gentianae Macrophyllae decoction pieces; Every part of 159.75g is put into respectively in three round-bottomed flasks, adds 8ml, 10ml, the 12ml times water gaging (using 3-6N hydrochloric acid adjust pH to be 3-4) of its decoction pieces weight; Decoct secondary; Each 2 hours, merge extractive liquid, was write down the volume of every part of extracting solution.Then, extractum and the total alkaloids amount in the mensuration extracting solution.
The mensuration of extractum: pipette extracting solution 50ml, be added to then in the evaporating dish that is dried to constant weight, use water bath method, descended dry 3 hours 105 ℃ of temperature again, move on to then in the exsiccator, placed therein 30 minutes, take by weighing weight then.It is measured the result and lists in table 1.
The mensuration of total alkaloids: pipette extracting solution 50ml, add the pH regulator to 9 of ammonia with extracting solution, reuse volume 50ml, 30ml, 30ml, the pure chloroform order of 20ml are successively extracted 4 times; Chloroform extracted solution merges back water washed twice; Each 50ml, water phase separated is carried out the low temperature evaporate to dryness after the washing chloroform extracted solution merges again; The residue that obtains is used the 5ml anhydrous alcohol solution, adds 15ml 0.01mol/L H again
2SO
4Volumetric solution, 15ml water and 3 C.I. 13020. indicator solutions with the titration of 0.02mol/L NaOH volumetric solution to terminal, calculate the total alkaloids amount:
Total alkaloids quantitative determination result sees table 1.
Table 1 Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Gentianae Macrophyllae three flavor medicines extract test
The result of the test of table 1 shows: 12 times of water gaging decoction effects are best, and 12 times of water gagings are very little with the difference of comparing of 10 times of amounts, therefore select for use the 10-12 times of water yield to decoct.
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 300 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add the water-wet of doubly measuring again in Radix Cynanchi Paniculati fine powder gross weight 1-2; Distilled 2-4 hour toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder.
Preferably, add the water-wet of 1 times of amount in the described Radix Cynanchi Paniculati fine powder, straight-through again water vapour distilled 2 hours.
Radix Cynanchi Paniculati has the wind dispelling removing dampness, antalgesic-antipruritic, promoting of the circulation of QI and removing the obstruction in the collaterals effect for Chinese medicine commonly used.The paeonol that Radix Cynanchi Paniculati contains has the antibacterial anti-inflammatory analgesia, and is analgesic, antiallergic, the effect of activating blood circulation to dissipate blood stasis.In bone spur pain-eliminating capsule, paeonol is used as medicine with crystal form, and its yield will directly influence the curative effect of medicine of the present invention.Therefore, the inventor furthers investigate the various factors that influences the paeonol extraction.Discover that except some influenced the factor that people that paeonol extracts know, it was also very big to its influence to add water distillation mode, studies but also have no talent.
According to existing industry conventional method, adopt 6 times of amounts, 8 times of amounts, 10,15,20 times of water gagings to carry out jacket steam when adding thermal distillation, the paeonol extraction effect is all undesirable; Still-process is difficult to control, and the distillate density unevenness is even, and distillation time is different in size; Time is long, and energy consumption is high, and yield is low.So these defectives that the inventor exists to prior art are groped through a large amount of tests; Finally find that a kind of extracting mode can address this problem; Be that Radix Cynanchi Paniculati carries out moistening with one times of water gaging earlier, the straight-through simultaneously water vapour of interlayer heating distills, and the paeonol yield promotes significantly; Time shortens significantly, and energy consumption reduces.
Existing industry conventional method and method of the present invention have been carried out contrast test.
The inventor has carried out 6 batches of tests, and every batch is used 200 kilograms of Radix Cynanchi Paniculati medical materials, and its medical material content of effective basic identical (about 1.7%) does not produce appreciable impact to statistical result.Adopt two kinds of distillation modes, a kind of is that prior art adopts 10 times of water gagings to carry out the jacket steam distillation, and another kind is that the present invention adopts 1 times of water gaging to carry out moistening, the straight-through simultaneously steam distillation of jacket steam heating.Other distillation condition is identical, and distillation time is to occur to distillate from distillate to end when no longer muddy.The distillate of collecting cools off, until separating out the paeonol crystal, filters, and the crystal natural drying that obtains, weigh (per time period crystallization content all is an accumulative total), and calculate the paeonol rate of transform in the Radix Cynanchi Paniculati.
The paeonol rate of transform=batch paeonol crystallization weight/batch medical material weight * medical material paeonol content
Resulting result of the test is listed in the table 2 and 3.
Table 2, add 10 times of water gagings of medical material and carry out extraction pot interlayer heating distillation extraction
Cumulated volume method three batch datas, distillation time needs 5-6 hour, and the paeonol crystallization rate of transform is about 50%.
Table 3, the straight-through steam of medical material moistening and extraction pot interlayer heating carrying out distillation extraction
Cumulated volume method three batch datas, distillation time needs 2-3 hour, and the paeonol crystallization rate of transform is about 80%
Can find out that by table 2,3 result adopt distillation mode of the present invention, the yield of paeonol is obvious more much higher than prior art; And amount of water reduces greatly; Distillation time also shortens significantly, therefore, extracts the energy consumption that is produced and very obviously reduces; Production efficiency obviously improves, and production cost reduces greatly.The most important thing is,, the product curative effect is improved greatly because the present invention improves the paeonol yield greatly.And avoided because long-time in the past the decoction distilled the poisonous side effect of medicine increase that causes the possible qualitative change of Radix Cynanchi Paniculati to cause.
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 200 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 300 weight portions of mixed in equal amounts again, mix with medicinal residues with described filtrating again after they are mixed; Adding the water of doubly measuring in said five kinds of Chinese medicine weight 8-12 then decocts 2-3 time; Each 2.0-3.0 hour, collecting decoction filtered; The filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, and concentrating under reduced pressure obtains thick paste again.
Formulate ministry standard according to State Food and Drug Administration; Standard numbering WS3-B-3944-98; Book page number: Z20-255, Radix Glycyrrhizae, Rhizoma Arisaematis, Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami extraction process only relate to decoct number of times and decocting time, do not relate to the water yield of use.Therefore, to 5 flavor medicines extraction having carried out amount of water researchs such as Flos Carthamis.
Take by weighing three parts of 5 flavor medicines such as Flos Carthami, wherein every part of medicine is Radix Glycyrrhizae 53.25g, Rhizoma Dioscoreae Hypoglaucae 106.5g, Rhizoma Dioscoreae Nipponicae 106.5g, Rhizoma Arisaematis 53.25g, Flos Carthami 106.5g.The water that adds respectively in 6,8,10 times of amounts of every part of medical material gross weight in every part of medicine decocts secondary, each 2 hours.With paste volume and glycyrrhizic acid extracted amount is the examination index.
The mensuration of said paste volume:
The extracting solution that obtains is concentrated into certain volume, and every part of concentrated solution pipettes two parts, each 25ml; Put in the evaporating dish that is dried to constant weight, use water bath method, be placed on again in 105 ℃ of baking ovens and dried 3 hours; Balance 30 minutes in exsiccator again, weighing obtains described paste volume.
The mensuration of said glycyrrhizic acid content:
Adopt high effective liquid chromatography for measuring:
A, instrument and reagent: high performance liquid chromatograph, EC2000, P200 II high pressure constant flow pump, UV200 II ultraviolet variable-wavelenght detector (Dalian Yilite Analytical Instrument Co., Ltd's production).
B, chromatographic condition: chromatographic column is closed silica gel for the octadecylsilane base key; Mobile phase is methanol-0.2mol/L Spirit of Mindererus .-glacial acetic acid (67: 33: 1); The detection wavelength is 250nm; Flow velocity is 1.0ml/min; Sample size is 10 μ l.Number of theoretical plate calculates by the monoammonium glycyrrhizinate peak should be not less than 2000.
These result of the tests are listed in the table below 4.
Table 4: the extraction result of five kinds of Chinese medicine such as Flos Carthami
Can be known by last table: when Radix Glycyrrhizae, Rhizoma Arisaematis, Rhizoma Dioscoreae Hypoglaucae, the extraction of Rhizoma Dioscoreae Nipponicae and Flos Carthami, it is suitable selecting the water of doubly measuring in every part of medicine gross weight 8-10 for use.
Described concentrating under reduced pressure is concentrating of under the temperature 60-80 ℃ of condition with pressure 0.01-0.10MPa, carrying out.
The equipment that said concentrating under reduced pressure uses is normally used equipment in the processing technique of Chinese herbs field, for example the prosperous vacuum decompression concentrator that reaches the sharp grand light industry and machinery company limited production in concentrating under reduced pressure pot, Wenzhou City of chemical equipment company limited production of Wuxi City section.
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry and pulverizing, obtains a kind of fine powder.
Described drying is carried out in temperature 60-80 ℃ vacuum drying oven, and the drying equipment of use for example is vacuum drying oven or the baking oven that the technical staff in present technique field knows.
(5) fine powder that lets step (4) obtain mixes with the paeonol crystal fine powder that step (3) obtains, and adds lubricant then, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
In the present invention, described lubricant is an excipient substance known to those skilled in the art.
Described lubricant is the lubricant that the technical staff in present technique field knows, and for example it is one or more lubricants that are selected from magnesium stearate, magnesium palmitate or silicon dioxide.Magnesium stearate is white fine and smooth powder, and good tack is arranged, and is evenly distributed after granule mixes and not easily separated, is the most frequently used lubricant.General consumption is 0.25-1%.
Certainly, in the present invention, can also use normally used other lubricant in medication preparation.
In the present invention; Capsule should be appreciated that it is that medicine is loaded in hollow hard capsules or is sealed in the elastomeric flexible capsule and the solid preparation of processing, and the material of processing said hollow hard rubber softgel shell or elastomeric flexible capsule shells is gelatin, glycerol, water and other medicinal materials.
Capsule has following characteristics:
1, to cover adverse drug smell flavor or improve medicine stability: be isolated from the outside because of medicine is contained in the capsule shells, avoided the influence of moisture, air, light, bad flavor or the unsettled medicine smelt of tool had covering to a certain extent, protection and Stabilization.
2, bioavailability of medicament is higher: the medicine in the capsule is directly to load in softgel shell with pulverulence; The influence of factor such as be not stressed; So dispersion rapidly, stripping and absorption in gastrointestinal tract, its bioavailability will be higher than pill, tablets and other formulations.
3, can delay the release and the positioning release medicine of medicine: can medicine be processed during slow-releasing granules incapsulates on demand, reach the effect of slow release prolongation of effect.
The hollow hard capsules that the present invention uses is extensive in the market product sold, for example the hollow hard capsules of hollow hard capsules, the Shanxi wide rubber capsule company limited production of Zhejiang oasis medicine capsule company limited production.
[beneficial effect]
Beneficial effect of the present invention is following:
The present invention is directed to these defectives that prior art exists, propose a kind of Radix Cynanchi Paniculati extracting mode, the paeonol yield in the Radix Cynanchi Paniculati is promoted significantly; The water yield of using during extraction reduces greatly; Distillation time also shortens significantly, obviously reduces so extract the energy that is consumed, and utilization rate of equipment and installations obviously improves; Production efficiency obviously improves, and production cost reduces greatly.The most important thing is,, the product curative effect is improved greatly because the present invention improves the paeonol yield greatly.And avoided because long-time in the past the decoction distilled the poisonous side effect of medicine increase that causes the possible qualitative change of Radix Cynanchi Paniculati to cause.
Therefore, the present invention has the economic benefit of unexpected technique effect and highly significant, and method of the present invention has very application prospects.
[description of drawings]
Fig. 1 is the flow sheet of bone spur pain-eliminating capsule of the present invention.
[specific embodiment]
Embodiment 1: the production of bone spur pain-eliminating capsule of the present invention
Bone spur pain-eliminating capsule production technology of the present invention is referring to accompanying drawing 1, and its production craft step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 80-100 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 80-100 order Semen Coicis fine powder 100 weight portions;
Then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder are mixed with said Semen Coicis fine powder, obtain a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3.5 of 10 times of amounts in the said decoction pieces mixture decocts 2 times, and each 2.0 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 1 times of amount of Radix Cynanchi Paniculati fine powder gross weight; Distilled 2 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 10 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 2.0 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 70 ℃ with pressure 0.01MPa under carried out concentrating under reduced pressure 120 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, in 70 ℃ of vacuum drying ovens of temperature, carries out drying, grinds and obtains a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains; Add then in said medicine gross weight 0.1% weight magnesium stearate; In the hollow hard capsules that the Zhejiang oasis medicine capsule company limited of packing into behind the mixing is produced, obtain described bone spur pain-eliminating capsule.
Embodiment 2: the production of bone spur pain-eliminating capsule of the present invention
Implementation step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 100-120 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 100-120 order Semen Coicis fine powder 100 weight portions, then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder is mixed with said Semen Coicis fine powder, obtains a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 4.0 of 10 times of amounts in the said decoction pieces mixture decocts 2 times, and each 2.5 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 1.5 times of amounts of Radix Cynanchi Paniculati fine powder gross weight; Distilled 2 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 12 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 3.0 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 70 ℃ with pressure 0.01MPa under carried out concentrating under reduced pressure 120 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, and is dry in 70 ℃ of vacuum drying ovens of temperature, pulverizes and obtains a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains; Add then in said medicine gross weight 0.1% weight magnesium palmitate; In the hollow hard capsules that the Zhejiang oasis medicine capsule company limited of packing into behind the mixing is produced, obtain described bone spur pain-eliminating capsule.
Embodiment 3: the production of bone spur pain-eliminating capsule of the present invention
Implementation step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 120-140 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 120-140 order Semen Coicis fine powder 100 weight portions, then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder is mixed with said Semen Coicis fine powder, obtains a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 4.0 of 10 times of amounts in the said decoction pieces mixture decocts 3 times, and each 3.0 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 2.0 times of amounts of Radix Cynanchi Paniculati fine powder gross weight; Distilled 3 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 12 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 2.0 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 70 ℃ with pressure 0.01MPa under carried out concentrating under reduced pressure 150 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry in 80 ℃ of vacuum drying ovens of temperature, pulverize and obtain a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains; Add then in said medicine gross weight 0.1% weight magnesium stearate; In the hollow hard capsules that the Zhejiang oasis medicine capsule company limited of packing into behind the mixing is produced, obtain described bone spur pain-eliminating capsule.
Embodiment 4: the production of bone spur pain-eliminating capsule of the present invention
Implementation step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 120-150 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 120-150 order Semen Coicis fine powder 100 weight portions, then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder is mixed with said Semen Coicis fine powder, obtains a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3.0 of 10 times of amounts in the said decoction pieces mixture decocts 3 times, and each 2.5 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 2.0 times of amounts of Radix Cynanchi Paniculati fine powder gross weight; Distilled 2.5 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 12 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 2.5 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 60 ℃ with pressure 0.05MPa under carried out concentrating under reduced pressure 130 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry in 65 ℃ of vacuum drying ovens of temperature, pulverize and obtain a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains, and adds then in said medicine gross weight 0.05% weight silicon dioxide and 0.05% weight magnesium stearate, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
Embodiment 5: the production of bone spur pain-eliminating capsule of the present invention
Implementation step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 100-150 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 100-150 order Semen Coicis fine powder 100 weight portions, then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder is mixed with said Semen Coicis fine powder, obtains a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3.6 of 8 times of amounts in the said decoction pieces mixture decocts 2 times, and each 2.5 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 1.0 times of amounts of Radix Cynanchi Paniculati fine powder gross weight; Distilled 2 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 10 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 2.0 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 60 ℃ with pressure 0.05MPa under carried out concentrating under reduced pressure 140 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry in 75 ℃ of vacuum drying ovens of temperature, pulverize and obtain a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains, and adds then in said medicine gross weight 0.05 weight % silicon dioxide and 0.05 weight % magnesium palmitate, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
Embodiment 6: the production of bone spur pain-eliminating capsule of the present invention
Implementation step is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
Use your the high speed Universalpulverizer of instrument and equipment company limited production of Hangzhou remittance that the equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 80-120 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 100 weight portions; Other takes by weighing Semen Coicis and pulverizes, sieves, and takes by weighing 80-120 order Semen Coicis fine powder 100 weight portions, then, the said Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder is mixed with said Semen Coicis fine powder, obtains a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 50 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3.0 of 10 times of amounts in the said decoction pieces mixture decocts 2 times, and each 2.0 hours, collecting decoction; Filter the filtrate for later use that obtains;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 150 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add water-wet again in 1.0 times of amounts of Radix Cynanchi Paniculati fine powder gross weight; Distilled 3 hours toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 100 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 150 weight portions of mixed in equal amounts again, mixing with medicinal residues with described filtrating again behind their mixed grindings; The water that adds then in 10 times of amounts of said five kinds of Chinese medicine weight decocts 2 times, and each 2.0 hours, collecting decoction; Filter; Filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, again 80 ℃ with pressure 0.10MPa under carried out concentrating under reduced pressure 100 minutes, obtain a kind of thick paste;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry in 65 ℃ of vacuum drying ovens of temperature, pulverize and obtain a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains, and adds then in said medicine gross weight 0.05% weight silicon dioxide and 0.05% weight magnesium palmitate, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
Claims (6)
1. the production method of a bone spur pain-eliminating capsule is characterized in that the step of this method is following:
(1) processing of the Radix Angelicae Dahuricae and Radix Angelicae Sinensis and Semen Coicis
The equivalent Radix Angelicae Dahuricae and Radix Angelicae Sinensis are pulverized together, sieved, take by weighing the 80-150 whitish eye root of Dahurian angelica and Radix Angelicae Sinensis fine powder 200 weight portions; In addition Semen Coicis is pulverized, sieved, take by weighing 80-150 order Semen Coicis fine powder 200 weight portions;
Then, the above-mentioned Radix Angelicae Dahuricae and Radix Angelicae Sinensis fine powder are mixed with the Semen Coicis fine powder, obtain a kind of mixture;
(2) processing of Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and Radix Gentianae Macrophyllae
Respectively get Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae decoction pieces of 100 weight portions, mixing is according to said decoction pieces mixture total weight amount meter; The water that adds the pH value 3-4 that 10-12 doubly measures in the said decoction pieces mixture decocts 2-3 time, and 2.0-3.0 hour at every turn, collecting decoction; Filter the filtrate for later use that obtains; The water of said pH value 3-4 is that the adjusting of drinking water using aqueous hydrochloric acid solution obtains; The concentration of said aqueous hydrochloric acid solution is 3-6N;
(3) processing of Radix Cynanchi Paniculati
Take by weighing Radix Cynanchi Paniculati fine powder 300 weight portions, place and in the interlayer extraction pot of the straight-through steam in bottom, to add the water-wet of doubly measuring again in Radix Cynanchi Paniculati fine powder gross weight 1-2; Distilled 2-4 hour toward the straight-through water vapour of extraction pot interlayer and extraction pot internal layer bottom then, collect residual medicine dreg and distillate, described distillate cools off; Until separating out the white crystals body; Filter separation and obtain crystal and filtrating, this crystal natural drying, porphyrize obtain said crystal fine powder;
Take by weighing the Radix Glycyrrhizae and Rhizoma Arisaematis 200 weight portions of mixed in equal amounts, take by weighing Rhizoma Dioscoreae Hypoglaucae, Rhizoma Dioscoreae Nipponicae and Flos Carthami 300 weight portions of mixed in equal amounts again, mix with medicinal residues with described filtrating again after they are mixed; Adding the water of doubly measuring in said five kinds of Chinese medicine weight 8-12 then decocts 2-3 time; Each 2.0-3.0 hour, collecting decoction filtered; The filtrating that filtrating that obtains and above-mentioned steps (2) obtain merges, and concentrating under reduced pressure obtains thick paste again;
(4) mixture that lets step (1) obtain mixes with the thick paste that step (3) obtains, dry and pulverizing, obtains a kind of fine powder;
(5) fine powder that lets step (4) obtain mixes with the crystal fine powder that step (3) obtains, and adds lubricant then, incapsulates behind the mixing, obtains described bone spur pain-eliminating capsule.
2. method according to claim 1 is characterized in that in step (2), and the water that adds the pH value 3-4 of 10 times of amounts in said Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata and the Radix Gentianae Macrophyllae fine powder decocts each 2.0 hours 2 times.
3. method according to claim 1 is characterized in that in step (3), and toward the water-wet of 1 times of amount of Radix Cynanchi Paniculati fine powder adding, straight-through again water vapour distilled 3 hours.
4. method according to claim 1 is characterized in that in step (3), and described concentrating under reduced pressure is under the temperature 60-80 ℃ of condition with pressure 0.01-0.10MPa, to carry out.
5. method according to claim 1 is characterized in that in step (4), described drying is carried out in temperature 60-80 ℃ vacuum drying oven.
6. method according to claim 1 is characterized in that described lubricant is one or more lubricants that are selected from magnesium stearate, magnesium palmitate or silicon dioxide.
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| CN2010102030677A CN101856472B (en) | 2010-06-18 | 2010-06-18 | Production method of spur pain-relieving capsule |
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| CN105194440A (en) * | 2015-10-30 | 2015-12-30 | 王玉龙 | Pharmaceutical composition for treating hyperostosis and preparation method of pharmaceutical composition |
| CN106511830A (en) * | 2016-12-06 | 2017-03-22 | 谭俊杰 | Traditional Chinese medicine composition for treating arthropathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277042A (en) * | 2000-04-07 | 2000-12-20 | 姜宾 | Prolifration treating bolus |
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277042A (en) * | 2000-04-07 | 2000-12-20 | 姜宾 | Prolifration treating bolus |
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药典委员会.骨刺消痛胶囊.《中华人民共和国卫生部药品标准中药成方制剂第20册》.1998,255. * |
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