CN101932353B - 毛细管气雾剂产生器的分配方法和系统 - Google Patents
毛细管气雾剂产生器的分配方法和系统 Download PDFInfo
- Publication number
- CN101932353B CN101932353B CN200880110018XA CN200880110018A CN101932353B CN 101932353 B CN101932353 B CN 101932353B CN 200880110018X A CN200880110018X A CN 200880110018XA CN 200880110018 A CN200880110018 A CN 200880110018A CN 101932353 B CN101932353 B CN 101932353B
- Authority
- CN
- China
- Prior art keywords
- flow
- liquid formulations
- generation unit
- aerosol generation
- capillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000012669 liquid formulation Substances 0.000 claims abstract description 45
- 239000007788 liquid Substances 0.000 claims abstract description 21
- 238000005086 pumping Methods 0.000 claims description 31
- 238000012387 aerosolization Methods 0.000 claims description 9
- 230000000903 blocking effect Effects 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 238000001802 infusion Methods 0.000 claims description 3
- 230000000541 pulsatile effect Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 description 13
- 239000000126 substance Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 8
- 238000011049 filling Methods 0.000 description 4
- 230000002085 persistent effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000011344 liquid material Substances 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A61M15/025—Bubble jet droplet ejection devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
- B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
- B05B15/52—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter for removal of clogging particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
- B08B9/0326—Using pulsations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0402—Cleaning, repairing, or assembling
- Y10T137/0419—Fluid cleaning or flushing
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Emergency Medicine (AREA)
- Nozzles (AREA)
- Spray Control Apparatus (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种分配液体或气雾剂而保持无阻塞毛细管系统的方法,该方法包括:以一流量从泵(30)将液体配方供给至气雾剂产生单元(40)的毛细管(42);和将流量从第一流量周期性地增加至第二流量。
Description
背景技术
在US5743251中已经描述了毛细管气雾剂技术和毛细管气雾剂产生器,其内容通过引用整体纳入本文。
发明内容
根据一个实施例,一种用于分配液体或气雾剂而保持无阻塞毛细管系统的方法包括:以一流量从泵送单元将液体配方供给至气雾剂产生单元的毛细管;和将流量从第一流量周期性地增加至第二流量。
根据另一个实施例,一种在药物输送系统中将液体配方分配至气雾剂产生单元的方法包括:以一流量从泵送单元将液体配方供给至气雾剂产生单元的毛细管;所述泵送单元具有阀装置和两个注射器泵,所述阀装置可操作以在利用一个注射器泵将液体配方输送至气雾剂产生单元期间将液体配方供给至另一个注射器泵的入口;在气雾剂产生单元的毛细管内使液体配方中的至少一部分蒸发;和在每个注射循环至少一次地将流量从第一流量增加至第二流量。
根据又一个实施例,一种用于保持无阻塞毛细管的系统包括:具有毛细管通道的气雾剂产生单元;液体配方;泵送单元,所述泵送单元以一流量将所述液体配方供给至所述气雾剂产生单元,其中在所述气雾剂产生单元的毛细管内将所述液体配方的至少一部分蒸发;和控制器,所述控制器操作所述泵送单元以便为了防止阻塞而提供流量的周期性增加。
根据再一个实施例,一种从流体源分配流体的方法包括:将流体供给至具有第一注射器泵和第二注射器泵的泵送单元,每个注射器泵具有吸入阀和排放阀;通过关闭吸入阀并且打开排放阀从所述第一注射器泵排放流体;和通过打开吸入阀并且关闭排放阀使所述第二注射器泵进行吸入操作以将流体抽吸到所述第二注射器泵中。
附图说明
图1是根据一个实施例的气雾剂产生系统的示意图。
图2是泵送单元和阀组件的示意图。
图3-5是根据一个实施例的阀组件的示意图。
图6是显示周期性地增加流量的优点和有效性的图表。
具体实施方式
气雾剂在多种应用中是有用的。例如,经常希望利用被吸入病人肺中的液体和/或固体(例如粉末)药剂等的细分颗粒的气雾喷射来治疗呼吸疾病或输送药物。气雾剂可通过下述方式由受热的毛细管气雾剂产生器产生:将呈液态的溶液或悬浮液供送至毛细管,同时充分加热毛细管以使得溶液(或悬浮液的载体部分)被挥发,使得溶液(或悬浮液)在从受热的毛细管排出时呈气雾形式。气雾剂产生系统可用于抽吸液体物质或配方,并使该液体物质或配方穿过用于连续气雾化输送的气雾剂产生器或毛细管通道子组件进行分配。
参照图1,示出了一种气雾剂产生系统或药物输送系统10,所述系统包括控制器20、泵送单元30和气雾剂产生单元40。系统10包括呈受热毛细管和/或毛细管通道42形式的气雾剂产生单元40。气雾剂产生单元40将毛细管42加热至足够高的温度以使被引入受热毛细管42中的液体物质或液体配方50至少部分挥发。被挥发的物质通过毛细管通道的出口从毛细管通道被驱逐出,即,来自液体物质源的液体背压使液体从出口排出。
如图1所示,气雾化系统或药物输送系统10包括控制器20,所述控制器适于操作和控制液体物质50至泵送单元30和气雾剂产生单元40的流动。根据一个实施例,控制器20可包括紧凑的可重新配置的输入/输出(I/O)控制器组件,和优选包括用户界面。
可想到的是,当在旨在或不旨在进行气雾化的情况下通过毛细通道分配某些液体时,液体或液体配方的性质可使覆层、凝聚物或沉淀物形成在毛细管通道内侧。另外,这种物质在毛细管或毛细管通道内的累积还可导致阻塞毛细管或毛细管通道。因此,希望的是具有一种通过周期性调整或改变液体配方的流量以便能够清洗或冲洗系统内的任何可能物质的系统和方法。液体配方流量的调整或改变还可保持系统的稳定的标称工作压力和提供质量恒定的可靠的气雾剂。
根据一个实施例,具有改进的可靠性和毛细管气雾剂产生系统的坚固性的气雾化系统或药物输送系统10可通过调整或改变水或液体配方的流量很短的持续时间以便能够清洗或冲洗毛细管或毛细管通道42内的任何可能物质而得到。在图1所示的气雾化系统或药物输送系统10中,毛细管通道和/或毛细管通道42被加热。当产生气雾剂时,由于水或液体配方50的蒸发和将蒸气/液体配方50泵送穿过气雾剂产生单元40出口处的减小的孔口或带尖端的毛细管,系统10可产生大约为1100至1200psi的显著背压。水或液体配方50中的大颗粒和次最佳蒸发还可使系统中的压力逐渐增加至3000至3500psi,在该压力下物质(或阻塞颗粒)或者从毛细管通道排出或者不可挽回地阻塞毛细管或毛细管通道42。
根据一个实施例,一种在药物输送系统中将液体配方分配至气雾剂产生单元40的方法包括下述步骤:将液体配方50分配至泵送单元30;以第一流量将液体配方50从泵送单元30供给至气雾剂产生单元40的毛细管42;在气雾剂产生单元40的毛细管42内使液体配方50的至少一部分蒸发;和将流量从第一流量周期性地增加至第二流量。流量在增加流量的每个这些很短持续时间之后返回第一流量。根据一个优选实施例,第二流量优选是第一流量的至少两倍。还可想到的是,通过增加系统10内的流量,系统10在气雾剂产生单元40的毛细管通道内经历了工作压力的增加。
在与图1所示的系统10一起使用时,用于分配液体配方而保持无阻塞毛细管的系统和/或方法的一个实例可通过以限定的泵送循环周期性地增加从泵送单元30到气雾剂产生单元40的流量来实现。根据一个实施例,无阻塞的毛细管通道可通过下述步骤实现:通过将来自阀组件或装置60的流量(即,第一流量,例如每秒钟20微升)增加至第二流量来清洗或冲洗毛细管或毛细管通道内的任何可能物质。根据一个实施例,第二流量是第一流量的至少两倍(即,大约每秒钟40微升)。另外,增加的流量优选具有很短的持续时间(即,在大约50秒钟的泵送循环中进行二(2)到四(4)秒钟)。
在一个优选的实施例中,毛细管或毛细管通道内的流量的周期性增加不包括毛细管内压力的任何减小。可想到的是,毛细管内压力的减小可导致阻塞毛细管42。因此,流量的增加优选与毛细管42内的压力保持和/或毛细管42内的压力增加同时发生。
根据一个实施例,系统10是一种连续输送系统,其中泵送单元30将液体配方50经由阀装置60连续地输送至毛细管或毛细管通道42。如图2所示,泵送单元30包括双注射器泵70、72和由多个阀62、64、66、68构成的阀装置,所述泵送单元允许同时操作双注射器泵70、72以连续地分配液体物质或液体配方50。双注射器泵70、72还优选产生用于打开和关闭多个阀62、64、66、68的信号并与可编程自动控制器20通讯。根据一个实施例,泵送单元50承受高达至少15MPa(2000psi)的背压,更优选承受20MPa至30MPa(3000psi至4000psi)的背压。
阀装置或阀组件60包括:可连接至液体配方或液体物质50的源的入口110;与入口110流体连通的第一和第二流动路径121、123;和与气雾剂产生装置40的入口流体连通的出口124。如图3所示,第一和第二阀62、64沿第一流动路径121定位,而第三和第四阀66、68沿第二流动路径123定位。根据一个实施例,阀62、64、66、68布置成使得第一流动路径121在第一阀(或吸入阀)62打开且第二阀(或排出阀)64关闭时向第一注射器泵70供给液体配方50,而第二流动路径123在第三阀(或吸入阀)66打开且第四阀(或排出阀)68关闭时向第二注射器泵72供给液体配方或液体物质50。第一流动路径121还在第一阀62关闭且第二阀64打开时将液体配方或液体物质50供给至气雾剂产生单元40。另外,第二流动路径123在第三阀66关闭且第四阀68打开时将液体配方或液体物质50供给至气雾剂产生单元40。
更特别地,现在参照图3-5,第一和第二注射器泵70和72在它们各自的输送冲程交替地与气雾剂产生单元40连通,而在它们各自的抽吸(吸入)冲程交替地与流体(配方)源连通,所有这些动作与阀62、64、66、68协作执行。
具体地参照图3,当第一注射器泵70排放时,注射器泵的输出沿着从第一注射器泵70至毛细管42的流动路径“X1”被引导。流动路径X1通过关闭阀62且打开阀64而建立。同时,第二注射器泵72执行其吸入冲程以便沿着在图3中标示为“X2”的路径从源经过通路144和入口110抽吸流体。为了建立该流动路径X2,阀66打开且阀68关闭。
参照图4,系统正逼近第一注射器泵70的排放冲程的末端,根据握手参数,系统在短暂的持续时间内同时执行在注射器泵72中一新的排放冲程的同时启动。以这种模式,第一注射器70的输出沿着由关闭阀62且打开阀64而建立的第一流动路径“Y1”被引导至毛细管42。类似地,第二注射器泵72的输出通过关闭阀66且打开阀68而沿着路径“Y2”被引导至毛细管42。
参照图5,第一注射器泵70执行其吸入冲程,其中配方从流体源50沿着通过打开阀62且关闭阀64而建立的路径“Z1”被抽吸。同时,第二注射器72继续执行其排放冲程以便利用阀66的关闭和阀68的打开而沿路径“Z2”将配方供给至毛细管42。
将会意识到的是,当第二注射器泵72完成其排放冲程时,第一注射器泵70将已经完成其吸入冲程并且根据握手参数已经启动其排放冲程。此时,流过系统的流动将类似于图4所示的流动,只是第一注射器泵70将在启动其排放冲程而第二注射器泵72将恰好完成其排放冲程。
例如,根据一个实施例,泵送单元30将液体配方50以大约每秒钟20微升(μl/s)分配至阀组件60,用于输送至毛细管或毛细管通道42。阀组件60包括一对注射器70、72,其中一个注射器70分配五十(50)秒钟,其后该注射器重新填充而另一个注射器72分配五十(50)秒钟。因而,可利用每50秒钟的注射器70、72的自然的周期性交接过程作为一种将液体配方的流量从20μl/s增加至40μl/s很短的持续时间的便利机会。
根据另一个实施例,流量的增加可通过在从第二注射器72分配的同时第一注射器70仍进行分配来实现。具体地,流量的重叠或增加可在二(2)到四(4)秒钟内发生。除了使流量增加或加倍之外,系统10还优选在注射器开始将液体配方50分配至气雾剂产生器40之前将注射器中的流体或液体配方50加压至接近工作压力的压力值。
在一个替代的实施例中,可使用单个注射器泵送单元30,其中流量被增加作为输送循环的一部分。根据单个注射器泵送系统,系统10具有限定的填充循环,在填充循环时,流量的短脉冲或周期性增加使工作压力增大并且将可累积在毛细管或毛细管通道42内部的任何物质排出。
应该理解的是,流量的周期性增加的定时可以是液体物质或配方50的性质或浓度、流量和气雾化参数的函数。例如,具有(药剂或其它物质的)较高浓度的液体物质或配方50优选需要流量的增加(即,冲洗)比具有较低浓度的液体配方50更频繁。
根据另一个实施例,将第一流量调整或改变至第二流量可通过多个短脉冲进行,其中多个短脉冲中的每一个以每10秒钟或更短时间一个脉冲的频率发生少于1秒钟的时间。另外,可想到的是通过增加流量,可实现系统内的工作压力增加10-20%,这可防止任何大量的大沉积堆积在毛细管42内部。
图6示出了气雾化系统中的流量的周期性增加的优点和有效性的一个实例。第一曲线80示出了在流量没有任何改变的情况下通常的毛细管压力状况。由于有几次故障模式,诸如配方颗粒尺寸、次最佳气雾化等,可看出毛细管42内的压力在几秒钟时间内上升。根据一个实施例,毛细管42内的堵塞物被从毛细管中排出或者导致不可挽回的阻塞。第二曲线82示出了流量每50秒钟加倍时的状况。流量在二(2)至四(4)秒钟内的加倍导致液体配方的工作压力增加10-20%,这通过防止任何大量的大颗粒堆积在毛细管内部而使毛细管无阻塞。流量的周期性增加不仅有助于保持毛细管无阻塞,而且还提供稳定的标称工作压力和产生质量恒定的气雾剂。
虽然已经描述了各种实施例,应该理解的是,可进行改变和修改对所属领域的技术人员来说是显而易见的。这种改变和修改可看作在其所附的权利要求书的权限和范围内。
Claims (13)
1.一种用于保持无阻塞毛细管的系统,所述系统包括:
具有毛细管通道的气雾剂产生单元;
液体配方;
泵送单元,所述泵送单元以一流量将所述液体配方供给至所述气雾剂产生单元,其中在所述气雾剂产生单元的毛细管内将所述液体配方的至少一部分蒸发;和
控制器,所述控制器操作所述泵送单元以便为了防止阻塞而提供流量的周期性增加,并且所述控制器针对具有更高浓度的液体配方增大使流量增加的频率。
2.如权利要求1所述的系统,其中流量的周期性增加还包括将所述流量从第一流量周期性地增加至第二流量,所述第二流量是所述第一流量的至少两倍。
3.如权利要求1所述的系统,其中所述泵送单元具有一对注射器泵,所述泵送单元包括阀装置,所述阀装置能够操作以在利用一个注射器泵将液体配方输送至气雾剂产生单元期间将液体配方供给至另一个注射器泵的入口,而且在每个注射循环至少一次地将流量从第一流量增加至第二流量。
4.如权利要求1所述的系统,其中,所述控制器以每10秒钟或更短时间一次脉冲的频率将流量从第一流量增加至第二流量并保持少于一秒钟的时间。
5.如权利要求1所述的系统,其中,所述控制器根据液体配方、第一流量和期望的气雾化参数来对流量周期性增加的定时进行调整。
6.一种分配液体或气雾剂而保持无阻塞毛细管系统的方法,所述方法包括:
以一流量从泵送单元将液体配方供给至气雾剂产生单元的毛细管;
将流量从第一流量周期性地增加至第二流量;和
针对具有更高浓度的液体配方增大使流量增加的频率。
7.如权利要求6所述的方法,还包括在气雾剂产生单元的毛细管内使液体配方中的至少一部分蒸发。
8.如权利要求6所述的方法,其中所述第二流量是所述第一流量的至少两倍。
9.如权利要求6所述的方法,其中所述泵送单元包括阀装置,所述阀装置能够操作以在利用一个注射器泵将液体配方输送至气雾剂产生单元期间将液体配方供给至另一个注射器泵的入口,而且其中将流量从第一流量增加至第二流量在每个注射循环进行至少一次。
10.如权利要求6所述的方法,其中所述系统具有一工作压力,而且其中将流量从所述第一流量周期性地增加至第二流量使系统内的工作压力增大。
11.如权利要求6所述的方法,还包括以每10秒钟或更短时间一次脉冲的频率将所述第一流量增加至第二流量并保持少于一秒钟的时间。
12.如权利要求6所述的方法,还包括根据液体配方、第一流量和期望的气雾化参数来对流量周期性增加的定时进行调整。
13.如权利要求6所述的方法,其中所述毛细管系统是药物输送系统。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97699107P | 2007-10-02 | 2007-10-02 | |
US60/976,991 | 2007-10-02 | ||
PCT/IB2008/003256 WO2009044280A2 (en) | 2007-10-02 | 2008-10-01 | Dispensing method and system of a capillary aerosol generator |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101932353A CN101932353A (zh) | 2010-12-29 |
CN101932353B true CN101932353B (zh) | 2013-07-03 |
Family
ID=40348133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880110018XA Active CN101932353B (zh) | 2007-10-02 | 2008-10-01 | 毛细管气雾剂产生器的分配方法和系统 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20090084865A1 (zh) |
EP (1) | EP2211955B1 (zh) |
JP (1) | JP5205463B2 (zh) |
KR (1) | KR101533471B1 (zh) |
CN (1) | CN101932353B (zh) |
AU (1) | AU2008306583A1 (zh) |
BR (1) | BRPI0817649B8 (zh) |
CA (1) | CA2701389C (zh) |
ES (1) | ES2623906T3 (zh) |
HU (1) | HUE032676T2 (zh) |
MX (1) | MX2010003494A (zh) |
PL (1) | PL2211955T3 (zh) |
PT (1) | PT2211955T (zh) |
WO (1) | WO2009044280A2 (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2842407T3 (es) | 2010-12-22 | 2021-07-14 | Syqe Medical Ltd | Sistema de administración de fármacos |
US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
ES2869448T3 (es) * | 2013-07-19 | 2021-10-25 | Graco Minnesota Inc | Sistema de lubricación de juntas multipunto |
WO2015010029A1 (en) * | 2013-07-19 | 2015-01-22 | Graco Minnesota Inc. | Pump changeover algorithm for spray system |
WO2015042412A1 (en) | 2013-09-20 | 2015-03-26 | E-Nicotine Technology. Inc. | Devices and methods for modifying delivery devices |
FR3019442A1 (fr) * | 2014-04-04 | 2015-10-09 | Agece Ecole Centrale D Electronique | Dispositif d'ajustement d'une quantite de nicotine inhalee par un utilisateur et terminal portable communiquant |
WO2016001922A1 (en) | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
EP3939639A1 (en) | 2014-06-30 | 2022-01-19 | Syqe Medical Ltd. | Drug dose cartridge for an inhaler device |
EP3954417A1 (en) | 2014-06-30 | 2022-02-16 | Syqe Medical Ltd. | Method and device for vaporization and inhalation of isolated substances |
US11298477B2 (en) | 2014-06-30 | 2022-04-12 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
WO2016001926A1 (en) | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Flow regulating inhaler device |
WO2016001924A2 (en) | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
EP3399972B1 (en) | 2016-01-06 | 2021-03-31 | Syqe Medical Ltd. | Low dose therapeutic treatment |
US10974299B2 (en) * | 2017-07-17 | 2021-04-13 | Desktop Metal, Inc. | Additive fabrication using variable build material feed rates |
CN111148579B (zh) * | 2017-12-14 | 2021-10-01 | 斯坦福设备有限公司 | 气雾剂产生器孔板到支撑件的安装 |
IT201800006391A1 (it) * | 2018-06-18 | 2019-12-18 | Sistema per la vaporizzazione molecolare di una sostanza liquida | |
US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3450092A (en) * | 1965-07-08 | 1969-06-17 | Vilbiss Co The De | Color change apparatus |
US5526962A (en) * | 1993-05-10 | 1996-06-18 | Medimpex Ets. | Double piston pump for administering medication |
CN1222089A (zh) * | 1996-05-15 | 1999-07-07 | 菲利普莫里斯生产公司 | 气溶胶和制备气溶胶的方法和设备 |
EP1066850A1 (en) * | 1999-07-08 | 2001-01-10 | Siemens-Elema AB | Medical Nebulizer |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4960992A (en) * | 1983-08-30 | 1990-10-02 | Research Corporation Technologies | Method and means for vaporizing liquids by means of heating a sample capillary tube for detection or analysis |
US4575609A (en) * | 1984-03-06 | 1986-03-11 | The United States Of America As Represented By The United States Department Of Energy | Concentric micro-nebulizer for direct sample insertion |
JP3042978B2 (ja) * | 1996-03-25 | 2000-05-22 | エムケー精工株式会社 | 洗車機 |
US6792940B2 (en) * | 1996-05-13 | 2004-09-21 | Universidad De Sevilla | Device and method for creating aerosols for drug delivery |
US5916524A (en) * | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
US6003512A (en) * | 1997-11-13 | 1999-12-21 | Lovelace Respiratory Research Institute | Dust gun-aerosol generator and generation |
US6276347B1 (en) * | 1998-09-25 | 2001-08-21 | Micro Coating Technologies, Inc. | Systems and methods for delivering atomized fluids |
US6501052B2 (en) * | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
US6640050B2 (en) * | 2001-09-21 | 2003-10-28 | Chrysalis Technologies Incorporated | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
US7004407B2 (en) * | 2001-12-04 | 2006-02-28 | Mystic Tan, Inc. | Uniform metering system for spray applications |
US6804458B2 (en) * | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
WO2004022242A1 (en) * | 2002-09-06 | 2004-03-18 | Chrysalis Technologies Incorporated | Aerosol generating device and method of use thereof |
US6772757B2 (en) * | 2002-10-25 | 2004-08-10 | Chrysalis Technologies Incorporated | Concentric controlled temperature profile fluid vaporizing device |
US20040223918A1 (en) * | 2003-05-07 | 2004-11-11 | Chrysalis Technologies Incorporated | Aerosolization of cromolyn sodium using a capillary aerosol generator |
ES2559410T3 (es) * | 2004-04-23 | 2016-02-12 | Philip Morris Products S.A. | Generadores de aerosol y métodos para producir aerosoles |
US7167776B2 (en) * | 2004-09-02 | 2007-01-23 | Philip Morris Usa Inc. | Method and system for controlling a vapor generator |
US7674671B2 (en) * | 2004-12-13 | 2010-03-09 | Optomec Design Company | Aerodynamic jetting of aerosolized fluids for fabrication of passive structures |
ES2675369T3 (es) * | 2006-10-02 | 2018-07-10 | Philip Morris Products S.A. | Sistema de suministro de presión alta continua |
-
2008
- 2008-10-01 MX MX2010003494A patent/MX2010003494A/es active IP Right Grant
- 2008-10-01 KR KR1020107009413A patent/KR101533471B1/ko active IP Right Grant
- 2008-10-01 EP EP08836420.3A patent/EP2211955B1/en active Active
- 2008-10-01 PT PT88364203T patent/PT2211955T/pt unknown
- 2008-10-01 WO PCT/IB2008/003256 patent/WO2009044280A2/en active Application Filing
- 2008-10-01 BR BRPI0817649A patent/BRPI0817649B8/pt active IP Right Grant
- 2008-10-01 ES ES08836420.3T patent/ES2623906T3/es active Active
- 2008-10-01 JP JP2010527567A patent/JP5205463B2/ja active Active
- 2008-10-01 US US12/285,314 patent/US20090084865A1/en not_active Abandoned
- 2008-10-01 CA CA2701389A patent/CA2701389C/en active Active
- 2008-10-01 HU HUE08836420A patent/HUE032676T2/en unknown
- 2008-10-01 PL PL08836420T patent/PL2211955T3/pl unknown
- 2008-10-01 CN CN200880110018XA patent/CN101932353B/zh active Active
- 2008-10-01 AU AU2008306583A patent/AU2008306583A1/en not_active Abandoned
-
2015
- 2015-03-13 US US14/657,489 patent/US20150182707A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3450092A (en) * | 1965-07-08 | 1969-06-17 | Vilbiss Co The De | Color change apparatus |
US5526962A (en) * | 1993-05-10 | 1996-06-18 | Medimpex Ets. | Double piston pump for administering medication |
CN1222089A (zh) * | 1996-05-15 | 1999-07-07 | 菲利普莫里斯生产公司 | 气溶胶和制备气溶胶的方法和设备 |
EP1066850A1 (en) * | 1999-07-08 | 2001-01-10 | Siemens-Elema AB | Medical Nebulizer |
Also Published As
Publication number | Publication date |
---|---|
CA2701389A1 (en) | 2009-04-09 |
CN101932353A (zh) | 2010-12-29 |
CA2701389C (en) | 2015-12-15 |
PT2211955T (pt) | 2017-06-29 |
BRPI0817649B8 (pt) | 2021-06-22 |
ES2623906T3 (es) | 2017-07-12 |
US20150182707A1 (en) | 2015-07-02 |
EP2211955A2 (en) | 2010-08-04 |
HUE032676T2 (en) | 2017-10-30 |
US20090084865A1 (en) | 2009-04-02 |
KR20100080823A (ko) | 2010-07-12 |
JP5205463B2 (ja) | 2013-06-05 |
WO2009044280A3 (en) | 2009-07-09 |
WO2009044280A2 (en) | 2009-04-09 |
BRPI0817649B1 (pt) | 2020-02-11 |
BRPI0817649A2 (pt) | 2017-05-16 |
AU2008306583A1 (en) | 2009-04-09 |
EP2211955B1 (en) | 2017-04-12 |
MX2010003494A (es) | 2010-06-09 |
JP2010540149A (ja) | 2010-12-24 |
KR101533471B1 (ko) | 2015-07-02 |
PL2211955T3 (pl) | 2017-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101932353B (zh) | 毛细管气雾剂产生器的分配方法和系统 | |
FR2792843A1 (fr) | Dispositif de commande de debit passif pour pompes implantables | |
JP4156801B2 (ja) | 患者制御薬品投与装置 | |
JP7403533B2 (ja) | 医療用ポンプ | |
EP1503820B1 (en) | Dispenser for patient infusion device | |
US6723072B2 (en) | Plunger assembly for patient infusion device | |
JP2010540149A5 (zh) | ||
CN101583394A (zh) | 持续高压输送系统 | |
US20040078028A1 (en) | Plunger assembly for patient infusion device | |
ATE430595T1 (de) | Vom patienten gesteuerte vorrichtung zur arzneimittelabgabe | |
CA2394559A1 (en) | System and method for application of medicament into the nasal passage | |
WO1997026998A3 (en) | Refillable pump dispenser and refill cartridge | |
WO2001058506A3 (en) | Drug delivery device and method | |
AU2001277135A1 (en) | Metered dose dispensing aerosol valve | |
RU2004117070A (ru) | Насос для инфузии | |
CN113165790B (zh) | 雾化器 | |
GB9724223D0 (en) | Drug delivery device | |
WO2015027000A2 (en) | Anti-clog pump nozzles, pumps and refill units | |
US20040084555A1 (en) | Device for mixing and delivering pharmaceutical compositions | |
JP3073979B1 (ja) | 薬液注入装置 | |
US20070073243A1 (en) | Fluid dosing device comprising gear transmission actuator | |
DE102022000980A1 (de) | Dosiervorrichtung | |
CA2592954A1 (en) | System and method for application of medicament into the nasal passage |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |